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ReviewArticle Dendrobium officinale Kimura et Migo: A Review ... Since 1994, polysaccharides of Dendrobium officinale havebeenextractedandanalyzed[5],andpolysaccharides gradually became

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  • Review Article Dendrobium officinale Kimura et Migo: A Review on Its Ethnopharmacology, Phytochemistry, Pharmacology, and Industrialization

    Hanxiao Tang, Tianwen Zhao, Yunjie Sheng, Ting Zheng, Lingzhu Fu, and Yongsheng Zhang

    Zhejiang Chinese Medical University, 548 Binwen Rd., Binjiang District, Hangzhou, China

    Correspondence should be addressed to Yongsheng Zhang; [email protected]

    Received 17 July 2016; Accepted 23 October 2016; Published 12 March 2017

    Academic Editor: Hilal Zaid

    Copyright © 2017 Hanxiao Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Ethnopharmacological Relevance. Dendrobii Officinalis Caulis, the stems ofDendrobium officinaleKimura etMigo, as a tonic herb in Chinese materia medica and health food in folk, has been utilized for the treatment of yin-deficiency diseases for decades.Methods. Information for analysis ofDendrobium officinaleKimura etMigowas obtained from libraries and Internet scientific databases such as PubMed, Web of Science, Google Scholar, ScienceDirect, Wiley InterScience, Ingenta, Embase, CNKI, and PubChem. Results. Over the past decades, about 190 compounds have been isolated from Dendrobium officinale Kimura et Migo. Its wide modern pharmacological actions in hepatoprotective effect, anticancer effect, hypoglycemic effect, antifatigue effect, gastric ulcer protective effect, and so on were reported. This may mainly attribute to the major and bioactive components: polysaccharides. However, other small molecule components require further study. Conclusions. Due to the lack of systematic data of Dendrobium officinale, it is important to explore its ingredient-function relationships with modern pharmacology. Recently, studies on the chemical constituents of Dendrobium officinale concentrated in crude polysaccharides and its structure-activity relationships remain scant. Further research is required to determine theDendrobium officinale toxicological action and pharmacological mechanisms of other pure ingredients and crude extracts. In addition, investigation is needed for better quality control and novel drug or product development.

    1. Introduction

    Dendrobium officinale Kimura et Migo spreads in several countries over the world, such as Japan, United States, and Australia, and it distributes more widely in China [1] (Table 1). Modern pharmacology research has confirmed that Dendrobium officinale and its polysaccharide fraction pos- sess anticancer, hepatoprotective, hypolipidemic, antifatigue, antioxidant, anticonstipation, hypoglycemic, gastric ulcer protective, and antihypertensive effects, immunoenhance- ment, and so on [2–4].

    Since 1994, polysaccharides of Dendrobium officinale have been extracted and analyzed [5], and polysaccharides gradually became research focus of Dendrobium officinale. Recently, the chemical compositions and pharmacological effects of Dendrobium officinale have attracted more and

    more attention. In this review, from substantial data about Dendrobium officinale, approximately 190 monomer compo- sitions and plenty of pharmacological researches studied in vivo and/or in vitro were summarized. In addition, the devel- opment of artificial cultivation of Dendrobium officinale accelerates the promotion of its industrialization in China. Patents and health care products were also improved by the combination of production and research mode.

    2. Pharmaceutical Botany

    Dendrobium, pertaining to the second largest family, Orchi- daceae, includes approximately l,400 species worldwide dis- tributed from tropical Asia to Oceania [6]. There are 74 species and 2 variants of genus Dendrobium Sw. in China [7]. Some of them can be processed as Dendrobii Caulis

    Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2017, Article ID 7436259, 19 pages https://doi.org/10.1155/2017/7436259

    https://doi.org/10.1155/2017/7436259

  • 2 Evidence-Based Complementary and Alternative Medicine

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  • Evidence-Based Complementary and Alternative Medicine 3

    (a) (b)

    Figure 1: (a) Dendrobium officinale Kimura et Migo; (b) tiepifengdou.

    (Chinese:石斛, shihu) of Chinesemateriamedica [8]. In 2005 Chinese Pharmacopoeia (ChP), tiepishihu (Chinese:鐵皮石 斛) was one species of medicinal shihu called Dendrobium candidum Wall. ex Lindl. [9]; however this Latin name was later disputed and considered the synonym of Dendrobium moniliforme (L.) Sw. [10, 11]. In 2010 ChP, tiepishihu was ren- amed as Dendrobium officinale Kimura et Migo (aka Den- drobium officinale, Figure 1(a)). This Latin name was firstly denominated by two Japanese scholars in 1936 when they found the new species of Dendrobium in China [12]. Facil- itating the preservation, the fibrous stems of Dendrobium officinale can

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