SPP1468 IMMUNOBONE Publicationlist

1. Cejka D, Hayer S, Niederreiter B, Sieghart W, Fuereder T, Zwerina J & Schett G. Mammalian Target of Rapamycin Signaling Is Crucial for Joint Destruction in Experimental Arthritis and Is Activated in Osteoclasts From Patients With Rheumatoid Arthritis. Arthritis and Rheumatism 62, 2294-2302, doi:10.1002/art.27504 (2010).

2. Heiland GR, Zwerina K, Baum W, Kireva T, Distler JH, Grisanti M, Asuncion F, Li XD, Ominsky M, Richards W, Schett G & Zwerina J. Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression. Annals of the Rheumatic Diseases 69, 2152-2159, doi:10.1136/ard.2010.132852 (2010).

3. Mei HE, Frolich D, Giesecke C, Loddenkemper C, Reiter K, Schmidt S, Feist E, Daridon C, Tony HP, Radbruch A & Dorner T. Steady-state generation of mucosal IgA(+) plasmablasts is not abrogated by B-cell depletion therapy with rituximab. Blood 116, 5181-5190, doi:10.1182/blood-2010-01-266536 (2010).

4. Nimmerjahn F, Lux A, Albert H, Woigk M, Lehmann C, Dudziak D, Smith P & Ravetch JV. Fc gamma RIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proceedings of the National Academy of Sciences of the United States of America 107, 19396-19401, doi:10.1073/pnas.1014515107 (2010).

5. Sahinbegovic E, Dallos T, Aigner E, Axmann R, Manger B, Englbrecht M, Schoniger-Hekele M, Karonitsch T, Stamm T, Farkas M, Karger T, Stolzel U, Keysser G, Datz C, Schett G & Zwerina J. Musculoskeletal Disease Burden of Hereditary Hemochromatosis. Arthritis and Rheumatism 62, 3792-3798, doi:10.1002/art.27712 (2010).

6. Schett G & Rudwaleit M. Can we stop progression of ankylosing spondylitis? Best Practice & Research in Clinical Rheumatology 24, 363-371, doi:10.1016/j.berh.2010.01.005 (2010).

7. Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G & Penninger JM. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468, 98-+, doi:10.1038/nature09387 (2010).

8. Stach CM, Bauerle M, Englbrecht M, Kronke G, Engelke K, Manger B & Schett G. Periarticular Bone Structure in Rheumatoid Arthritis Patients and Healthy Individuals Assessed by High-Resolution Computed Tomography. Arthritis and Rheumatism 62, 330-339, doi:10.1002/art.27252 (2010).

9. Zaiss MM, Frey B, Hess A, Zwerina J, Luther J, Nimmerjahn F, Engelke K, Kollias G, Hunig T, Schett G & David JP. Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis. Journal of Immunology 184, 7238-7246, doi:10.4049/jimmunol.0903841 (2010).

10. Anthony RM & Nimmerjahn F. The role of differential IgG glycosylation in the interaction of antibodies with Fc gamma Rs in vivo. Current Opinion in Organ Transplantation 16, 7-14, doi:10.1097/MOT.0b013e328342538f (2011).

11. Appel H, Maier R, Wu P, Scheer R, Hempfing A, Kayser R, Thiel A, Radbruch A, Loddenkemper C, Sieper J. Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther. 2011 Jun 20;13(3):R95. doi: 10.1186/ar3370. (2011)

12. Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Brauer R & Tuckermann JP. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proceedings of the National Academy of Sciences of the United States of America 108, 19317-19322, doi:10.1073/pnas.1105857108 (2011).

13. Conaway HH, Pirhayati A, Persson E, Pettersson U, Svensson O, Lindholm C, Henning P, Tuckermann J, Lerner UH. Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor. J Biol Chem. 2011 Sep 9;286(36):31425-36. doi: 10.1074/jbc.M111.247734. Epub 2011 Jun 29. (2011)

14. Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Köhler A, Peschke K, Vöhringer D, Waskow C, Krieg T, Müller W, Waisman A, Hartmann K, Gunzer M, Roers A. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens. Immunity. 2011 Jun 24;34(6):973-84. doi: 10.1016/j.immuni.2011.03.028. (2011)

15. Finzel S, Englbrecht M, Engelke K, Stach C & Schett G. A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis. Annals of the Rheumatic Diseases 70, 122-127, doi:10.1136/ard.2010.132423 (2011).

16. Finzel S, Ohrndorf S, Englbrecht M, Stach C, Messerschmidt J, Schett G & Backhaus M. A Detailed Comparative Study of High-Resolution Ultrasound and Micro-Computed Tomography for Detection of Arthritic Bone Erosions. Arthritis and Rheumatism 63, 1231-1236, doi:10.1002/art.30285 (2011).

17. Finzel S, Rech J, Schmidt S, Engelke K, Englbrecht M, Stach C & Schett G. Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion. Annals of the Rheumatic Diseases 70, 1587-1593, doi:10.1136/ard.2010.148395 (2011).

18. Hess A, Axmann R, Rech J, Finzel S, Heindl C, Kreitz S, Sergeeva M, Saake M, Garcia M, Kollias G, Straub RH, Sporns O, Doerfler A, Brune K & Schett G. Blockade of TNF-alpha rapidly inhibits pain responses in the central nervous system. Proceedings of the National Academy of Sciences of the United States of America 108, 3731-3736, doi:10.1073/pnas.1011774108 (2011).

