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Appendix I

List of unique phosphortyrosine sites identified in E. coli K12 strain MG1655

Gene Protein name Protein

accession Petide sequence Phosphosite

aceA isocitrate lyase NP_418439.1 LLAyNcSPSFNWQK Y4(Phospho)

aceB malate synthase A NP_418438.1 DAVNGTISyTNEAGK Y9(Phospho)

aceB malate synthase A NP_418438.1 DAVNGTISYTNEAGKIyQ

LKPNPAVLIcR Y17(Phospho)

ahpC alkyl hydroperoxide reductase, C22 subunit NP_415138.1 AAQyVASHPGEVcPAK Y4(Phospho)

aldB aldehyde dehydrogenase B NP_418045.4 MTNNPPSAQIKPGEyGFP

LK Y15(Phospho)

appY DNA-binding global transcriptional activator NP_415096.1 KLITSNSysINVVAQK Y8(Phospho)S9(Phospho)

asnB asparagine synthetase B NP_415200.1 DVIyHIETYDVTTIR Y4(Phospho)

asnB asparagine synthetase B NP_415200.1 EcFEAyLPASVAWR Y6(Phospho)

asnS asparaginyl tRNA synthetase NP_415450.1 KFENPVyWGVDLSSEHE

R Y7(Phospho)

aspA aspartate ammonia-lyase NP_418562.4 EVPADAyYGVHTLR Y7(Phospho)

aspA aspartate ammonia-lyase NP_418562.4 GEYQyLNPNDHVNK Y5(Phospho)

atpD F1 sector of membrane-bound ATP synthase,

beta subunit NP_418188.1 NIAIEHSGySVFAGVGER Y9(Phospho)

betA choline dehydrogenase, a flavoprotein NP_414845.1 STAGyFVANGMPVR Y5(Phospho)

bisC biotin sulfoxide reductase NP_418007.3 IREAYGPASIFAGSyGWR Y15(Phospho)

cheZ phosphatase of chemotaxis regulator CheY NP_416395.1 LyYVVQMTAQAAER Y2(Phospho)

cheZ phosphatase of chemotaxis regulator CheY NP_416395.1 LYyVVQMTAQAAER Y3(Phospho)

codA cytosine deaminase NP_414871.1 TFALAQKyDR Y8(Phospho)

cyoA cytochrome bo terminal oxidase subunit II NP_414966.1 LGSQIyAmAGmQTR Y6(Phospho)

cysJ sulfite reductase, alpha subunit, flavoprotein NP_417244.1 sRAPVAAPSqSVATGAVN

EIHTSPySK

S1(Phospho)Y25(Phospho

)

cysU sulfate/thiosulfate transporter subunit NP_416919.1

tLLDALMDLPFALPTAVA

GLtLASLFsVNGFyGEWLAK

T1(Phospho)T21(Phospho

)S27(Phospho)Y32(Phospho)

dhaM dihydroxyacetone kinase subunite M-specific,

PTS-like enzyme NP_415716.4 ELSQQYQQLDDEyLQAR Y13(Phospho)

dhaM dihydroxyacetone kinase subunite M-specific,

PTS-like enzyme NP_415716.4 ELSQQyQQLDDEYLQAR Y6(Phospho)

dps Fe-binding and storage protein NP_415333.1 SKATNLLyTR Y8(Phospho)

efp elongation factor EF-P NP_418571.1 ATyYSNDFR Y3(Phospho)

efp elongation factor EF-P NP_418571.1 ATYySNDFR Y4(Phospho)

elaB conserved protein NP_416769.1 VSQASDSYYyR Y10(Phospho)

eno enolase NP_417259.1 DAGyTAVISHR Y4(Phospho)

etk cryptic autophosphorylating protein tyrosine

kinase Etk NP_415501.1

ASTAYSYGYNyYGYSYSEKE

Y11(Phospho)



ASTAYSYGYNYYGYSyS

EKE Y16(Phospho)



ASTAYSyGYNYYGYSYSEKE

Y7(Phospho)



ASTAYSYGyNYYGYSYS

EKE Y9(Phospho)

fbaA fructose-bisphosphate aldolase, class II NP_417400.1 ANEAyLQGQLGNPKGED

QPNKK Y5(Phospho)

fbaB fructose-bisphosphate aldolase class I NP_416600.4 AINYGyTDDRVYSK Y6(Phospho)

fbp fructose-1,6-bisphosphatase I NP_418653.1 GGIYLyPSTASHPDGK Y6(Phospho)

fdhE formate dehydrogenase formation protein NP_418327.1 FAALIAHAQEVVLyDHPL

EMDLTAR Y14(Phospho)

fdx [2Fe-2S] ferredoxin NP_417020.1 VTDEDLVVEIPRyTINHA

R Y13(Phospho)

frdB fumarate reductase (anaerobic), Fe-S subunit NP_418577.1 MAQLNSQNGVWScTFV

GycSEVcPK Y18(Phospho)

frr ribosome recycling factor NP_414714.1 ASPSLLDGIVVEyYGTPT

PLR Y13(Phospho)

frr ribosome recycling factor NP_414714.1 ASPSLLDGIVVEYyGTPT

PLR Y14(Phospho)

ftsA ATP-binding cell division protein involved in

recruitment of FtsK to Z ring NP_414636.1

VLHVIPQEYAIDyQEGIK

NPVGLSGVR Y13(Phospho)

ftsK DNA translocase at septal ring sorting daughter

chromsomes NP_415410.1 sQEyIEDKEVTLTK Y4(Phospho)

fumA fumarate hydratase (fumarase A), aerobic Class I NP_416129.1 LASAKYyDELPTEGNEH

GQAFR Y7(Phospho)

fumB anaerobic class I fumarate hydratase (fumarase

B) NP_418546.1

LASAHyYDELPTEGNEH

GQAFR Y6(Phospho)

gapA glyceraldehyde-3-phosphate dehydrogenase A NP_416293.1 GANFDKyAGQDIVSNASc

TTNcLAPLAK Y7(Phospho)

gapA glyceraldehyde-3-phosphate dehydrogenase A NP_416293.1 LVSWYDNETGySNK Y11(Phospho)

gapA glyceraldehyde-3-phosphate dehydrogenase A NP_416293.1 LVSWyDNETGYSNK Y5(Phospho)

gatA galactitol-specific enzyme IIA component of

PTS NP_416597.1 SSAIyLLRPTNK Y5(Phospho)

gatB galactitol-specific enzyme IIB component of

PTS NP_416596.1

VNEIETyMDGVHLIcTTAK

Y7(Phospho)

gatY D-tagatose 1,6-bisphosphate aldolase 2, catalytic

subunit NP_416599.2

NAFSQALKNyLTEHPEAT

DPR Y10(Phospho)


subunit NP_416599.2

NYLTEHPEATDPRDyLQSAK

Y15(Phospho)


subunit NP_416599.2 QyHHPLAIHLDHHTK Y2(Phospho)

gatZ D-tagatose 1,6-bisphosphate aldolase 2, subunit NP_416598.1 IRyYWPHSR Y3(Phospho)

gatZ D-tagatose 1,6-bisphosphate aldolase 2, subunit NP_416598.1 KVLIEATSNQVNQFGGyT

GMTPADFR Y17(Phospho)

gatZ D-tagatose 1,6-bisphosphate aldolase 2, subunit NP_416598.1 MVyEAHSTDYQTR Y3(Phospho)

gatZ D-tagatose 1,6-bisphosphate aldolase 2, subunit NP_416598.1 YyWPHSR Y2(Phospho)

glf UDP-galactopyranose mutase, FAD/NAD(P)-

binding NP_416540.1 VGDEPYyPVNDNK Y7(Phospho)

glf UDP-galactopyranose mutase, FAD/NAD(P)-

binding NP_416540.1 YYDMHQVISAALyQVK Y13(Phospho)

glnA glutamine synthetase NP_418306.1 IHPGEAMDKNLyDLPPEE

AK Y12(Phospho)

glnB regulatory protein P-II for glutamine synthetase NP_417048.1 GAEymVDFLPK Y4(Phospho)

glnK nitrogen assimilation regulatory protein NP_414984.1 GAEySVNFLPK Y4(Phospho)

glpD sn-glycerol-3-phosphate dehydrogenase, aerobic,

FAD/NAD(P)-binding NP_417884.1 yLEHYEFR Y1(Phospho)

glpK glycerol kinase NP_418361.1 LINDAYDSEyFATK Y10(Phospho)

glpK glycerol kinase NP_418361.1 LINDAyDSEYFATK Y6(Phospho)

glpK glycerol kinase NP_418361.1 NTyGTGcFMLMNTGEK Y3(Phospho)

glyA serine hydroxymethyltransferase NP_417046.1 VMQAQGSQLTNKYAEGy

PGK Y17(Phospho)

glyA serine hydroxymethyltransferase NP_417046.1 VMQAQGSQLTNKyAEGY

PGKR Y13(Phospho)

glyS glycine tRNA synthetase, beta subunit NP_418016.1 DKLEPyFTEGR Y6(Phospho)

gpmA phosphoglyceromutase 1 NP_415276.1 HyGALQGLNK Y2(Phospho)

gpt guanine-hypoxanthine phosphoribosyltransferase NP_414773.1 HVDTVcISSyDHDNQR Y10(Phospho)

groL Cpn60 chaperonin GroEL, large subunit of

GroESL NP_418567.1 QqIEEATSDyDREKLQER Y10(Phospho)

groS Cpn10 chaperonin GroES, small subunit of

GroESL NP_418566.1 VGDIVIFNDGyGVK Y11(Phospho)

grxB glutaredoxin 2 (Grx2) NP_415582.1 LYIYDHcPycLK Y9(Phospho)

grxD glutaredoxin-4 NP_416171.1 FAyVDILQNPDIR Y3(Phospho)

hns global DNA-binding transcriptional dual

regulator H-NS NP_415753.1

KLQQyREMLIADGIDPNE

LLNSLAAVK Y5(Phospho)



