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I Translation.
Low water solubility of many active
substances is a significant problem in
pharmaceutical industry. Substances with
good permeability, low solubility and
velocity in physiological liquids are a long-
standing limiting factor for absorption. In
spite of this, these drugs show good
biological availability in the most cases thatis explained,
according to many authors, by
a positive influence of auxiliary substances
on the solubility of active substance. In
order to chec this hypothesis the series of
testing were undergone for determining the
substance solubility and velocity ofsolubility in microni!ed
powder, granulates
and commercial tablets. The results
obtained by testing powder sample were
lower than those on the solubility balance of
nimesulid, indicating that is inappropriate
to use the device for testing solubilityvelocity to determine
lipophilic substance
solubility.
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Slaba rastvorl"ivost u vodi veliog bro"a
ativnih supstanci predstavl"a !na#a"an
problem !a farmaceutsu industri"u. $od
supstanci o"e posedu"u dobru
permeabilnost, slaba rastvorl"ivost i br!ina
rastvaran"a %velocity& u fi!iolo'im
te#nostima ve( du)e vreme su
ograni#ava"u(i fator !a apsorpci"u. Ipa, u
ve(ini slu#a"eva ovi leovi poa!u"u dobrubiolo'u raspolo)ivost
%bioavailability&, 'to
se, po neim autorima, ob"a'n"ava
po!itivnim utica"em pomo(nih materi"a na
rastvorl"ivost ativne supstance. * cil"u
ispitivan"a ove hipote!e %hypothesis&,
sprovedena "e seri"a testova !a utvrd"ivan"erastvorl"ivosti
supstance, ao i n"ene br!ine
rastvaran"a i! mironi!iranog prasa,
granulata i omerci"alnih tableta. +e!ultati
dobi"eni ispitivan"em u!ora pra'a bili su
ni)i u odnosu na podate o ravnote)no"
rastvorl"ivosti nimesulida, 'to ua!u"e dani"e podesno oristiti
ured"a" !a ispitivan"e
br!ine rastvaran"a !a odred"ivan"e
rastvorl"ivosti lipofilnih supstanci.
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Low water solubility of many active
substances is a significant problem in
pharmaceutical industry. Substances with
good permeability, low solubility and
velocity in physiological liquids are a long-
standing limiting factor for absorption. In
spite of this these drugs show good
biological availability in the most cases that
is explained, according to many authors, by
a positive influence of auxiliary substanceson the solubility of
an active substance. In
order to chec this hypothesis the series of
testing were undergone for determining the
substance solubility and velocity of
solubility in microni!ed powder, granulates
and commercial tablets,. The resultsobtained by testing powder
sample were
lower than those on the solubility balance of
nimesulid, indicating an inappropriate use
of device in testing solubility velocity to
determine lipophilic substance solubility.
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