19. Hildebrand D, Heeg K & Kubatzky KF. Pasteurella multocida Toxin-Stimulated Osteoclast Differentiation Is B Cell Dependent. Infection and Immunity 79, 220-228, doi:10.1128/iai.00565-10 (2011).

20. Köhler A, De Filippo K, Hasenberg M, van den Brandt C, Nye E, Hosking MP, Lane TE, Männ L, Ransohoff RM, Hauser AE, Winter O, Schraven B, Geiger H, Hogg N, Gunzer M. G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood. 2011 Apr 21;117(16):4349-57. doi: 10.1182/blood-2010-09-308387. (2011)

21. Luther J, Driessler F, Megges M, Hess A, Herbort B, Mandic V, Zaiss MM, Reichardt A, Zech C, Tuckermann JP, Calkhoven CF, Wagner EF, Schett G & David JP. Elevated Fra-1 expression causes severe lipodystrophy. Journal of Cell Science 124, 1465-1476, doi:10.1242/jcs.079855 (2011).

22. Lux A, Nimmerjahn F. Impact of differential glycosylation on IgG activity. Adv Exp Med Biol. 2011;780:113-24. doi: 10.1007/978-1-4419-5632-3_10. (2011)

23. Polzer K, Neubert K, Meister S, Frey B, Baum W, Distler JH, Guckel E, Schett G, Voll RE & Zwerina J. Proteasome Inhibition Aggravates Tumor Necrosis Factor-

Mediated Bone Resorption in a Mouse Model of Inflammatory Arthritis. Arthritis and Rheumatism 63, 670-680, doi:10.1002/art.30177 (2011).

24. Rauch A, Gossye V. Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP, De Bosscher K. An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation. FASEB J. 2011 Apr;25(4):1323-32. doi: 10.1096/fj.10-173393. (2011).

25. Schett G. Structural Bone Changes in Spondyloarthritis: Mechanisms, Clinical Impact and Therapeutic Considerations. American Journal of the Medical Sciences 341, 269-271, doi:10.1097/MAJ.0b013e31820f8b29 (2011).

26. Schulze J, Bickert T, Beil FT, Zaiss MM, Albers J, Wintges K, Streichert T, Klaetschke K, Keller J, Hissnauer TN, Spiro AS, Gessner A, Schett G, Amling M, McKenzie ANJ, Horst AK & Schinke T. Interleukin-33 Is Expressed in Differentiated Osteoblasts and Blocks Osteoclast Formation From Bone Marrow Precursor Cells. Journal of Bone and Mineral Research 26, 704-717, doi:10.1002/jbmr.269 (2011).

27. Waisman A.T helper cell populations: as flexible as the skin? Eur J Immunol. 2011 Sep;41(9):2539-43. doi: 10.1002/eji.201141938. (2011).

28. Winter O, Mohr E, Manz RA. Alternative cell types form a Multi-Component-Plasma-Cell-Niche. Immunol Lett. 2011 Dec 30;141(1):145-6. doi: 10.1016/j.imlet.2011.07.006. (2011).

29. Zaiss MM, Kurowska-Stolarska M, Bohm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY & Schett G. IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF-alpha-Mediated Bone Loss. Journal of Immunology 186, 6097-6105, doi:10.4049/jimmunol.1003487 (2011).

30. Zwerina K, Baum W, Axmann R, Heiland GR, Distler JH, Smolen J, Hayer S, Zwerina J & Schett G. Vitamin D receptor regulates TNF-mediated arthritis. Annals of the Rheumatic Diseases 70, 1122-1129, doi:10.1136/ard.2010.142331 (2011).

31. Bay-Jensen AC, Leeming DJ, Kleyer A, Veidal SS, Schett G & Karsdal MA. Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study. Rheumatology International 32, 3565-3572, doi:10.1007/s00296-011-2237-8 (2012).

32. Bohm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J, Zech C, Stock M, Scholtysek C, Engelke K, Hess A, Tuckermann JP, Schett G & David JP. RSK2 protects mice against TNF-induced bone loss. Journal of Cell Science 125, 2160-2171, doi:10.1242/jcs.096008 (2012).

33. Bohm S, Schwab I, Lux A & Nimmerjahn F. The role of sialic acid as a modulator of the anti-inflammatory activity of IgG. Seminars in Immunopathology 34, 443-453, doi:10.1007/s00281-012-0308-x (2012).

34. Brennan-Speranza TC, Henneicke H, Gasparini SJ, Blankenstein KI, Heinevetter U, Cogger VC, Svistounov D, Zhang YQ, Cooney GJ, Buttgereit F, Dunstan CR, Gundberg C, Zhou H & Seibel MJ. Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation 122, 4172-4189, doi:10.1172/jci63377 (2012).

35. Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G. A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 2012 Feb 15;21(4):784-98. doi: 10.1093/hmg/ddr510. (2012)

36. Eitzinger N, Surmann-Schmitt C, Bosl M, Schett G, Engelke K, Hess A, von der Mark K & Stock M. Ucma is not necessary for normal development of the mouse skeleton. Bone 50, 670-680, doi:10.1016/j.bone.2011.11.017 (2012).

