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NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
1
NK
R 2
2:
Hø
feb
er
og
all
erg
isk
helå
rss
nu
e (
allerg
isk
rh
ino
co
nju
ncti
vit
is),
PIC
O 7
:
Alle
rgen
-sp
ec
ifik
im
mu
nte
rap
i, h
uss
tøv
mid
er.
Rev
iew
in
form
ati
on
Au
tho
rs
Sun
dhe
dssty
rels
en
1
1[E
mpty
aff
ilia
tion
]
Cita
tion
exam
ple
: S
. N
KR
22
: H
øfe
be
r o
g a
llerg
isk h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:
Alle
rge
n-s
pe
cifik
im
mu
nte
rap
i, h
usstø
vm
ide
r..
Co
chra
ne
Data
base
of S
yste
ma
tic R
evie
ws [
Ye
ar]
, Is
sue
[Is
su
e].
Ch
ara
cte
ris
tic
s o
f s
tud
ies
Ch
ara
cte
risti
cs o
f in
clu
de
d s
tud
ies
Eifan 2010
Meth
od
sS
tud
y d
esig
n:
Ra
nd
om
ized
co
ntr
olle
d tri
al
Stu
dy g
rou
pin
g:
Pa
ralle
l g
rou
p
Op
en
Lab
el:
YE
S
Clu
ste
r R
CT
:
Pa
rtic
ipan
tsB
as
elin
e C
ha
racte
ris
tics
Inte
rve
ntio
n
Age (Years):
7.0
0 (
1.7
7)
Gender males: 6
Patients with asthma and rhinitis
: 1
1
Patients with asthma only
: 2
Patients with rhinitis only
: 3
Total rhinitis symptoms score (m, sd):
1.8
(0.9
)
Total medication score
: 2
.40
(1
.4)
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
2
Number of patients
: 1
6
Con
tro
l
Age (Years):
7.5
7 (
1.9
8)
Gender males: 7
Patients with asthma and rhinitis
: 1
0
Patients with asthma only
: 4
Patients with rhinitis only
: 2
Total rhinitis symptoms score (m, sd):
1.5
6 (
1.0
5)
Total medication score
: 2
.50
(1
.50
)
Number of patients
: 1
6
Inc
lud
ed
cri
teri
a:
All
pa
tien
ts h
ad t
o h
ave
skin
te
st
positiv
ity a
nd
se
rum
sIg
Eon
ly t
o D
.pt
an
d/o
r D
.f.
Exc
lud
ed
cri
teri
a:
Patie
nts
with p
oly
sen
sitiz
atio
n to
oth
er
ae
roalle
rgen
s, syste
mic
im
mu
nolo
gic
al dis
ord
ers
,seve
re
asth
ma w
ith f
orc
ed
exp
irato
ry v
olu
me
in
1 s
(FE
V1
) o
70%
, seve
re a
top
ic d
erm
atitis a
nd
pre
vio
us u
se
of
alle
rge
n
imm
un
oth
era
py w
ere
exclu
ded
fro
m t
he t
ria
l.
Inte
rve
nti
on
sIn
terv
en
tio
n C
ha
rac
teri
sti
cs
Inte
rve
ntio
n
Description
: S
CIT
HD
Mm
ed
ica
tion
an
tih
ista
min
es, in
tran
asal cort
ico
ste
roid
s,
an
tihis
tam
inesa
nd
ora
l ste
roid
s
Con
tro
l
Description
: m
edic
ation
an
tih
ista
min
es, in
tra
na
sal cort
ico
ste
roid
s,
an
tihis
tam
inesa
nd
ora
l ste
roid
s
Ou
tco
me
sContinuous:
TR
SS
TM
S
TS
S (
Tota
l sym
pto
m s
core
)
Dichotomous:
Ad
ve
rse
eve
nts
Dro
po
uts
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
3
Iden
tifi
ca
tio
nS
po
ns
ors
hip
so
urc
e:
Th
is w
ork
was s
up
po
rte
d b
y T
he M
arm
ara
Un
ive
rsityS
cie
ntific R
ese
arc
h C
om
mitte
e (
BA
PK
O n
o.
TIP
/SA
GT
US
-14
060
7-0
11
4,
200
7).
Co
un
try
: T
urk
ey
Sett
ing
:
Co
mm
en
ts:
Au
tho
rs n
am
e:
A. O
. E
ifa
n
Ins
titu
tio
n:
Div
isio
n o
f P
ed
iatr
ic A
llerg
y a
nd I
mm
un
olo
gy,
Marm
ara
Un
ive
rsity M
ed
ica
l F
acu
lty,
Ista
nbu
l, T
urk
ey
Em
ail
: a
.eifan
@im
pe
ria
l.ac.u
k
Ad
dre
ss:
Aa
rif
O.
