Statistics: Unlocking the Power of Data Lock 5 Hypothesis Testing, Synthesis STAT 101 Dr. Kari Lock Morgan 10/4/12 SECTION 4.5, Essential Synthesis B Connecting

Statistics: Unlocking the Power of Data Lock5

Hypothesis Testing,Synthesis

STAT 101

Dr. Kari Lock Morgan

10/4/12

SECTION 4.5, Essential Synthesis B• Connecting intervals and tests (4.5)• Statistical versus practical significance (4.5)• Multiple testing (4.5)• Synthesis activities


• Exam 1: Thursday 10/11• Open only to a calculator and one double sided

page of notes prepared by you• Emphasis on conceptual understanding

Exam 1


• Last year’s midterm, with solutions, are available on the course website (under documents)

• Review problems are posted for you to work through

• Doing problems is the key to success!!!

Practice


• Work lots of practice problems! • Take last year’s exams under realistic

conditions (time yourself, do it all before looking at the solutions, etc.)

• Prepare a good cheat sheet and use it when working problems

• Read the corresponding sections in the book if there are concepts you are still confused about

Keys to In-Class Exam Success


• Monday• Heather 4 – 6pm, Old Chem 211A• Sam, 6 – 9pm, Old Chem 211A

• Tuesday• Kari 1:30 – 2:30 pm, Old Chem 216• Tracy 5 – 7 pm, Old Chem 211A

• Wednesday• Kari 1 – 3pm, Old Chem 216• Tracy 4:30 – 5:30 pm, Old Chem 211A• Heather 8 – 9pm, Old Chem 211A

• Thursday• Kari 1 – 2:30 pm, Old Chem 216

Office Hours Next Week


Clickers

Reminder: sharing clickers is a case of academic dishonesty and will be treated as such.

If caught clicking in with two clickers, everyone involved will

• receive a 0 for their entire clicker grade (10% of the final grade)

• be reported to the dean to follow up regarding academic dishonesty


Body TemperatureWe created a bootstrap distribution for average

body temperature by resampling with replacement from the original sample (


Body TemperatureWe also created a randomization distribution to see

if average body temperature differs from 98.6F by adding 0.34 to every value to make the null true, and then resampling with replacement from this modified sample:


Body TemperatureThese two distributions are identical (up to

random variation from simulation to simulation) except for the center

The bootstrap distribution is centered around the sample statistic, 98.26, while the randomization distribution is centered around the null hypothesized value, 98.6

The randomization distribution is equivalent to the bootstrap distribution, but shifted over


Body Temperature

Bootstrap Distribution

Randomization DistributionH0: = 98.6Ha: ≠ 98.6

98.26 98.6


Body Temperature

Bootstrap Distribution

98.26 98.4

Randomization DistributionH0: = 98.4Ha: ≠ 98.4


Intervals and Tests

If a 95% CI misses the parameter in H0, then a two-tailed test should reject H0

at a 5% significance level.

If a 95% CI contains the parameter in H0, then a two-tailed test should not reject H0

at a 5% significance level.


Intervals and TestsA confidence interval represents the range of

plausible values for the population parameter

If the null hypothesized value IS NOT within the CI, it is not a plausible value and should be rejected

If the null hypothesized value IS within the CI, it is a plausible value and should not be rejected


• Using bootstrapping, we found a 95% confidence interval for the mean body temperature to be (98.05, 98.47)

• This does not contain 98.6, so at α = 0.05 we would reject H0 for the hypotheses

H0 : = 98.6Ha : ≠ 98.6

Body Temperatures


Both Father and Mother

“Does a child need both a father and a mother to grow up happily?”

• Let p be the proportion of adults aged 18-29 in 2010 who say yes. A 95% CI for p is (0.487, 0.573).

• Testing H0: p = 0.5 vs Ha: p ≠ 0.5 with α = 0.05, wea) Reject H0

b) Do not reject H0

c) Reject Ha

d) Do not reject Ha

0.5 is within the CI, so is a plausible value for p.

http://www.pewsocialtrends.org/2011/03/09/for-millennials-parenthood-trumps-marriage/#fn-7199-1

http://www.pewsocialtrends.org/2011/03/09/for-millennials-parenthood-trumps-marriage/



Both Father and Mother

“Does a child need both a father and a mother to grow up happily?”

• Let p be the proportion of adults aged 18-29 in 1997 who say yes. A 95% CI for p is (0.533, 0.607).

• Testing H0: p = 0.5 vs Ha: p ≠ 0.5 with α = 0.05, wea) Reject H0

b) Do not reject H0

c) Reject Ha

d) Do not reject Ha

0.5 is not within the CI, so is not a plausible value for p.

http://www.pewsocialtrends.org/2011/03/09/for-millennials-parenthood-trumps-marriage/#fn-7199-1




Intervals and TestsConfidence intervals are most useful when you

want to estimate population parameters

Hypothesis tests and p-values are most useful when you want to test hypotheses about population parameters

Confidence intervals give you a range of plausible values; p-values quantify the strength of evidence against the null hypothesis


Interval, Test, or Neither?

Is the following question best assessed using a confidence interval, a hypothesis test, or is statistical inference not relevant?

On average, how much more do adults who played sports in high school exercise than adults who did not play sports in high school?

a) Confidence intervalb) Hypothesis testc) Statistical inference not relevant




Do a majority of adults riding a bicycle wear a helmet?





On average, were the 23 players on the 2010 Canadian Olympic hockey team older than the 23 players on the 2010 US Olympic hockey team?



• With small sample sizes, even large differences or effects may not be significant

• With large sample sizes, even a very small difference or effect can be significant

• A statistically significant result is not always practically significant, especially with large sample sizes

Statistical vs Practical Significance


• Example: Suppose a weight loss program recruits 10,000 people for a randomized experiment.