37. Garbe AI, Roscher A, Schüler C, Lutter AH, Glösmann M, Bernhardt R, Chopin M, Hempel U, Hofbauer LC, Rammelt S, Egerbacher M, Erben RG, Jessberger R. Regulation of bone mass and osteoclast function depend on the F-actin modulator SWAP-70. J Bone Miner Res. 2012 Oct;27(10):2085-96. doi: 10.1002/jbmr.1670. (2012).

38. Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P & Schett G. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. Journal of Clinical Investigation 122, 1791-1802, doi:10.1172/jci60975 (2012).

39. Heiland GR, Appel H, Poddubnyy D, Zwerina J, Hueber A, Haibel H, Baraliakos X, Listing J, Rudwaleit M, Schett G & Sieper J. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Annals of the Rheumatic Diseases 71, 572-574, doi:10.1136/annrheumdis-2011-200216 (2012).

40. Hildebrand D, Sahr A, Wolfle SJ, Heeg K & Kubatzky KF. Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling. Cell Communication and Signaling 10, doi:10.1186/1478-811x-10-22 (2012).

41. Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G & Distler JHW. Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Annals of the Rheumatic Diseases 71, 785-789, doi:10.1136/annrheumdis-2011-200883 (2012).

42. Horn A, Palumbo K, Cordazzo C, Dees C, Akhmetshina A, Tomcik M, Zerr P, Avouac J, Gusinde J, Zwerina J, Roudaut H, Traiffort E, Ruat M, Distler O, Schett G, Distler JH. Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum. 2012 Aug;64(8):2724-33. doi: 10.1002/art.34444. (2012).

43. Keller J, Catala-Lehnen P, Wintges K, Schulze J, Bickert T, Ito W, Horst AK, Amling M & Schinke T. Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis. Biochemical and Biophysical Research Communications 417, 217-222, doi:10.1016/j.bbrc.2011.11.088 (2012).

44. Kertesz Z, Gyori D, Kormendi S, Fekete T, Kis-Toth K, Jakus Z, Schett G, Rajnavolgyi E, Dobo-Nagy C & Mocsai A. Phospholipase C gamma 2 is required for basal but not oestrogen deficiency-induced bone resorption. European Journal of Clinical Investigation 42, 49-60, doi:10.1111/j.1365-2362.2011.02556.x (2012).

45. Kleyer A, Scholtysek C, Bottesch E, Hillienhof U, Beyer C, Distler JHW, Tuckermann JP, Schett G & Kronke G. Liver X Receptors Orchestrate Osteoblast/Osteoclast Crosstalk and Counteract Pathologic Bone Loss. Journal of Bone and Mineral Research 27, 2442-2451, doi:10.1002/jbmr.1702 (2012).

46. Kubatzky KF. Pasteurella multocida and immune cells. Curr Top Microbiol Immunol. 2012;361:53-72. doi: 10.1007/82_2012_204. (2012).

47. Lehmann B, Schwab I, Bohm S, Lux A, Biburger M & Nimmerjahn F. Fc gamma RIIB: a modulator of cell activation and humoral tolerance. Expert Review of Clinical Immunology 8, 243-254, doi:10.1586/eci.12.5 (2012).

48. Mei HE, Schmidt S & Dorner T. Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity. Arthritis Research & Therapy 14, doi:10.1186/ar3909 (2012).

49. Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R. Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol. 2012 Sep 25;361(1-2):1-11. doi: 10.1016/j.mce.2012.03.026. (2012).

50. Mumtaz IM, Hoyer BF, Panne D, Moser K, Winter O, Cheng QY, Yoshida T, Burmester GR, Radbruch A, Manz RA, Hiepe F. Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: implications for the treatment of autoimmunity. J Autoimmun. 2012 Sep;39(3):180-8. doi: 10.1016/j.jaut.2012.05.010. (2012).

51. Rauner M, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G, Distler JHW, Albers J, Schulze J, Schinke T, Bornhauser M, Platzbecker U & Hofbauer LC. WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. Journal of Bone and Mineral Research 27, 575-585, doi:10.1002/jbmr.1488 (2012).

52. Ruiz-Heiland G, Horn A, Zerr P, Hofstetter W, Baum W, Stock M, Distler JH, Nimmerjahn F, Schett G & Zwerina J. Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. Annals of the Rheumatic Diseases 71, 400-407, doi:10.1136/ard.2010.148262 (2012).

53. Schett G & Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nature Reviews Rheumatology 8, 656-664, doi:10.1038/nrrheum.2012.153 (2012).

54. Schett G, Pap T, Muller-Ladner U & Kamradt T. Osteoimmunology - IMMUNOBONE - Understanding the interaction between bone and immune system. Zeitschrift Fur Rheumatologie 71, 138-139, doi:10.1007/s00393-012-0954-3 (2012).

55. Schulze J, Weber K, Baranowsky A, Streichert T, Lange T, Spiro AS, Albers J, Seitz S, Zustin J, Amling M, Fehse B & Schinke T. p65-Dependent production of interleukin-1 beta by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts. Cancer Letters 317, 106-113, doi:10.1016/j.canlet.2011.11.016 (2012).

56. Simon S, Guthke R, Kamradt T & Frey O. Multivariate analysis of flow cytometric data using decision trees. Frontiers in Microbiology 3, doi:10.3389/fmicb.2012.00114 (2012).