Eifa
n,
Marm
ara
Un
ive
rsityM
ed
ical F
acu
lty,
Pe
dia
tric
Alle
rgy a
ndC
linic
al Im
mun
olo
gy,
Ista
nbu
l, T
urk
ey
No
tes
Ide
nti
fic
ati
on
:
Part
icip
an
ts:
Stu
dy d
esig
n:
Bas
elin
e c
hara
cte
ris
tic
s:
Kirsten Skamstrup Hansen
me
dic
atio
n s
co
re s
eem
s to
be
both
use
of b
eta
-2 a
go
nis
t =
asth
ma
med
ica
tion
an
d
an
tih
ista
min
es
Inte
rven
tio
n c
ha
rac
teri
sti
cs
:
Pre
trea
tme
nt:
Co
nti
nu
ou
s o
utc
om
es
:
Dic
ho
tom
ou
s o
utc
om
es
:
Ad
vers
e o
utc
om
es:
Ris
k o
f b
ias ta
ble
Bia
sA
uth
ors
'
jud
ge
me
nt
Su
pp
ort
fo
r ju
dg
em
en
t
Ra
nd
om
seq
uen
ce g
en
era
tio
n (
se
lection
bia
s)
Lo
w r
isk
Qu
ote
: "U
sin
g a
co
mpu
ter-
ge
ne
rate
d r
an
dom
izatio
n m
eth
od,
patie
nts
we
re
ran
do
miz
ed
"
Allo
ca
tio
n c
on
ce
alm
ent
(se
lectio
n b
ias)
Un
cle
ar
risk
Com
me
nt:
No
t de
scrib
ed
Blin
din
g o
f pa
rtic
ipan
ts a
nd
pe
rso
nn
el (p
erf
orm
ance
bia
s)
Hig
h r
isk
Com
me
nt:
Op
en la
and
ou
tcom
e s
elf-r
ep
ort
ed
Blin
din
g o
f ou
tco
me a
sse
ssm
ent
(dete
ction
bia
s)
Un
cle
ar
risk
Com
me
nt:
Pro
ba
bly
not
ou
tco
me is s
elf-r
ep
ort
ed.
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
4
Incom
ple
te o
utc
om
e d
ata
(att
ritio
n b
ias)
Lo
w r
isk
Com
me
nt:
2/1
6, 2
/16 d
rop
out
in b
oth
gro
up
s.
Eq
ual d
ropo
ut
Se
lective
re
port
ing
(re
po
rtin
g b
ias)
Un
cle
ar
risk
Com
me
nt:
De
scrib
ed
ou
tco
me
se
em
s a
ssessed
bu
t n
o tri
al p
roto
co
l.
Oth
er
bia
sLo
w r
isk
Pichler 1997
Meth
od
s
Pa
rtic
ipan
ts
Inte
rve
nti
on
s
Ou
tco
me
s
Iden
tifi
ca
tio
n
No
tes
Ris
k o
f b
ias ta
ble
Bia
sA
uth
ors
' ju
dg
em
en
tS
up
po
rt f
or
jud
ge
men
t
Ra
nd
om
seq
uen
ce g
en
era
tio
n (
se
lection
bia
s)
Un
cle
ar
risk
Allo
ca
tio
n c
on
ce
alm
ent
(se
lectio
n b
ias)
Un
cle
ar
risk
Blin
din
g o
f pa
rtic
ipan
ts a
nd
pe
rso
nn
el (p
erf
orm
ance
bia
s)
Un
cle
ar
risk
Blin
din
g o
f ou
tco
me a
sse
ssm
ent
(dete
ction
bia
s)
Un
cle
ar
risk
Incom
ple
te o
utc
om
e d
ata
(att
ritio
n b
ias)
Un
cle
ar
risk
Se
lective
re
port
ing
(re
po
rtin
g b
ias)
Un
cle
ar
risk
Oth
er
bia
sU
ncle
ar
risk
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
5
Varney 2003
Meth
od
s
Pa
rtic
ipan
ts
Inte
rve
nti
on
s
Ou
tco
me
s
Iden
tifi
ca
tio
n
No
tes
Fro
m A
RIA
Gu
ide
line
Ris
k o
f b
ias ta
ble
Bia
sA
uth
ors
'
jud
gem
en
tS
up
po
rt f
or
jud
ge
men
t
Ra
nd
om
seq
uen
ce g
en
era
tio
n
(sele
ctio
n b
ias)
Low
ris
kcom
pute
r-ge
nera
ted
ra
ndo
m n
um
be
rs.
Allo
ca
tio
n c
on
ce
alm
ent
(se
lectio
n
bia
s)
Low
ris
kno
r access t
o t
he r
an
dom
iza
tion
co
de
, w
hic
h w
as k
ep
t lo
cke
d a
nd
sea
led
by a
do
cto
r n
ot in
vo
lve
d w
ith t
he
stu
dy.
Th
e c
od
e w
as o
nly
op
en
ed a
fte
r a
ll th
e d
ata
ha
d b
ee
n c
olle
cte
d a
nd w
ere
re
ad
y fo
r sta
tistica
l
an
aly
sis
.
Blin
din
g o
f pa
rtic
ipan
ts a
nd
pe
rso
nn
el (p
erf
orm
ance
bia
s)
Low
ris
kT
he
tri
al w
as p
erf
orm
ed
as a
dou
ble
-blin
d, ra
ndo
miz
ed
, p
laceb
o-c
on
tro
lled s
tud
y,
Blin
din
g o
f ou
tco
me a
sse
ssm
ent
(dete
ction
bia
s)
Un
cle
ar
risk
AL
K).