• A difference in average weight loss of only 0.5 lbs could be found to be statistically significant

• Suppose the experiment lasted for a year. Is a loss of ½ a pound practically significant?

Statistical vs Practical Significance


Diet and Sex of Baby•Are certain foods in your diet associated with whether or not you conceive a boy or a girl?

•To study this, researchers asked women about their eating habits, including asking whether or not they ate 133 different foods regularly

•A significant difference was found for breakfast cereal (mothers of boys eat more), prompting the headline “Breakfast Cereal Boosts Chances of Conceiving Boys”.

http://www.newscientist.com/article/dn13754-breakfast-cereals-boost-chances-of-conceiving-boys.html

http://www.newscientist.com/article/dn13754-breakfast-cereals-boost-chances-of-conceiving-boys.html


“Breakfast Cereal Boosts Chances of Conceiving Boys”

I’m pregnant (with identical twins!), and am very curious about whether I’m going to have boys or girls!

I eat breakfast cereal every morning. Do you think this boosts my chances of having boys?

a) yesb) noc) impossible to tell


Hypothesis TestsFor each of the 133 foods studied, a hypothesis test was conducted for a difference between mothers who conceived boys and girls in the proportion who consume each food

State the null and alternative hypotheses

If there are NO differences (all null hypotheses are true), about how many significant differences would be found using α = 0.05?

A significant difference was found for breakfast cereal (mothers of boys eat more), prompting the headline “Breakfast Cereal Boosts Chances of Conceiving Boys”. How might you explain this?


Hypothesis TestsState the null and alternative hypotheses

If there are NO differences (all null hypotheses are true), about how many significant differences would be found using α = 0.05?

A significant difference was found for breakfast cereal (mothers of boys eat more), prompting the headline “Breakfast Cereal Boosts Chances of Conceiving Boys”. How might you explain this?

pb: proportion of mothers who have boys that consume the food regularlypg: proportion of mothers who have girls that consume the food regularly

H0: pb = pg

Ha: pb ≠ pg

133 0.05 = 6.65

Random chance; several tests (about 6 or 7) are going to be significant, even if no differences exist


Multiple Testing

When multiple hypothesis tests are conducted, the chance that at least one test

incorrectly rejects a true null hypothesis increases with the number of tests.

If the null hypotheses are all true, α of the tests will yield statistically significant results

just by random chance.


www.causeweb.orgAuthor: JB Landers

http://www.causeweb.org/


Multiple Comparisons• Consider a topic that is being investigated by research teams all over the world

Using α = 0.05, 5% of teams are going to find something significant, even if the null hypothesis is true


Multiple Comparisons

•Consider a research team/company doing many hypothesis tests

Þ Using α = 0.05, 5% of tests are going to be significant, even if the null hypotheses are all true


• This is a serious problem

• The most important thing is to be aware of this issue, and not to trust claims that are obviously one of many tests (unless they specifically mention an adjustment for multiple testing)

•There are ways to account for this (e.g. Bonferroni’s Correction), but these are beyond the scope of this class

Multiple Comparisons


Publication Bias

• publication bias refers to the fact that usually only the significant results get published

• The one study that turns out significant gets published, and no one knows about all the insignificant results

• This combined with the problem of multiple comparisons, can yield very misleading results


http://xkcd.com/882/

Jelly Beans Cause Acne!








SummaryIf a null hypothesized value lies inside a 95% CI,

a two-tailed test using α = 0.05 would not reject H0

If a null hypothesized value lies outside a 95% CI, a two-tailed test using α = 0.05 would reject H0

Statistical significance is not always the same as practical significance

Using α = 0.05, 5% of all hypothesis tests will lead to rejecting the null, even if all the null hypotheses are true


SynthesisYou’ve now learned how to successfully

collect and analyze data to answer a question!

Let’s put that to use…


Exercise and PulseDoes just 5 seconds of exercise increase pulse rate? What are the cases and variables? Are they categorical or

quantitative? Identify explanatory and response. Does the question imply causality? How would you collect data

to answer it? Merge with 3 other groups to collect data. (check pulse rate) Visualize and summarize your data. Before doing any formal

inference, take a guess at answering the question. Conduct a hypothesis test to answer the question. State your

hypotheses, calculate the p-value, make a conclusion in context. How much does 5 seconds of exercise increase pulse rate by?

State the parameter of interest and give and interpret a confidence interval.

http://www.webmd.com/heart/taking-a-pulse-heart-rate

http://www.webmd.com/heart/taking-a-pulse-heart-rate


Tongue Curling

What proportion of people can roll their tongue?

Can you roll your tongue? (a) Yes (b) No Visualize and summarize the data. What is your

point estimate? Give and interpret a confidence interval. Tongue rolling has been said to be a dominant

trait, in which case theoretically 75% of all people should be able to roll their tongues. Do our data provide evidence otherwise?


Tuesday

Tuesday’s class with be a review session There will be no clicker questions and no

new material, so attendance is optional I’ll spend the first half reviewing the key

topics we’ve covered so far, and then will have open Q and A


To DoRead Essential Synthesis A, B

Prepare for Exam 1 (Thursday, 10/11) Study

Make page of notes for Exam 1

Do review problems

Take practice exam

Solutions under documents on course webpage

http://stat.duke.edu/courses/Fall12/sta101.002/ReviewExam1.pdf

http://stat.duke.edu/courses/Fall12/sta101.002/exam1inclass_S12.pdf

Documents

Statistics: Unlocking the Power of Data Lock 5 Hypothesis Testing, Synthesis STAT 101 Dr. Kari Lock Morgan 10/4/12 SECTION 4.5, Essential Synthesis B Connecting