LQQyREMLIADGIDPNEL

LNSLAAVK Y4(Phospho)

htpG molecular chaperone HSP90 family NP_415006.1 ALSNPDLyEGDGELR Y8(Phospho)

icd isocitrate dehydrogenase specific for NADP+ NP_415654.1 TVTyDFER Y4(Phospho)

infA translation initiation factor IF-1 NP_415404.1 ILTGDKVTVELTPyDLSK Y14(Phospho)

lsrF putative autoinducer-2 (AI-2) aldolase NP_416034.1 IAAEMGAQIIKTyYVEK Y13(Phospho)

luxS S-ribosylhomocysteine lyase NP_417172.1 VQDQNQIPELNVyQcGTY

QMHSLQEAQDIAR Y13(Phospho)

map methionine aminopeptidase NP_414710.1 IcNDYIVNEQHAVSAcLG

yHGYPK Y19(Phospho)

map methionine aminopeptidase NP_414710.1 IcNDYIVNEQHAVSAcLG

YHGyPK Y22(Phospho)

mntH manganese/divalent cation transporter NP_416893.1 MTNyRVESSSGR Y4(Phospho)

mreB cell wall structural complex MreBCD, actin-like

component MreB NP_417717.2 IKHEIGSAyPGDEVR Y9(Phospho)

nadR bifunctional DNA-binding transcriptional

repressor/ NMN adenylyltransferase NP_418807.4

TAIKQQGcTLQqVADASGMtKGyLSqLLNAK

T20(Phospho)Y23(Phospho)

nagD ribonucleotide monophosphatase NP_415201.1 AAyFVANGAR Y3(Phospho)

nagD ribonucleotide monophosphatase NP_415201.1 GFyPAcGALcAGIEK Y3(Phospho)

ndk

multifunctional nucleoside diphosphate kinase

and apyrimidinic endonuclease and 3'-phosphodiesterase

NP_417013.1 ADyADSLTENGTHGSDS

VESAAR Y3(Phospho)

nfuA iron-sulfur cluster scaffold protein F NP_417873.1 DLTEHQRGEHSyY Y13(Phospho)

oppA oligopeptide ABC transporter substrate-binding

protein NP_415759.1

AQGNMPAyGYTPPYTDG

AK Y8(Phospho)

osmY hyperosmotically inducible periplasmic protein NP_418793.1 isKTLLAVMLTSAVATGSAyAEnnAqTTNESAGQKVD

SSMNK

S2(Phospho)Y20(Phospho

)

pck phosphoenolpyruvate carboxykinase NP_417862.1 MQLIGGTWyGGEMKK Y9(Phospho)

pdxB erythronate-4-phosphate dehydrogenase NP_416823.1 KVDIGTSHIAGyTLEGK Y12(Phospho)

pepB aminopeptidase B NP_417018.4 AVDLISNVAGDRVTyR Y15(Phospho)

pepE (alpha)-aspartyl dipeptidase NP_418445.1 RSAVFIPFAGVTQTWDDy

TAK Y18(Phospho)

pflB pyruvate formate lyase I NP_415423.1 SEPIKGDVLNyDEVMER Y11(Phospho)

phoP DNA-binding response regulator in two-

component regulatory system with PhoQ NP_415648.1

ESWQDKVEVLSAGADDy

VTKPFHIEEVMAR Y17(Phospho)

ppc phosphoenolpyruvate carboxylase NP_418391.1 MNEQySALR Y5(Phospho)

proQ RNA chaperone YP_026161.1 yLYGVKPGATR Y1(Phospho)

proQ RNA chaperone YP_026161.1 YLyGVKPGATR Y3(Phospho)

proS prolyl-tRNA synthetase NP_414736.1 VVAAAIEQNyDER Y10(Phospho)

proX glycine betaine transporter ligand binding

protein NP_417165.1

FyRExVFVnGAAQGYLID

KK* Y2(Phospho)

prs phosphoribosylpyrophosphate synthase NP_415725.1 LyTSLGDAAVGR Y2(Phospho)

ptsI PEP-protein phosphotransferase of PTS system

(enzyme I) NP_416911.1

HMTADAAAHEVIEGQAS

ALEELDDEyLKER Y26(Phospho)

purB adenylosuccinate lyase NP_415649.1 TARDEVILPyWR Y10(Phospho)

pyrG CTP synthetase NP_417260.1 SQGLDDyIcKR Y7(Phospho)

recT DNA recombinase NP_415865.1 nVQLIIGyRGmIDLAR Y8(Phospho)

rfaF ADP-heptose:LPS heptosyltransferase II WaaF NP_418077.1 KGDAAEGyHQSLIDITPQ

R Y8(Phospho)

rfbA dTDP-glucose pyrophosphorylase NP_416543.1 NNYGQYLyK Y8(Phospho)

rplN 50S ribosomal subunit protein L14 NP_417769.1 yAGVGDIIKItIK Y1(Phospho)T11(Phospho

)

rpmF 50S ribosomal subunit protein L32 NP_415607.1 HHITADGyYR Y8(Phospho)

rpoA RNA polymerase, alpha subunit NP_417754.1 IAyNVEAAR Y3(Phospho)

rpsA 30S ribosomal subunit protein S1 NP_415431.1 HEAWITLEKAyEDAETVT

GVINGK Y11(Phospho)

serC 3-phosphoserine/phosphohydroxythreonine

aminotransferase NP_415427.1 TTADYVDAGyWAASAIK Y10(Phospho)

sgrR DNA-binding transcriptional dual regulator NP_414611.1 LEEGCyYLLFDSR Y6(Phospho)

sgrR DNA-binding transcriptional dual regulator NP_414611.1 VLyYRPLR Y3(Phospho)

sucC succinyl-CoA synthetase, beta subunit NP_415256.1 LVTyQTDANGQPVNQILV

EAATDIAK Y4(Phospho)

sucC succinyl-CoA synthetase, beta subunit NP_415256.1 YGLPAPVGyAcTTPR Y9(Phospho)

tig peptidyl-prolyl cis/trans isomerase (trigger

factor) NP_414970.1

GLIEEMASAyEDPKEVIEF

YSK Y10(Phospho)

tnaA tryptophanase/L-cysteine desulfhydrase, PLP-

dependent NP_418164.4 AMySIAK Y3(Phospho)


dependent NP_418164.4

EAFDTGVRyDFKGNFDL

EGLER Y9(Phospho)


dependent NP_418164.4 ETyKYADMLAMSAK Y3(Phospho)


dependent NP_418164.4 ETYKyADMLAMSAK Y5(Phospho)


dependent NP_418164.4 FAENAyFIK Y6(Phospho)


dependent NP_418164.4 GLTFTyEPK Y6(Phospho)



LLPHIPADQFPAqALAcEL

yK Y20(Phospho)



MVAFSNyFFDTTQGHSQI

NGcTVR Y7(Phospho)


dependent NP_418164.4 NIFGyQYTIPTHQGR Y5(Phospho)


dependent NP_418164.4 NIFGYQyTIPTHQGR Y7(Phospho)


dependent NP_418164.4 SyYALAESVK Y2(Phospho)


dependent NP_418164.4 SYyALAESVK Y3(Phospho)



