~ * * * * * * * * * • * * * * * * * * * • * * * * * * * * * * * * * * * * * * * CALIFORNIA TUMOR TISSUE REGISTRY

LOS ANGELES COUNTY • UN IVERSITY OF SOUTHERN CALIFORNIA

PROTOCOL

FOR

MONTHLY STUDY SLIDES

NOVEMBER 1988

MALE GENITALIA TUMORS - PART II

*. * * * * * * * *' * * * * * * * * * * * * *. * * * * * * * *. * * * * * * *

CONTRIBUTOR: W. E. Carroll , M.D. NOVEMBER 1988 - CASE NO. 1 Santa Barbara, California

TISSUE FROM: Left scrotum ACCESSION NO. 21442

CLINICAL ABSTRACT:

History: A 39-year-old asymptomatic male was .admitted on 1-30-1973 because on physical examination a nodule was palpated in the left scrotal area.

Physical examination: Well developed, wel l nourished male in no acute dis­tress. A very firm nodule was found in the ~ower pole of the left epididymis. The nodule did not transilluminate.

SURGERY: (January 31, 1973)

A left epididymectomy was performed. A midline scrotal inci sion was made and the l eft testicle brought into view. A firm round mass on the lower pole of the epididymis was removed by sharp dissection.

GROSS PATHOLOGY:

The specimen consisted of tan-pink epididymal tissue measuring 6 ems. in length, up to 1cm in diameter and weighing 19 gram. At one end was a hard, round mass measuring 2 x 2.2 x 2 em. This mass was covered by a soft, tan­pink movable capsule. A convoluted hard, white string-like structure was contained within the same capsule and measured 8 em in length and up to 1 em. in diameter and contained thick white cloudy fluid:

CONTRIBUTOR: Paul Ortega, M. D. NOVEMBER 1988 - CASE NO. 2 San Francisco, California

TISSUE FROM: Left scrotum ACCESSION NO. 12195

CLINICAL ABSTRACT:

History: A 19-year-old white male was admitted with a complaint of a rapidly enlarging painless mass in the region of the left testicle and epididymis of 5 or 6 months' duration.

Physical examination: A stony hard mass was palpated in the left scrotum at the anterior and lateral aspect of the testicle. This mass could not be separated from the testis. There were no palpable inguinal lymph nodes.

SURGERY:

Left orchiectomy was performed.

GROSS PATHOLOGY:

The specimen consisted of testicle with attached spermatic cord weighing 135 gram. The testis was grossly. unremarkable. Anterior-laterally was an ovoid tumor measuring 5.5 em. in greatest dimension. It had a firm, rubbery con­sistency and a uniform grayish-white col or. The cut surface had a lobulated or whorled fibrous appearance. The mass was intimately associated with the tunic, partially enveloped the epididymis but did not involve the testicular parenchyma.

CONTRIBUTOR: Ronald T. Mihata, M. 0. Harold Reikes, M. D. Riverside, California

TISSUE FROM: Penis

CLINICAL ABSTRACT:

NOVEMBER 1988 - CASE NO. 3

ACCESSION NO. 20949

History: A 70-year-old Caucasina male had bleeding and a purulent dis­charge from the penis for about 1 mont h. There was also some pain and swelling fo the penis.

Physical examination revealed phimosis with foul-smelling discharge from fo'reskin. A tumor of the underlying glans presented as a necrotic mass which extended to the coronal sul cus . There was no inguinal lymphadenopathy.

SURGERY: (June 7, 1974)

Excisional biopsy of foreskin lesion was performed findings: A 2.5 em. exophytic mass extruded into the wound. The inner surface of the foreskin and the glans were also invaded by multiple warty lesions measuring from 0.3 to 1.0 em.

GROSS PATHOLOGY:

The ovoid mass measured 4 x 3.5 x 2.5 em. and consisted of yellow-tan firm tissue with surface exudate (part B) . The foreskin consisted of two sheets of wrinkled skin 5.5 and 5 em. in greate.st extent. The mucous membrane showed mul tiple granular elevation (parte ).

CONTR IBUTOR: Samuel 0. Yoshida,' M. 0. NOVEMBER 1988 - CASE NO. 4 Los Angeles, California

TISSUE FROM: Left testis ACCESSION NO. 25700

CLINICAL ABSTRACT:

History: A 23-year-old male had a painful lump at t he lower pole of the l eft testis for 1 month. Dysuri a or urethral discharge denied. The initial clini cal diagnosis was epididymiti s and he was started on treatment with Amp,icillin. A urological consultation was performed .

Physical examination : A 2.5 em. mass was found in the lower pole of the left testis and stat ultrasound of testis reveal ed a solid mass which was separate from the testis.

