108
Tutorial COMPACT Mehrkens H.-H., Geiger P., Winckelmann J. Department of Anesthesiology/Intensive Care Medicine and Pain Therapy Ulm Rehabilitation Hospital and University Clinic PERIPHERAL REGIONAL ANAESTHESIA 2nd Expanded Edition

RKU Brochure

  • Upload
    h95br

  • View
    55

  • Download
    3

Embed Size (px)

DESCRIPTION

Regional anaesthesia

Citation preview

Tutorial COMPACTMehrkens H.-H., Geiger P., Winckelmann J.Department of Anesthesiology/Intensive Care Medicine and Pain TherapyUlm Rehabilitation Hospital and University Clinic

PERIPHERAL REGIONAL ANAESTHESIA

2nd Expanded Edition

RKU_Umschlag_eng2.indd 1 18.08.09 14:04

Preface

After so many of our colleagues have expressed the wish for a pocket edition of our Peripheral Regional Anesthesia Tutorial published by the Ulm Reha-bilitation Hospital (RKU), we have now complied by offering this compact version. The fundamentals contained in this condensed guide still grow from the now almost 20 years of clini-cal and practical experience gained in our hospital. This book differs from the previous, more comprehensive Tutorial Script in that it includes many new developments and supplemental information. These shall be incorporated into the next edition of the tutorial script and its coming Internet version.

It is here that I would like to extend my very special thanks to the managing Senior Physician of our Department, Dr. Peter Geiger. Without his tireless assistance, the production of the compact version of this pocket tutorial would not have been possible. Additional thanks go to B. Braun Melsungen, whose continuing technical and financial support have been invalu-able for the completion of this work.

Ulm, June 2004 Prof. H.-H. Mehrkens, M.D.

Prof. H.-H. Mehrkens, M.D. Director, Dept. of Anesthesiology/Intensive Care Medicine

RKU_Compact_e_V6_neu.indd 1 21.09.09 14:00

2

Preface to the 2nd Expanded Edition

Now, five years after the first pocket edition of the “Peripheral Regional An-esthesia Tutorial” appeared, the time is right to pay tribute to the rapid-paced developments taking place in this field of medicine. In doing so, we have made special efforts to include ultrasound-guided nerve block techniques when-ever we felt it was sensible. Certainly, our daily routine has become unimagi-nable without visualization of the nerves we want to block. At the same time, we believe that nerve stimulation and ultrasonographic visualization are not competing methods. In-deed, seeing as not every block is equally suited for one or the other of the two, a command of both is required. In many cases, combining ultrasound with nerve stimulation yields major advan-tages.

Nerve blocks guided by ultrasound thrive on visual dynamics. For that reason, we have intentionally refrained from using static pictures of needle positions or of the local anaesthetic’s spread around the target structures. Instead, this booklet has placed par-ticular emphasis on the “ultrasonographic normal situs” at typical puncture sites, which should assist the reader in identifying key structures. Motion images shall be made available on an updated Tutorial DVD soon.

P. M. Geiger, M.D. Medical Director, Department of Anesthesiology/Intensive Care Medicine and Pain Therapy

RKU_Compact_e_V6_neu.indd 2-3

3

-e , -

. c d -l

y d

It is here that I would like to extend my special thanks to Prof. H.-H. Mehrkens, MD, my predecessor and the initiator of the “Tu-torial Series”, who regularly takes time off from his retirement to lend us his valuable advice. My managing senior physician, Dr. Jörg Winckelmann, also deserves great recognition for his untir-ing commitment to the production of this new edition. Not least, I would like to thank B. Braun Melsungen AG: without the com-pany’s support, this project would not have been possible. We authors hope that this current pocket-sized version will be used effectively and we are equally looking forward, as in the past, to its readers’ critiques and constructive suggestions on the Internet Forum www.nerveblocks.net.

Ulm, August 2009 P. M. Geiger, MD

21.09.09 14:00

4

General

Contents

Nerve stimulation ..................................................... 4

Transcutane nerve stimulation ................................ 8

Sonography ............................................................ 10

Drugs ....................................................................... 13

Anatomy: Diagram of the brachial plexus ............ 14

Anatomy: Diagram of the lumbosacral plexus ..... 15

Continuing education materials ............................. 94

Upper extremity

Anterior interscalene nerve block ......................... 18

Posterior interscalene nerve block ........................ 24

Supraclavicular brachial block ............................... 28

Infraclavicular block ............................................... 30

Axillary nerve block ............................................... 36

Suprascapular nerve block .................................... 42

RKU_Compact_e_V6_neu.indd 4-5

5

Lower extremity

Psoas compartment block .................................... 46

Femoral nerve block ............................................. 50

Saphenous nerve block ........................................ 56

Obturator nerve block ........................................... 62

Parasacral sciatic nerve block .............................. 68

Transgluteal sciatic nerve block ........................... 72

Anterior sciatic nerve block .................................. 76

Subtrochanteric sciatic nerve block ..................... 80

Lateral distal sciatic nerve block ........................... 84

Popliteal sciatic nerve block .................................. 90

21.09.09 14:00

6

Nerve stimulation

Catheter technique

•Unipolarneedlesinaplasticintroducerofvaryinglengths e.g.: Contiplex® D Sets with a flexible and non-wired catheter or Contiplex® S (B. Braun Melsungen AG)

Single shot technique

•Unipolarneedlesofvaryinglength e.g., Stimuplex® D or Stimuplex® D Plus for ultrasound-

guided nerve blocks (B. Braun Melsungen AG)

Nerve stimulator

• Currentrangefrom1.0–0.1mA• Pulseduration0.1ms(mixednerve)

1.0 ms (sensory nerve)• Constantsquarewavepulseoverawideimpedancerange

e.g. Stimuplex® HNS 11 and Stimuplex® HNS 12 (B. Braun Melsungen AG)

RKU_Compact_e_V6_neu.indd 6-7

7

Equipment

Contiplex® D (B. Braun Melsungen AG)

Stimuplex® HNS 12 (B. Braun Melsungen AG)

Contiplex® Tuohy, Contiplex® S (B. Braun Melsungen AG)

Stimuplex® D / Stimuplex® D Plus (B. Braun Melsungen AG)