TLcVVQEGFPTyGGLEGG

AMER Y12(Phospho)

tufB protein chain elongation factor EF-Tu (duplicate

of tufA) NP_418407.1 ELLSQyDFPGDDTPIVR Y6(Phospho)


of tufA) NP_418407.1 FESEVyILSKDEGGR Y6(Phospho)


of tufA) NP_418407.1 GITINTSHVEyDTPTR Y11(Phospho)


of tufA) NP_418407.1 GYRPQFyFR Y7(Phospho)


of tufA) NP_418407.1 HYAHVDcPGHADyVK Y13(Phospho)


of tufA) NP_418407.1 HyAHVDcPGHADYVK Y2(Phospho)

ugpQ glycerophosphodiester phosphodiesterase,

cytosolic NP_417906.1 ILVyTVNKPQR Y4(Phospho)

uspA universal stress global response regulator NP_417952.1 AVSMARPyNAK Y8(Phospho)

uvrY DNA-binding response regulator in two-

component regulatory system with BarA NP_416424.1

VmQAGAAGyLSKGAAP

QEVVSAIRSVySGQR

Y9(Phospho)Y27(Phosph

o)

wzc protein-tyrosine kinase NP_416564.4 ASAyQDYGYYEYEYK Y4(Phospho)

wzc protein-tyrosine kinase NP_416564.4 ASAYQDYGyYEYEYK Y9(Phospho)

xthA exonuclease III NP_416263.1 IIMAEIPSLLGNVTVINGy

FPQGESR Y19(Phospho)

yaeH conserved protein, UPF0325 family NP_414705.1 TVVADGVGQGyKEVQEI

SPNLR Y11(Phospho)

ybbN DnaK co-chaperone, thioredoxin-like protein NP_415025.4 AIPTVyLFQNGQPVDGFQ

GPQPEEAIR Y6(Phospho)

ybfA predicted protein NP_415228.1 EyPAWLIFLRR Y2(Phospho)

ybiT fused predicted transporter subunits of ABC

superfamily: ATP-binding components NP_415341.1

DRIyALPEMSEEDGYKVA

DLEVK Y4(Phospho)


superfamily: ATP-binding components NP_415341.1

IYALPEMSEEDGyKVADL

EVK Y13(Phospho)


superfamily: ATP-binding components NP_415341.1 YGEMDGySAEAR Y7(Phospho)

yebC conserved protein, UPF0082 family NP_416378.1 cGGNLGTDGSVAyLFSK Y13(Phospho)

yeeX conserved protein NP_416511.4 GDYEDRVDDyIIKNAELS

K Y10(Phospho)

yejH predicted ATP-dependent DNA or RNA helicase NP_416689.1 HGYLTPPERLDMPVVQyDFSRLqAQSNGLFSEADL

nR

Y17(Phospho)

yfgM conserved protein, UPF0070 family NP_417008.1 mEIyENENDQVEAVKR Y4(Phospho)

yfiD autonomous glycyl radical cofactor NP_417074.1 AGyAEDEVVAVSK Y3(Phospho)

ygaU predicted protein NP_417151.1 QVYGNANLyNK Y9(Phospho)

yhiQ predicted SAM-dependent methyltransferase NP_417954.1

LqLIHAsSLtALTDITPRPQ

VVyLDPMFPHKQKSALVK

S7(Phospho)T10(Phospho

)Y23(Phospho)

yihA GTP-binding protein required for normal cell

division, EngB in EHEC NP_418301.3

LVDLPGyGYAEVPEEMK

R Y7(Phospho)

yihA GTP-binding protein required for normal cell

division, EngB in EHEC NP_418301.3

LVDLPGYGyAEVPEEMKR

Y9(Phospho)

yjgF conserved protein, UPF0131 family NP_418664.2

SKTIATENAPAAIGPyVQ

GVDLGnMIITSGQIPVNPK

Y16(Phospho)

yjiM predicted 2-hydroxyglutaryl-CoA dehydratase NP_418755.4 TDKcPyFYFSDLVVGETTc

DGK Y6(Phospho)

yjiM predicted 2-hydroxyglutaryl-CoA dehydratase NP_418755.4 TDKcPYFyFSDLVVGETTc

DGK Y8(Phospho)

yjiY predicted inner membrane protein NP_418774.2 LDPTRAtPAVINNDGLNy

VPTnR

T7(Phospho)Y18(Phospho

)

yjjK transporter subunits of ABC superfamily: ATP-

and membrane binding components NP_418808.1

RLDEVyALYADPDADFDKLAAEQGR

Y6(Phospho)

zipA cell division protein involved in Z ring assembly NP_416907.1 DDDSyDEDVEDDEGVGE

VR Y5(Phospho)

znuC zinc transporter subunit: ATP-binding

component of ABC superfamily NP_416372.1 GAEQLGIyR Y8(Phospho)

Appendix II

List of unique phosphotyrosine sites identified in EHEC O157:H7 strain TUV93


accession Pepetide sequence Peptide phosphosite

accB acetyl-CoA carboxylase biotin carboxyl

carrier protein subunit NP_289823.1

AAPAASFPVMQQAyAAPMMQQPAQSNAAAPATVPSM

EAPAAAEISGHIVR

Y14(Phospho)

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 EQVAyYKEDEK Y5(Phospho)

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 QIGIYSPNGQQyTPQDR Y12(Phospho)

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 QIGIySPNGQQYTPQDR Y5(Phospho)

aceF dihydrolipoamide acetyltransferase NP_285811.1 yINIGVAVDTPNGLVVPVFK Y1(phospho)

ackA acetate kinase NP_288870.1 YVEDNyATKEDAKR Y6(Phospho)

acpP acyl carrier protein NP_287228.1 ITTVQAAIDyINGHQA Y10(Phospho)

adhE bifunctional acetaldehyde-CoA/alcohol

dehydrogenase NP_287484.1

AAySSGKPAIGVGAGNTPV

VIDETADIKR Y3(Phospho)


dehydrogenase NP_287484.1 EYLPASyHEGSKNPVAR Y7(Phospho)


dehydrogenase NP_287484.1 FATHGGyLLQGK Y7(Phospho)


dehydrogenase NP_287484.1 ILINTPASQGGIGDLyNFK Y16(Phospho)


dehydrogenase NP_287484.1 NGALNAAIVGQPAyK Y14(Phospho)


dehydrogenase NP_287484.1 NHFASEYIYNAyKDEK Y12(Phospho)


dehydrogenase NP_287484.1 NHFASEyIYNAYKDEK Y7(Phospho)


dehydrogenase NP_287484.1 NHFASEYIyNAYKDEK Y9(Phospho)


dehydrogenase NP_287484.1 QTAFSQyDRPQAR Y7(Phospho)


dehydrogenase NP_287484.1 VSyFGQK Y3(Phospho)


dehydrogenase NP_287484.1 IyKFPK Y2(phospho)



LVAMGGIGHTSCLyTDQDNQPAR

Y14(phospho)

ahpC alkyl hydroperoxide reductase subunit C NP_286332.1 AAQyVASHPGEVcPAK Y4(Phospho)

alaC glutamate-pyruvate aminotransferase

AlaC, Z3644 NP_288949.1 LcTVAQRPDTHGySTSR Y13(Phospho)

alaS alanyl-tRNA synthetase NP_289243.1 EASGFGADyNAMIR Y9(Phospho)

alaS alanyl-tRNA synthetase NP_289243.1 GAMALFGEKyDERVR Y10(Phospho)

alaT aminotransferase AlaT NP_288864.1 NLPTAQGyCDSK Y8(phospho)

aroC chorismate synthase NP_288903.1 DVFRPGHADYTyEQK Y12(phospho)

aroG phospho-2-dehydro-3-deoxyheptonate

aldolase NP_286475.1 MNyQNDDLR Y3(Phospho)

asnB asparagine synthetase B NP_286388.1 AVGVHQSAyK Y9(Phospho)

asnB asparagine synthetase B NP_286388.1 DVIyHIETYDVTTIR Y4(Phospho)

asnB asparagine synthetase B NP_286388.1 EcFESyLPASVAWR Y6(Phospho)

asnB asparagine synthetase B NP_286388.1 LSIVDVNAGAQPLyNQQK Y14(Phospho)

asnS asparaginyl-tRNA synthetase NP_286805.1 KFENPVyWGVDLSSEHER Y7(Phospho)

asnS asparaginyl-tRNA synthetase NP_286805.1 HSIEyLR Y5(phospho)

aspA aspartate ammonia-lyase NP_290772.1 EVPADAyYGVHTLR Y7(Phospho)

aspA aspartate ammonia-lyase NP_290772.1 GEYQyLNPNDHVNK Y5(Phospho)

aspA aspartate ammonia-lyase NP_290772.1 GEyQYLNPNDHVNK Y3(phospho)

aspC aromatic amino acid aminotransferase NP_286803.1 INLGIGVyKDETGKTPVLTS

VK Y8(Phospho)

atpA F0F1 ATP synthase subunit alpha NP_290373.1 DSVGAVVMGPyADLAEGM Y11(Phospho)