Th
e d
octo
rs c
arr
yin
g o
ut
the S
IT h
ad
no
kn
ow
led
ge o
f, n
or
acce
ss t
o th
e r
and
om
iza
tio
n c
od
e, w
hic
h
wa
s k
ep
t lo
cke
d a
nd
sea
led
by a
do
cto
r n
ot in
vo
lve
d w
ith t
he s
tud
y.
Incom
ple
te o
utc
om
e d
ata
(att
ritio
n
bia
s)
Low
ris
kT
he
re w
ere
dro
pou
ts e
arly in
th
e s
tudy,
an
d d
ate
were
in
su
ffic
ien
t o
n th
e s
ub
jects
fo
r a
n inte
ntion
-to
tre
at
an
aly
sis
. N
o f
low
ch
art
.
Se
lective
re
port
ing
(re
po
rtin
g b
ias)
Un
cle
ar
risk
No
stu
dy p
roto
col
Oth
er
bia
sL
ow
ris
k
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
6
Footnotes
Ch
ara
cte
risti
cs o
f e
xc
lud
ed
stu
die
s
Ali 2008
Re
as
on
fo
r e
xc
lus
ion
no
t R
CT
, re
tro
sp
ective
desig
n
Antunez 2008
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
co
mpa
rato
r
Aydogan 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Backer 2010
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Bergmann 2012
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Bergmann 2012a
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Bergmann 2014
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
7
Bozek 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Bush 2011
Re
as
on
fo
r e
xc
lus
ion
liqu
id a
llerg
en s
tallo
ral
Casanovas 2007
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
co
mpa
rato
r
CelioMurillo 2014
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
CelioMurillo 2014a
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
D'Anneo 2010
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
stu
dy d
esig
n
deBot 2012
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Demoly 2011
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
8
Demoly 2011a
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Demoly 2011b
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Demoly 2013
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Dreborg 2012
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
stu
dy d
esig
n
Guim
araesJunqueirdeQueiros 2008
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Hauswald 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
stu
dy d
esig
n
Inal 2007
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
pa
tie
nt p
opu
latio
n
Marogna 2010
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
stu
dy d
esig
n
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
9
Martin Munoz 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Morris 2012
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Mosbech 2014
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
pa
tie
nt p
opu
latio
n
Olaguibel 2008
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
stu
dy d
esig
n
Petersen 2013
Re
as
on
fo
r e
xc
lus
ion
Ob
serv
ation
el stu
dy
Pfaar 2010
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Reha 2007
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
pa
tie
nt p
opu
latio
n
Riechelm
ann 2010
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
10
Santos 2010
Re
as
on
fo
r e
xc
lus
ion
no
fu
ll te
xt a
rtic
le
Shao 2014
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Tabar 2011
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Tahamiler 2008
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
co
mpa
rato
r
Tahamiler 2008a
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
co
mpa
rato
r
Wang 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Yonekura 2010
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Yukselen 2012
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
11
Yukselen 2013
Re
as
on
fo
r e
xc
lus
ion
Wro
ng
inte
rve
ntio
n
Footnotes
Ch
ara
cte
risti
cs o
f s
tud
ies
aw
ait
ing
cla
ss
ific
ati
on
Footnotes
Ch
ara
cte
risti
cs o
f o
ng
oin
g s
tud
ies
Footnotes
Refe
ren
ce
s t
o s
tud
ies
Inc
lud
ed
stu
die
s
Eifan 2010
Eifa
n,A
. O
.; A
kko
c,T
.; Y
ildiz
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ele
s,S
.; O
zd
em
ir,C
.; B
ah
cecile
r,N
. N
.; B
arl
an
,I. B
.. C
linic
al eff
ica
cy a
nd
im
mu
nolo
gic
al m
ech
an
ism
s o
f su
blin
gua
l an
d
su
bcu
tane
ous im
mun
oth
era
py in
asth
matic/r
hin
itis
ch
ildre
n s
en
sitiz
ed
to h
ou
se
du
st
mite:
An
op
en
ra
ndo
miz
ed c
on
tro
lled
tria
l.. C
linic
al an
d E
xp
eri
me
nta
l A
llerg
y
20
10
;40
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Pichler 1997
Pic
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t a
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Alle
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99
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[Em
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]
NK
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Hø
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alle
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rssn
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(a
llerg
isk r
hin
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nju
nctivitis
), P
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2-J
un
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15
Re
vie
w M
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Ex
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Ali 2008
Ali
I; G
oksa
l K
; O
za
n B
; G
uls
en
D. L
ong
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rm a
llerg
en
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im
mu
no
the
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ith lo
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alle
rgen
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im
mu
nolo
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The
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00
8;2
5(1
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r fo
llow
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imm
uno
log
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l re
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ren t
reate
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ith
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blin
gua
l
imm
un
oth
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Co
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ou
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dm
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Ayd
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Su
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mo
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ensitiz
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Backer 2010
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The
ho
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im
mun
oth
era
py t
able
t p
rovid
es im
pro
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qu
alit
y o
f
life in
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with
hou
se
dust
mite
alle
rgy..
Alle
rgy:
Eu
rope
an J
ou
rnal o
f A
llerg
y a
nd
Clin
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l Im
mun
olo
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01
0;6
5(J
ou
rna
l A
rtic
le):
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Bergmann 2012
Berg
ma
nn
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ad
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urr
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M.;
Ze
ldin
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atie
nt b
ene
fits
of tr
eatm
en
t w
ith
50
0IR
and
30
0IR
su
blin
gu
al ta
ble
ts o
f h
ou
se d
ust m
ite
alle
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n
extr
act..