SURGERY: (April 2, 1986)

A l eft radical orchiectomy was performed. Findings: There was a hard white scirrhous type mass that seemed to come from the lower pole of the testis.

GROSS PATHOLOGY:

The specimen consisted of a 4. 2 x 3 x 3 em. testicle, an 8 x 2 em. portion of spermati c cord with a 5.5 x 4. 5 x 3 em. tan-pink lobulated tumor attached to the inferior poles of the testis and spermatic cord. Tumor was completely separate from the testicle but had focal fi~rous adhesions to the tunica albuginea of the inferior testicular pole. Cut sections showed lobular tan-white trabeculati ons with focal areas of softening. There was no invasion into spermatic cord.

CONTRIBUTOR: Clifford N. Tschetter, M. D. NOVEMBER 19B8 • CASE NO . 5 Hayward, California

TISSUE FROM: Right testis ACCESSION NO. 17612

CLINICAL ABSTRACT:

History: This 14-year-old Caucasian mal e presented with a nontender rig~t testicular mass noticeable for six months. It had rapidly increased in size for the two months prior to admission.

Phtsical examination: A very finn, long , flat semicircular mass was noted in the ower pole of the right testis.

Laboratory report: Hemogram and urinalysis were normal and human chorionic gonadotropin level was not elevated.

SURGERY: (July 3, 1968)

A right orchiectomy was performed. Five days later, the right scrotum was removed.

GROSS PATHOLOGY:

The specimen consisted of a testis and 10 em. segment of spermatic cord. Attached to, but separate from the lower pole of the testis and epididymis was a reddish-tan well circumscribed firm mass which measured 6 x 4 x 2.5 em. On cut section it had a smooth tan-white glistening appearance. The tunica albuginea was intact. The testis had a normal tan cut surface and was grossly uninvolved by the tumor which appeared to have arisen from the tunica albuginea.

CONTRIBUTOR: Melvin Friedman, M. D. NOVEMBER 1988 - CASE NO. 6 Oakland, California

TISSUE FROM: Perineum ACCESSION NO. 6590

CLINICAL ABSTRACT:

History: In May 1952, 61-year-old male Caucasian noted a painless mass on left side of the perineum. He was seen in September 1952 and surgery advised for diagnosis and removal. He refused surgery at this time. He was seen again in January 1954 and agreed to immediate surgery for the perineal mass which to the best of his knowledge had not increased or decreased in size. The surgeon was uncertain as to the relation of this ma~s to the bulbospongiosus .

Laboratory data : Serology negative. Urinalysis and hemogram normal.

SURGERY:

On January 13, 1954 - excision of mass from left perineum was perfomed.

GROSS PATHOLOGY:

The specimen consisted of a 7 x 6 x 6 em. ragged, partially lobulated grey and pink mass. Cut surface revealed edematous gray tissue with a central ragged cystic area. The cut surface was streaked with grey-yellow and brown and appeared finely granular. A few irregular areas wer~ colored pinkish red.

CONTRIBUTOR: C. J. McCammon, M. D. Palm Spring, California

TISSUE FROM: Right testicle & segment of spennatic cord

CLINICAL ABSTRACT:

NOVEMBER 1988 - CASE NO. 7

ACCESSION NO. 10750

History: A 42-year-old Caucasian male has been in good health. Approximately 6 months prior to his admission to the hospital he noticed a mass in the right scrotum above the testicle. The mass increased somewhat in size and at the time of admission to the hospital it measured approximately 10 em. in diameter. It was located immediately· above the right testicle.

On physical examination the mass appeared to extend into the right inguinal canal. It was not fixed to the scrotal skin surfaces and was finn .

SURGERY: (December 17, 1959)

A right indirect inguinal hernia repair was performed and at the time of this surgery the mass was also removed along with a segment of the spennatic cord. Findings: The tumor was encapsulated and was closely applied to the spermatic cord. For this reason the right testicle and the spermatic cord were removed enbloc with the mass.

GROSS PATHOLOGY:

The specimen included the right testicle and a segment of spermatic cord measuring 20 em . in length. The tumor was a large spheroidal encapsulated lesion, measuring 10 x 8 em. in the regions of greatest diameter. The cut surfaces were homogeneous, glistening, and light tan brown in color. In several areas cystic spaces were present. Gross examination revealed the tumor to have been completely removed. The vas deferens was closely applied to the capsular surface of the mass but was distinctly free from it. The testicle and epididymis were completely free of the tumor and appeared grossly normal.

