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Second Semester Organic Chemistry Options : Bioorganic or Organic Mechanism and Synthesis. Albert Matlin and Jason Belitsky Department of Chemistry and Biochemistry Oberlin College, Oberlin, OH. Motivation. More flexibility and choice for Chemistry majors. - PowerPoint PPT Presentation
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Second Semester Organic Chemistry Options:
Bioorganic or Organic Mechanism and Synthesis
Albert Matlin and Jason BelitskyDepartment of Chemistry and Biochemistry
Oberlin College, Oberlin, OH
Motivation
1. More flexibility and choice for Chemistry majors.
2. Introduce Biological Chemistry into the Chemistry major.
3. Offer an Organic Chemistry course (Chem 254) that is more relevant to students interested in biological sciences: Biochemistry, Biology, Molecular Biology, Neuroscience and Pre-Medical.
4. Offer a second semester Organic Chemistry course primarily for majors.
5. Biology department reduced the chemistry requirement for their major to one semester of organic chemistry.
"New" Curriculum: Chemistry Major (1994)
"New" Curriculum: Chemistry Major (1994)
"New" Curriculum: Chemistry Major (1994)
Date Topic(s)
Sept. 6 Introduction, Acid-Base, Formal Charge
Sept. 8 Covalent Bonding and Hybridization
Sept. 13 Nomenclature, Alkanes and Alkenes
Sept. 15 Conformations of Alkanes/Cycloalkanes
Sept. 20 Free Radical Halogenation
Sept. 22 Stereochemistry
Sept. 29, Oct. 4 Nucleophilic Substitution, SN2, SN1
Oct. 6,11 Elimination Reactions
Oct. 13 Addition Reactions, Alkenes
Oct. 20 Addition Reactions, Conjugated -systems
Nov. 1 Infrared and Mass Spectroscopy
Nov. 3,8 Nuclear Magnetic Resonance Spectroscopy
Nov. 10 Aromaticity
Nov. 15 Electrophilic Aromatic Substitution
Nov. 17 Reactions of Alcohols, Oxidation
Nov. 29 Carbonyl Chemistry: Ketones, Aldehydes, Grignards
Dec 1 Carbonyl Chemistry: Imines, Synthesis, Amines, AcetalsDec 6 Carboxylic Acids
Dec 8 Carboxylic Acid Derivatives
Dec 13 Enolates, Aldol Condensation
Chem 205: Principles of Organic Chemistry• ~130 students a year. Offered Spring and Fall
Topics Not Covered in Chem 205 (Partial List) EpoxidesEthers (except for EAS)ThiolsDiolsPhenols (except for EAS)Diels Alder ReactionAlkynes (except acetylide basicity and nucleophilicity)Allylic radical substitution (NBS)Polymerization
Date Topics
February 7 Radical Reactions
February 9 Radical Polymerization
February 14 Additions Reactions to p-systems: AlkynesFebruary 16 CarbenesFebruary 21 Reduction of of p-systems
February 23 Oxidation of p-systems
March 1 Reactions of Ethers and Epoxides March 6 Synthesis March 8 p-Molecular Orbital Theory
March 13 Frontier MO theory, UV Spectroscopy
March 15,20 Pericyclic Reactions
April 3 Electrophilic Aromatic Substitution
April 5 Reaction of Aromatic side chains and SubstituentsApril 10 Diazonium salts and Synthesis of Aromatic Compounds
April 12 Carbanions, Organometallic Reagents
April 19, 24 Enolates
May 1 Conjugate Addition and Michael ReactionsMay 3 Multi-Step Synthesis
May 8 Nucleophilic Aromatic Substitution
May 10 Benzynes
Chem 325: Organic Mechanisms and Synthesis~20 students a year. Offer in the Spring semester.
Chem 254: Bioorganic Chemistry (Jason Belitsky)~60 students a year. Offered in the Spring
semester Week Topics 1 Class Introduction 1 Basics of Chemistry and Molecular Biology 2 Covalent / Noncovalent /Small /Large 2 Carboxyls / Esters / Amides / Amines 3 Aromatic & Heterocyclic Chemistry 3 Metals in Biology 4 Metals in Synthesis 5 Carbonyl Chemistry 5 Enolate Chemistry 6 Lipids 6 Lipid / Natural Product Biosynthesis 7 Carbohydrates 9 Peptide / Protein Synthesis 9 Protein Structure 10 Enzymatic Catalysis 11 Phosphate Esters, Nucleotides 12 Nucleic Acids 13 Biological Information Flow 13 Drug Discovery 14 Biological Probes 14 Chemical Biology
Textbook for Bioorganic Chemistry ????
Textbook for Bioorganic Chemistry ????
Bill Fuchsman has written a manuscript for his course. Email at: [email protected]
"New" Curriculum: Chemistry Major (1994)