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Results of Operations for the First Half of the Fiscal Year Ending March 31, 2019
October 25, 2018
IR Contact: Business Strategy & Management Dept. (TEL: +81-(0)6-6456-4633 E-mail: [email protected])
The information, forecasts, etc. available in this material are the Company’s judgment as of the preparation date thereof and do not always guarantee the accuracy of these information. Further, the Company and the information provider will not be responsible for any damages incurred according to these information. * The material is not prepared for the purpose of soliciting investments.
1. Overview of the Nihon Trim Group Business Pages 2 - 17
2. Business Performance, Indices, etc. Pages 18 - 22
3. Supplementary Materials Pages 23 - 31
2
The Trim Group is an entrepreneurial venture,
aspiring to become a global group of
medical companies through
the Water Healthcare Business and
the Medical Business!
3
4
Consolidated earnings forecast for the fiscal year ending March 31, 2019; Revised upward
Net salesOperating
profitOrdinary
profitProfit attributable
to owners of parentNet income per
share
Forecast announced previously (A)Million yen
15,340
Million yen
2,130
Million yen
2,030
Million yen
1,210
Yen
149.11
Forecast announced this time (B) 15,430 2,440 2,345 1,460 182.04
Change (B-A) 90 310 315 250 -
Percentage change (%) 0.6 14.6 15.5 20.7 -
(Reference)Results for the previous fiscal year (ended March 31, 2017)
14,027 1,606 1,681 1,181 143.36
1. The Direct Sales Division has remained strong.2. The cost of sales ratio of a new product TRIM ION GRACE (launched in Sept. 2017) has been
improved thanks to an increase in production volume.
1. Shifting to the B-to-B oriented package sales with “Health and Productivity Management” as a key concept
2. Further elucidation of the effects of EHW
3. Expanding business overseas
4. Starting a full-scale sales of the electrolyzed water hemodialysis
5. Hospital operation in China
6. Strengthening and expanding the foundation of regenerative medicine-related business
(From our “Results of Operations for the Fiscal Year Ended March 31, 2018”)
5
Trim Group’s Challenges in FY3/19Plan to make proactive up-front investments for making a leap into a medical company
6
Medical equipment manufacture certification number:
229AGBZX00069000
Electrolyzed Hydrogen Water (EHW) apparatus business
1. Home-use controlled medical device with an effect of improving gastrointestinal problems
2. Advantages of EHW systems: (1) Health benefit(2) Low running cost(3) Eco-friendly
“The new habit of water healthcare”
1. Achieve sales from a B2C channel that has been developed in the course of establishing a B2B channel with the “Health and Productivity Management” concept
2. Start new initiatives aimed at developing corporate clients to whom we can offer proposals
3. Pursue collaboration with health insurance associations and major players in other industries
<Monthly trend in units sold per seminar>
Recovery Trend on Sales Efficiency in Workplace Sales
7
1.5
1.7
1.9
2.1
2.3
2.5
2.7
2.9
3.1
3.3
3.5
Apr. May Jun. Jul. Aug. Sep. Oct. Nov. Dec. Jan. Feb. Mar.
34th Term 35th Term 36th Term 37th Term
8
Title: A Day When “Water” Took on ValuePrice: 1,620 yen (VAT included)Released on: May 28, 2018Published by: DIAMOND, Inc.ISBN: 978-4-478-08438-0
1. The early days of NIHON TRIM
2. The history of studies on electrolyzed hydrogen water (EHW)[Contributors who described the details of joint researches](1) Dr. Sanetaka Shirahata, Professor Emeritus, Kyushu University(2) Dr. Munenori Kawamura, Honorary Director, Kyowa Hospital(3) Dr. Masaaki Nakayama, Visiting Professor, Tohoku University Hospital (Director,
Nephrology Department and Director, Kidney Center, St. Luke’s International Hospital)(4) Dr. Katsumi Ishikawa, Deputy Director and Professor (currently, Professor Emeritus), Kochi
University
(5) Dr. Naoki Sasaki, Professor, Joint Faculty of Veterinary Medicine, Yamaguchi University
(6) Dr. Yasuyoshi Watanabe, Director, Center for Life Science Technologies, RIKEN
A Day When “Water” Took on ValueWritten by Shinkatsu Morisawa, President, NIHON TRIM CO., LTD.