CONTRIBUTOR: Paul R. Thompson, M. 0. NOVEMBER 19B8 - CASE NO. 8 Pasadena, California

TISSUE FROM: Penis ACCESSION NO . 11136

CLINICAL ABSTRACT:

History: A 74-year-old Caucasian male had small scaly lesions on glans penis for 4 years, which were treated by a dermat ologist in Utah. Six months prior to admission lesions became larger and circumcision with desiccation of lesions was performed. The lesion continued to progress and patient was admitted for biopsy and possible amputation.

SURGERY : (June 28, 1960)

Amputation of penis with bilateral superficial inguinal and femoral lymph node dissections was performed.

GROSS PATHOLOGY:

Specimen consisted of segment of penis measuring 3.5 in length and 3 em. in diameter at the base. The distal end measured 2.5 em. and had a round brownish­grey coarsely granular lesion involving entire dorsal aspect and infiltrating into the urethral meatus. On section it measured up to 1 em. in thickness. Sixteen left inguinal and 13 right inguinal lymph nodes were submitted appearing greyish-white and averaged O.B-1.0 em. in diameter.

CONTRIBUTOR: W. H. LeCheminant, M. 0. NOVEMBER 1988 - CASE NO. 9 Provo, Utah

TISSUE FROM: Penis ACCESSION NO. 13413

CLINICAL ABSTRACT:

History: A 73-year-old Caucasian male developed an ulcer on his prepuce about 2 months prior to hospi talization. Two weeks prior to definitive surgery a circumcision was performed elsewhere and the pathologic diagnosis was chronic inflammation. In the 2 week period subsequent to circumcision, a large, fungating, bleeding tumor of the glans developed.

SURGERY: (December 1963)

The penis was amputated.

GROSS PATHOLOGY:

A 7 em. in length by 4.4 em. in diameter penis had a ·glans markedly distorted by a 5.4 x 4 x 3 em. , fungating, crusted tumor which partly obscured the urethral meatus. At the base of the glans and partially beneath the lip of foreskin was a gray-white, cauliflower-like, papi llary lesion which virtually encircled the glans and penetrated to 0.8 em. beneath the skin surface where the process was well demarcated from underlying tissue. A 5.0 em. ulcer of the foreskin communicated with a 0.7 em. sinus tract. Sectioning of the glans revealed focal, glistening white and gray mottled areas which extended about 1.5 em. into the shaft of the penis.

CONTRIBUTOR: Joelle lambert, M. D. Milton Bassis, M. b.

NOVEMBER 1988 - CASE NO. 10

San Francisco, California

TISSUE FROM: left testis ACCESSION NO. 26065

CLINICAL ABSTRACT:

History: This 30-year-old male had a 3 months' history of a lump in the left scrotal sac. The lump had been increasing in size and was associated with slight discomfort. He gave no history of trauma or infection.

Physical examination: A firm, nontender, approximately 3 x 1.5 em. mass was located at the superolateral aspect of the left testis.

Radiographs: Scrotal ultrasound showed an approximately 4 em. in diameter multifocal and solid intratesticular mass in the superior half of the left testis. CT scan of the abdomen showed several lymph nodes, ag9regating to 1.5 em., located in the left para-aortic area at the level of the lower pole of the left kidney. The chest x-ray was negative.

Laboratory data: The alpha fetoprotein level was normal and beta HCG level was slightly higher (3.0) than the upper limit of normal (2.5).

SURGERY: (January lB, 1987)

The patient underwent left radical orchiectomy.

GROSS PATHOLOGY:

The testicle measured 5.5 x 3.5 x 3.5 em. The tunica was unremarkable . On sectioning the upper and lateral poles of the testicle were replaced by multiple nodules of tan-white tumor measuring in aggregater 4.0 x 2.5 x 3.0 em. The cut surface of the tumor was slightly bulging and lobulated with small areas of punctate hemorrhage. The remainder of the testis was unremarkable. The epididymis and spermatic cord were grossly free of tumor .

CONTRIBUTOR: Steven B. Jobst, M. D. NOVEMBER 1988 - CASE NO. 11 San Luis Obispo, California

TISSUE FROM: Prostate ACCESSION NO. 25506

CLINICAL ABSTRACT:

History: This 42-year-old Caucasian male had urinary inconsistence, urinary frequency and nocturia for two years. He presented with difficulty urinating and was referred to a urologist whose impression was that he had

.obstructive uropathy secondary to prostatic enlargement.

Physical examination: Enlarged prostate with bladder outlet obstruction. No skin lesion noted.

SURGERY: (July 22, 1985)

The patient underwent transurethral resection ' of the prostate.