K

atpD F0F1 ATP synthase subunit beta NP_290371.1 AAPSyEELSNSQELLETGIK Y5(Phospho)

atpD F0F1 ATP synthase subunit beta NP_290371.1 MPSAVGyQPTLAEEMGVLQ

ER Y7(Phospho)

atpD F0F1 ATP synthase subunit beta NP_290371.1 NIAIEHSGySVFAGVGER Y9(Phospho)

atpD F0F1 ATP synthase subunit beta NP_290371.1 VyDALEVQNGNER Y2(phospho)

atpG F0F1 ATP synthase subunit gamma NP_290372.1 SWDYLyEPDPK Y6(phospho)

bcp thioredoxin-dependent thiol peroxidase NP_289033.1 SFMGKTyDGIHR Y7(Phospho)

bioB biotin synthase NP_286538.1 LANAGLDYYNHNLDTSPEF

yGNIITTR Y20(Phospho)

bioB biotin synthase NP_286538.1 TGAcPEDcKycPQSSR Y10(Phospho)

bisC biotin sulfoxide reductase NP_290136.1 EAYGPASIFAGSyGWR Y13(Phospho)

carB carbamoyl phosphate synthase large

subunit NP_285727.1 LAVGyTLDELMNDITGGR Y5(Phospho)

cesT type III secretion system Tir chaperone

protein NP_290260.1 IEEISSSDNKHyYAGR Y12(Phospho)


protein NP_290260.1 IEEISSSDNKHYyAGR Y13(Phospho)

cheZ phosphatase of chemotaxis regulator CheY NP_288318.1 DRLYyVVQMTAQAAER Y5(Phospho)

chuX heme-binding protein involved in iron

acquisition NP_290084.1 HGyFNLR Y3(Phospho)

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGYVGyEEGGYLTE

AVR Y11(Phospho)

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGyVGYEEGGYLTE

AVR Y8(Phospho)

clpB protein disaggregation chaperone NP_289147.1 MSELQyGKIPELEKQLEAAT

QLEGK Y6(Phospho)

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGYVGYEEGGyLTE

AVRR Y16(phospho)

clpP ATP-dependent Clp protease proteolytic

subunit NP_286179.1

VMIHQPLGGyQGQATDIEIH

AR Y10(Phospho)

cnu oriC-binding nucleoid-associated protein NP_288061.1 LYDHLNyTLTDDQELINMY

R Y7(Phospho)

csrA RNA chaperone and carbon storage

regulator NP_289242.1 EVSVHREEIyQR Y10(Phospho)

cydB cytochrome d terminal oxidase

polypeptide subunit II NP_286462.1 NTHSLy Y6(Phospho)

cysB transcriptional regulator of cystein regulon NP_287924.1 YIVEVVNHNLNVSSTAEGL

yTSQPGISK Y20(Phospho)

dapD 2,3,4,5-tetrahydropyridine-2,6-carboxylate

N-succinyltransferase NP_285860.1 FADyDEAR Y4(phospho)

dinI DNA damage-inducible protein I NP_287195.1 IQyAFPDNEGHVSVR Y3(Phospho)

dnaK molecular chaperone DnaK NP_285706.1 AKIELSSAQQTDVNLPyITA

DATGPK Y17(Phospho)

dnaK molecular chaperone DnaK NP_285706.1 VLENAEGDRTTPSIIAyTQD

GETLVGQPAKR Y17(Phospho)

dps DNA starvation/stationary phase

protection protein Dps NP_286576.1 SKATNLLyTR Y8(Phospho)

eae type III secretion system intimin

adherence protein NP_290259.1 MITHGcyTR Y7(Phospho)

efp elongation factor P NP_290780.1 ATyYSNDFR Y3(Phospho)

efp elongation factor P NP_290780.1 ATYySNDFR Y4(Phospho)

emrR transcriptional repressor MprA NP_289235.1 HEDFPyQEILLTR Y6(Phospho)

engB ribosome biogenesis GTP-binding protein

YsxC NP_290489.2 LVDLPGYGyAEVPEEMKR Y9(Phospho)

eno phosphopyruvate hydratase NP_289333.1 DAGyTAVISHR Y4(Phospho)

eno phosphopyruvate hydratase NP_289333.1 GMPLyEHIAELNGTPGK Y5(Phospho)

eno phosphopyruvate hydratase NP_289333.1 IEEALGEKAPyNGRK Y11(Phospho)

entE enterobactin synthase subunit E NP_286321.1 IIHTQGyPMcPDDEVWVAD

AEGNPLPQGEVGR Y7(Phospho)

era GTP-binding protein Era NP_289123.1 FLGAELPySVTVEIER Y8(phospho)

espA type III secretion system secreted protein

EspA NP_290256.1 SDVQSLQyR Y8(Phospho)

espB type III secretion system secreted protein

EspB NP_290254.1 QLAQSyQIQQAVFESQNK Y6(Phospho)


EspB NP_290254.1 SLENFQQGNLELyKQDVR Y13(Phospho)

espD type III secretion system secreted protein

EspD NP_290255.1 NSNEIyMDGQTK Y6(Phospho)

espJ type III secretion system secreted protein

EspJ NP_288436.1 ITPENTPPMLLSyR Y13(Phospho)


EspJ NP_288436.1 TSySLTK Y3(Phospho)

espP type V secretion system secreted serine

protease, pO157 encoded YP_325580.1 QqALERyGVNYKGEK Y7(Phospho)

etk cryptic autophosphorylating protein

tyrosine kinase Etk NP_286918.1 ASTAYSYGYNYYGySYSEK Y14(Phospho)


tyrosine kinase Etk NP_286918.1

ASTAYSYGYNYYGYsySEK

E

S15(Phospho)Y16(Phosph

o)



AsTAYSYGYNyYGYSYSEK

E S2(Phospho)Y11(Phospho)



AsTAYSYGYNYyGYSYSEK




AsTAySYGYNYYGYsYSEK

E

S2(Phospho)Y5(Phospho)

S15(Phospho)



AsTAYSYGyNYYGYSYSEK




ASTAYSyGYNYYGYSYSEK

E Y7(Phospho)

etp phosphotyrosine-protein phosphatase NP_286919.2 EIPDPyRK Y6(phospho)

fabG 3-ketoacyl-(acyl-carrier-protein) reductase NP_287227.1 IITIGSVVGTMGNGGQANy

AAAK Y19(Phospho)

fabI enoyl-(acyl carrier protein) reductase NP_287908.1 AIPNyNVMGLAK Y5(Phospho)

fbaA fructose-bisphosphate aldolase class II NP_289492.2 ANEAyLQGQLGNPKGEDQP

NKK Y5(Phospho)

fbaA fructose-bisphosphate aldolase class II NP_289492.2 DSVSyGVVK Y5(Phospho)

fbaB fructose-bisphosphate aldolase classI NP_288599.2 AINYGyTDDRVYSK Y6(Phospho)

fcI fucose synthetase NP_288539.1 GLENTYNWFLENQLQyRG Y16(Phospho)

feoA ferrous iron transport protein A NP_289948.1 MQyTPDTAWK Y3(Phospho)

fhuC iron-hydroxamate transporter ATP-binding

subunit NP_285847.1 MQEyTNHSDTTFALR Y4(Phospho)

fliD flagellar capping protein NP_288385.1 LSAyGtLKsALTTFQTAnTAL

SK

Y4(Phospho)T6(Phospho)

S9(Phospho)

folP dihydropteroate synthase NP_289751.2 TMQEAPKyDDVFAEVNR Y8(Phospho)

frr ribosome recycling factor NP_285866.1 ASPSLLDGIVVEyYGTPTPL

R Y13(Phospho)

frr ribosome recycling factor NP_285866.1 ASPSLLDGIVVEYyGTPTPL

R Y14(Phospho)

fruR DNA-binding transcriptional regulator

FruR NP_285776.1 EHNyHPNAVAAGLR Y4(Phospho)

ftsA cell division protein FtsA NP_285790.1 VLHVIPQEYAIDyQEGIKNP

VGLSGVR Y13(Phospho)

ftsK DNA translocase FtsK NP_286767.1 DDTWVDEDEyEDDEEYED

ENHGKQHESR Y10(Phospho)

ftsK DNA translocase FtsK NP_286767.1 DDTWVDEDEYEDDEEyED

ENHGKQHESR Y16(Phospho)

ftsK DNA translocase FtsK NP_286767.1 MDDDEEITyTAR Y9(Phospho)

ftsK DNA translocase FtsK NP_286767.1 sQEyTEDKEVTLTK Y4(Phospho)

ftsK DNA translocase FtsK NP_286767.1 yGEQYQHDVPVNAEDADA

AAEAELAR Y1(Phospho)

ftsK DNA translocase FtsK NP_286767.1 YGEQyQHDVPVNAEDADA

AAEAELAR Y5(Phospho)

ftsZ cell division protein FtsZ NP_285791.1 QVQQPVMDRyQQHGMAPL

TQEQKPVAK Y10(Phospho)

ftsZ cell division protein FtsZ NP_285791.1 VVNDNAPQTAKEPDyLDIP

AFLRK Y15(Phospho)

fumA fumarase A = fumarate hydratase class I;