Ranked No. 1 in the Overall category
at Sanseido Bookstore, Yurakucho Shop(for the week of Sept. 17 to 23, 2018)
Ranked No. 1 in the single issue book category
at Kinokuniya, Umeda Main Shop(for the week of Aug. 20 to 26, 2018)
TV advertising started in October 2018 in the timeframe of the TV show “Wake Up! Plus” on Yomiuri Television, starting from 8:00 a.m. every Saturday
(Hosted by Jiro Shinbo)
A New TV Commercial
9
FY3/12FY3/11 FY3/13 FY3/14 FY3/15 FY3/17FY3/16 FY3/18
Stock-type Business: Sales of Water Purification Cartridges
FY3/19(Forecast)
10
2,219 2,417
2,649
3,062 3,114
3,536
3,884 4,142
4,290
<Trend of purification cartridge sales>
(Millions of yen)
1H results
2,200
More Empirical Evidence and New fields
1. Identifying the mechanism for the benefits of EHW
(Basic / animal / human /Clinical studies)
RIKENBasic, animal and clinical studiesare simultaneously promoted
2. Effects of drinking EHW on diabetes (Clinical studies)School of Medicine, Tohoku University
Plan to post a paper around Jan.2019
3. Effects of drinking EHW on lifestyle diseases
(Clinical studies)Susaki City, Kochi Prefecture; Kochi Medical School
Scheduled to be completed at the end of March 2019
Effects on reduction of healthcare expenditures
(Epidemiological survey)Scheduled to start in the next fiscal year
4. Identifying the physical properties of EHW
(Basic)School of Engineering, The University of Tokyo
Plan to post a paper aroundApr. 2019
5. Understanding the effects on reducing depression by drinking EHW
(Animal) Karolinska Institute Now under research
6. Effects of drinking EHW on race horses
(Animal)Joint Faculty of Veterinary Medicine, Yamaguchi University
Started a new joint research
7. Effects of drinking EHW on exercise performance
(Human)Faculty of Sport and Health Science, Ritsumeikan University
Plan to post a paper by the end of 2018
8. Identifying the effects of the mechanism for the benefits of EHW
(Basic)Faculty of Human Sciences, Waseda University
Joint research started in Apr. 2018
9. Demonstration of cultivation of Kangen Vegetables
(Basic)Faculty of Agriculture and Marine Science, Kochi University
Now under research
10. Effects of EHW on maintaining freshness of fish
(Basic)Technology, School of Systems Engineering, Kochi University
Acquired significant data and now applying for patent
11. Effects of EHW on maintaining freshness of sliced fish
(Basic)School of Marine Science and Technology, Tokai University
Joint research started in Aug. 2018
11
12
1. Joint research with School of Medical Science, Tohoku University
Revealed significant effect on diabetic patients by drinking EHW at clinical trials (double blinded)
A paper to be submitted around January 2019.
2. Joint research with School of Engineering, The University of Tokyo
Acquired the data that can explain the highly anti-oxidant(*1) mechanism of EHW
A paper to be submitted around April 2019 (to an academic journal with the highest quality standards)
Joint Researches that have significantly helped Expand the use of EHW
(*1) A paper published on the U.S. scientific journal "PLOS ONE 12(2): e0171192 (2017)"
EHW exerts about five times more intracellular reactive oxygen species (ROS)-scavenging activity than bubbling hydrogen water with the same dissolved hydrogen content (Refer to P. 24).