GROSS PATHOLOGY:

The specimen consisted of 15 grams of transurethrally resected prostatic tissue with particles measuring 1.5 x 3 x 4.5 em. They were of pale, reddish­tan color, rubbery elastic consistency.

CONTRIBUTOR: Richard D. Schneider, M. D. NOVEMBER 1988 - CASE NO. 12 Los Angeles, California

TISSUE FROM: Prostate ACCESSION NO. 25732

CLINICAL ABSTRACT:

History: This 78-year-old male was seen in the emergency room for acute uri nary retention. He had experienced nocturia, hesitancy urgency, intermittent and slow stream and occasional suprapubic discomfort and backache prior to admission.

. Ph3sical exami nation: The patient was healthy, alert, wel l developed, and

appeare younger than stated age. Rectal examination revealed a grade II enlarged prostate {left greater than right). No hard endurations of nodules were palpated.

SURGERY: {June 9, 1986)

The patient underwent suprapubic prostatectomy.

GROSS PATHOLOGY:

The specimen consisted of two pieces of rubbery f i rm prostati c tissue, weighing a total of 23 grams. The larger piece consisted of two lobes, measuring 5.5 x 3.5 x 2 em. There were numerous golden yellow nodules protruding from the surface . The smaller piece was tan gray and measured 2.5 x 1.7 x 1.2 em. On section there were subcapsular golden yellow nodules of varying sizes as well as deeper tan gray nodules. ·

STUDY GROUP CASES FOR

NOVEMBER 1988

CASE NO. 1 - ACCESSION NO. 21442

LOS ANGELES: Adenomatoid tumor - 6

SAN BERNARDINO (INLAND): Adenomatoid tumor- 10

LONG BEACH: Adenomatoid tumor - 7

NORTH DAKOTA: Apenomatoid tumor - 1

MARTINEZ: Adenomatoid tumor - 7

SEATTLE : Adenomatoid tumor, cellula-r - 7

BAKERSFIELD: Adenomatoid tumor - 2; adrenal rest tumor - 1

OAKLAND: Adenomatoid 'tumor - 7

FRESNO: Adenoma to i d - 11

SAN FRANCISCO: Adenomatoid tumor - 4

FOLLOW-UP:

Not available.

DIAGNOSIS:

Adenomatoid tumor, epididymis

REFERENCES:

Miller, Frederick and Lieberman, Moses: Local Invasion in Adenomatoid Tumors.. Cancer 21: 933~939, 1968.

;raxy, J. B. , Batti fora, H. Oyasu, R.: Adenomatoi·d Tumors: A Light Microscopic, Histochemical and Ultrastructural Study. Cancer 34:306-316, 1974.

Broth, Gene, Bullock, Weldon K. and Morrow, James: Epididymal Tumors: Report of 15 New Cases Including Review of Literature. Histochemical Study of the So-called Adenomatoid Tumor . J~. Urol . 100.:530-536, 1968.

Trai ner, Thomas D.: Histology of the Normal Testis . Am. J. Surg. Path. 11 (10): 797-809' 1987.

CASE NO. 2 - ACCESSION NO . 12195 NOVEMBER 19B8

LOS ANGELES: Undifferentiated rhabdomyosarcoma, arising from tunica epididymis - 6

SAN BERNARDINO (INLAND): Rhabdomyosarocma - 6, sarcoma NOS - 3, leiomyosarcoma - 1

LONG BEACH: Rhabdomyosarcoma - 7

NORTH DAKOTA: Embryonal rhabdomyosarcoma - 1

MARTINEZ: Rhabdomyosarcoma - 7

SEATTLE: Sarcoma, NOS - 7

BAKERSFIELD: Rhabdomyosarcoma - 3

OAKLAND: Mal ignant messenchymal tumor, ·favor rhabdomyosarcoma - 7

FRESNO: Juvenile rhabdomyosarcoma - 11

SAN FRANCISCO: Embryonal rhabdomyosarocma - 4

CONSULTATION:

AF1P, Washington D. C.: Mesenchymal tumor, probably a myosaroma arising extratesticularly in the tunica albuginea .

SPECIAL STAIN:

Muscle Specific Actin : Positive

FOLLOW-UP:

Lost to follow-up.

DIAGNOSIS:

Rhabdomyosarcoma, tunica epididymis

REFERENC ES :

Arean, V. M. , Kreager, J . A.: Paratesticular Rhabdomyosarcoma. Am. J. Clin. Pathol. 43:418-427, 1965.

Batsakis, John· G.: Urogential Rhabdomyosarcoma: Histogenesis and Cl assi­fication . J. Urol. 90:180-186, 1963.