21.09.09 14:00

8

Transdermal nerve stimulation

Stimulation and injection technique

1. Initial current 1.0 mA

2. Pulse duration 0.1 ms (mixed nerve) or

3.Thresholdcurrent0.3–0.2mA

4.Aspirationtest5–10mlLAinjectedslowly

5. Increase to 1.0 mA initial current No stimulatory response

6. Administration of remaining LA 1.0 mA

7. Catheter placement after primary LA administration

Upper extremity: Approx. 3 cm beyond the end of the introducer sheath

Lower extremity: Approx. 4 cm beyond the end of the introducer sheath

8. Catheter aspiration test

Recurring stimulatory response: may indicate (partial) intra-vascular needle position. Attempt careful aspiration, perform reinjection slowly with constant verbal moni-toring.

use the SENS mode setting on the stimulator

RKU_Compact_e_V6_neu.indd 8-9

9

Block technique

•Prerequisite:superficiallocationofthenerves•Changethesettingsonthenervestimulatorto:Pulseduration1.0ms,baselineamplitude2.5–3.0mA,•Goodconductivityofthepentip(electrodegel,water)•Continuousimpedancedisplay(HNS12)canbehelpfulas

an indirect measure of “unimpeded” current flow

Technique

Areas of application

•Forprimaryorientationbeforeblockinganerve•Todemonstratespecificstimulatoryresponses(for training purposes)

Stimuplex® Pen / Stimuplex® Guide

The Stimuplex Pen can be used together with the nerve stimulator to locate nerves transdermally and to trigger the corresponding motor response.PEG (Percutaneous Electrode Guidance)The Stimuplex® Guide first induces percutaneous stimulation with the sterile needle and then the actual nerve block.

21.09.09 14:00

10

Sonography

Practical procedural tips

•Createergonomiccircumstances(patient,puncturingphysician, ultrasound imager)

• Performa“trialsonography”fororientation•Sterileprepinsertionsiteandtransducer•Advancetheinsertionneedleintotargetareaanddeliver

local anaesthetic•Correctneedlepositionandinjectmorelocalanaesthetic as needed

Transverse to ultrasound plane (so called „short axis“)

In-plane with ultrasound beam (so called „log axis“)

General prerequisites

•Knowledgeof(incisional)anatomy•Proper material (ultrasound imager, needles, local anaesthetics)•Routine application (to train hand-eye coordination)

Distance to the targetis often long

Usually short distance to target (nerve/plexus)

Difficult to visualise needle tip

Needle and target area fully visualised

Advantages DisadvantagesInsertion

Insertion techniques

RKU_Compact_e_V6_neu.indd 10-11

11

Technique

Short axis (out-of-plane technique)

Long axis (in-plane technique)

21.09.09 14:00

12

Equipment

Stimuplex® D Plus (B. Braun Melsungen AG)

Stimuplex® Needle Guide (B. Braun Melsungen AG)

Ultrasound imager requirements (e.g. GE Venue 40)

•Compactandrobust•Easytooperate•Quicklyreadyand mobile (boot time etc.)•Suitablehigh-frequencytransducer(7–12MHz)

conventional needle shaft Stimuplex® D Plus

(new echogenic needle shaft)

RKU_Compact_e_V6_neu.indd 12-13

13

Drugs

Drugs

Conventional, medium-acting local anesthetics (LA) like• prilocaine•mepivacaine

and long-acting ones like • ropivacaine• bupivacaine.

For anesthesia, we prefer a combination of • prilocaine1%(20–40ml)andropivacaine0.5–0.75% (10–20ml).

This combination has the advantage that a LA with com-parably low toxicity is given primarily and inadvertent intravascular injections mostly occur during the prodromal stage. Subsequently, a long-acting LA is administered to achieve a blockade of sufficient duration.

Foranalgesia,0.2%ropivacaineisgenerallyadministered.The preferred mode of delivery is through a PCA pump equipped with basal rate and bolus settings or by continu-ous infusion through the nerve catheter. Intermittant bolus injections are rarely used.

21.09.09 14:00

14

Intoxication

CARDIO-CIRCULATORY

CEREBRAL

Asystolia

BradycardiaExtrasystolesHypotension

HypertensionTachycardia

Seizure

ConfusionDizzinessTinnitus

Metallic taste

Mentally “abnormal”

Degree ofintoxication

Local anesthetic-induced systemic intoxication

RKU_Compact_e_V6_neu.indd 14-15

15

Drugs

21.09.09 14:00

16

A Upper trunkB Middle trunkC Lower trunkD Lateral cordE Posterior cordF Medial cord

1 Dorsal scapular nerve.2 Suprascapular nerve3 Subclavian nerve4 Pectoral nerves

5 Musculocutaneus nerve6 Axillary nerve7 Radial nerve 8 Median nerve9 Ulnar nerve10 Medial brachial cutaneous nerve11 Medial antebrachial cutaneous nerve 12 Long thoracic nerve13 Subscapular nerve14 Axillary artery15 Thoracodorsal nerve

Brachial plexus Anatomy

A

BC

DE

F

123

5

6

78

910 11

12

1415

RKU_Compact_e_V6_neu.indd 16-17

17

1 Lateral femoral cutaneous nerve

2 Femoral nerve

3 Genitofemoral nerve

4 Sciatic nerve

5 Obturator nerve

6 Pudendal nerve

Lumbosacral plexus Anatomy

1

2

3

4 5 6

21.09.09 14:00

18

Nerve stimulation

Approach according to Meier

Contraindications

•Contralateralphrenicandrecurrentparesis

Side effects / complications

•Horner´ssyndrome•Phrenicparesis•Recurrentparesis•Vesselpuncture(externaljugularvein)

Anatomical landmarks

•Sternocleidomastoidmuscle•Superiorthyroidnotch•Scalenusgap•VIB(verticalinfraclavicularblockade)point

Indications

•Operativeproceduresontheshoulder,proximalupperarm and lateral clavicle

•Analgesia

1 Sternocleidomastoid muscle,

2 Thyroid notch, 3 Puncture site

RKU_Compact_e_V6_neu.indd 18-19

19

1

23

Anterior interscalene nerve block

Anatomical landmarks

21.09.09 14:00

20

Nerve stimulation

Blockade technique The patient lies supine, head turned slightly to contralateral side, shoulder and arm positioned comfortably.