57. Skjot-Arkil H, Schett G, Zhang C, Larsen DV, Wang Y, Zheng Q, Larsen MR, Nawrocki A, Bay-Jensen AC, Henriksen K, Christiansen C, Alexandersen P, Leeming DJ & Karsdal MA. Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis. Clinical and Experimental Rheumatology 30, 371-379 (2012).

58. Surmann-Schmitt C, Sasaki T, Hattori T, Eitzinger N, Schett G, Von der Mark K & Stock M. The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity. Journal of Cellular Physiology 227, 2207-2216, doi:10.1002/jcp.22957 (2012).

59. Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M. Selective glucocorticoid receptor modulation maintains bone mineral

density in mice. J Bone Miner Res. 2012 Nov;27(11):2242-50. doi: 10.1002/jbmr.1688. (2012).

60. Uderhardt S, Herrmann M, Oskolkova OV, Aschermann S, Bicker W, Ipseiz N, Sarter K, Frey B, Rothe T, Voll R, Nimmerjahn F, Bochkov VN, Schett G & Kronke G. 12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance. Immunity 36, 834-846, doi:10.1016/j.immuni.2012.03.010 (2012).

61. Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC & Furlow JD. A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. American Journal of Physiology-Endocrinology and Metabolism 302, E1210-E1220, doi:10.1152/ajpendo.00512.2011 (2012).

62. Zwerina K, Koenders M, Hueber A, Marijnissen RJ, Baum W, Heiland GR, Zaiss M, McLnnes I, Joosten L, van den Berg W, Zwerina J & Schett G. Anti IL-17A therapy inhibits bone loss in TNF-alpha-mediated murine arthritis by modulation of the T-cell balance. European Journal of Immunology 42, 413-423, doi:10.1002/eji.201141871 (2012).

63. Albrecht A, Finzel S, Englbrecht M, Rech J, Hueber A, Schlechtweg P, Uder M & Schett G. The structural basis of MRI bone erosions: an assessment by microCT. Annals of the Rheumatic Diseases 72, 1351-1357, doi:10.1136/annrheumdis-2012-201982 (2013).

64. Appel H, Maier R, Bleil J, Hempfing A, Loddenkemper C, Schlichting U, Syrbe U, Sieper J. In situ analysis of interleukin-23- and interleukin-12-positive cells in the spine of patients with ankylosing spondylitis. Arthritis Rheum. 2013 Jun;65(6):1522-9. doi: 10.1002/art.37937. (2013).

65. Aschenberg S, Finzel S, Schmidt S, Kraus S, Engelke K, Englbrecht M, Rech J & Schett G. Catabolic and anabolic periarticular bone changes in patients with rheumatoid arthritis: a computed tomography study on the role of age, disease duration and bone markers. Arthritis Research & Therapy 15, doi:10.1186/ar4235 (2013).

66. Baschant U, Culemann S & Tuckermann J. Molecular determinants of glucocorticoid actions in inflammatory joint diseases. Molecular and Cellular Endocrinology 380, 108-118, doi:10.1016/j.mce.2013.06.009 (2013).

67. Braun T, Lepper J, Heiland GR, Hofstetter W, Siegrist M, Lezuo P, Gaestel M, Rumpler M, Thaler R, Klaushofer K, Distler JHW, Schett G & Zwerina J. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. Journal of Bone and Mineral Research 28, 936-947, doi:10.1002/jbmr.1816 (2013).

68. Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G & Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Annals of the Rheumatic Diseases 72, 1732-1736, doi:10.1136/annrheumdis-2013-203345 (2013).

69. De Filippo K, Dudeck A, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N. Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood. 2013 Jun 13;121(24):4930-7. doi: 10.1182/blood-2013-02-486217. (2013).

70. El Malki K, Karbach SH, Huppert J, Zayoud M, Reissig S, Schüler R, Nikolaev A, Karram K, Münzel T, Kuhlmann CR, Luhmann HJ, von Stebut E, Wörtge S, Kurschus FC, Waisman A. An alternative pathway of imiquimod-induced psoriasis-

like skin inflammation in the absence of Interleukin-17 receptor a signaling. J Invest Dermatol. 2013 Feb;133(2):441-51. doi: 10.1038/jid.2012.318. (2013).

71. Finzel S, Kraus S, Schmidt S, Hueber A, Rech J, Engelke K, Englbrecht M & Schett G. Bone anabolic changes progress in psoriatic arthritis patients despite treatment with methotrexate or tumour necrosis factor inhibitors. Annals of the Rheumatic Diseases 72, 1176-1181, doi:10.1136/annrheumdis-2012-201580 (2013).

72. Finzel S, Rech J, Schmidt S, Engelke K, Englbrecht M & Schett G. Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study. Annals of the Rheumatic Diseases 72, 396-400, doi:10.1136/annrheumdis-2011-201075 (2013).

73. Föhse L, Reinhardt A, Oberdörfer L, Schmitz S, Förster R, Malissen B, Prinz I. Differential postselection proliferation dynamics of αβ T cells, Foxp3+ regulatory T cells, and invariant NKT cells monitored by genetic pulse labeling. J Immunol. 2013 Sep 1;191(5):2384-92. doi: 10.4049/jimmunol.1301359. (2013).

74. Hasenberg M, Stegemann-Koniszewski S & Gunzer M. Cellular immune reactions in the lung. Immunological Reviews 251, 189-214, doi:10.1111/imr.12020 (2013).