Littman, Robert T. : Tessler, Arthur N. and Val ensi, Quentin: Paratesticular Rhabdomyosarcoma. A Case Presentation and Review of the liverature. J . Ural . 108: 290-296, 1972.

Rosas-Uribe, A., Luna, H. A., Guinn, G. A.: Paratesticul ar Rhabdomyosarcoma. Am. J. Surg. 120:787-791, 1970.

Banik, S., Guha, P. K.: Paratesticular Rhabdomyosarcoma and Leiomyosarcomas: A Cl ini copathological Review. J. Urol. 121:823-826, 1979.

CASE NO. 3 - ACCESSION NO. 20949 NOVEMBER 1988

LOS ANGELES: Osteosarcoma - 6

SAN BERNARDINO (INLAND}: Osteosarocma - 9; metaplast ic carcinoma - 1

LONG BEACH: Extraskeleta l osteosarcoma - 7

NORTH DAKOTA: Osteosarcoma - 1

MARTINEZ: Extraskeletal osteogenic sarcoma - 8

SEATTLE: Osteogeni c sarcoma - 7

BAKERSFIELD: Malignant mixed mesenchymal tumor - 1; extraskeletal osteogenic sarcoma - 1; rhabdomyosarcoma with osseous differentiation- 1

OAKLAND: Osteosarcoma, soft tissue - 7

FRESNO: Extra osseous osteogenic sarcoma - 11

SAN FRANCISCO: Extra-osseous osteosarcoma - 3; mali gnant fibrous histiocytoma with osseous metaplasia - 1

FOLLOW-UP:

Re-admitted two years later with brain , liver and lung metastases. Lung metastases were first demonstrated in September 1975 by x-rays· and scan . No biops i e·s were performed . He received no radiation or chemotherapy. Oi scharged to a nursing home for terminal care on 4-16-76.

DIAGNOSIS:

Extraskeletal osteosarocma, foreskin of penis

REFERENCES:

Allan, C. J. and Soule , E. H.: Osteogenic Sarcoma of the Somatic Soft Tissues . Clini copathologic Study of 26 Cases and Review of Literature. Cancer 27:1121-1133, 1971.

Rao, U. , Ch.eng, A. and Didolkar , M. S.: Extraosseous Osteogenic Sarcoma. Cancer 41:1488-19~6, 1978.

CASE NO. 4 - ACCESSION NO. 25700 NOVEMBER 1988

LOS ANGELES: Paratesticular embryonal rhabdomyosarcoma - 6

SAN BERNARDINO (INLAND): Rhabdomyosarcoma - 10

LONG BEACH: Rhabdomyosarcoma - 7

NORTH DAKOTA: Rhabdomyosarcoma - 1

MARTINEZ: Rhabdomyosarcoma - 8

SEATTLE: Sarcoma - NOS - 3; synovial sarcoma - 1; neurosarcoma - 2; rhabdomyo­sarcoma - 1

BAKERSFIELD: Malignant mesenchymal tumor - 1; leiomyosarcoma - 2

OAKLAND: Rhabdomyosarcoma - 7

FRESNO : Rhabdomyosarcoma - 10; mali gnant gonadoblastoma - 1

FOLLOW-UP:

Following orchiectomy and retroperitoneal dissection he underwent radiation therapy (5000 rads to left groin and 4,400 rads to paraortic area-completed 6/23/86). He also received 6 cycles of chemotherapy consi st ing of Vincristine, Adriamycin and Cytoxan (compl eted 4/27/87).

He was l ast hospitalized in September 1987 at which t ime he was noted to have widespread metastatic disease to retroperitoneum and liver. He refused further treatment and was discharged to a nursing care facility for conservati ve suppor tive care.

SPECIAL STAIN:

Muscle Specific Actin: Pos1tive

DIAGNOSIS:

Embryonal rhabdomyosarcoma, paratesticular

REFERENCES:

Arean, Victor M., Kreager, John A. : Paratesticular Rhabdomyosarcoma . Am. J. Cl 1n .. , Pathol. 43:418-427, 1965 .

Batsakis, J. G.: Urogenital Rhabdomyosarcoma: Histogenes i s and Classification. J. Urol. 90:180-186, 1963.

Littman, R., , Tessler, A. N., Valensi, Q.: Paratesticular Rhabdomyosarcoma. A Case Presentation and Review of the Literature. J. Urol . 108:290-296, 1972.

Rosas-Uri be, Artuno, Luna, Marino A. and Guinn, Gene A.: Paratesticular Rhabdo­myosarcoma . Am. J . Surg. 120:787-791, 1970.

Banik, S. and Guha, P. K.: Paratesticular Rhabdomyosarcoma and Leiomyosarcomas. A Clinicopathologi cal Review. J. Urol. 121 :823-826 , 1979.

