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Potassium Insulin Regulation

Yunita Wannur Azah

Postgraduate Biomedical ScienceFaculty Of Medicine

University Sumatera Utara

2016

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Potassium is important why?

Potassium is a mineral that is essential for the function

of all our cells, tissues and organs in our body.

Substances associated with the electrical charges in the

body, along with sodium, chloride, calcium and

magnesium.

Potassium also helps muscle contraction, fluid balance

and maintain the heart rate.

Cogswell et al, Sodium and Potassium Intake Among US Adult, 2012, 96(3):647-57

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Potassium Function

Some hormonal factors may play a role in potassium

homeostasis hormones including insulin

Participates in many metabolic processes, e.g. regulationof protein and glycogen synthesis

Maintance osmotic and acid base balance between intra

and extra cell

Maintain resting membrane potential (RMP) of cellular

membrane

Cogswell et al, Sodium and Potassium Intake Among US Adult, 2012, 96(3):647-57

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Insulin Secretion by Cell Pancreatic

Insulin secretion by cells depend by three

main factors: Blood glucose levels

ATP-sensitive K channels

Voltage-sensitive Calcium

Nepton S, Beta Cell Function and Failure, Type 1 Diabetic ,2013

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In the resting cell with normal

ATP levels, potassium diffuses

follow concentration gradients

through the canal Potassium_ATP

If the glucose level increases,increased production of ATP, ATP

will close the potassium channels,

which causes cell depolarizationFrances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005

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Beta Cell Biology Consorium,2004

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Frances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005

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Disfunction of insulin regulation

due to mutation

Frances M. Ashcroft, The Journal of Clinical Investigation, Volume 115, Number 8 August 2005

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