Puncture site:Posterior edge of the sternocleidomastoid muscle at the level ofthethyroidnotch(1.5–2cmabovethecricoid).Insertiondirection tangential to the course of the plexus in the direction of the VIB point or anterior axillary line.

Puncturedepth:2–4cm.

Positive stimulatory response from the upper trunk (lateral cord): biceps and/or brachial muscle.

Dosage

20–40mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mmAdvance the soft plastic catheter max. 3 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 20-21

21

?contralateral

level

direction

(lateral

What to do when ...?

Stimulation of the axillary nerve (deltoid mus-cle) or radial nerve (triceps muscle) occurs:Leave the needle in place u Administer LA.

Stimulation of the suprascapular nerve (leva-tor scapulae muscle) occurs: The insertion direction is too lateral and dorsal u Retract the needle, advance it markedly more to the ventral and somewhat more medial.

Stimulation of the phrenic nerve (unilateral singultus) occurs: The insertion direction is too ventral and medial u Retract the needle, ad-vance it slightly more to the lateral and dorsal.

Blood is aspirated: Retract the needle, check direction of puncture u Readvance needle.

Potential errors and hazards

Always avoid a medial direction of puncture:•Riskofpuncturinglargevessels(carotidand

vertebral arteries, internal jugular vein).•Riskofintrathecalinjection=highspinal!

(Most suitable and reliable stimulatory response: bicepsand/orbrachialmuscle=mostlateralpart of plexus [C5])

Anterior interscalene nerve block

!

?

21.09.09 14:00

22

Sonography

Nerve block techniqueShort axis is preferable (catheter placement), long axis possiblefor Single shot

Sonoanatomic landmarks:- Sternocleidomastoid muscle- Scalenus anterior and scalenus medius muscles- Nerve roots of the brachial plexus

Blockade objective:Infiltrateatleastthesuperiorroots(C5–C7)withlocalanaes-thetic. As a general rule, 15 - 20 ml will suffice.

Practical tip:The ideal insertion site is most successfully located by tilting the transducer from the supraclavicular to the interscalene position, following the plexus fibres.

RKU_Compact_e_V6_neu.indd 22-23

23

-

e ,

Anterior interscalene nerve block

Sonoanatomic landmarks

med

ial

late

ral

21.09.09 14:01

24

Nerve stimulation

Approach according to Pippa

Contraindications

•Contralateralphrenicandrecurrentparesis

Side effects / complications

•Horner´ssyndrome•Phrenicparesis•Recurrentparesis•Vesselpuncture

Indications

•Operativeproceduresontheshoulder,proximalupperarm and lateral clavicle

•Analgesia

Anatomical landmarks

•SpinousprocessC7(vertebraprominens)•SpinousprocessC6•Cricoid•Sternocleidomastoidmuscle

1 C6, 2 C7, 3 Puncture site

RKU_Compact_e_V6_neu.indd 24-25

25

site

1

2

3

Posterior interscalene nerve block

Anatomical landmarks

21.09.09 14:01

26

Nerve stimulation

Blockade technique Patient is in axially aligned recumbent position (or seated); the cervical spine is flexed backwards; shoulder and arm are relaxed.

Puncture site:3 cm midline between the two spinous processes C6 and C7, Insertiondirection5–10°tothelateral,aimedattheheightofthe cricoid.

Puncturedepth:6–8cm,dependingonthedistancebetweenpuncture site and posterior edge of the sternocleidomastoid muscle.

A promising stimulatory response elicited from the upper trunk (lateral sheath): biceps muscle and/or brachial muscle and/or deltoid muscle.

Dosage

30–50mlLA

Catheter technique

e.g. Contiplex®D-Set,80–110mmAdvance the soft plastic catheter max. 3 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,80–100mm

RKU_Compact_e_V6_neu.indd 26-27

27

?; e

, f

d

k r

What to do when ...?

Stimulation of the axillary nerve (deltoid mus-cle) or radial nerve (triceps muscle) occurs:Leave needle in situ u Inject a slow, fraction-ated dose of local anaesthetic.

Stimulation of the suprascapular nerve (leva-tor scapulae muscle) occurs: Insertion direc-tion too lateral u Retract the needle, advance it slightly to the medial and slightly deeper.

Stimulation of the phrenic nerve (unilateral singultus) occurs: Insertion direction too deep and too medial uRetract the needle, advance it more to the lateral and less deep.

Blood is aspirated: retract the needle, check puncture direction uReadvance the needle.

Potential errors and hazards

Always avoid a medial insertion direction:•Riskofpuncturingthevertebralartery.•Riskofintrathecalinjection=highspinal!

(Most suitable and reliable stimulatory re-sponse: bicepsand/orbrachialmuscle=mostlateralpart of plexus [C5])

Posterior interscalene nerve block

!

?

21.09.09 14:01

28

Sonography

Preliminary note:The supraclavicular plexus block is a classic indication for the use of ultrasound guidance since it can reliably depict delicate structures like the subclavian artery and the pleura, in particular. Or, stated the other way around: Do not perform supraclavicular blocks without ultrasound.

Nerve block technique:Long (single-shot technique) and short axis (catheter tech-nique) possible

Sonoanatomic landmarks:- Anterior scalene and middle scalene muscles- Subclavian artery- First rib- Pleura

Blockade objective:To infiltrate all parts of the plexus (here: trunks) with local anaesthetic.

RKU_Compact_e_V6_neu.indd 28-29

29

for depict

pleura, perform

local

Supraclavicular brachial block

Sonoanatomic landmarks

med

ial

late

ral

21.09.09 14:01

30

Nerve stimulation

Approach according to Kilka, Geiger, Mehrkens

Contraindications

•Chestdeformities•Healed,butdislocated(shortened)fractureoftheclavicle

Side effects / complications

•Horner´ssyndrome•Phrenicparesis•Vesselpuncture(cephalicvein,subclavianarteryandvein)•Pneumothorax

Indications

•Operativeproceduresonthedistalupperarm,forearmand hand

•Analgesia

Anatomical landmarks

•Suprasternalnotch•Lateraledgeoftheacromion• Infraclavicularfossa

1 Lateral edge of acromion, 2 Suprasternal notch,

3 Infraclavicular fossa, 4 Puncture site

RKU_Compact_e_V6_neu.indd 30-31

31

s

2

31

4

Infraclavicular block

Anatomical landmarks

21.09.09 14:01

32

Nerve stimulation

Blockade technique The patient is supine, with his hand relaxed on abdomen.

