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Specific functional effects of
memantine treatment in patients with
moderate to severe Alzheimer’s
disease
Doody R., Wirth Y., Schmitt F. and Möbius H.J.
Dement Geriatr Cogn Disord 2004; 18: 227-232
Baseline Characteristics
Doody et al., Dement Geriatr Cogn Disord 2004
US Study EU Study
Patients completing study, n (%) 97 (77%) 84 (67%) 39 (95%) 37 (97%)
Gender, femalen (%) 91 (72%) 79 (63%) 29 (71%) 24 (63%)
Mean age (years) 75.9 76.3 73.4 74.9
Race, Caucasiann (%) 112 (89%) 115 (91%) 41 (100%) 38 (100%)
Mean MMSEscore at baseline 7.7 8.1 6.7 6.8
Memantine Placebo Memantine Placebo(N = 126) (N = 126) (N = 41) (N = 38)
Residential status outpatients nursing home patients
* p < 0.05, # p < 0.10
Beneficial Effects of Memantine on Function in AD Outpatients (I)
Mean change (±SEM) from baseline in ADCS-ADL19 item scores (US trial)
Improvement
-0.6 -0.4 -0.2 0 0.2-0.8
Worsening
0.4
Get around outside of his/her home
Dispose of garbage or litter
Find his/her personal belongings
Clear dishes from table after meal
Pay attention to conversation
Watch television
Use a telephone
Memantine
Placebo
#
*
*
*
#
Doody et al., Dement Geriatr Cogn Disord 2004
Mean change (±SEM) from baseline in ADCS-ADL19 item scores
Improvement
-0.6 -0.4 -0.2 0 0.2-0.8
Worsening
0.4
Turn light off without help
Turn light on without help
Turn off faucet without help
Run water from a faucet to wash
Obtain a hot or cold beverage
Left on his/her own
Memantine
Placebo
Beneficial Effects of Memantine on Function in AD Outpatients (II)
Doody et al., Dement Geriatr Cogn Disord 2004
Mean change (±SEM) from baseline in ADCS-ADL19 item scores (US trial)
Improvement
-0.6 -0.4 -0.2 0 0.2-0.8
Worsening
0.4
Physically getting dressed
Grooming
Bathing
Toiletting
Walking
Eating
Memantine
Placebo
Beneficial Effects of Memantine on Function in AD Outpatients (III)
Doody et al., Dement Geriatr Cogn Disord 2004
Mean change (±SEM) from baseline in ADCS-ADL19 item scores
Improvement
-0.6 -0.4 -0.2 0 0.2-0.8
Worsening
0.4
* p < 0.05, # p < 0.10
Pay attention to conversationTurn light off
Dispose of garbageTurn faucet off
Get around outsideUse a telephone
Run water from a faucet Walking
Watch televisionClear dishes from table
Find personal belongingsTurn light on
ToilettingEating
GroomingLeft on his/her own
BathingObtain a beverage
Getting dressed
*
*
*
#
#
Memantine
Placebo
Consistent Beneficial Effects on Function in AD Outpatients
Doody et al., Dement Geriatr Cogn Disord 2004
* p < 0.05
Mean change (±SEM) from baseline in G2-scale scores (EU study)
Improvement
Mobility in bed
Ability to stand up
Ability to move
Ability to wash
Ability to bath/take a shower
Ability to dress
Ability to eat
Ability to drink
Use of toilet
0 -0.2 -0.4 -0.6 -0.8 Memantine
Placebo
0.2
*
*
*
*
*
*
Beneficial Effects of Memantine on Function in Nursing Home Patients (I)
Doody et al., Dement Geriatr Cogn Disord 2004
# p < 0.10
Mean change (±SEM) from baseline in G2-scale scores(EU study)
Improvement
Understanding
Communicates
Orientation
Recognition of persons
Group activities
Hobbies
Sleeping-waking rhythm
Behaviour
0 -0.2 -0.4 -0.6 -0.8 Memantine
Placebo
0.2
#
#
Beneficial Effects of Memantine on Function in Nursing Home Patients (II)
Doody et al., Dement Geriatr Cogn Disord 2004
Summary
The ADL single item analyses consistently confirm that
memantine monotherapy provides significant benefits
on functional abilities for patients with moderate to
severe Alzheimer’s disease.
The benefits have been demonstrated in both
outpatients (Reisberg et al., 2003) and nursing home
patients (Winblad and Poritis, 1999).
The positive effects of memantine on function may not
only have a positive impact on the patient but also on
the caregiver and healthcare resource utilization.