13
Pristine
1. Bottled water business in Indonesia (PT. SUPER WAHANA TEHNO)
1) Net sales for 1H of FYE March 31, 2019: 52,934 million rupiah (up 26.5% year-on-year)
(equivalent to 407 million yen based on the exchange rate of IDR/JPY: 0.0077)
2. EHW apparatus sales business in overseas markets
1) China (Trim (Guangzhou) Water & Health Co., Ltd.) Net sales for 1H of FYE March 31, 2019: Approx. 3.3 million yuan (up 28.7% year on year)
(equivalent to 55.9 million yen based on the exchange rate of CNY/JPY: 16.66)
2) Vietnam and other newly-entered countries incl. India, Cambodia, Philippines and Thailand
EHW apparatus to be sold overseas: 10,000 units/year in three year
Expanding overseas businesses
16,940 22,306
41,813 41,861
52,934 35,649
50,980
81,380
91,507
112,000
0
20,000
40,000
60,000
80,000
100,000
120,000
FYEMar. 31, 2015
FYEMar. 31, 2016
FYEMar. 31, 2017
FYEMar. 31, 2018
FYEMar. 31, 2019
1H Full Year
(million rupiah)
14
1. Adopted by two facilities for multiple patients and one facility for individual patients during 2Q. (St. Luke's International Hospital, which has adopted EWH for individual patients, plans to adopt more.)Currently under negotiation with 250 hospitals (with a gross sales amount of 5,500 million yen)/4,396 facilities and 135,000 beds nationwide (as of Dec. 31, 2016)
2. Benefits of EWH to hospital management:Mitigates the problem of decreasing revenue from conventional dialysis by reducing drug costs and labor costs (through mitigated workload of nursing staff and medical technicians).Cost-benefit analysis has revealed that there is a positive effect of 410,860 thousand yen for 5 years (assuming 50 beds and 150 patients).
Electrolyzed Water Hemodialysis® will become a globally recognized standard treatment.
136
123
111
100 91
141
133
126
119
112
90
100
110
120
130
140
150
Nu
mb
er
of
rem
ain
ing
pat
ien
ts (
pe
rso
ns)
Period of dialysis
Number of patients by FY (persons) (50 beds and 150 individuals assumed)
通常透析
電解水透析
Assuming that all patients who newly developed cardio-cerebrovascular disorder will transfer out.
1st year 2nd year 3rd year 4th year 5th year
Conventional hemodialysis
Electrolyzed water hemodialysis
* Mortality rate: 9.6% (2015 JSDT statistics data)* Transfer due to death or complication reduced by 41%
(Presented by Dr. Masaaki Nakayama at the 62nd Annual Meeting of the Japanese Society for Dialysis)
<< Reducing the number of patients who newly developed cardio-cerebrovascular disorder or deceased >>
15
1. Opened Beijing HanKun Hospital, a flagship hospital in China
1) Began accepting outpatients for diabetes treatment and rehabilitation on July 25, 2018, and inpatients on October 2018.
2) After the upfront investments period, the hospital is expected to contribute to the Group’s earnings from FYE3/2020 onward
Loss on investment in equity method affiliates: 102 million yen for 1H of FYE March 31, 2019 and approx. 180 million yen for the full year of FYE March 31, 2019 (estimate).
3) Anticipating sales of 5 billion yen with operating margin of over 20%.
2. Started actions to deploy multiple institutions in China Candidate sites: Dalian, Shanghai, Hsian, Inner Mongolia, etc.
Launching hospital management business in China
Beijing HanKun Hospital
16
The largest private cord blood bank in Japan set the path to growth
1. Aiming to achieve the storage rate of 1% in 5 years (3 times the current rate)
2. Started a joint research with The Institute of Medical Science, The University of Tokyo in September 2018 Aiming to build a banking system of cells derived from fetal appendages such as umbilical cord and its clinical application.
(Reference) Number of storages: 45,030; Number of hospitals collecting cells: 1,940 (as of September 30, 2018)
270
290
310
330
350
370
390
410
430
450
4月 5月 6月 7月 8月 9月 10月
Number of monthly storage samples
2018年3月 2019年3月
↑ Up approx. 50% year-on-year
“Nikkei Shimbun”October 17, 2018 Evening Edition
Apr. May Jun. Jul. Aug. Sep. Oct.