CASE NO. 5 - ACCESSION NO. 17612 NOVEMBER 1988

LOS ANGELES: Rhabdomyosarcoma - 6

SAN BERNARDINO (INLAND): Juvenile rhabdomyosarcoma - 10

LONG BEACH: Rhabdomyosarcoma - 7

NORTH DAKOTA: Rhabdomyosarcoma - 1

MARTI NEZ: Rhabdomyosarcoma, embryonal - 8

SEATTLE: Embyonal rhabdomyosarcoma -.1

BAKERSFIELD: liposarcoma - 2; rhabdomyosarcoma - 1

OAKLAND: Rhabdomyosarcoma - 7

FRESNO: Embryonal rhabdomyosarcoma - 11

SAN FRANCISCO: Embryonal rhabdomyosaroma - 4

FOllOW-UP:

The patient was l ast seen by his physic ian on May 10, 1972 with no evidence of recurrence at that time. The patient has si nce moved out of t he area .

SPECIAL STAINS:

PTAH: Cross striat ions were identified by scime pathologists Muscle Specific Actin: Positive

DIAGNOSIS:

Rhabdomyosarcoma, tunica vaginalis, lower pole of t estis, and epididymis

REFERENCES:

Arean , V. M., Kreager , J. A. : Parat es ti cul ar Rhabdomyosarcoma. Am. J . Cl in. , Pathol. 43:418-427 , 1965.

. Batsakis, J. G.: Urogenital Rhabdomyosarcoma: Histogenesi s and Calssi­fication. J. Urol. 90:180- 186 , 1963.

Littman, R., Tessler, A. N., Valensi , Q.: Paratesticul ar Rhabdomyosarcoma. A Case Presentation and Review of the literature . J. Urol . 108:290-296, 1972.

Rosas-Urube, A., luna , M. A., Guinn, G. A.: Paratesticular Rhabdomyosarcoma. Am. J. Surg . 120:787-791, 1970.

Banik, S. , Guha , P. K. : Paratesticular Rhabdomyosarcoma and Leiomyosarcomas.: A Cl inicopathol ogical Review. J . Urol. 121:823-826, 1979.

CASE NO. 6 - ACCESSION NO. 6590

LOS ANGELES: Hemangiopericytoma - 3; angiosarcoma - 4

SAN BERNARDINO (INLAND): Angiosarcoma- 10

LONG BEACH: Hemangiopericytoma - 6, angiosarcoma - 1

NORTH DAKOTA: Angiosarcoma - 1

MARTINEZ: Hemangioperi cytoma - 8

NOVEMBER 1988

SEATTLE: Angiosarcoma, with focal hemangiopericytic pattern - 8

BAKERSFIELD: Hemangioendothelioma - 3

OAKLAND: Angiosarcoma- 6; Kaposi's sarcoma- 1

FRESNO: Hemangiopericytoma - 8; epithelial hemangioendothelioma - 1; malignant hemangioendothelioma- 1; angiosarcoma- 1

SAN FRANCISCO: Hemangiopericytoma - 2; hemangioendothelioma - 1

FOLLOW-UP:

No evidence of disease i n June 1957.

SPECIAL STAINS:

Muscle Specific Actin: Postive Factor VIII: Negative on tumor cells

DIAGNOSIS:

Hemang1opericytoma, perineum

REFERENCES:

Enzinger , F. M. and Smith , B. H. : Hemang1oper icytoma .' An analysis of 106 Cases. Hum. Path. 7:61-82i 1976.

McMaster, Michael J., Soule , Edward H., and Ivins John C.: Hemangiopericytoma. A Clinicopathologic Study and Long Term Follow-up of 60 patient s. Cancer 36:2232-2244 , December 1975.

CASE NO. 7 - ACCESSION NO. 10750 NOVEMBER 1988

LOS ANGELES: liposarcoma - 3; sarcoma, NOS - 1; spindle cel l tumor, NOS- 2

SAN BERNARDINO (INLAND): liposarcoma- 9

LONG BEACH: Myxoid liposarcoma - 7

NORTH DAKOTA: Fasciitis - 1

MARTINEZ: liposarcoma- 4; angiomyxoma- 4

SEATTLE: Mesenchymal tumor, type und~termined - 8

BAKERSFIELD: Myxoma, right Vas - 2; fibrous pseudotumor - 1

OAKLAND: Rhabdomyosarcoma - 7

FRESNO: Nodular fasciitis - 6; pseudotumor - 4; low-grade l iposarcoma - 1

SAN FRANCISCO: Myxoid l iposarcoma - 4

FOLLOW-UP:

The patient recovered frotn surgery without incidence and was in perfect health as of April 22, 1960. No current follow-up available.