Alle
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Eu
rope
an J
ou
rnal o
f A
llerg
y a
nd
Clin
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l Im
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01
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7(J
ou
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Bea
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se
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ub
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ual a
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mu
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ts in a
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rh
initis
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NK
R 2
2:
Hø
feb
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og
alle
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k h
elå
rssn
ue
(a
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isk r
hin
oco
nju
nctivitis
), P
ICO
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..2
2-J
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15
Re
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13
Bergmann 2014
Berg
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A.;
Zeld
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ffic
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ual ta
ble
ts o
f
ho
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dust
mite
alle
rge
n e
xtr
acts
in
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lts w
ith a
llerg
ic r
hin
itis
.. J
ou
rna
l o
f A
llerg
y a
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33
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61
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py:
a d
ou
ble
-blin
d,
pla
ceb
o-c
on
tro
lled
stu
dy in
eld
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atie
nts
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alle
rgic
rhin
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me
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01
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Bush 2011
Bush
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Sw
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ahlb
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s,M
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blin
gua
l im
mu
no
the
rap
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esu
lts o
f a U
S t
ria
l..
Jo
urn
al of
Alle
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Clin
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l Im
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01
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27
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81
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Casa
no
vas M
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art
in R
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en
ez C
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ab
alle
ro R
; F
ern
an
dez-C
ald
as E
. S
afe
ty o
f im
mun
oth
era
py w
ith t
hera
pe
utic v
accin
es c
on
tain
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dep
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ente
d a
nd
po
lym
eri
zed
alle
rge
n e
xtr
acts
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linic
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Exp
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en
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00
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7(3
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40
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CelioMurillo 2014
Celio
Mu
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Ro
drig
uez S
an
tos,O
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au
rra
baq
uio
Mira
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ua
rez,M
. A
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arm
ole
jo,M
. A
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nd
sa
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mu
noth
era
py s
pe
cifie
s w
ith
extr
acts
of m
ite
s o
n t
he
alle
rgic
rh
inoco
nju
nctivitis
an
d b
ron
chia
l a
sth
ma..
Alle
rgy: E
uro
pea
n J
ou
rna
l o
f A
llerg
y a
nd C
linic
al Im
mu
no
log
y 2
01
4;6
9(J
ourn
al
Art
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CelioMurillo 2014a
Celio
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Ro
drig
uez S
an
tos,O
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ua
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aurr
ab
aqu
io M
ira
nd
a,A
. M
.. S
tud
io d
ou
ble
blin
d p
laceb
o w
ith
Mites t
he
rape
utic v
accin
es f
or
the
trea
tme
nt o
f bro
nch
ial a
sth
ma
an
d a
llerg
ic r
hin
osin
usitis
.. A
llerg
y:
Eu
rope
an J
ou
rna
l o
f A
llerg
y a
nd
Clin
ica
l Im
mun
olo
gy 2
014
;69
(Jou
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rtic
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D'Anneo 2010
D'A
nn
eo,R
. W
.; B
run
o,M
. E
.; F
ala
gia
ni,P
.. S
ub
ling
ual a
llerg
oid
im
mu
noth
era
py:
A n
ew
4-d
ay in
du
ction
pha
se
in
pa
tie
nts
alle
rgic
to
hou
se d
ust m
ite
s..
Inte
rna
tio
nal
Jo
urn
al of
Imm
uno
path
olo
gy a
nd
Ph
arm
aco
log
y 2
01
0;2
3(2
):5
53-5
60.
[DO
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NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
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ag
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5.3
14
deBot 2012
de
Bo
t,C
. M
.; M
oed
,H.; B
erg
er,
M.
Y.;
Ro
der,
E.;
Ho
p,W
. C
.; d
e G
roo
t,H
.; d
e J
on
gste
,J.
C.;
va
n W
ijk,R
. G
.; B
ind
els
,P. J.;
van
de
r W
ou
den
,J.
C.. S
ublin
gua
l
imm
un
oth
era
py n
ot
eff
ective
in
ho
use
dust
mite
-alle
rgic
ch
ildre
n in p
rim
ary
ca
re..