Mar. 2018 Mar. 2019
Drinking water EHW apparatus business 38.0 billion yen
Medical/advanced medical care
To be developed into a mainstay business in the future
Electrolyzed water hemodialysis®
Cord blood bank
Cell drug discovery
Regenerative/reproductive medicine-
related equipment
Hospital operation in China
32.0 billion yen
Agriculture
Establishing Kangen Vegetable® brand
Sale of EHW apparatus for growing
Kangen Vegetables
2.0 billion yen
Industrial
Cleansing system for dies,
semiconductors and other items
Rust prevention
0.5 billion yen
OverseasEHW apparatus (China, Taiwan)
Bottled water (Indonesia)20.0 billion yen
New business - 7.5 billion yen
Become a 100 billion yen company by FY3/27
17
The Business Goals of the Trim GroupTransform from a household medical device supplier into a medical company
1. Water Healthcare Business: Prioritize prevention to reduce treatment and nursing home care
2. Establish new business vectors in business domains including the fields of medical care, advanced medical care, and agriculture
3. Gain global presence with technologies made in JapanTarget business volume per year
18
1. Overview of the Nihon Trim Group Business Pages 2 - 17
2. Business Performance, Indices, etc. Pages 18 - 22
3. Supplementary Materials Pages 23 - 31
19
Amount % Amount %
Net sales 6,944 100.0% 7,900 100.0% 955 13.8%
Cost of sales 1,785 25.7% 2,187 27.7% 401 22.5%
Gross profit 5,158 74.3% 5,712 72.3% 554 10.7%
SG&A expenses 4,156 59.9% 4,337 54.9% 180 4.3%
Operating profit 1,001 14.4% 1,375 17.4% 374 37.3%
Non-operating income 81 1.2% 67 0.9% -13 -16.5%
Non-operating expenses 12 0.2% 112 1.4% 100 823.5%
Ordinary profit 1,070 15.4% 1,330 16.8% 260 24.3%
Extraordinary income - - - - - -
Extraordinary losses 0 0.0% 11 0.1% 11 7160.3%
Profit before income taxes 1,070 15.4% 1,318 16.7% 248 23.2%
Income taxes 369 5.3% 466 5.9% 96 26.1%
Profit attributable to non-controlling interests 35 0.5% 25 0.3% -10 -28.7%
Profit attributable to owners of parent 664 9.6% 827 10.5% 162 24.4%
Net income per share 23.21 yen 29.0%
Change
(Amount)Change (%)
79.93 yen 103.13 yen
(Rounded down to millions
of yen)
1H FY3/18 Results 1H FY3/19 Results
1H FY3/19 Results: Consolidated Statement of Income
20
Amount % Amount %
(Flow-type business)
DS Division (workplace sales) 1,983 28.6% 2,412 30.5% 428 21.6%
HS Division (installation and referral sales) 849 12.2% 989 12.5% 140 16.5%
SS Division (store event sales) 240 3.5% 352 4.5% 112 46.8%
MS Division (OEM and wholesale sales) 390 5.6% 397 5.0% 7 2.0%
MS Division (after-sales services) 141 2.0% 153 1.9% 11 8.4%
EHW systems sales, total 3,605 51.9% 4,305 54.5% 700 19.4%
(Stock-type business)
Cartridges 2,187 31.5% 2,200 27.9% 13 0.6%
(Sales of subsidiaries)
TRIM (Guangzhou) Water & Health Co., Ltd. 42 0.6% 55 0.7% 12 30.0%
PT. SUPER WAHANA TEHNO 351 5.1% 407 5.2% 55 15.9%
(Others) 311 4.5% 330 4.2% 19 6.2%
Total 6,498 93.6% 7,300 92.4% 801 12.3%
Regenerative medicine 425 6.1% 544 6.9% 119 28.0%
Electrolyzed water hemodialysis and
MGO measurement0 0.0% 14 0.2% 14 22580.2%
Others 20 0.3% 40 0.5% 20 99.3%
Total 445 6.4% 599 7.6% 153 34.5%
6,944 100.0% 7,900 100.0% 955 13.8%Consolidated, total
Change
(%)(Rounded down to millions of yen)
Wate
r He
althcare
Bu
sine
ssM
edical B
usin
ess
1H FY3/18 Results 1H FY3/19 Results Change
(Amount)
1H FY3/19 Results: Sales by Business Segment
21