75. Herz B, Albrecht A, Englbrecht M, Welsch GH, Uder M, Renner N, Schlechtweg P, Paul D, Lauer L, Engelke K, Janka R, Rech J, Schett G, Finzel S. Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis. Ann Rheum Dis. 2014 Jun;73(6):1101-6. doi: 10.1136/annrheumdis-2012-202850. Epub 2013 Apr 26. (2013).

76. Hilmi D, Parcina M, Bode K, Ostrop J, Schuett S, Heeg K, Ziebuhr W, Sommerburg O & Bekeredjian-Ding I. Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction. International Journal of Medical Microbiology 303, 61-69, doi:10.1016/j.ijmm.2012.12.008 (2013).

77. Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, Bonora E, Tilg H, Willeit J & Schett G. Blockade of receptor activator of nuclear factor-kappa B (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nature Medicine 19, 358-363, doi:10.1038/nm.3084 (2013).

78. Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, Schett G. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014 May;73(5):854-60. doi: 10.1136/annrheumdis-2012-202958. (2013).

79. Kubatzky KF, Kloos B & Hildebrand D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins 5, 1664-1681, doi:10.3390/toxins5091664 (2013).

80. Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Kronke G, Spencer B, Distler O, Schett G & Distler JHW. Autophagy regulates TNF alpha-mediated joint destruction in experimental arthritis. Annals of the Rheumatic Diseases 72, 761-768, doi:10.1136/annrheumdis-2012-201671 (2013).

81. Lux A & Nimmerjahn F. Of Mice and Men: The Need for Humanized Mouse Models to Study Human IgG Activity in Vivo. Journal of Clinical Immunology 33, S4-S8, doi:10.1007/s10875-012-9782-0 (2013).

82. Mihai S & Nimmerjahn F. The role of Fc receptors and complement in autoimmunity. Autoimmunity Reviews 12, 657-660, doi:10.1016/j.autrev.2012.10.008 (2013).

83. Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M & Figge MT. Automated Characterization and Parameter-Free Classification of Cell Tracks Based on Local Migration Behavior. Plos One 8, doi:10.1371/journal.pone.0080808 (2013).

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166. Weber FC, Németh T, Csepregi JZ, Dudeck A, Roers A, Ozsvári B, Oswald E, Puskás LG, Jakob T, Mócsai A, Martin SF. Neutrophils are required for both the sensitization and elicitation phases of contact hypersensitivity. J Exp Med. 2015 Jan 12;212(1):15-22. doi: 10.1084/jem.20130062. (2015).

167. Yeremenko N, Zwerina K, Rigter G, Pots D, Fonseca JE, Zwerina J, Schett G & Baeten D. Tumor Necrosis Factor and Interleukin-6 Differentially Regulate Dkk-1 in the Inflamed Arthritic Joint. Arthritis & Rheumatology 67, 2071-2075, doi:10.1002/art.39183 (2015).

168. Albus E, Sinningen K, Winzer M, Thiele S, Baschant U, Hannemann A, Fantana J, Tausche AK, Wallaschofski H, Nauck M, Völzke H, Grossklaus S, Chavakis T, Udey MC, Hofbauer LC, Rauner M. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a novel anti-inflammatory factor in rheumatoid arthritis in mice and humans. J Bone Miner Res. 2016 Mar;31(3):596-605. doi: 10.1002/jbmr.2721. (2016).

169. Aschermann S, Englbrecht M, Bergua A, Spriewald BM, Said-Nahal R, Breban M, Schett G & Rech J. Presence of HLA-B27 is associated with changes of serum levels of mediators of the Wnt and hedgehog pathway. Joint Bone Spine 83, 43-46, doi:10.1016/j.jbspin.2015.03.019 (2016).

170. Atkinson SM, Bleil J, Maier R, Kuhl AA, Thorn M, Serikawa K, Fox B, Kruse K, Haase C, Skov S, Nansen A & Syrbe U. Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model. Arthritis Research & Therapy 18, doi:10.1186/s13075-016-0931-3 (2016).

171. Biermann MHC, Podolska MJ, Knopf J, Reinwald C, Weidner D, Maueroder C, Hahn J, Kienhofer D, Barras A, Boukherroub R, Szunerits S, Bilyy R, Hoffmann M, Zhao Y, Schett G, Herrmann M & Munoz LE. Oxidative Burst-Dependent NETosisis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation. Frontiers in Immunology 7, doi:10.3389/fimmu.2016.00557 (2016).

172. Bleil J, Maier R, Hempfing A, Sieper J, Appel H, Syrbe U. Granulation Tissue Eroding the Subchondral Bone Also Promotes New Bone Formation in Ankylosing Spondylitis. Arthritis Rheumatol. 2016 Oct;68(10):2456-65. doi: 10.1002/art.39715. (2016).

173. Chen GL, Luo YB, Eriksson D, Meng X, Qian C, Bauerle T, Chen XX, Schett G & Bozec A. High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6. Oncotarget 7, 26653-26669, doi:10.18632/oncotarget.8474 (2016).

174. Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G & Bozec A. Th2 and eosinophil responses suppress inflammatory arthritis. Nature Communications 7, doi:10.1038/ncomms11596 (2016).

175. Derer A, Bohm C, Grotsch B, Grun JR, Grutzkau A, Stock M, Bohm S, Sehnert B, Gaipl U, Schett G, Hueber AJ & David JP. Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis. Annals of the Rheumatic Diseases 75, 413-421, doi:10.1136/annrheumdis-2014-205618 (2016).

176. Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, Cavalcante AR, Kraus S, Tabosa TP, Figueiredo C, Hueber AJ, Kocijan R, Cavallaro A, Schett G,

Sticherling M & Rech J. Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis. Annals of the Rheumatic Diseases 75, 2068-2074, doi:10.1136/annrheumdis-2015-208821 (2016).

177. Fennen M, Pap T & Dankbar B. Smad-dependent mechanisms of inflammatory bone destruction. Arthritis Research & Therapy 18, doi:10.1186/s13075-016-1187-7 (2016).

178. Figueiredo CP, Simon D, Englbrecht M, Haschka J, Kleyer A, Bayat S, Hueber A, Pereira RMR, Rech J & Schett G. Quantification and Impact of Secondary Osteoarthritis in Patients With Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis. Arthritis & Rheumatology 68, 2114-2121, doi:10.1002/art.39698 (2016).

179. Finan B, Clemmensen C, Zhu ZM, Stemmer K, Gauthier K, Muller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sanchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Doring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Kohrle J, Rozman J, Fuchs H, Gailus-Durner V, de Angelis MH, Hofmann SM, Yang B, Tschop MH, DiMarchi R & Muller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell 167, 843-+, doi:10.1016/j.cell.2016.09.014 (2016).

180. Fleischer SJ, Daridon C, Fleischer V, Lipsky PE & Dorner T. Enhanced Tyrosine Phosphatase Activity Underlies Dysregulated B Cell Receptor Signaling and Promotes Survival of Human Lupus B Cells. Arthritis & Rheumatology 68, 1210-1221, doi:10.1002/art.39559 (2016).

181. Harre U, Schett G. [Association between bone catabolism and anti-citrullinated protein antibodies in rheumatoid arthritis]. Z Rheumatol. 2016 Oct;75(8):809-811. (2016).

182. Hartmann K, Koenen M, Schauer S, Wittig-Blaich S, Ahmad M, Baschant U & Tuckermann JP. MOLECULAR ACTIONS OF GLUCOCORTICOIDS IN CARTILAGE AND BONE DURING HEALTH, DISEASE, AND STEROID THERAPY. Physiological Reviews 96, 409-447, doi:10.1152/physrev.00011.2015 (2016).

183. Haschka J, Englbrecht M, Hueber AJ, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Wendler J, Schuch F, Ronneberger M, Lorenz HM, Nuesslein H, Alten R, Demary W, Henes J, Schett G & Rech J. Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Annals of the Rheumatic Diseases 75, 45-51, doi:10.1136/annrheumdis-2014-206439 (2016).

184. Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G. High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients. J Crohns Colitis. 2016 May;10(5):532-40. doi: 10.1093/ecco-jcc/jjw012. (2016).

185. Javaheri T, Kazemi Z, Pencik J, Pham HTT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DNT, Wiedner M, Tomazou EM, Logan M, Hartmann C, Tuckermann JP, Kenner L, Mikula M, Dolznig H, Uren A, Richter GH, Grebien F, Kovar H & Moriggl R. Increased survival and cell cycle

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186. Kleyer A, Krieter M, Oliveira I, Faustini F, Simon D, Kaemmerer N, Cavalcante A, Tabosa T, Rech J, Hueber A & Schett G. High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA A combined MRI/CT study. Seminars in Arthritis and Rheumatism 46, 143-150, doi:10.1016/j.semarthrit.2016.05.002 (2016).

187. Lin NY, Chen CW, Kagwiria R, Liang RF, Beyer C, Distler A, Luther J, Engelke K, Schett G & Distler JHW. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss. Annals of the Rheumatic Diseases 75, 1203-1210, doi:10.1136/annrheumdis-2015-207240 (2016).

188. Liu P, Baumgart M, Groth M, Wittmann J, Jack HM, Platzer M, Tuckermann JP & Baschant U. Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation. Scientific Reports 6, doi:10.1038/srep32112 (2016).

189. Maueroder C, Mahajan A, Paulus S, Gosswein S, Hahn J, Kienhofer D, Biermann MH, Tripal P, Friedrich RP, Munoz LE, Neurath MF, Becker C, Schett GA, Herrmann M & Leppkes M. Menage-a-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs. Frontiers in Immunology 7, doi:10.3389/fimmu.2016.00583 (2016).

190. Munoz LE, Bilyy R, Biermann MHC, Kienhofer D, Maueroder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y & Herrmann M. Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation. Proceedings of the National Academy of Sciences of the United States of America 113, E5856-E5865, doi:10.1073/pnas.1602230113 (2016).

191. Nimmerjahn F. Immunomodulation of immunothrombocytopenia. Seminars in Hematology 53, S10-S12, doi:10.1053/j.serninhema_ol.2016.04.004 (2016).

192. Pieterse E, Jeremic I, Czegley C, Weidner D, Biermann MHC, Veissi S, Maueroder C, Schauer C, Bilyy R, Dumych T, Hoffmann M, Munoz LE, Bengtsson AA, Schett G, van der Vlag J & Herrmann M. Blood-borne phagocytes internalize urate microaggregates and prevent intravascular NETosis by urate crystals. Scientific Reports 6, doi:10.1038/srep38229 (2016).

193. Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K & Schett G. Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment. Annals of the Rheumatic Diseases 75, 1637-1644, doi:10.1136/annrheumdis-2015-207900 (2016).

194. Reinhardt A, Yevsa T, Worbs T, Lienenklaus S, Sandrock I, Oberdorfer L, Korn T, Weiss S, Forster R & Prinz I. Interleukin-23-Dependent/T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice. Arthritis & Rheumatology 68, 2476-2486, doi:10.1002/art.39732 (2016).

195. Ripich T, Chacon-Martinez CA, Fischer L, Pernis A, Kiessling N, Garbe AI & Jessberger R. SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells. Plos One 11, doi:10.1371/journal.pone.0161060 (2016).

196. Schminke B, Trautmann S, Mai B, Miosge N & Blaschke S. Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. European Journal of Immunology 46, 440-445, doi:10.1002/eji.201545910 (2016).

197. Simon D, Faustini F, Kleyer A, Haschka J, Englbrecht M, Kraus S, Hueber AJ, Kocijan R, Sticherling M, Schett G & Rech J. Analysis of periarticular bone changes in patients with cutaneous psoriasis without associated psoriatic arthritis. Annals of the Rheumatic Diseases 75, 660-666, doi:10.1136/annrheumdis-2014-206347 (2016).

198. Tu JW, Zhang YQ, Kim S, Wiebe E, Spies CM, Buttgereit F, Cooper MS, Seibel MJ & Zhou H. Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis. American Journal of Pathology 186, 1293-1301, doi:10.1016/j.ajpath.2015.12.025 (2016).

199. Uluckan O, Jimenez M, Karbach S, Jeschke A, Grana O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G & Wagner EF. Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts. Science Translational Medicine 8, doi:10.1126/scitranslmed.aad8996 (2016).

200. Wehmeyer C, Frank S, Beckmann D, Bottcher M, Cromme C, Konig U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T & Dankbar B. Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Science Translational Medicine 8, doi:10.1126/scitranslmed.aac4351 (2016).

201. Win SJ, Kuhl AA, Sparwasser T, Hunig T & Kamradt T. In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. European Journal of Immunology 46, 1193-1202, doi:10.1002/eji.201546104 (2016).

202. Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y & Herrmann M. New insights into Neutrophil extracellular Traps: Mechanisms of Formation and Role in inflammation. Frontiers in Immunology 7, doi:10.3389/fimmu.2016.00302 (2016).

203. Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu XY, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP & Zhao BH. Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption. Journal of Immunology 198, 3436-3447, doi:10.4049/jimmunol.1601716 (2017).

204. Boeltz S, Munoz LE, Fuchs TA & Herrmann M. Neutrophil Extracellular Traps Open the Pandora's Box in Severe Malaria. Frontiers in Immunology 8, doi:10.3389/fimmu.2017.00874 (2017).

205. Bozec A & Soulat D. Latest perspectives on macrophages in bone homeostasis. Pflugers Archiv-European Journal of Physiology 469, 517-525, doi:10.1007/s00424-017-1952-8 (2017).

206. Bozec A & Zaiss MM. T Regulatory Cells in Bone Remodelling. Current Osteoporosis Reports 15, 121-125, doi:10.1007/s11914-017-0356-1 (2017).

207. Catrina AI, Svensson CI, Malmstrom V, Schett G & Klareskog L. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis. Nature Reviews Rheumatology 13, 79-86, doi:10.1038/nrrheum.2016.200 (2017).

208. Chakraborty S, Kloos B, Harre U, Schett G & Kubatzky KF. Pasteurella multocida Toxin Triggers RANKL-independent Osteoclastogenesis. Frontiers in Immunology 8, doi:10.3389/fimmu.2017.00185 (2017).

209. Chakraborty S, Kloos B, Roetz N, Schmidt S, Eigenbrod T, Kamitani S & Kubatzky KF. Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells

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210. Engdahl C, Bang H, Dietel K, Lang SC, Harre U & Schett G. Periarticular Bone Loss in Arthritis Is Induced by Autoantibodies Against Citrullinated Vimentin. Journal of Bone and Mineral Research 32, 1681-1691, doi:10.1002/jbmr.3158 (2017).

211. Figueiredo CP, Bang H, Cobra JF, Englbrecht M, Hueber AJ, Haschka J, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K, Rech J & Schett G. Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs. Annals of the Rheumatic Diseases 76, 399-407, doi:10.1136/annrheumdis-2016-209297 (2017).

212. Hannemann N, Jordan J, Paul S, Reid S, Baenkler HW, Sonnewald S, Bauerle T, Vera J, Schett G & Bozec A. The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages. Journal of Immunology 198, 3605-3614, doi:10.4049/jimmunol.1601330 (2017).

213. Harre U & Schett G. Cellular and molecular pathways of structural damage in rheumatoid arthritis. Seminars in Immunopathology 39, 355-363, doi:10.1007/s00281-017-0634-0 (2017).

214. Kiechl S, Schramek D, Widschwendter M, Fourkala EO, Zaikin A, Jones A, Jaeger B, Rack B, Janni W, Scholz C, Willeit J, Weger S, Mayr A, Teschendorff A, Rosenthal A, Fraser L, Philpott S, Dubeau L, Keshtgar M, Roylance R, Jacobs IJ, Menon U, Schett G & Penninger JM. Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget 8, 3811-3825, doi:10.18632/oncotarget.14013 (2017).

215. Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Mann L, Brenzel A, Engel DR, Figge MT, Kurts C & Gunzer M. Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy. Journal of the American Society of Nephrology 28, 452-459, doi:10.1681/asn.2016020232 (2017).

216. Kroner J, Kovtun A, Kemmler J, Messmann JJ, Strauss G, Seitz S, Schinke T, Amling M, Kotrba J, Dudeck J, Dudeck A, Ignatius A. Mast cells are critical regulators of bone fracture-induced inflammation and osteoclast formation and activity. J Bone Miner Res. 2017 Aug 4. doi: 10.1002/jbmr.3234. (2017).

217. Krumbholz G, Junker S, Meier FMP, Rickert M, Steinmeyer J, Rehart S, Lange U, Frommer KW, Schett G, Muller-Ladner U & Neumann E. Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin. Clinical and Experimental Rheumatology 35, 406-414 (2017).

218. Lang SC, Harre U, Purohit P, Dietel K, Kienhofer D, Hahn J, Baum W, Herrmann M, Schett G & Mielenz D. Neurodegeneration Enhances the Development of Arthritis. Journal of Immunology 198, 2394-2402, doi:10.4049/jimmunol.1601472 (2017).

219. Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX & Tuckermann JP. Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis. Cell Death and Differentiation 24, 672-682, doi:10.1038/cdd.2016.165 (2017).

220. Mbalaviele G, Novack DV, Schett G & Teitelbaum SL. Inflammatory osteolysis: a conspiracy against bone. Journal of Clinical Investigation 127, 2030-2039, doi:10.1172/jci93356 (2017).

221. Mihai S, Albert H, Ludwig RJ, Iwata H, Bjorck L, Collin M & Nimmerjahn F. In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury. Experimental Dermatology 26, 691-696, doi:10.1111/exd.13163 (2017).

222. Minas TZ, Surdez D, Javaheri T, Tanaka M, Howarth M, Kang HJ, Han J, Han ZY, Sax B, Kream BE, Hong SH, Celik H, Tirode F, Tuckermann J, Toretsky JA, Kenner L, Kovar H, Lee S, Sweet-Cordero EA, Nakamura T, Moriggl R, Delattre O & Uren A. Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model. Oncotarget 8, 34141-34163, doi:10.18632/oncotarget.9388 (2017).

223. Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Muller TD, Tschop MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP & Moriggl R. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 66, 272-286, doi:10.2337/db16-0381 (2017).

224. Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Huebert AJ, Daum P, Heidkamp GF, Ge CR, Bohm S, Lux A, Schuh W, Magorivskal I, Nandakumar KS, Lonnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Bluml S, Nimmerjahn F, Schett G & Kronke G. Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease. Nature Immunology 18, 104-113, doi:10.1038/ni.3579 (2017).

225. Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Canete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW & Ramming A. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nature Medicine 23, 938-+, doi:10.1038/nm.4373 (2017).

226. Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G & Kronke G. The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation. Journal of Immunology 198, 3878-3885, doi:10.4049/jimmunol.1600638 (2017).

227. Simon D, Derer A, Andes FT, Lezuo P, Bozec A, Schett G, Herrmann M & Harre U. Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone 105, 35-41, doi:10.1016/j.bone.2017.08.013 (2017).

228. Simon D, Kleyer A, Stemmler F, Simon C, Berlin A, Hueber AJ, Haschka J, Renner N, Figueiredo C, Neuhuber W, Buder T, Englbrecht M, Rech J, Engelke K & Schett G. Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis. Journal of Bone and Mineral Research 32, 722-730, doi:10.1002/jbmr.3025 (2017).

229. Siracusa F, Alp OS, Maschmeyer P, McGrath M, Mashreghi MF, Hojyo S, Chang HD, Tokoyoda K & Radbruch A. Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation. European Journal of Immunology 47, 1900-1905, doi:10.1002/eji.201747063 (2017).

230. Stein M, Dutting S, Mougiakakos D, Bosl M, Fritsch K, Reimer D, Urbanczyk S, Steinmetz T, Schuh W, Bozec A, Winkler TH, Jack HM & Mielenz D. A defined

metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1. Cell Death and Differentiation 24, 1239-1252, doi:10.1038/cdd.2017.52 (2017).

231. Ubieta K, Garcia M, Grotsch B, Uebe S, Weber GF, Stein M, Ekici A, Schett G, Mielenz D & Bozec A. Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription. Journal of Experimental Medicine 214, 2059-2071, doi:10.1084/jem.20160514 (2017).

232. Werner D, Simon D, Englbrecht M, Stemmler F, Simon C, Berlin A, Haschka J, Renner N, Buder T, Engelke K, Hueber AJ, Rech J, Schett G & Kleyer A. Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis. Arthritis & Rheumatology 69, 1580-1587, doi:10.1002/art.40148 (2017).

233. Wunderlich C, Oliviera I, Figueiredo CP, Rech J & Schett G. Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis. Seminars in Arthritis and Rheumatism 46, 709-714, doi:10.1016/j.semarthrit.2016.09.011 (2017).

234. Zundler S, Klingberg A, Schillinger D, Fischer S, Neufert C, Atreya I, Gunzer M & Neurath MF. Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut. Gastroenterology 153, 898-900, doi:10.1053/j.gastro.2017.07.022 (2017).