Pe
dia
tric
alle
rgy a
nd
im
mu
nolo
gy : o
ffic
ial p
ub
licatio
n o
f th
e E
uro
pe
an S
ocie
ty o
f
Ped
iatr
ic A
llerg
y a
nd
Im
mu
nolo
gy 2
01
2;2
3(2
):15
0-1
58
. [D
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]
Demoly 2011
Dem
oly
,P.; W
orm
,M.;
Fo
kken
s,W
.; T
aba
r,A
.; N
gu
ye
n,H
.; D
e B
ea
um
ont,
O.;
Me
lac,M
.; M
on
tagu
t,A
.; B
erg
man
n,K
.. P
ost-
tre
atm
en
t e
ffic
acy o
f su
blin
gu
al a
llerg
en
imm
un
oth
era
py t
able
ts in
ad
ult p
atie
nts
suff
erin
g fro
m h
ouse
dust
mite
rela
ted
alle
rgic
rh
initis
.. A
llerg
y: E
uro
pea
n J
ou
rna
l o
f A
llerg
y a
nd C
linic
al Im
mu
no
log
y
20
11
;66
(Jou
rnal A
rtic
le):
13
8. [D
OI: h
ttp
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x.d
oi.o
rg/1
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995
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11
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60
5.x
]
Demoly 2011a
Dem
oly
,P.; W
orm
,M.;
Fo
kken
s,W
.; T
aba
r,A
.; N
gu
ye
n,H
.; D
e B
ea
um
ont,
O.;
Me
lac,M
.; M
on
tagu
t,A
.; B
erg
man
n,K
.. R
ela
tio
nsh
ip b
etw
een
alle
rgic
dis
ea
se s
everi
ty
an
d t
he t
reatm
en
t eff
ica
cy o
f ho
use
du
st m
ite t
able
ts fo
r su
blin
gua
l im
mu
no
thera
py.. A
llerg
y:
Eu
rope
an J
ou
rna
l of
Alle
rgy a
nd
Clin
ica
l Im
mun
olo
gy 2
011
;66
(Jou
rnal
Art
icle
):1
38
. [D
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99
5.2
01
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26
05
.x]
Demoly 2011b
Dem
oly
,P.; W
orm
,M.;
Fo
kken
s,W
.; T
aba
r,A
.; N
gu
ye
n,H
.; D
e B
ea
um
ont,
O.;
Me
lac,M
.; M
on
tagu
t,A
.; B
erg
man
n,K
.. T
he
re
latio
nsh
ip b
etw
een
alle
rgic
dis
ea
se s
eve
rity
an
d q
ua
lity o
f lif
e in p
atien
ts t
reate
d w
ith
su
blin
gu
al im
mun
oth
era
py ta
ble
ts fo
r h
ouse
dust
mite
-ind
uce
d r
hin
itis
.. A
llerg
y:
Eu
rope
an J
ou
rnal o
f A
llerg
y a
nd
Clin
ica
l
Imm
un
olo
gy 2
011
;66
(Jo
urn
al A
rtic
le):
63
1.
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Demoly 2013
Dem
oly
,P. M
.; B
erg
man
n,K
. -C
; M
ela
c,M
.; N
gu
yen
,H.; F
rere
ux,M
.; Z
eld
in,R
. K
.. O
nse
t of
actio
n o
f sub
lingu
al ta
ble
ts o
f ho
use
du
st m
ite a
llerg
en
extr
acts
in a
dults..
Jo
urn
al of
Alle
rgy a
nd
Clin
ica
l Im
mu
nolo
gy.C
on
fere
nce
: 2
013
Ann
ual M
ee
tin
g o
f th
e A
me
rica
n A
cad
em
y o
f A
llerg
y,
Asth
ma
and
Im
mu
nolo
gy,
AA
AA
I 20
13 S
an
Anto
nio
, T
X U
nite
d S
tate
s.C
on
fere
nce
Sta
rt:
20
130
222
Co
nfe
ren
ce
En
d: 2
01
302
26.C
onfe
ren
ce
Pub
lica(T
RU
NC
AT
ED
20
13
;13
1(2
SU
PP
L.
1):
AB
37.
[DO
I:
htt
p:/
/dx.d
oi.o
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0.1
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12.1
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17]
Dreborg 2012
Dre
bo
rg S
; Le
e T
H; K
ay A
B;
Du
rha
m S
R. Im
mun
oth
era
py is a
llerg
en-s
pe
cific
: a
dou
ble
-blin
d tri
al o
f m
ite
or
tim
oth
y e
xtr
act
in m
ite a
nd
gra
ss d
ual-
alle
rgic
pa
tie
nts
..
Inte
rna
tio
nal a
rchiv
es o
f alle
rgy a
nd
im
mu
nolo
gy 2
01
2;1
58
(1):
63
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. [D
OI:
10.1
15
9/0
00
33
064
9]
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
15
Guim
araesJunqueirdeQueiros 2008
Gu
ima
rae
s J
un
qu
eir d
e Q
ue
iro
s M
; O
live
ira
Silv
a D
A; A
lve
s R
; F
uku
hara
Chib
a H
; S
oa
res d
e A
mara
l V
B; d
e A
lmeid
a K
C; Y
no
ue L
H; d
e O
liveir
a R
ese
nde
R;
Cam
arg
o S
ope
lete
MC
; R
odri
gue
s S
ilva
Se
gun
do G
; F
err
eir
a d
e S
ousa
Mo
reir
a P
; S
un
g S
J; T
ake
tom
i E
A.
Mite
-sp
ecific
im
mun
oth
era
py u
sin
g a
llerg
en
an
d/o
r
ba
cte
ria
l e
xtr
acts
in
ato
pic
pa
tie
nts
in
Bra
zil.
. Jo
urn
al o
f In
ve
stiga
tion
al A
llerg
olo
gy &
Clin
ica
l Im
mun
olo
gy 2
00
8;1
8(2
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4-9
2. [D
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Hauswald 2013
Hau
sw
ald
, B
.; W
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H.;
Becker,
F.; B
ecke
r, S
.; S
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J.;
Wu
ste
nb
erg
, E
.. T
ole
rabili
ty o
f a
new
fa
st u
pdo
sed
im
mun
olo
gic
ally
enh
ance
d s
ub
cuta
ne
ou
s
imm
un
oth
era
py f
orm
ula
tio
n w
ith a
n o
ptim
ized
alle
rge
n to
adju
va
nt ra
tio u
nd
er
routin
e p
ractice
co
nd
itio
ns:
A n
on
inte
rven
tion
al o
bserv
ation
al stu
dy.