A Healthy Financial Condition (Consolidated)
Percentage of the amount in current assets: 81.3%
* TSE listed-company average: 30.1%(with the reference to the aggregate summary of financial results for the fiscal year ended March 31, 2018 on the Tokyo Stock Exchange website)
(Rounded down to millions of yen) As of Mar. 31, 2018 As of Sep. 30, 2018
Current assets 17,050 17,135
A: Cash and deposits 11,520 11,129
B: Accounts receivable-installment
2,495 2,797
A + B: Total 14,016 13,926
Non-current assets 6,987 7,067
Total assets 24,038 24,203
(Rounded down to millions of yen) As of Mar. 31, 2018 As of Sep. 30, 2018
Total assets 24,038 24,203
Net assets 17,425 16,976
Equity ratio 72.5% 70.1%
25 2530
35
50 50
60 60 60 60
22
DividendsDividend policy: Emphasize paying stable dividends, while payout ratio to improve gradually
Shareholder special benefit plan: 30% discount coupon for Nihon Trim products
Dividend trend (Yen)2-for-1 stock split in October 2013
FY3/19 (fct.)FY3/10 FY3/12FY3/11 FY3/13 FY3/14 FY3/15 FY3/17FY3/16 FY3/18
Adjusted for the number of shares after the stock split
23
1. Overview of the Nihon Trim Group Business Pages 2 - 17
2. Business Performance, Indices, etc. Pages 18 - 22
3. Supplementary Materials Pages 23 - 31
24
1) EHW exerts about five times more intracellular reactive oxygen species (ROS)-scavenging activity than bubbling hydrogen water with the same dissolved hydrogen content (0.9 ppm)
2) Even after hydrogen was removed, EHW retains about 60% of its ROS-scavenging activity while bubbling hydrogen water lost it. (This activity is equivalent to about 3 times the activity of hydrogen water.)
3) The results indicate that EHW contains an additional intracellular antioxidative factor other than hydrogen (predicted to be platinum nanoparticles).
Comparison of intracellular ROS content after treatment with culture medium prepared with EHW or hydrogen water with the same dissolved hydrogen concentration(Excerpt from the paper, partially edited)
Changes in amount of intracellular ROS after removal of dissolved hydrogen
Superiority of EHW to Bubbling Hydrogen WaterJoint paper published on the U.S. scientific journal PLOS ONE - 12(2): e0171192 (2017)
Am
ou
nt
of
intr
ace
llula
r R
OS
Adding ROS (ROS-added water)
Removing hydrogenP
ure
wat
er
Pu
re w
ater
Pu
rifi
ed w
ater
Hyd
roge
n w
ater
(Pu
rifi
ed w
ater
+ H
2 )
Hyd
roge
n w
ater
(Pu
re w
ater
+ H
2 )
EHW
EHW EH
W
Hyd
roge
n w
ater
(Pu
re w
ater
+ H
2 )H
ydro
gen
wat
er(P
uri
fied
wat
er +
H2 )
10
%
Red
uct
ion
50
%
Red
uct
ion
50% Reduction
30% Reduction
Am
ou
nt
of
intr
acel
lula
r R
OS
25
344
396372
452399
498
398
571
0
100
200
300
400
500
600
Japanese mustardspinach
Green springonion
Spinach Fruit tomato
Concentional
EHW
Unit: ¥10,000
Increase in sales for 5 years: ¥3,750 thousand* Annual average increase in sales
of 4 types of vegetables below: ¥750 thousand/yr x 5 years
Net increase in income: ¥2,850 thousand (for 5 years)
Fruit tomato – Yield: Up 10%, Unit price: Up 15%
Strawberries (grown in Tamana, Kumamoto)
1) Equipment cost: ¥800 thousand・ EHW apparatus main unit:
¥800 thousand (AG-10)
2) Annual increase in expenses: Approx. 20,000 yen
・ Cartridge: 2 units/year x ¥2,000/unit = ¥4,000・ Electricity: ¥1,333/month x 12 months = ¥16,000
Melons (grown in Kusatsu, Shiga)
EHWSize: 6L
Sugar content: 18 deg.
ConventionalSize: 3L
Sugar content: 14 deg.