aerobic isozyme NP_288047.1 TPEGyASGSLGPTTAGR Y5(Phospho)

fur ferric uptake regulator NP_286398.1 LTNHSLYLyGHCAEGDCR Y9(phospho)

fusA elongation factor G NP_289887.1 ILFyTGVNHK Y4(Phospho)

fxsA F exclusion of bacteriophage T7 NP_290773.2 MPGGGFSAGTGGGNTFDG

EyQR Y20(Phospho)

gadB glutamate decarboxylase isozyme NP_287662.1 NWIDKEEyPQSAAIDLR Y8(Phospho)

gapA glyceraldehyde-3-phosphate


GANFDKyAGQDIVSNAScT

TNcLAPLAK Y7(Phospho)


dehydrogenase NP_288215.1 LVSWyDNETGYSNK Y5(Phospho)

gatZ putative tagatose 6-phosphate kinase 1 NP_288597.1 KVLIEATSNQVNQFGGyTG

MTPADFR Y17(Phospho)

gcvP glycine dehydrogenase NP_289471.1 NLFCSCVPISEyQ Y12(phospho)

gdhA glutamate dehydrogenase NP_288194.1 MDQTySLESFLNHVQK Y5(Phospho)

glgC glucose-1-phosphate adenylyltransferase NP_289975.1 MKGENWyR Y7(Phospho)

glmS glucosamine--fructose-6-phosphate

aminotransferase NP_290368.1 RQDIESNLQyDAGDKGIYR Y10(Phospho)

glnA glutamine synthetase NP_290495.1 GGyFPVPPVDSAQDIR Y3(Phospho)

glnA glutamine synthetase NP_290495.1 IHPGEAMDKNLyDLPPEEA

K Y12(Phospho)

glnA glutamine synthetase NP_290495.1 LVPGyEAPVMLAYSAR Y5(Phospho)

glnA glutamine synthetase NP_290495.1 MTPHPVEFELYySV Y12(phospho)

glnB regulatory protein P-II for glutamine

synthetase NP_289109.1 GAEymVDFLPK Y4(Phospho)

glnL nitrogen regulation protein NR(II)/NtrB

sensory histidin kinase NP_290494.1 tAFQLTLHGERyRLAAR

T1(Phospho)Y12(Phospho)

glpG intramembrane serine protease GlpG NP_289967.1 YLAASWQAGHTGSGLHyR Y17(Phospho)

glpK glycerol kinase NP_290555.1 LINDAyDSEYFATK Y6(Phospho)

gltA type II citrate synthase NP_286436.1 QLYTGyEKR Y6(Phospho)

glyA serine hydroxymethyltransferase NP_289107.1 EMNIADyDAELWQAMEQE

K Y7(Phospho)

glyA serine hydroxymethyltransferase NP_289107.1 MIIGGFSAySGVVDWAK Y9(Phospho)

glyA serine hydroxymethyltransferase NP_289107.1 VMQAQGSQLTNKyAEGYP

GKR Y13(Phospho)

glyA serine hydroxymethyltransferase NP_289107.1 VMQAQGSQLTNKYAEGyP

GKR Y17(Phospho)

gmd GDP-mannose dehydratase NP_288540.1 ESTPFyPR Y6(Phospho)

gmd GDP-mannose dehydratase NP_288540.1 IDHIyQDPHGSNPNFHLHYG

DLTDSSNLTR Y5(Phospho)

gmd GDP-D-mannose dehydratase NP_288559.1 SPyAVAK Y3(Phospho)

gmk guanylate kinase NP_290228.1 TQPLyDTQVSVSHTTR Y5(Phospho)

gnd 6-phosphogluconate dehydrogenase NP_288534.1 DyFGAHTYK Y2(phospho)

gpmA phosphoglyceromutase NP_286476.1 FTGWyDVDLSEK Y5(Phospho)

gpmA phosphoglyceromutase NP_286476.1 HyGALQGLNK Y2(Phospho)

gpt xanthine-guanine

phosphoribosyltransferase NP_285955.1 HVDTVcISSyDHDNQR Y10(Phospho)

greA transcription elongation factor GreA NP_289755.2 EHGDLKENAEyHAAR Y11(Phospho)

groEL Cpn60 chaperonin GroEL, large subunit of

GroESL NP_290776.1

GYLSPyFINKPETGAVELESPFILLADKK

Y6(Phospho)

groEL Cpn60 chaperonin GroEL, large subunit of

GroESL NP_290776.1 QQIEEATSDyDREK Y10(Phospho)

groES Cpn10 chaperonin GroES, small subunit

of GroESL NP_290775.1 VGDIVIFNDGyGVKSEK Y11(Phospho)

guaB inosine 5'-monophosphate dehydrogenase NP_289062.1 GSSDRyFQSDNAADKLVPE

GIEGR Y6(Phospho)

guaC guanosine 5'-monophosphate

oxidoreductase NP_285800.1 HVGGVAEyR Y8(Phospho)


oxidoreductase NP_285800.1 SAcTyVGASR Y5(Phospho)

gyrB DNA gyrase subunit B NP_290332.1 SNSyDSSSIK Y4(Phospho)

hdhA 7-alpha-hydroxysteroid dehydrogenase NP_288055.1 NINMTSyASSK Y7(Phospho)

hemL glutamate-1-semialdehyde

aminotransferase NP_285850.1 SENLySAAR Y5(Phospho)

hemY putative protoheme IX biogenesis protein NP_290430.1 LAEGDyQQVEK Y6(Phospho)

hha hemolysin expression-modulating protein NP_286201.1 NKyELSDNELAVFYSAADH

R Y3(phospho)

hisC histidinol-phosphate aminotransferase NP_288526.1 NLTPyQSAR Y5(phospho)

hisS histidyl-tRNA synthetase NP_289067.1 AGIEHGLLyNQEQR Y9(Phospho)



LQQyREMLIADGIDPNELL

NSLAAVK Y4(Phospho)


regulator H-NS NP_287482.1 YSyVDENGETK Y3(Phospho)

holE DNA polymerase III subunit theta NP_288279.1 LPyEPK Y3(Phospho)

hslU ATP-dependent protease ATP-binding

subunit HslU NP_290562.1 FTEVGyVGKEVDSIIR Y6(Phospho)

htpG heat shock protein 90 NP_286214.1 ALSNPDLyEGDGELR Y8(Phospho)

ibpA heat shock protein IbpA NP_290325.1 TYLyQGIAER Y4(Phospho)

icd isocitrate dehydrogenase specific for

NADP+ NP_287350.1 TVTyDFER Y4(Phospho)

iha bifunctional enterobactin receptor/adhesin

protein NP_286713.1 DGQLGSLTGGyDR Y11(Phospho)

ihfB integration host factor subunit beta NP_286787.1 GFGSFSLHyR Y9(phospho)

infA translation initiation factor IF-1 NP_286761.1 ILTGDKVTVELTPyDLSK Y14(Phospho)

infB translation initiation factor IF-2 NP_289744.1 AREVALyR Y7(Phospho)

infB translation initiation factor IF-2 NP_289744.1 MAEENKWTDNAEPTEDSS

DyHVTTSQHAR Y20(Phospho)

infB translation initiation factor IF-2 NP_289744.1 YYSVIyNLIDEVK Y6(Phospho)

infC translation initiation factor IF-3 NP_288152.1 IMDYGKFLyEK Y9(Phospho)

iscU scaffold protein for assembly and transfer

of iron-sulfur clusters NP_289086.1 AySEKVIDHYENPR Y2(Phospho)

iscU scaffold protein for assembly and transfer

of iron-sulfur clusters NP_289086.1 VIDHyENPR Y5(Phospho)

ispG 4-hydroxy-3-methylbut-2-en-1-yl

diphosphate synthase NP_289068.1 SGLyEDGVRK Y4(Phospho)

kdsA 2-dehydro-3-deoxyphosphooctonate

aldolase NP_287461.1 SSIHSyRGPGLEEGMK Y6(phospho)