SPECIAL STAINS:

AMP: Negative except for capsular and perivascular connective tissue. Fat Stain: Positive only in a few of the small spindloid cell s . S-100: Negative

DIAGNOSIS:

Liposarcoma, spermatic cord

REFERENCES:

Arlen, Myron , Grabstald, Harry, and Whitmore, Wrillet F.: Malignant tumors of the spermatic cord . Cancer 23:525-532, March 1969.

Watta, N. S., Singh, S. M., and Bapna, B. C.: Liposarcoma of the spermatic cord. Report of a Case and Review of the Literature J. Urol. 106:888-889, 1971.

CASE NO. 8 - ACCESSION NO. 11136

LOS ANGELES: Epidermoid carcinoma, grade I - 6

SAN BERNARDINO (INLAND): Verrucous carcinoma - 10

LONG BEACH: Verrucous carcinoma - 7

NORTH DAKOTA: Squamous cell carcinoma - 1

MARTINEZ: Squamous cel l carcinoma - 8

SEATTLE: Well differentiated squamous carcinoma - 8

NOVEMBER 1988

BAKERSFIELD: Giant condyloma 1; squamous cell carcinoma, well differentiated - 1

OAKLAND: Verrucous carcinoma - 4; well differentiated squamous cell carcinoma - 3

FRESNO: Verrucous carcinoma - 10; pseudoepitheliomatous hyperplasia - 1

SAN FRANCISCO: Verrucal squamous cell carcinoma - 4

FOLLOW-UP:

Not ava i lable.

Lymph nodes: Negative

DIAGNOSIS:

Epidermoid carcinoma, grade I, penis

REFERENCES:

Fur long, John H., and Uhle, Charles A. W.: Cancer of the Penis: A Report of 88 Cases. J . Urol. 69:550-555, 1953.

Staubitz, w. J. , Lent, M. H. , Oberkircher, 0. J.: Carcinoma of the Penis. Cancer 8:373-378 , 1955.

Merrin, Claude E.: Cancer of the Penis. Cancer 45:1973-1979, 1980.

CASE NO. 9 - ACCESSION NO. 13413 NOVEMBER 1988

LOS ANGELES: Well to poor ly squamous cell carci noma with pseudosarcomatous features - 1; keratinizing and spindle squamous cell carcinoma - 6

SAN BERNARDINO (INLAND): Squamous cell carcinoma , spindle cell type - 5; sarcoma, NOS - 4; melanoma - 1

LONG BEACH : Spindle cell, squamous cell carcinoma - 7

NORTH DAKOTA: Malignant fibrous histiocytoma- 1

MARTINEZ: Squamous cell carcinoma , spindle cell type- 8

SEATTLE: Spindle cell squamous carcinoma with verrucous surface component - 8

BAKERSFIELD: Squamous cell carcinoma wi t h pseudosarcomatous changes - 3

OAKLAND: Spindle cell squamous carcinoma - 7

FRESNO: Squamous cell carcinoma, spindle cell type - 9; fibrous hi stiocytoma - 1; pseudosarcomatous rea~tion - 1

SAN FRANCISCO: Spindle cel l, squamous cell carci noma - 4

FOLLOW-UP:

In March, 1964, the private physician said the tumor "was growing by leaps and bounds". The patient subsequently died in 1964. No auto~sy was performed .

DIAGNOSIS:

Well to poorly differentiated squamous cell carcinoma with pseudosarcomatous features, penis

REFERENCES:

Furlong, J. H. , Uhle, c. A. W.: Cancer of the Penis: A Report of 88 Cases. J. Urol . 69:550-555, 1953.

Staubitz, W. J., Lent, M. H. , Oberkircher , 0. J.: Carcinoma of the Penis. Cancer 8:373-378, 1955 .

Merrin, Claude E.: Cancer of the Penis. Cancer 45:1973-1979, 1980.

Harris M.: Spindle Cell Squamous Carci noma: Ultras tructural Observati ons Histopathol. 6:197-210, June 1981.