Comparison of annual sales – Estimated based on the assumption of field scale of 10 ares and 4 crops/year for leaf vegetables
* Data provided by Japan Food Research Laboratories and Kochi University
* How sales were calculated: (Example) Japanese mustard spinachUnit price of ¥430/kg times conventional yield of 2 tons times 116% times 4 crops = ¥3,990 thousand * Unit price increase rate for tomato is 115% (Unit prices and yields were calculated based on
production/shipment indexes for the year 2013 by the Kochi Pref. Horticultural Federation)
* For illustrative purposes only. The actual results may vary depending on environments and conditions of cultivation.
Benefits of introducing EHW apparatus for Kangen VegetablesEstimate of increase in farmers’ income by yield increase/quality improvement
Leaf vegetable yields at Nangoku Style Co., Ltd., etc.
Rat
io t
o c
on
ven
tio
nal
met
ho
d
Japanesemustardspinach(6 crops)
Basil(1 crop)
Greenspringonion
(3 crops)
Mesclun(1 crop)
Spinach(4 crops)
Chinesechive
(6 crops)
Rat
io t
o t
ap w
ater
Rat
io t
o t
ap w
ater Vitamin C
Antioxidant Activity Polyphenol
Sugar content of fruit tomato
Standard tomato: 7 or higherEHW tomato: 9.6 to 9.8
Overall balance improved
Rat
io t
o t
ap w
ater
Yields
26
It suggests that “electrolyzed water hemodialysis" suppresses the death or development of cardio-cerebrovascular disease in chronic dialysis patients, leading to a possible improvement in prognosis of patients.
Note: Hazard ratio 0.59 (95% confidence interval: 0.38 - 0.92) When the incidence in conventional dialysis is 1, it is 41% lower at 0.59 in electrolyzed water hemodialysis. It indicates that statistically, electrolyzed water hemodialysis is significantly effective.
The percentage of patients not suffering deaths or complications is significantly higher. [Key points in the paper]
(1) In Japan, the incidence of cardio-cerebrovascular complications in dialysis patients is extremely high, which is the main cause of death.
(2) The number of deaths of dialysis patients treated with “electrolyzed water hemodialysis” and the effect on the occurrence of cardio-cerebrovascular disease were investigated.
(3) It was revealed that “electrolyzed water hemodialysis" reduces the number of death and risk of developing cardio-cerebrovascular disease by 41%.
[The paper published on:]
British scientific journal “Scientific Reports 8, Article number: 254 (2018)”http://www.nature.com/articles/s41598-017-18537-x (Posted on January 10, 2018)
Online journal from Nature Publishing Group which publishes Nature. Impact factor: 4.847 (2016)
Next-generation Dialysis Method “Electrolyzed Water Hemodialysis”Paper published on Scientific Reports, British scientific online journal
Hazard ratio 0.59 (95% CI 0.38 - 0.92) Note
Electrolyzed water hemodialysis patient group
Conventional dialysis patient group
Pro
po
rtio
n o
f p
atie
nts
no
t su
ffer
ing
dea
th o
r o
ccu
rren
ce o
f ca
rdio
-cer
ebro
vasc
ula
r d
isea
ses
Since dialysis patients suffer death or complications over time, the graphs decline toward the right.While the conventional dialysis group (green) is descending fast, the electrolyzed water hemodialysis group (blue) is declining slowly, indicating that it is less likely to have their occurrence.