L7066

hypothetical protein L7066 encoded by pO157

YP_325626.1 QASAyFAK Y5(Phospho)

lon DNA-binding ATP-dependent protease La NP_286181.1 SQREyYLNEQMK Y5(Phospho)

lpdA dihydrolipoamide dehydrogenase NP_285812.1 GISyETATFPWAASGR Y4(Phospho)

lpdA dihydrolipoamide dehydrogenase NP_285812.1 TQVVVLGAGPAGySAAFR Y13(Phospho)

maeB malic enzyme NP_289015.1 DLALAySPGVAAPcLEIEKD

PLK Y6(Phospho)

manX PTS system, mannose-specific IIAB

component NP_288253.1

AAPTPAKPMGPNDyMVIGL

AR Y14(Phospho)

manZ PTS system mannose-specific transporter

subunit IID NP_288255.1 YYGVAYGySK Y8(Phospho)

manZ PTS system mannose-specific transporter

subunit IID NP_288255.1 YYGVAyGYSK Y6(phospho)

map methionine aminopeptidase NP_285862.1 GFHEEPQVLHyDSR Y11(Phospho)

map methionine aminopeptidase NP_285862.1 IcNDYIVNEQHAVSAcLGyH

GYPK Y19(Phospho)

map methionine aminopeptidase NP_285862.1 IcNDYIVNEQHAVSAcLGYH

GyPK Y22(Phospho)

metH B12-dependent methionine synthase NP_290646.1 IEQNYSGPTVyVQNASR Y11(Phospho)

mntH manganese transport protein MntH NP_288962.1 MTNyRVESSSGR Y4(Phospho)

mogA molybdenum cofactor biosynthesis protein

MogA NP_285701.1

ASSGVyQDKGIPALEEWLTS

ALTTPFELETR Y6(Phospho)

mraY phospho-N-acetylmuramoyl-pentapeptide-

transferase NP_285783.1 MAPIHHHyELK Y8(phospho)

mrcB penicillin-binding protein 1b NP_285845.1 RRYEDDDDYDDyDDYEDE

EPmPR Y12(Phospho)

mrcB penicillin-binding protein 1b NP_285845.1 RRYEDDDDYDDYDDyEDE

EPMPR Y15(Phospho)

mrcB penicillin-binding protein 1b NP_285845.1 RRyEDDDDYDDYDDYEDE

EPMPR Y3(Phospho)

mukB cell division protein MukB NP_286799.1 ELAyLSADDLR Y4(Phospho)

nagD ribonucleotide monophosphatase NP_286389.1 GFyPAcGALcAGIEK Y3(Phospho)

narX narX sensory histidine kinase NP_287470.1 MQSyRLLAAVPLSEK Y4(Phospho)

ndk nucleoside diphosphate kinase NP_289071.1 ADyADSLTENGTHGSDSVE

SAAR Y3(Phospho)

nrdB ribonucleotide-diphosphate reductase

subunit beta NP_288809.1 AyTTFSQTK Y2(Phospho)

nuoB NADH dehydrogenase subunit B NP_288861.1 RPLSWVVGDQGVyR Y13(phospho)

nuoI NADH dehydrogenase subunit I NP_288855.1 MYPEEPVyLPPR Y8(Phospho)

nuoI NADH dehydrogenase subunit I NP_288855.1 QDLVYEKEDLLISGPGKYP

EYNFyR Y24(Phospho)

ompA outer membrane protein A NP_286832.1 IGSDAyNQGLSER Y6(Phospho)

ompR osmolarity response regulator NP_289945.1 GREySAMER Y4(Phospho)

ompR osmolarity response regulator NP_289945.1 yLTEQGFqVRSVAnAEQMD

R Y1(Phospho)

paaY putative transferase NP_289841.1 SSyNPDGNPLTIGEDVTVGH

K Y3(Phospho)

pckA phosphoenolpyruvate carboxykinase NP_289943.1 MQLIGGTWyGGEMKK Y9(Phospho)

pepB aminopeptidase B NP_289080.2 GITFDSGGySIK Y9(phospho)

pepD aminoacyl-histidine dipeptidase (peptidase

D) NP_285954.1

IcSIPHPSyHEEQLAEYIVGWAK

Y9(Phospho)

pepE peptidase E NP_290648.1 RSAVFIPFAGVTQTWDDyT

AK Y18(Phospho)

per perosamine synthetase NP_288542.1 QyWHDVIGYNYR Y2(Phospho)

per perosamine synthetase NP_288542.1 YIPVyQPSLTGK Y5(Phospho)

pfkA 6-phosphofructokinase NP_290545.1 MVQLDRySVSDMINR Y7(Phospho)

pflB formate acetyltransferase 1 NP_286778.1 DAIPTQSVLTITSNVVyGK Y17(Phospho)

pflB formate acetyltransferase 1 NP_286778.1 LPFAyAK Y5(Phospho)

pflB formate acetyltransferase 1 NP_286778.1 THNQGVFDVyTPDILR Y10(Phospho)

pflB formate acetyltransferase 1 NP_286778.1 VSGyAVR Y4(Phospho)

pgi glucose-6-phosphate isomerase NP_290659.1 FAAyFQQGNMESNGK Y4(Phospho)

pgk phosphoglycerate kinase NP_289493.1 SLyEADLVDEAKR Y3(Phospho)

plsB glycerol-3-phosphate acyltransferase NP_290675.2 VFTyYTPKEESIK Y4(Phospho)

plsB glycerol-3-phosphate acyltransferase NP_290675.2 VFTYyTPKEESIK Y5(phospho)

pntB pyridine nucleotide transhydrogenase NP_288037.1 SMNTGyAGVQNPLFFK Y6(Phospho)

ppa inorganic pyrophosphatase NP_290858.1 AQIAHFFEHyKDLEK Y10(Phospho)

ppc phosphoenolpyruvate carboxylase NP_290593.1 MNEQySALR Y5(Phospho)

proA gamma-glutamyl phosphate reductase NP_285960.1 NIAySFLPALSK Y4(phospho)

proP proline/glycine betaine transporter NP_290744.1 EILVEHyDNIEQK Y7(Phospho)

proS prolyl-tRNA synthetase NP_285888.1 VVAAAIEQNyDER Y10(Phospho)

prsA ribose-phosphate pyrophosphokinase NP_287453.1 IANRLyTSLGDAAVGR Y6(Phospho)

pspG phage shock protein G NP_290683.2 YQRyDR Y4(phospho)

pta phosphate acetyltransferase NP_288871.1 HQFAQSLNyEIAK Y9(Phospho)

pta phosphate acetyltransferase NP_288871.1 VAMLSySTGTSGAGSDVEK Y6(Phospho)

ptr protease III NP_289373.1 EVLAyR Y5(phospho)

purB adenylosuccinate lyase NP_287345.1 TARDEVILPyWR Y10(Phospho)

purC phosphoribosylaminoimidazole-

succinocarboxamide synthase NP_289029.1 QAELyRGK Y5(Phospho)


succinocarboxamide synthase NP_289029.1 TVySTENPDLLVLEFR Y3(Phospho)

purH bifunctional

phosphoribosylaminoimidazolecarboxami

de formyltransferase/IMP cyclohydrolase

NP_290638.1 ALSyNNIADTDAALEcVK Y4(Phospho)

purM phosphoribosylaminoimidazole synthetase NP_289052.1 TDKTSLSyKDAGVDIDAGN

ALVGR Y8(Phospho)

purR DNA-binding transcriptional repressor

PurR NP_288094.1 ELHySPSAVAR Y4(Phospho)


PurR NP_288094.1 SVADGPFRDyRR Y10(Phospho)

putP major sodium/proline symporter NP_287020.1 FAEADAHyHSAPPSR Y8(Phospho)

pykF pyruvate kinase NP_288110.1 LNFSHGDyAEHGQR Y8(Phospho)

rcsB transcriptional regulator RcsB NP_288797.1 ISAGGyGDKR Y6(Phospho)

rcsB transcriptional regulator RcsB NP_288797.1 LDAHVLITDLSMPGDKyGD

GITLIK Y17(Phospho)

recA recombinase A NP_289246.1 IVEIyGPESSGK Y5(phospho)

rfaD ADP-L-glycero-D-mannoheptose-6-

epimerase NP_290202.1 AAGyDKPFK Y4(Phospho)

rfaF ADP-L-glycero-D-mannoheptose-6-

epimerase NP_290203.1 LITGyHK Y5(phospho)

rhlB ATP-dependent RNA helicase RhlB NP_290410.1 LGLAYGGDGyDKQLK Y10(phospho)

rimJ ribosomal-protein-S5-alanine N-

acetyltransferase NP_287200.1 MFGyR Y4(Phospho)

rne ribonuclease E NP_287218.1 APAPEyVPEAPR Y6(Phospho)

rne ribonuclease E NP_287218.1 EYFPANySAHGRPNIK Y7(Phospho)

rne ribonuclease E NP_287218.1 VRyEQSVAEETVVAPVAEET

VAAEPIVQEAPAPR Y3(Phospho)

rpiA ribose-5-phosphate isomerase A NP_289482.1 LGGRPEyR Y7(phospho)

rplB 50S ribosomal protein L2 NP_289878.1 LEyDPNR Y3(phospho)

rplC 50S ribosomal protein L3 NP_289881.1 DLANDGyR Y7(phospho)

rplE 50S ribosomal protein L5 NP_289869.1 AKLHDyYKDEVVK Y6(Phospho)

rplE 50S ribosomal protein L5 NP_289869.1 AKLHDYyKDEVVK Y7(Phospho)

rplE 50S ribosomal protein L5 NP_289869.1 EQIIFPEIDyDKVDR Y10(Phospho)

rplE 50S ribosomal protein L5 NP_289869.1 GNySMGVR Y3(Phospho)