Jou
rna
l o
f
Inve
stig
atio
nal A
llerg
olo
gy a
nd C
linic
al Im
mu
no
log
y 2
01
3;2
3(7
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71-4
77.
[DO
I: ]
Inal 2007
Ina
l A
; A
ltin
tas D
U;
Yilm
az M
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ara
ko
c G
B;
Ke
nd
irli
SG
; S
ert
de
mir Y
. P
reve
ntio
n o
f n
ew
se
nsitiz
atio
ns b
y s
pecific
im
mun
oth
era
py in
ch
ildre
n w
ith
rh
initis
and
/or
asth
ma m
on
ose
nsitiz
ed
to
hou
se
dust
mite
.. J
ou
rnal o
f In
ve
stig
atio
nal A
llerg
olo
gy &
Clin
ica
l Im
mu
nolo
gy 2
007
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OI: ]
Marogna 2010
Ma
rogn
a,M
.; S
pad
olin
i,I.
; M
asso
lo,A
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ano
nic
a,G
. W
.; P
assala
cq
ua
,G..
Lo
ng
-lasting
eff
ects
of
su
blin
gu
al im
mu
noth
era
py a
ccord
ing
to
its
du
ratio
n:
A 1
5-y
ear
pro
spe
ctive
stu
dy..
Jo
urn
al o
f A
llerg
y a
nd C
linic
al Im
mu
nolo
gy 2
01
0;1
26
(5):
96
9-9
75.
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I: h
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01
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30]
Martin Munoz 2013
Ma
rtin
-Mu
noz,M
. F
.; P
ine
da
,F.; M
uin
os,T
.; F
on
tan
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Ne
vo
t,S
.; B
osqu
e,M
.; J
ura
do P
alo
mo,J
.; T
orr
ed
em
er,
A.;
Va
lde
soir
o,L
.; M
art
inez C
an
ava
te,A
. M
.; P
ed
em
on
te
Ma
rco,C
.. C
han
ges in
IL
-10 a
nd
spe
cific
antib
od
ies a
sso
cia
ted
to
su
cce
ssfu
l D
erm
ato
ph
ag
oid
es p
tero
nyssin
us im
mu
no
the
rap
y in c
hild
ren
du
rin
g t
he f
irst
yea
r of
trea
tme
nt..
Alle
rgolo
gia
et
Imm
un
opa
tho
log
ia 2
01
3;4
1(1
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-10
. [D
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05
]
Morris 2012
Mo
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.; L
ow
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The
odo
ropo
ulo
s,D
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uqu
ette
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.; M
orr
is,D
. L
.. Q
ualit
y o
f lif
e im
pro
vem
en
t w
ith
su
blin
gu
al im
mun
oth
era
py: A
pro
sp
ective s
tud
y o
f
eff
icacy..
Jou
rnal o
f A
llerg
y 2
012
;(Jo
urn
al A
rtic
le).
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Mosbech 2014
Mo
sbe
ch,H
.; D
ecke
lma
nn
,R.; d
e B
lay,F
.; P
asto
rello
,E. A
.; T
reb
as-P
ietr
as,E
.; A
nd
res,L
. P
.; M
alc
us,I
.; L
jorr
ing
,C.;
Ca
non
ica
,G.
W.. S
tand
ard
ized
qu
alit
y (
SQ
) ho
use
du
st
mite s
ub
ling
ual im
mu
noth
era
py t
ab
let
(AL
K)
redu
ces inh
ale
d c
ort
ico
ste
roid
use
wh
ile m
ain
tain
ing
asth
ma c
on
tro
l: a
ra
nd
om
ized
, do
uble
-blin
d,
pla
ce
bo
-con
trolle
d t
rial..
Jo
urn
al o
f A
llerg
y &
Clin
ical Im
mu
no
log
y 2
01
4;1
34
(3):
568
-57
5.e
7. [D
OI:
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x.d
oi.org
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6/j.ja
ci.2
014
.03
.019
]
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
16
Olaguibel 2008
Ola
gu
ibe
l,J.
M.. L
on
g-t
erm
be
nefits
of
sp
ecific
im
mu
no
the
rap
y (
SIT
).. D
rug
s o
f T
oda
y 2
00
8;4
4(S
up
pl B
):3
9-4
1.
[DO
I: ]
Petersen 2013
Pete
rse
n,K
. D
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ron
bo
rg,C
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ars
en
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N.; D
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yrd
-Ha
nse
n,D
.. P
atien
t re
late
d o
utc
om
es in a
rea
l lif
e p
rosp
ective f
ollo
w u
p s
tud
y:
Alle
rgen
im
mun
oth
era
py
incre
ase
qu
alit
y o
f lif
e a
nd
red
uce
sic
k d
ays..
201
3;(
Jou
rna
l A
rtic
le).
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55
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Pfa
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O.; K
lime
k,L
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ag
er,
A.;
Bra
utig
am
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Safe
ty o
f a
dep
igm
ente
d, p
oly
meri
zed
va
ccin
e f
or
the
tre
atm
en
t of
alle
rgic
rhin
oco
nju
nctivitis
an
d a
llerg
ic a
sth
ma..