Observation period (days)
27
Excerpt from Joint Research Reports
[2010]Nephrology Dialysis Transplantation Jointly authored paper with Tohoku Univ. School of MedicineIntake of water with high levels of dissolved hydrogen produced by electrolysis suppresses ischemia-induced cardio-renal injury in Dahl salt sensitive rats Cytotechnology Jointly authored paper with Kyushu Univ.Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitusBioscience, Biotechnology, and Biochemistry Jointly authored paper with Kyushu Univ.Extension of the lifespan of caenorhabditis elegans by electrolyzed reduced waterNephrology Dialysis Transplantation Jointly authored paper with Tohoku Univ. School of MedicineA novel bioactive hemodialysis system using dissolved dihydrogen(H2) produced by water electrolysisNephrology Dialysis Transplantation Jointly authored paper with National Taiwan Univ. Medical SchoolElectrolyzed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic hemodialysis[2009]Nephron Clinical Practice Jointly authored paper with Tohoku Univ. School of MedicineBiological effect of electrolyzed water in hemodialysis[2008]Vascular Medicine Jointly authored paper with Tohoku Univ. School of MedicineInvestigation of participation of methylglyoxal on cardio renal syndromeLangmuir Jointly authored paper with Kyushu University Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticlesBiological & Pharmaceutical Bulletin Jointly authored paper with Kyushu Univ.Inhibitory effect of electrolyzed reduced water on tumor angiogenesis[2007]Hemodialysis International Jointly authored paper with Tohoku Univ. School of MedicineLess-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water [2006]Kidney International Vol.70 Jointly authored paper with National Taiwan Univ. Medical SchoolElectrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients[2005]Cytotechnology 2005 Jointly authored paper with Kyushu Univ.Electrolyzed reduced water supplemented with platinum nanoparticles suppresses promotion of two-stage cell transformation[2003]Kidney International 2003 Jointly authored paper with National Taiwan Univ. Medical SchoolReduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced waterCytotechnology 2003 Jointly authored paper with Graduate School of Kyushu Univ. Protective mechanism of reduced water against alloxan-induced pancreatic β-cell damage: scavenging effect against reactive oxygen species[1997]BBRC Jointly authored paper with Graduate School of Kyushu Univ.Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage
[2018]Scientific Reports Jointly authored paper with Tohoku Univ. Novel hemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study[2017]PLOS ONE Jointly authored paper with Tohoku Univ. Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observationEquine Science Jointly authored paper with Obihiro Univ. of Agriculture and Veterinary Medicine Effect of drinking electrolyzed hydrogen water on gastrointestinal manifestation in racehorses at Oi racetrack (a. k. a. Tokyo City Keiba)PLOS ONE Jointly authored paper with Kyushu Univ. and Faculty of Medicine, Univ. of TokyoElectrolyzed hydrogen water has stronger intracellular reactive oxygen scavenging ability on HT 1080 cells than hydrogen water of the same hydrogen concentration[2016]Renal Replacement Therapy Jointly authored paper with Fukushima Medical Univ. and Tohoku Univ. School of MedicineThe hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectivesJournal of the Veterinary Medicine Jointly authored paper with Obihiro University of Agriculture and Veterinary MedicineEffect of drinking electrolyzed hydrogen water on prevention of the development of gastric ulcers in horses caused by non-steroidal anti-inflammatory drugs[2014]Clinical and Experimental Nephrology Jointly authored paper with Tohoku Univ. The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration riseEnvironmental control in biology Jointly authored paper with Kochi Univ.Effects of deoxidized nutrient solution on growth of komatsuna plants[2013]Hemodialysis International Jointly authored paper with Fukushima Medical Univ.Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patientsMedical Gas Research Jointly authored paper with Tohoku Univ. Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water[2012]PLOS ONE Jointly authored paper with Karolinska Institute and Kyushu Univ.Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in MiceCytotechnology Jointly authored paper with Kyushu Univ.Electrolyzed reduced water scavenges active oxygen species and suppresses cancer cell invasion[2011]Trends in Food Science and Technology Jointly authored paper with Kyushu Univ.Advanced research on the health benefit of reduced waterBMC Proceedings Jointly authored paper with Kyushu Univ.The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticlesBMC Proceedings Jointly authored paper with Kyushu Univ.Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticlesBioscience, Biotechnology, and Biochemistry Jointly authored paper with Kyushu Univ.Mechanism of the lifespan extension of caenorhabditis elegans by electrolyzed reduced water
28
Strengthen Business Foundation in Fields of Regenerative and Restoration Medicine and Reproductive Medicine (for Fertility Treatment)
Icellator from Tissue Genesis LLC
High-performance, Compact Programmable Deep Freezer
from STREX
1. Human Life CORD- Developing medicines made in Japan based on cells derived from human placenta and umbilical cord -
1) Concluded license agreement with Tissue Genesis LLC (Hawaii, USA) for research and development of stem cell isolation and extraction equipment for clinical use and its sales in Japan and China. (August 2017)Aiming to acquire certification for medical device for clinical use.