rplE 50S ribosomal protein L5 NP_289869.1 IRQGyPIGcK Y5(Phospho)

rplF 50S ribosomal protein L6 NP_289866.1 DGyADGWAQAGTAR Y3(Phospho)

rplF 50S ribosomal protein L6 NP_289866.1 KLQLVGVGyR Y9(Phospho)

rplM 50S ribosomal protein L13 NP_289799.1 TDKVyYHHTGHIGGIK Y5(Phospho)

rplM 50S ribosomal protein L13 NP_289799.1 TDKVYyHHTGHIGGIK Y6(Phospho)

rplO 50S ribosomal protein L15 NP_289862.1 RGFEGGQMPLyR Y11(Phospho)

rplQ 50S ribosomal protein L17 NP_289855.1 AGDNAPMAyIELVDR Y9(Phospho)

rplR 50S ribosomal protein L18 NP_289865.1 SGFQyHGR Y5(Phospho)

rplT 50S ribosomal protein L20 NP_288150.1 AGQyAYR Y4(Phospho)

rplT 50S ribosomal protein L20 NP_288150.1 GyYGAR Y2(phospho)

rplU 50S ribosomal protein L21 NP_289760.1 MyAVFQSGGK Y2(Phospho)

rplV 50S ribosomal protein L22 NP_289876.1 KVSQALDILTyTNKK Y11(Phospho)

rplY 50S ribosomal protein L25 NP_288768.1 AQDVQRHPyKPK Y9(Phospho)

rpmE 50S ribosomal protein L31 NP_290567.1 DIHPKyEEITAScScGNVMK Y6(Phospho)

rpmE2

50S ribosomal protein L31 type B NP_286014.1 SHPFyTGK Y5(Phospho)

rpmF 50S ribosomal protein L32 NP_287223.1 HHITADGyYR Y8(Phospho)

rpmF 50S ribosomal protein L32 NP_287223.1 HHITADGYyR Y9(Phospho)

rpmG 50S ribosomal protein L33 NP_290216.1 LVSSAGTGHFyTTTK Y11(Phospho)

rpoA DNA-directed RNA polymerase subunit

alpha NP_289856.1 IAyNVEAAR Y3(Phospho)


alpha NP_289856.1 LLVDAcySPVER Y7(Phospho)

rpoB DNA-directed RNA polymerase subunit

beta NP_290618.1

IVIKVNEDEMyPGEAGIDIYNLTK

Y11(Phospho)


beta NP_290618.1 MVySYTEK Y3(Phospho)


beta NP_290618.1 STGSySLVTQQPLGGK Y5(Phospho)


beta NP_290618.1 SVFPIQSySGNSELQYVSYR Y8(Phospho)

rpoC DNA-directed RNA polymerase subunit

beta' NP_290619.1 LIPAGTGYAyHQDR Y10(Phospho)


beta' NP_290619.1 LIPAGTGyAYHQDR Y8(Phospho)


beta' NP_290619.1 SVITVGPyLR Y8(Phospho)

rpsF 30S ribosomal protein S6 NP_290830.1 RQLAyPINK Y5(Phospho)

rpsG 30S ribosomal protein S7 NP_289888.1 VGGSTyQVPVEVRPVRR Y6(Phospho)

rpsI 30S ribosomal protein S9 NP_289798.1 AENQYyGTGR Y6(Phospho)

rpsI 30S ribosomal protein S9 NP_289798.1 MAENQyYGTGR Y6(Phospho)

rpsJ 30S ribosomal protein S10 NP_289882.1 DQyEIR Y3(phospho)

rpsN 30S ribosomal protein S14 NP_289868.1 RVALADKyFAK Y8(Phospho)

rpsP 30S ribosomal protein S16 NP_289162.1 KRPFyQVVVADSR Y5(Phospho)

rpsQ 30S ribosomal protein S17 NP_289872.1 FVKHPIyGK Y7(Phospho)

rpsR 30S ribosomal protein S18 NP_290832.1 YLSLLPyTDRHQ Y7(Phospho)

rpsU 30S ribosomal protein S21 NP_289640.1 EFyEKPTTER Y3(Phospho)

rrmJ 23S rRNA methyltransferase J NP_289753.1 WLQEHFSDKyVQQAQK Y10(Phospho)

sapC peptide transport permease protein NP_287896.1 PYDSVySEKRPPGTLR Y6(Phospho)

sbcB exonuclease I NP_288516.2 NFPGTLDyAEQQR Y8(phospho)

secA preprotein translocase subunit SecA NP_285794.1 GVHVVTVNDyLAQR Y10(Phospho)

secA preprotein translocase subunit SecA NP_285794.1 KQLLEyDDVANDQR Y6(Phospho)

secF preprotein translocase subunit SecF NP_286148.1 AQEyTVEQLNHGR Y4(Phospho)

secY preprotein translocase subunit SecY NP_289861.1 ANLKGyGR Y6(Phospho)

secY preprotein translocase subunit SecY NP_289861.1 VyAAQSTHLPLK Y2(Phospho)

selD selenophosphate synthetase NP_288197.1 LTQySHGAGcGcK Y4(Phospho)

serC phosphoserine aminotransferase NP_286782.1 GQFAAVPLNILGDKTTADY

VDAGyWAASAIK Y24(Phospho)

serS seryl-tRNA synthetase NP_286770.1 FAGDLFHTRPLEEEADTSNy

ALIPTAEVPLTNLVR Y20(Phospho)

slyX hypothetical protein NP_289895.1 ASQPSNIASQAEETPPPHy Y19(Phospho)

sms DNA repair protein RadA NP_291002.1 LSGyAGSAGVAK Y4(Phospho)

sspA stringent starvation protein A NP_289797.1 IIMEYLDERFPHPPLMPVyP

VAR Y19(Phospho)

sucA 2-oxoglutarate dehydrogenase E1

component NP_286442.1

YAGRPASASPAVGyMSVHQK

Y14(Phospho)

sucC succinyl-CoA synthetase subunit beta NP_286444.1 LVTyQTDANGQPVNQILVE

AATDIAK Y4(Phospho)

sufC cysteine desulfurase ATPase component NP_288116.1 SFIIVTHyQR Y8(Phospho)

surA peptidyl-prolyl cis-trans isomerase SurA NP_285750.1 LAyDGLNYNTYR Y3(Phospho)

talB transaldolase B NP_285700.1 KLSyTGEVK Y4(Phospho)

terC putative phage inhibition, colicin

resistance and tellurite resistance protein NP_286709.1 SGDDDDEIEDySQHLAYR Y11(Phospho)

thrS threonyl-tRNA synthetase NP_288153.1 TGHWDNyKDAMFTTSSEN

R Y7(Phospho)

tig Peptidyl-prolyl cis/trans isomerase (trigger

factor) NP_286178.1

GLIEEMASAyEDPKEVIEFY

SK Y10(Phospho)

tnaA tryptophanase NP_290344.1 SyYALAESVK Y2(Phospho)

topA DNA topoisomerase I NP_287925.1 LYEAGYITyMR Y9(Phospho)

trkA NAD-binding component of TrK

potassium transporter NP_289851.1 AyYGGPLIGNALSTMR Y2(Phospho)


potassium transporter NP_289851.1 AYyGGPLIGNALSTMR Y3(Phospho)

tsf elongation factor Ts NP_285864.1 VAALEGDVLGSyQHGAR Y12(Phospho)

tuf elongation factor Tu NP_289886.1 GITINTSHVEyDTPTR Y11(Phospho)

tuf elongation factor Tu NP_289886.1 HYAHVDcPGHADyVK Y13(Phospho)

tuf elongation factor Tu NP_289886.1 HyAHVDcPGHADYVK Y2(Phospho)

tuf elongation factor Tu NP_290611.1 ELLSQyDFPGDDTPIVR Y6(Phospho)

tuf elongation factor Tu NP_290611.1 GYRPQFyFR Y7(Phospho)

tus DNA replication terminus site-binding

protein NP_288045.1 ARyDLVDR Y3(phospho)

tyrB aromatic amino acid aminotransferase NP_290687.1 VDAyAGDPILTLMER Y4(Phospho)

udp uridine phosphorylase NP_290463.1 SIGATTHVGVTASSDTFYPG

QERyDTYSGR Y24(Phospho)

udp uridine phosphorylase NP_290463.1 YDTySGR Y4(phospho)

upp uracil phosphoribosyltransferase NP_289051.2 NEETLEPVPyFQK Y10(Phospho)

upp uracil phosphoribosyltransferase NP_289051.2 ISVVGMyRNEETLEPVPYF

QK Y7(phospho)

uspA universal stress protein; broad regulatory

function? NP_290066.1 AVSMARPyNAK Y8(Phospho)


function? NP_290066.1

VSLIHVDVNySDLYTGLIDV

NLGDMQK Y10(Phospho)