CASE NO. 10 - ACCESSION NO. 26065 NOVEMBER 19B8

LOS ANGELES: Seminoma and embryonal carcinoma - 6

SAN BERNARDINO (INLAND}: Seminoma - 9; seminoma with embryonal carcinoma - 1

LONG BEACH: Mixed germ cell tumor (seminoma with embryonal carcinoma) - 7

NORTH DAKOTA: Seminoma - 1

MARTINEZ: Seminoma with embryonal carcinoma - B

SEATTLE: Seminoma invading rete testi.s - 8

BAKERSFIELD: Seminoma - 2; mixed germ-cell tumor - 1

OAKLAND: Seminoma - 6; seminoma with focal yolk-sac tumor - 1

FRESNO: Seminoma - 10; seminoma with embryonal carcinoma - 1

SAN FRANCISCO: Seminoma with intratubular component - 4

FOLLOW-UP:

This patient was last seen on February 25 , 19B8. He was doing well with no evidence of metastatic tumor. There is a history of acute hepatitis A, which developed in September 1987.

DIAGNOSIS:

Mixed seminoma and embryonal carcinoma, testicle

REFERENCES:

Mostofi, F. K., Price, E. B.: Tumors of the Male Genital System: Series 2, Fascicle 8, Atlas of Tumor Pathology , Washington, D. c., Armed Forces Institute of Pathology 1973.

Mostofi, F. K.: Pathology of Germ Cell Tumors of the Testes . Cancer 45: 1735-1754, 1980.

Merrin, Claude: Seminoma . Urol, Cli~ics North Am. 4(3):379-392 , 1977 • .

Johnso~. D. E., Gomez, Jesus J. and Ayala, Alberto G.: Histologic Factors Affect ing Prognosis of Pure Seminoma of the Testes. South. Med. J. 6g:1173-1174, 1976. .

Giannone, L., Wolff, S. N. : Recent Progress in the treatment of Seminoma. Oncology 2:21-30, 1988.

CASE NO. 11 - ACCESSION NO. 25506

LOS ANGELES : Plexiform neurofibroma - 6

SAN BERNARDINO (INLAND): Plexiform neurofibroma- 10

LONG BEACH: Neurofibromatosis - 7

NORTH DAKOTA: Neurofibromat osis - 1

MARTINEZ: Neurofibromatosis - 7; malakoplakia - 1

SEATTLE: Neurofibromatosis - 8

BAKERSFIELD: Neurofibroma - 2; neural hyperplasia - 1

OAKLAND: Plexiform neurofibroma - 4; hamartoma - 3

FRESNO: Neurofibroma - 11

SAN FRANCISCO: Neurofibromatosis - 4

SPECIAL STAIN:

S-100: Positive

FOLLOW- UP:

NOVEMBER 1988

The patient was a prisoner and is now lost to follow-up.

DIAGNOSIS:

Plexiform neurofibroma, prostate

REFERENCE:

Deniz, Engin Shimkus, George C. and Weller, C. Grafton: Pelvic Neuro­fibromatosis ; Localized Von Recklinghausen's Disease of .the Bladder. J. Urol . 96:906-909, 1966.

CASE NO. 12 - ACCESSION NO. 25732 NOVEMBER 1988

LOS ANGELES: Prostatic carcinoma - 6

SAN BERNARDINO (INLAND): Adenocarci noma of prostate - 9; prostatic duct adeno­carcinoma - 1

LONG BEACH: Endometrioid adenocarcinoma - 7

NORTH DAKOTA: Endometrial type of prostatic type of adenocarcinoma - 1

MARTINEZ: Adenocarci noma - 6; adenocarcinoma, with in-situ component - 2

SEATTLE: Prostatic adenocarcinoma - 8

BAKERSFIELD: Adenocarcinoma, endometrioid - 3

OAKLAND: Adenocarcinoma with endometrioi d carcinoma - 7

FRESNO: Papill ary adenocarcinoma - 11

SAN FRANCISCO: Papillar~ adenocarcinoma - 4

FOLLOW-UP:

Chest x-ray was normal (6/10/86) - Bone scan showed no evidence of metastatic disease (6/13/86) -Al kal ine Phosphate was 63 with upper normal being 140 and acid phosphate was 0.65 with upper normal being 0.63.

DIAGNOSIS:

Prostatic adenocarcinoma, prostate

REFERENCES:

Prout, G. R. , Jr.: Prognosis and Staging of Prostatic Carcinoma. Cancer 32:1096-1103, 1973.

McaCullough , 0. L.: Prognos is and Staging of Prostati~ Cancer in Skinner, 0. G. , OeKernion, J. B. (eds.): Genitourinary Cancer. Philadelphia, W. B. Saunders , 1978, pp. 305.

Bostwick, D. G. ~ Kindrachuk, R. W., Rouse, R. V.: Prostatic Adenocarcinoma Endometrioid Features: Clinical , Pathology, and Ultrastructural Findings. Am. J. Surg. Path. 9:595-609, 1985.

McNeal, John E.: Normal Histology of the Prostate. Am. J . Surg . Path. 12(8) :619-633, August 1988.