Puncture site:Half the distance between the jugular fossa and the ventral endof theacromion–directlyunderneath theclavicle. (Themedial edge of Mohrenheim’s fossa is used to confirm the insertion site). Insertion direction must be absolutely perpen-dicular to the supporting surface (operating table).

Puncturedepth:2–4cm.

Positive stimulatory response from the posterior cord:ExtensororflexormuscleD1–3(=radialormediannerve).

Dosage

30–50mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mmAdvance the soft plastic catheter max. 3 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 32-33

33

?abdomen.

ventral

the -

.

What to do when ...?Lateral landmarks (ventral apophysis of acro-mion) cannot be found: Palpation of the clavicle from medial to lateral leads to the acromioclavic-ular joint u The lateral edge of the acromion is located ventral and lateral. Palpation of the crest of the scapula from dorsal to lateroventral leads to the acromion and stops at the correct site.

Stimulation of the musculocutaneous nerve (bi-ceps muscle = lateral cord) occurs: Puncture is too medial and superficial u Retract the needle, shiftitsubcutaneouslytothelateral(0.3–0.5cm)andthenadvanceitperpendicularly(!)ap-prox.0.5–1cmdeeperthanbefore.

Blood is aspirated: Puncture site is too medial or too far away from the lower clavicular edge u Re-tract the needle, check lateral landmarks (ventral apophysis of the acromion) and readvance the needle.

Potential errors and hazards•Puncturetoomedial(establishalateralland-

mark as described above).•Punctureisnotperformedinaperpendicular

direction.•Puncturedepthorientation:estimateddistance

between surface and palpable lower clavicular margin + 1 cm (Beware > 4 cm in persons with asthenic physiques ).

Infraclavicular block

!

?

21.09.09 14:01

34

Sonography

Preliminary note:As a general rule, ultrasound visualization of the infraclavicu-lar cords is less pronounced than of the supraclavicular. It may sometimes be helpful to extend the arm.

Nerve block technique:Short and long axis possible

Sonoanatomic landmarks:- Subclavian artery and vein- Pectoralis major and minor muscles - Pleura

Blockade objective:To infiltrate all cords with local anaesthetic

RKU_Compact_e_V6_neu.indd 34-35

35

It

Infraclavicular block

Sonoanatomic landmarks

cran

ial

caud

al

21.09.09 14:01

36

Nerve stimulation

Approach according to de Jong

Contraindications

•Noparticular

Side effects / complications

•Haematomaiftheradialarteryisinjured

Indications

•Operativeproceduresontheelbow,forearmandhand•Analgesia

Anatomical landmarks

•Axillaryartery•Coracobrachialismuscle•Medialbicipitalgroove•Pectoralismajorandminormuscles

= Puncture site

RKU_Compact_e_V6_neu.indd 36-37

37

Axillary blockade

Anatomical landmarks

21.09.09 14:01

38

Nerve stimulation

Blockade technique With the patient supine, the shoulder joint is abducted 90°,elbowjointextended90°.

Puncture site:Slightly above the axillary artery in the gap between artery and coracobrachialis muscle, at the highest point in the axilla and slightly beneath the pectoralis major muscle.

Inserttheneedleapprox.30°paralleltotheaxillaryartery,tak-ing a very superficial course.

Puncturedepth:1–3cm.

A promising stimulatory response elicited from the median nerve or, rather, from the radial nerve: flexor digitorum mus-cles / extensor digitorum muscles.

Dosage

30–50mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mm Advance the soft plastic catheter 5 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 38-39

39

?90°,

artery axilla

-

median -

What to do when ...?

There is no stimulatory response:The puncture has probably gone too deep u Re-tract the needle and advance at a flatter (more tan-gential) angle, watching out for any “fascial click“.

Stimulation of the musculocutaneous nerve:The needle is not positioned within the neurov-ascular sheathu Retract the needle, advance it less deep and more tangential to the artery.

Potential errors and hazards

•Puncturetoodeep.•Difficultiesidentifyingtheaxillaryartery.

Axillary blockade

!

?

21.09.09 14:01

40

Sonography

Nerve block technique:Short axis is preferable

Sonoanatomic landmarks:- Axillary artery and vein- Triceps brachii muscle

Blockade objective:To infiltrate all four main nerves of the brachial plexus with local anaesthetic

RKU_Compact_e_V6_neu.indd 40-41

41

Axillary blockade

Sonoanatomic landmarks

cran

ial

caud

al

21.09.09 14:01

42

Nerve stimulation

Approach according to Meier

Contraindications

•Noparticular

Side effects / complications

•Noparticular

Indications

•Frozenshoulder(forpainmanagementandmobilizationtherapy)

•Analgesia

Anatomical landmarks

•Spineofscapula

1 Lateral end of the spine of scapula,

2 Medial end of the spine of scapula, 3 Puncture site

RKU_Compact_e_V6_neu.indd 42-43

43

2

3

1

Suprascapular nerve block

Anatomical landmarks

21.09.09 14:01

44

Nerve stimulation

The patient is seated, hand on their contralateral shoulder.

1–2cmcranialandmedialtothemid-spine.Insertiondirec-tion approx. 45° caudad and lateral towards the humerushead.

Puncturedepth:3–5cm.

Positive stimulatory response: supraspinatus or infraspinatus muscles.

Dosage

10–20mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mmAdvance the soft plastic catheter < 3 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 44-45

45

?-

infraspinatus

What to do when ...?

There is no stimulation response:Try to find the floor of the supraspinous fossa or retract the needle and advance it at a flatter angle towards the humerus head.

Note two important aspects:1. A muscular stimulatory response is not im-

perative to achieve blockade. 2. The suprascapular nerve is not involved in the(sensory)skinsupplyoftheshoulder!