Am
eri
can
Jo
urn
al of
Rh
inolo
gy a
nd A
llerg
y 2
010
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220
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Reha 2007
Reh
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M;
Eb
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. S
pecific
im
mun
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era
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ffe
ctive
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reve
ntio
n o
f n
ew
sen
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Alle
rgolo
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Imm
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path
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Effic
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glu
tara
lde
hyd
e-m
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ifie
d h
ou
se
du
st
mite e
xtr
act
in
alle
rgic
rh
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.. A
me
rica
n J
ou
rna
l of
Rh
ino
logy a
nd
Alle
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01
0;2
4(5
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10
4-e
10
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Santos 2010
San
tos,C
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esha
mw
ala
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Vis
sam
se
tti,S
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ala
nt,J.;
Sw
am
i,R
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ad
ea
u,K
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afe
ty o
f d
ua
l alle
rgen
su
blin
gua
l im
mun
oth
era
py in
su
bje
cts
with d
erm
ato
ph
ago
ide
s
fari
nae
an
d t
imo
thy g
rass a
llerg
y.. A
nna
ls o
f A
llerg
y,
Asth
ma
and
Im
mu
nolo
gy 2
01
0;1
05
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]
Shao 2014
Sha
o J
; C
ui Y
-X; Z
hen
g Y
-F; P
en
g H
-F; Z
hen
g Z
-L;
Ch
en
J-Y
; L
i Q
; C
ao
L-F
. E
ffic
acy a
nd
safe
ty o
f sub
lingu
al im
mu
noth
era
py in
child
ren a
ge
d 3
-13
ye
ars
with
alle
rgic
rh
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.. A
me
rica
n jo
urn
al o
f rh
inolo
gy &
alle
rgy 2
01
4;2
8(2
):1
31-9
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OI:
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01
4.2
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006
]
Tabar 2011
Tab
ar,
A. I.
; A
rro
ab
arr
en,E
.; E
ch
ech
ipia
,S.; G
arc
ia,B
. E
.; M
art
in,S
.; A
lva
rez-P
ueb
la,M
. J.. T
hre
e y
ears
of
spe
cific
im
mu
noth
era
py m
ay b
e s
uff
icie
nt in
ho
use
du
st
mite
re
sp
irato
ry a
llerg
y..
Jo
urn
al of
Alle
rgy a
nd
Clin
ical Im
mu
nolo
gy 2
01
1;1
27
(1):
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.e3
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oi.org
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6/j.ja
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.10
.025
]
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
17
Tahamiler 2008
Tah
am
iler
R; S
ari
tza
li G
; C
ana
kcio
glu
S;
Ozco
ra E
; D
iric
an
A. C
om
pari
son
of
the lo
ng
-term
eff
ica
cy o
f sub
cuta
ne
ou
s a
nd
su
blin
gua
l im
mun
oth
era
pie
s in p
ere
nn
ial
rhin
itis
.. O
rl; Jo
urn
al of
Oto
-Rh
ino
-Lary
ngo
log
y &
its
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ted
Spe
cia
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00
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0(3
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am
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R.; C
ana
kcio
glu
,S.;
Yilm
az,S
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ak,H
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on
g-t
erm
im
mun
oth
era
py fo
r p
ere
nn
ial alle
rgic
rh
initis
: R
ela
tio
nsh
ip o
f spe
cific
Ig
G leve
ls t
o s
kin
-pri
ck t
est
resu
lts a
nd c
linic
al sym
pto
ms a
nd
sig
ns..
Ea
r, N
ose
an
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at
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008
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Wang 2013
Wa
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Ch
en
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Ch
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Li,K
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ua
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.; L
u,J
. -H
; L
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.. F
ast
onse
t o
f action
of
su
blin
gu
al im
mu
noth
era
py in h
ou
se d
ust m
ite-i
ndu
ced
alle
rgic
rh
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: A
mu
ltic
en
ter,
ra
nd
om
ized
, do
uble
-blin
d,
pla
ceb
o-c
on
tro
lled
tria
l.. L
ary
ng
osco
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20
13
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3(6
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34-1
340
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eku
ra,S
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ka
mo
to,Y
.; S
aku
rai,D
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ori
gu
chi,S
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an
aza
wa
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aka
no
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udo
u,F
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maru
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ond
a,K
.; H
oshio
ka
,A.; S
him
ojo
,N.;
Ko
hno
,Y.. S
ublin
gua
l
imm
un
oth
era
py w
ith h
ou
se
du
st
extr
act
for
ho
use
dust-
mite
alle
rgic
rh
initis
in
ch
ildre
n.. A
llerg
olo
gy In
tern
atio
na
l 20
10;5
9(4
):3
81-3
88.
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Yukselen 2012
Yukse
len A
.; K
en
dir
li S
G.;
Yilm
az M
.; A
ltin
tas D
U.; K
ara
ko
c G
B..
Effe
ct o
f on
e-y
ea
r su
bcu
tane
ous a
nd s
ub
ling
ual im
mu
noth
era
py o
n c
linic
al a
nd
lab
ora
tory
pa
ram
ete
rs in c
hild
ren
with
rh
initis
an
d a
sth
ma
: a
ra
ndo
miz
ed,
pla
ceb
o-c
on
tro
lled
, do
uble
-blin
d,
dou
ble
-dum
my s
tud
y..