2) Concluded a joint research agreement with The Institute of Medical Science, The University of Tokyo, to conduct a joint research on using umbilical cord-derived mesenchymal stem cells. (September 2017)
3) Concluded a joint research agreement with Kansai Medical University for the research on repair and regenerative treatment for minimally invasive breast reconstruction. (October 2017)
4) Concluded a domestic exclusive agent agreement with Inabata & Co., Ltd . (headquartered in Osaka City, TSE 1, OSE 1 ) regarding the equipment in 1) above. (August 2018)
5) Aiming to acquire manufacturing and sales approval in FY3/20.
2. STREX- Abundant know-how on equipment in the fields of regenerative and reproductive medicine -
1) Sales for FY3/19 (plan): 100 million yen
2) Developing, manufacturing, and selling unique products based on proprietary technologies such as Stretch System, Procreate System, and Deep Freezer.
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1. Opened in Nishi-Shinbashi , Minato-ku, Tokyo (on August 8, 2018).
2. With low carbohydrate recipes under the supervision of a registered dietitian, the amount of carbohydrate is equivalent to as contained in one-half to one piece of onigiri (rice ball) even if you eat all dishes of a full dinner course (7 dishes including appetizer, soup-type dish, tempura and main dish).
Japanese cuisine YuitsumugiA restaurant serving healthy low-carbohydrate Japanese cuisine and wines
Japanese cuisine YuitsumugiA restaurant serving healthy, low-carbohydrate Japanese cuisine and wines
Sansui Building 2F, 1-16-2, Nishi-Shinbashi, Minato-ku, Tokyo 105-0004Tel. +81-3-6435-478
Lunch: 11:30 a.m. – 2:00 p.m.
Dinner: 5:30 p.m. – 9:30 p.m.
Wine Bar: 9:30 p.m. – midnight
Closed on Sundays and holidays
Corporate Overview
Main businessManufacture and sale of household medical device (EHW apparatus)
Established June 12, 1982
Headquarters22F, Herbis Ent, 2-2-22 Umeda, Kita-ku, Osaka, Japan
Tel. +81-(0)6-6456-4600 Fax. +81-(0)6-6455-3951
Capital 992,597,306 yen
SharesListed on the First Section of the Tokyo Stock Exchange
Securities Identification Code: 6788
Issued shares 8,656,780 shares
Shareholders 3,637 (as of the end of September 2018)
Employees (consolidated)
487 (as of the end of September 2018)
President Shinkatsu Morisawa
Main banksSumitomo Mitsui Banking Corporation
Sumitomo Mitsui Trust Bank, Limited
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HERBIS ENT, where the Company’s
headquarters are located
Member of Nippon Keidanren, Japan Business Federation
Member of Industrial Promotion Committee, Kansai Economic Federation
Member, Japan Hospital AssociationDirector, Functional Water Foundation
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Water Healthcare Business Medical Business
Japan
Trim Medical Holdings Inc. (Holding company; established in May 2007)
StemCell Institute Inc.(Private cord blood bank; established in August 1999)
Trim Medical Institute Co., Ltd.(Contract measurements of glycolytic metabolites and sales of electrolyzed water hemodialysis system; established in December 2007)
Human Life CORD Japan Inc.(R&D, production and sales of Japanese cell medicines; established in April 2017)
STREX Inc.(Research and development, manufacture and sales of medical equipment; formed capital alliance in May 2017)
Overseas
Han Kun International Holdings Limited(China business; a specified purpose company established in December 2015)
Japan
Trim Electric Machinery Co., Ltd. (Production factory; established in February 1990) ISO9001: 2015 ISO13485: 2016
Trim Life Support Co., Ltd.(After-sales services; established in February 2012)
Overseas
TRIM (Guangzhou) Water & Health Co., Ltd.(Based in China; established in October 2005)
PT SUPER WAHANA TEHNO(Based in Indonesia; invested in October 2006) ISO: 22000: 2005
MEDFIRST TRIM CO., LTD.(Based in Taiwan; established in April 2012)
(The City of Nankoku, Kochi Prefecture: completed in 2002)