Potential errors and hazards•Punctureismadetoodeepandsteep.

Suprascapular nerve block

!

?

21.09.09 14:01

46

Nerve stimulation

Approach according to Chayen

Contraindications

•Extremehyperlordosis(relative)•Coagulationdisorders

Side effects / complications

•Vesselpuncture(paravertebralveins)•Disseminationsimilartoepiduralanesthesia(contralateral)•High(total)spinalanesthesia

Indications

•Operativeproceduresinthelumbarplexussupplyarea• Incombinationwithproximalsciaticnerveblockforcom-

plicated operations on the whole leg distal to the hip (total knee arthroplasty, cruciate ligament replacement ...)

•Analgesia

Anatomical landmarks

•Posteriorsuperioriliacspine• Iliaccrest•SpinousprocessL4•CostalprocessL5

1 Iliac crest, 2 Posterior superior iliac spine,

3 Spinous process L 4, 4 Puncture site

RKU_Compact_e_V6_neu.indd 46-47

47

2

3

4

1

Psoas compartment block

Anatomical landmarks

21.09.09 14:01

48

Nerve stimulation

Blockade technique The patient is in the lateral recumbent position (or seated), the cervical spine is flexed backwards.

Puncture site:3 cm caudad and 4 cm paramedian to the spinous process of L4. Sagittal insertion direction; upon contact with the trans-verse process of L5, retract needle slightly, correct downward and advance over the transverse process (2 cm). Alternatively: Divide the connecting line between the spinous process of L4 and the posterior superior iliac spine in thirds; insert the needle at the transition from the medial to lateral third.

Puncturedepth:6–10cm.

Positive stimulatory response from the femoral nerve: quadri-ceps muscle (usually the vastus lateralis muscle). Puncture is also possible at the level of the transverse process L4; now ad-vance the caudad aligned needle under the transverse process.

Dosage

30–50mlLA,testdose5ml

Catheter technique

e.g. Contiplex®D-Set,80–110mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,80–120mm

RKU_Compact_e_V6_neu.indd 48-49

49

?the

f -d : 4 e

-s -.

What to do when ...?Stimulation of the obturator nerve (contrac-tion of the adductor group) occurs: Puncture direction is too medial uRetract the needle, then lateralize it somewhat.

Stimulation of the fourth lumbar nerve (= lum-bosacral trunk, contractions in the peroneal group) occurs:Puncture direction is much too medial u Re-tract the needle; advance it markedly in the lateral direction.

No transverse process contact and no stimulatory response is achieved:Puncture site and/or direction may be too lat-eral u Check the distance between puncture site and midline (max. 4 cm), and, if needed, adjust the puncture direction to the patient‘s position. Adequate stimulatory response may also be possible without prior transverse proc-esscontact!

Potential errors and hazardsAlways avoid a medial puncture direction (towards the spinal column)!•Riskofepiduralorevenintrathecaldissemina-

tion of the LA. Perform a test dose.

Psoas compartment block

!

?

21.09.09 14:01

50

Nerve stimulation

Femoral nerve block

Contraindications

•Noparticular

Side effects / complications

•Vesselpuncture(ofthefemoralveinorartery)

Indications

•Operativeproceduresinareassupplyingthefemoraland lateral femoral cutaneous nerves

• Incombinationwithproximalsciaticnerveblock,op-erative procedures on the whole leg (from distal thigh to foot)

•Analgesia

Anatomical landmarks

•Groin•Femoralartery•Anteriorsuperioriliacspine•Pubictubercle• Inguinalligament

1 Anterior superior iliac spine,

2 Pubic tubercle, 3 Puncture site

RKU_Compact_e_V6_neu.indd 50-51

51

spine,

2

3

1

Femoral nerve block

Anatomical landmarks

21.09.09 14:01

52

Nerve stimulation

Blockade technique The patient lies on his back, his leg loosely abducted and turned to the outside.

Puncture site:2cmcaudadtothegroin,1–2cmlateraltothefemoralar-tery.Puncturedirection:30–45°cranialparalleltotheartery.

Puncturedepth:2–4cm.

Positive stimulatory response from the femoral nerve: Rectus muscle of the thigh (“dancing patella“).

Dosage

20–40mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 52-53

53

?and

-artery.

Rectus

What to do when ...?

Stimulation of the sartorius muscle (medial contraction) occurs:Puncture direction usually too medial u Retract the needle, and shift it slightly to the lateral.

Direct stimulation of the sartorius muscle (rare):Puncture direction is usually too lateral u Shift the needle slightly to the medial.

Femoral artery puncture:Retract the needle u Shift puncture direction to the lateral.

Potential errors and hazards•LA injection in the case of sartorius muscle

stimulation.

Femoral nerve block

!

?

21.09.09 14:01

54

Sonography

Nerve block techniqueBoth long and short axis insertion is possible

Sonoanatomic landmarks:- Femoral artery and vein- Iliac fascia- Iliopsoas muscle

Blockade objective:To infiltrate the entire femoral nerve with local anaesthetic

RKU_Compact_e_V6_neu.indd 54-55

55

Femoral nerve block

Sonoanatomic landmarks

late

ral

med

ial

21.09.09 14:01

56

Nerve stimulation

Saphenous nerve block

Contraindications

•Noparticular

Side effects / complications

•Noparticular

Indications

•Operativeproceduresintheareasupplyingthesaphen-ous nerve

• Incombinationwithdistalsciaticnerveblockforopera-tions on the whole lower leg and foot

•Analgesia

Anatomical landmarks

•Patellarcrest•Sartoriusmuscle•Vastusmedialismuscle

= Puncture site

RKU_Compact_e_V6_neu.indd 56-57

57

Saphenous nerve block

Anatomical landmarks

21.09.09 14:01

58

Nerve stimulation

Blockade technique The patient is supine on his back, with the extended leg in a neutral position, rotated slightly outwardly.

Puncture site:Approx.2–4cmcranialandmedialtothesuperioredgeofthe patella. Insert needle perpendicularly into the palpable space between the sartorius muscle and the vastus medialis muscle. Insert the needle perpendicular through the muscle up to the subsartorial fatty tissue.

Puncturedepth:3–5cm.