Inte
rna
tio
nal a
rchiv
es o
f alle
rgy a
nd
imm
un
olo
gy 2
012
;15
7(3
):28
8-9
8.
[DO
I: 1
0.1
15
9/0
00
32
756
6]
Yukselen 2013
Yukse
len A
; K
end
irli
SG
; Y
ilma
z M
; A
ltin
tas D
U; K
ara
ko
c G
B.
Tw
o y
ear
follo
w-u
p o
f clin
ica
l a
nd in
flam
ma
tion
para
me
ters
in
ch
ildre
n m
ono
sen
sitiz
ed
to m
ite
s
un
de
rgoin
g s
ub
cu
tan
eo
us a
nd
sub
lingu
al im
mun
oth
era
py..
Asia
n P
acific
jo
urn
al of
alle
rgy a
nd
im
mu
nolo
gy /
la
unch
ed
by th
e A
llerg
y a
nd
Im
mu
no
log
y S
ocie
ty o
f
Tha
iland
20
13
;31
(3):
23
3-4
1.
[DO
I: 1
0.1
29
32/A
P0
276
.31
.3.2
01
3]
Data
an
d a
naly
se
s
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
18
1 Im
mu
ne t
hera
py v
s C
on
tro
l
Ou
tco
me
or
Su
bg
rou
pS
tud
ies
Pa
rtic
ipan
tsS
tati
sti
ca
l M
eth
od
Eff
ec
t E
sti
mate
1.1
Na
sa
l sym
pto
m s
core
(T
ota
l n
asa
l
sym
pto
m s
core
)
256
Std
. M
ean
Diffe
ren
ce
(IV
, R
and
om
, 9
5%
CI)
-3.2
4 [-5
.71
, -0
.77
]
1
.1.1
Nasa
l sym
pto
m s
co
re, F
inal va
lue 1
2
mon
ths
256
Std
. M
ean
Diffe
ren
ce
(IV
, R
and
om
, 9
5%
CI)
-3.2
4 [-5
.71
, -0
.77
]
1.2
Med
icin
sco
rer
(Me
dic
atio
n s
co
re)
256
Std
. M
ean
Diffe
ren
ce
(IV
, R
and
om
, 9
5%
CI)
-0.5
4 [-1
.12
, 0
.03
]
1
.2.1
Me
dic
atio
n s
co
re, F
ina
l va
lue
12 m
on
ths
256
Std
. M
ean
Diffe
ren
ce
(IV
, R
and
om
, 9
5%
CI)
-0.5
4 [-1
.12
, 0
.03
]
1.4
An
afy
laksi (A
na
ph
yla
xis
)3
Ris
k R
atio
(IV
, F
ixe
d,
95%
CI)
No
tota
ls
1
.4.1
Ana
fyla
ksi, F
ina
l valu
e 1
2 m
on
ths
3R
isk R
atio
(IV
, F
ixe
d,
95%
CI)
No
tota
ls
Fig
ure
s
Fig
ure
1 (
An
aly
sis
1.1
)
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
19
Fore
st
plo
t o
f co
mpa
riso
n: 1
Im
mu
ne t
hera
py v
s C
on
tro
l, o
utc
om
e: 1
.1 N
asa
l sym
pto
m s
co
re (
To
tal n
asa
l sym
pto
m s
co
re).
Fig
ure
2 (
An
aly
sis
1.2
)
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
20
Fore
st
plo
t o
f co
mpa
riso
n: 1
Im
mu
ne t
hera
py v
s C
on
tro
l, o
utc
om
e: 1
.2 M
ed
icin
score
r (M
ed
ica
tion
score
).
Fig
ure
3 (
An
aly
sis
1.4
)
NK
R 2
2:
Hø
feb
er
og
alle
rgis
k h
elå
rssn
ue
(a
llerg
isk r
hin
oco
nju
nctivitis
), P
ICO
7:.
..2
2-J
un
-20
15
Re
vie
w M
an
ag
er
5.3
21
Fore
st
plo
t o
f co
mpa
riso
n: 1
Im
mu
ne t
hera
py v
s C
on
tro
l, o
utc
om
e: 1
.4 A
na
fyla
ksi (A
nap
hyla
xis
).
![A Dimensions: [mm] B Recommended land pattern: [mm] D ... · 2013-03-12 2013-01-13 2012-12-10 2012-10-29 2012-08-27 2006-05-05 DATE SSt SSt SSt SSt SSt SSt SSt BY SSt COt COt SSt](https://img.dokumen.tips/doc/110x75/604b228bc93c005c75431c51/a-dimensions-mm-b-recommended-land-pattern-mm-d-2013-03-12-2013-01-13.jpg)
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![A Dimensions: [mm] B Recommended land pattern: [mm] D ... · 2005-12-16 DATE SSt SSt SSt SSt SSt SSt SSt BY SSt SSt SMu SMu SSt ... RDC Value 600 800 1000 0.20 High Cur rent ... 350](https://img.dokumen.tips/doc/110x75/5c61318009d3f21c6d8cb002/a-dimensions-mm-b-recommended-land-pattern-mm-d-2005-12-16-date-sst.jpg)