Electrical paresthesias at the medial calf at a pulse duration of 1.0 ms and/or a motor response from the muscular branches of the sartorius muscle are promising responses.

Dosage

10–15mlLA

Catheter technique

e.g. Contiplex®D-Set,55–80mmAdvance the soft plastic catheter 3 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,50–80mm

RKU_Compact_e_V6_neu.indd 58-59

59

?a

ofpalpable medialis muscle

of branches

What to do when ...?

Motor stimulatory response from the sartorius muscle is a promising response: u Inject local anaesthetic

Patient is uncooperative:Femoral nerve block (as described above) with reduced LA volume (20 ml).Alternative technique: Subcutaneous infiltra-tion below the medial knee joint from the me-dial head of the gastrocnemius muscle to the tibialtuberosity(10–15mlLA).

Potential errors and hazards•Noparticular.

Saphenous nerve block

!

?

21.09.09 14:01

60

Sonography

Nerve block technique:Long axis (single-shot) is preferable

Sonoanatomic landmarks:- Sartorius muscle

Blockade objective:Infiltrate the saphenous nerve with local anaesthetic

RKU_Compact_e_V6_neu.indd 60-61

61

Saphenous nerve block

Sonoanatomic landmarks

cran

ial

caud

al

21.09.09 14:01

62

Nerve stimulation

Obturator nerve block

Contraindications

•Noparticular

Side effects / complications

•Vesselpuncture(obturatorarteryorvein)

Indications

•Suppressionoftheadductorreflexfortransurethrallateral bladder wall resection

•Treatmentofadductorspasm•Adjuncttofemoralnerveblocksforpostoperative

medial knee joint pain •Analgesia

Anatomical landmarks

•Originoftheadductorlongusmuscle•Pubictubercle•Femoralartery•Anteriorsuperioriliacspine

1 Adductor longus muscle, 2 Puncture site

RKU_Compact_e_V6_neu.indd 62-63

63

Obturator nerve block

Anatomical landmarks

1

2

21.09.09 14:01

64

Nerve stimulation

Blockade technique The patient is supine on his back, his leg is rotated outwardly and abducted.

Puncture site:5 – 10 cmbeneath the pubic tubercle directly lateral to thetendon origin of the adductor longus muscle. Puncture direc-tion approx. 45° craniolateral pointing towards the anteriorsuperior iliac spine.

Puncturedepth:4–6cm.

Positive stimulatory response from adductor group.

Dosage

10–15mlLA

Catheter technique

e.g. Contiplex® D-Set, 80 mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 80 mm

RKU_Compact_e_V6_neu.indd 64-65

65

?outwardly

-

anterior

What to do when ...?

Persistent adductor spasm despite (proper) obturator nerve block occurs:Perform an additional femoral nerve block, which will block any accessory obturator nerve that runs together with femoral nerve.

Note:The adductor reflex for transurethral lateral bladder wall can only be reliably suppressed by a separate obturator nerve block (not by a femoralnerveblocknorspinalanesthesia!).

Potential errors and hazards•Noparticular.

Obturator nerve block

!

?

21.09.09 14:01

66

Sonography

Nerve block technique:Long axis is preferable

Sonoanatomic landmarks:- Femoral artery and vein- Pectineus muscle - Adductor muscles (longus and brevis)

Blockade objective:Infiltrate the anterior and posterior branch of the obturator nerve

RKU_Compact_e_V6_neu.indd 66-67

67

obturator

Obturator nerve block

Sonoanatomic landmarks

late

ral

med

ial

21.09.09 14:01

68

Nerve stimulation

Approach according to Mansour

Contraindications

•Noparticular

Side effects / complications

•Vesselpuncture(inferiorglutealartery)

Indications

•Operativeproceduresinareassupplyingthesciaticnerve

• Incombinationwithpsoascompartmentblock/femoralnerve block for operations on the whole leg

•Analgesia

Anatomical landmarks

•Posteriorsuperioriliacspine• Ischialtuberosity

1 Greater trochanter, 2 Posterior superior iliac spine,

3 Ischial tuberosity, 4 Puncture site

RKU_Compact_e_V6_neu.indd 68-69

69

2

34

1

Parasacral sciatic nerve block

Anatomical landmarks

21.09.09 14:01

70

Nerve stimulation

Blockade technique The patient is placed in the lateral recumbent position, hip flexed45°,knee flexed70°,orbothkneesagainst theabdo-men (favorable when combined with a psoas compartment block).

Puncture site:Approx.5–6cmcaudadtotheposteriorsuperioriliacspinealong the connecting line to the ischial tuberosity. Insertion direction20–30°caudadtomidlinebetweenischialtuberos-ity and greater trochanter.

Puncturedepth:6–8cm.

Promising stimulatory response from the tibial and peroneal nerves: Extensors and/or flexors of feet/toes, ischiocrural muscle group

Dosage

20–30mlLA

Catheter technique

e.g. Contiplex®D-Set,80–110mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,80–120mm

RKU_Compact_e_V6_neu.indd 70-71

71

?hip -

compartment

Insertion

-

peroneal ischiocrural

What to do when ...?

Bone contact occurs:Shift puncture site further caudad or puncture direction more caudad.

No stimulatory response is elicited:Shift puncture direction more caudad and lateral.

Potential errors and hazards

•LAinjectionuponstimulatoryresponsefromthe gluteal muscles.

Parasacral sciatic nerve block

!

?

21.09.09 14:01

72

Nerve stimulation

Approach according to Labat

Contraindications

•Noparticular

Side effects / complications

•Vesselpuncture(inferiorglutealartery)

Indications

•Operativeproceduresinareassupplyingthesciaticnerve

• Incombinationwithpsoascompartmentblock/femoralnerve block for operations on the whole leg

•Analgesia

Anatomical landmarks

•Posteriorsuperioriliacspine•Greatertrochanter•Sacralhiatus

1 Greater trochanter, 2 Posterior superior iliac spine,

3 Ischial tuberosity, 4 Sacral hiatus, 5 Puncture site

RKU_Compact_e_V6_neu.indd 72-73

73

2

3

4

1

Transgluteal sciatic nerve block

Anatomical landmarks

5

21.09.09 14:01

74

Nerve stimulation

Blockade technique The patient is placed in the lateral recumbent position; hip flexed45°,kneeflexed70°(“stablerecumbentposition“).

Puncture site:4–5cmmediocaudalonthemid-perpendicularlinesbetweengreater trochanter and posterior superior iliac spine; con-necting line between the greater trochanter and sacral hiatus intersects the insertion point at the mid-perpendicular line. Insertion direction perpendicular to the surface.

Puncturedepth:5–8cm.

Promising stimulatory response from the tibial and peroneal nerves: Extensors and/or flexors of feet/toes, ischiocrural muscle group

Dosage

20–30mlLA

Catheter technique

e.g. Contiplex®D-Set,80–110mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,80–100mm

RKU_Compact_e_V6_neu.indd 74-75

75

?hip

-

hiatus line.

peroneal ischiocrural

What to do when ...?

Contractions of the gluteus maximus muscle (= direct muscular stimulation or stimulation of the muscular branches of the gluteal mus-cle): Continue to advance the needle until the typical response is elicited.

Bone contact, no stimulatory response: Correct insertion direction to midline between greater trochanter and ischial tuberosity.

Potential errors and hazards

•LAinjectionuponstimulatoryresponsefrom the gluteal muscles.

Transgluteal sciatic nerve block

!

?

21.09.09 14:01

76

Nerve stimulation

Approach according to Meier

Contraindications

•Noparticular

Side effects / complications

•Vesselpuncture(femoralarteryandvein,inferiorglutealartery and vein)

•Neuralinjury(femoralnerve)

Indications

•Operativeproceduresintheareasupplyingofthesci-atic nerve

• Incombinationwithpsoascompartmentblock/femoralnerve block for operations on the whole leg

•Analgesia

Anatomical landmarks

•Anteriorsuperioriliacspine•Pubicsymphysis•Greatertrochanter• Compartmentbetweensartoriusandrectusfemorismuscles.

1 Anterior superior iliac spine, 2 Pubic symphysis,

3 Greater trochanter, 4 Puncture site

RKU_Compact_e_V6_neu.indd 76-77

77

2

3

4

1

Anterior sciatic nerve block

Anatomical landmarks

21.09.09 14:01

78

Nerve stimulation

Blockade technique The patient is supine on his back, with the leg in a neutral position.

Puncture site:Divide into thirds the line connecting the anterior superior iliac spine and the middle of the pubic symphysis. A perpendicular line at the transition from the medial to the middle third inter-sects a parallel line to the inguinal ligament through the greater trochanter at the insertion point. Palpate the muscle compart-ment and, using two fingers, press against the femur, forcing the vessels to the medial. Insert the needle sagittally and 70 –80°tothecranial,withouttouchingthefemur.Alternatively, target the muscle compartment about 8-10 cm caudad of the femoral nerve insertion site

Puncturedepth:8–15cm.

Positive stimulatory response from the peroneal or tibial nerves: extensors or flexors of the foot/toes.

Dosage

20–30mlLA

Catheter technique

e.g. Contiplex® D-Set, 110 mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,100–150mm

RKU_Compact_e_V6_neu.indd 78-79

79

?.

c r -r -g 0

m

tibial

What to do when ...?

Primary femur contact occurs: Insertion point too far to the lateral u Retract the needle and shift insertion to the medial.

Primary vessel puncture (femoral vein or ar-tery): Insertion too far medial u Retract the needle and shift the insertion to the lateral.

Deep vessel puncture (gluteal artery and vein): Correct insertion direction slightly to the lateral.

Stimulation of femoral nerve branches: Retract the needle and “bypass“ stimulation area.

Potential errors and hazards

•Aneutrallegpositionisimperative.

Anterior sciatic nerve block

!

?

21.09.09 14:01

80

Nerve stimulation

Approach according to Guardini

Contraindications

•Status secondary to total ipsilateral hip replacement (relative)

Side effects / complications

•Noparticular

Indications

•Operativeproceduresintheareasupplyingofthesci-atic nerve

• Incombinationwithpsoascompartmentblock/femoralnerve block for operations on the whole leg

•Analgesia

Anatomical landmarks

•Greatertrochanter• Ischialtuberosity

1 Greater trochanter,

2 Ischial tuberosity, 3 Puncture site

RKU_Compact_e_V6_neu.indd 80-81

81

Subtrochanteric sciatic nerve block

Anatomical landmarks

2

3

1

21.09.09 14:01

82

Nerve stimulation

Blockade technique The patient is supine, with the leg in a neutral position or ro-tated slightly inwards. Padding under the lower leg and pelvic helps with orientation.

Puncture site:Approx.2 cmdorsal and3 –4 cmdistal to thegreater tro-chanter. Insertion direction horizontal and somewhat cranial towards the ischial tuberosity without femur contact.

Puncturedepth:6–10cm.

Positive stimulatory response from the peroneal or tibial nerves: extensors and/or flexors of feet/toes, ischiocrural muscle group

Dosage

20–30mlLA

Catheter technique

e.g. Contiplex®D-Set,80–110mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,80–100mm

RKU_Compact_e_V6_neu.indd 82-83

83

?-tated slightly inwards. Padding under the lower leg and pelvic

-cranial

tibial ischiocrural

What to do when ...?

Femur contact occurs: Insertion too far ventral u Move insertion more to the dorsal.

No stimulatory response is elicited: u Direct insertion a little to the ventral and emphasize inward rotation in the hip joint.

Alternative technique:Leg is rotated slightly inward with flexed knee joint “upright“ on the table. Puncture site: 2–3cmcaudadfromthemid-point of the line connecting greater trochanter and ischial tuberosity. Insert the needle in the cranial and slightly medial direction (modified dorsodorsal access according to Raj).

Potential errors and hazards

•Makesurethatthelegisinaneutralposition(with a slight inward rotation).

Subtrochanteric sciatic nerve block

!

?

21.09.09 14:01

84

Preliminary note:It is occasionally difficult to visualise the nerves due to their deep location (with linear high-frequency transducer).

Block technique:Long axis is preferable, short axis possible

Sonoanatomic landmarks:Gluteal muscles

Blockade objective:To infiltrate the entire nerve with local anaesthetic

Sonography

RKU_Compact_e_V6_neu.indd 84-85

85

p

Subtrochanteric sciatic nerve block

Sonoanatomic landmarksla

tera

l

med

ial

21.09.09 14:01

86

Nerve stimulation

Lateral distal sciatic nerve block

Contraindications

•Stent(relative)

Side effects / complications

•Vesselpuncture(poplitealartery/vein)

Indications

•Operativeproceduresintheareassupplyingthesciaticnerve on the whole lower leg and foot

• Incombinationwithsaphenousnerveblockforopera-tions of the whole lower leg

•Analgesia

Anatomical landmarks

•Patellarcrest•Vastuslateralismuscle•Longheadofthebicepsfemorismuscle

1 Patellar crest, 2 Puncture site

RKU_Compact_e_V6_neu.indd 86-87

87

Lateral distal sciatic nerve block

Anatomical landmarks

2

1

21.09.09 14:01

88

Nerve stimulation

Blockade technique The patient is supine on his back, with the leg in a neutral po-sition (rotated slightly inwards), padding under the lower leg.

Puncture site:Approx.3–8cmabovethepatellainthelateralmusclecom-partment between lower edge of the vastus lateralis muscle and biceps femoris muscle. Insertion direction slightly dor-socranial.

Puncturedepth:3–5cm.

Positive stimulatory response from the peroneal or tibial nerves: extensors or flexors of the foot/toes.

Dosage

20–40mlLA

Catheter technique

e.g. Contiplex®D-Set,55–80mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex®D,50–80mm

RKU_Compact_e_V6_neu.indd 88-89

89

?-leg.

-muscle

-

tibial

What to do when ...?

No stimulatory response is elicited: Insertion direction is usually too far ventral u Correct to the dorsal.

Femur contact occurs:Puncture site and/or insertion direction too far to the ventral u Check puncture site, correct to dorsal if needed; shift insertion direction more to the dorsal.

Vessel puncture popliteal artery/vein:Puncture too deep and too ventral u Retract the needle, correct insertion direction to the dorsal, reduce insertion depth.

Potential errors and hazards

•Makesurethatthelegisinaneutralposition (with a slight inward rotation).

Lateral distal sciatic nerve block

!

?

21.09.09 14:01

90

Nerve block technique:Long axis is preferable

Sonoanatomic landmarks:Medial edge of the long head of the biceps femoris muscle

Blockade objective:To infiltrate the entire sciatic nerve or its two terminal branches with local anaesthetic

Practical tip:The patient’s calf is placed on an elevated arm extension, for ex-ample. This allows the ultrasound beam to be directed from the dorsal onto the distal sciatic nerve cranial to the popliteal fossa.

Sonography

RKU_Compact_e_V6_neu.indd 90-91

91

s

e

Lateral distal sciatic nerve block

Sonoanatomic landmarks

late

ral

med

ial

21.09.09 14:01

92

Nerve stimulation

Popliteal sciatic nerve block

Contraindications

•Stent(relative)

Side effects / complications

•Vesselpuncture(poplitealartery/vein)

Indications

•Operativeproceduresintheareasupplyingthesciaticnerve of the lower leg and foot

•Operationsonthewholelowerextremityincombinationwith a saphenous nerve block.

•Analgesia

Anatomical landmarks

•Poplitealfossa•Poplitealfold•Longheadofthebicepsfemorismuscle•Medialandlateralepicondyleofthefemur

1 Lateral epicondyle of the femur,

2 Medial epicondyle of the femur, 3 Puncture site

RKU_Compact_e_V6_neu.indd 92-93

93

2

3

1

Popliteal sciatic nerve block

Anatomical landmarks

21.09.09 14:01

94

Nerve stimulation

Blockade technique The patient is either in the prone position or lying on his side, leg extended.

Puncture site:Approx.8–12cmabovethefoldofthepoplitealfossaatthemedial edge of the biceps femoris muscle, laterally marking thepoplitealfossa.Insertiondirectionapprox.30°cranialandslightly medial.

Puncturedepth:2–4cm.

Positive stimulatory response from the peroneal and tibial nerves: extensors or flexors of the foot/toes.

Dosage

20–40mlLA

Catheter technique

e.g. Contiplex® D-Set, 55 mmAdvance the soft plastic catheter < 4 cm beyond the end of the introducer sheath.

Single shot technique

e.g. Stimuplex® D, 50 mm

RKU_Compact_e_V6_neu.indd 94-95

95

?side,

marking

tibial

What to do when ...?

Femur contact occurs:Insertion too deep and too medial Retract the needle u Correct puncture direction or insertion site to the lateral , reduce insertion depth.

Vessel puncture popliteal artery/vein:Puncture too deep and too medial Retract the needle u Correct insertion direction to the lat-eral, reduce insertion depth.

Potential errors and hazards

•Puncturesiteistoofarcaudad(poplitealfold): It may be that the tibial nerve (med.) and peroneal nerve (lat.) are separated so far apart that complete blockade cannot be achieved with a single LA injection at the two sciatic branches.

Popliteal sciatic nerve block

!

?

21.09.09 14:01

www.nerveblocks.net

Online Tutorial and Discussion Forum

Other publications appearing in this series

• Brochure(DINA4) Peripheral Regional Anesthesia at the Ulm Rehabilitation Hospital

• InteractiveDVDTutorial Peripheral Regional Anesthesia at the Ulm Rehabilitation Hospital

These materials can berequested at your B. Braun partner in your country

B. Braun Melsungen AGCarl-Braun-Straße 134212 MelsungenGermanyTel. +49 5661 71 4657Fax. +49 5661 75 4657 E-mail: [email protected]

The state of medical knowledge is subject to constant change due to new research and clinical evidence. The authors of this book have been very careful to comply with the current state of the art. Nevertheless, users of this information carry their own responsi-bility and liability when establishing the diagnosis and implementing therapy.

The Tutorial was made possible by the kind support of B. Braun Melsungen AG.

Nr. 6064605

RKU_Compact_e_V6_neu.indd 96 21.09.09 14:01

B

The Tutorial was made possible by the kind support of B. Braun Melsungen AG.

RKU_Umschlag_eng2.indd 2 18.08.09 14:04

B. 03. Nr. 6064605 . /1 B01 10