vacB exoribonuclease R NP_290809.2 SQDPFQEREAEKyANPIPSR Y13(Phospho)

wbdP glycosyl transferase NP_288541.1 FNEQyYR Y5(Phospho)

wbdP glycosyl transferase NP_288541.1 FNEQYyR Y6(Phospho)

wbdP glycosyl transferase NP_288541.1 IyTEYNPDVYLVcTGATQDY

R Y2(Phospho)

wbdP glycosyl transferase NP_288541.1 IYTEyNPDVYLVcTGATQDY

R Y5(Phospho)

wbdP glycosyl transferase NP_288541.1 NHySLNDAMVK Y3(Phospho)

wbdP glycosyl transferase NP_288541.1 WFADySGNIAK Y5(phospho)

wcaD putative colanic acid biosynthesis protein NP_288562.1 yLIYSNSYVLNFIK Y1(Phospho)

wcaG putative UDP-galactose 4-epimerase NP_288548.1 VHSSGFVAPyTLSQGLDR Y10(Phospho)

wcaG putative UDP-galactose 4-epimerase NP_288548.1 TLQyEFVHAK Y4(phospho)

wzc tyrosine kinase NP_288566.2 ASAyQDYGYYEYEYK Y4(Phospho)

wzc tyrosine kinase NP_288566.2 ASAYQDyGYYEYEYK Y7(Phospho)

wzc tyrosine kinase NP_288566.2 ASAYQDYGYYEyEYKSDA

K Y12(Phospho)

wzc tyrosine kinase NP_288566.2 ASAYQDYGYYEYEyKSDA

K Y14(Phospho)

wzy O antigen polymerase NP_288545.1 LSRNENISyNcDL Y9(Phospho)

xasA acid sensitivity protein, putative

transporter NP_287663.1 ARSPHyIVMNDK Y6(Phospho)

yabN transcriptional regulator SgrR NP_285766.1 VLyYRPLR Y3(phospho)

yaeH hypothetical protein NP_285859.1 KTVVADGVGQGyKEVQEIS

PNLR Y12(Phospho)

yaiB hypothetical protein NP_286120.1 LIDQVEGALyEVKPDASIPD

DDTELLR Y10(Phospho)

yaiE hypothetical protein Z0487 NP_286129.1 MLQSNEyFSGK Y7(phospho)

yajD hypothetical protein Z0511 NP_286151.1 EFVySNLR Y4(phospho)

ybeZ predicted protein with nucleoside

triphosphate hydrolase domain NP_286385.1 VLEQSAESVPEyGK Y12(Phospho)

ybfA hypothetical protein NP_286412.1 MELyR Y4(Phospho)

ybfA hypothetical protein NP_286412.1 ATGDFy Y6(phospho)

ybgI putative hydrolase-oxidase NP_286425.1 LNSAAISDyAPNGLQVEGK Y9(Phospho)

ybiI hypothetical protein NP_286567.1 DLQKPAYTGyNR Y10(Phospho)

ybiI hypothetical protein NP_286567.1 DLQKPAyTGYNR Y7(Phospho)

ybiO putative transport protein NP_286572.1 WLAKTITLSPHtQRNyPELQ

K

T12(Phospho)Y16(Phosph

o)

ybjC hypothetical protein NP_286616.1 LAPQLMNRPPQySR Y12(Phospho)

ycbB L,D-transpeptidase YcbB NP_286800.1 FQQAPGPRNSLGRyK Y14(Phospho)

ycfU outer membrane-specific lipoprotein

transporter subunit LolC NP_287250.1 AAATQPAEALRyE Y12(Phospho)

yciH translation initiation factor Sui1 NP_287915.1 LVySTETGRIDEPK Y3(Phospho)

ydaA universal stress protein UspE NP_287853.1 cDLLVIKPDQyQTPVELDDE

EDD Y11(Phospho)

ydcH hypothetical protein NP_287734.1 KEGSDDRGyNAEVVR Y9(Phospho)

ydfG 3-hydroxy acid dehydrogenase NP_287611.1 NHGHIINIGSTAGSWPyAGG

NVYGATK Y17(Phospho)

ydiA PEP synthetase regulatory protein NP_288137.1 THGLNPNNLNKyDAR Y12(Phospho)

ydiA PEP synthetase regulatory protein NP_288137.1 PLVFySIVLPEIR Y5(phospho)

yebC hypothetical protein NP_288301.1 cGGNLGTDGSVAyLFSK Y13(Phospho)

yecN hypothetical protein NP_288306.2 VAyGDGGFSELQSAIR Y3(Phospho)

yeeF putative amino acid/amine transport

protein NP_288519.1 SFRNPVPQyEDVA Y9(Phospho)

yejO putative ATP-binding component of a

transport system NP_288772.1

VNDDGKFNNDVAGTRGVy

QAGIR Y18(Phospho)

yfiD stress-induced alternate pyruvate formate-

lyase subunit NP_289137.1 AGyAEDEVVAVSK Y3(Phospho)

yfiD stress-induced alternate pyruvate formate-

lyase subunit NP_289137.1 LGDIEyR Y6(Phospho)

ygaG S-ribosylhomocysteinase LuxS NP_289238.1 VQDQNQIPELNVyQcGTYQ

MHSLQEAQDIAR Y13(Phospho)

ygaG S-ribosylhomocysteinase LuxS NP_289238.1 VQDQNQIPELNVYQcGTyQ

MHSLQEAQDIAR Y18(Phospho)

ygdE putative RNA 2'-O-ribose

methyltransferase NP_289361.1 DAGVLANyETPK Y8(Phospho)

ygfB Hypothetical protein Z4246 NP_289477.2 NIAQLGYDEDEDQEELEmS

LEEIIEyVR Y26(Phospho)

yggX hypothetical protein Z4307 NP_289534.1 EVHIEGyTPEDKK Y7(Phospho)

yhcB Conserved protein NP_289801.1 LAESEASNDQAPVQMPRDy

SEGASGLLR Y19(Phospho)

yhcB Conserved protein NP_289801.1 NKAELDEyREELVSHFAR Y8(Phospho)

yhcB Conserved protein NP_289801.1 QLyQHMAK Y3(Phospho)

yhcB Conserved protein NP_289801.1 QQQALQyELEK Y7(Phospho)

yhcB Conserved protein NP_289801.1 SAELLDTMAHDyR Y12(Phospho)

yheS putative ABC transporter ATP-binding

protein NP_289900.1 LAQQQAMyESQQER Y8(Phospho)

yhgI Iron-sulfur cluster scaffold protein NP_289954.1 DLTEHQRGEHSyY Y12(phospho)

yhjE major facilitator superfamily (MFS) of

transporters protein NP_290103.1

M(ox)QAtATTLDHEQEytPIN

sR Y14(phospho)

yibK tRNA methyltransferase NP_290189.1 AGLDyHEFTAVTR Y5(Phospho)

yibO phosphoglyceromutase NP_290195.1 VATyDLQPEMSSAELTEK Y4(Phospho)

yifE hypothetical protein NP_290396.1 RFHTLSGGKPQVEGAEDyT

DSDD Y18(Phospho)

yihI GAP-like protein that activates GTPase

activity of Der NP_290491.1

LGLSyDDDEEEEEDEKQEDMMR

Y5(Phospho)

yjbQ hypothetical protein Z5655 NP_290689.1 TVPDNGNyEHDYEGADDM

PSHIK Y8(phospho)

yjgF hypothetical protein NP_290875.1 TIATENAPAAIGPyVQGVDL

GNMIITSGQIPVNPK Y14(Phospho)

ylaC hypothetical protein NP_286199.1 VcyNGEWYNTR Y3(Phospho)

yleA isopentenyl-adenosine A37 tRNA

methylthiolase MiaB NP_286386.1 TWGcQMNEyDSSK Y9(Phospho)

yqgF holliday junction resolvase-like protein NP_289521.1 SGLFEQGGyR Y9(Phospho)

yqiA esterase YqiA NP_289611.1 HIyDLK Y3(phospho)

Z034

2

putative LysR-like transcriptional

regulator NP_285993.1 EMVVAsPsyLAANsTPVHPR

S6(Phospho)S8(Phospho)

Y9(Phospho)S14(Phospho)

Z036

7 unknown protein encoded in ISEc8 NP_286017.1 VyDPAVQRPLR Y2(Phospho)

Z1121 hypothetical protein NP_286656.1 HLLyLSNEDKEK Y4(Phospho)

Z1121 hypothetical protein NP_286656.1 YIYYFPNENSPFyTLK Y13(Phospho)

Z153

3 putative oxidoreductase NP_287037.1

AYADDFAEYNIQINGIAPGY

yVsEMTAIIYNNPKIK

Y21(Phospho)S23(Phosph

o)

Z2040

hypothetical protein Z2040 NP_287504.1 VNyFIKDLWDL Y3(Phospho)

Z359 hypothetical protein NP_288905.1 LIQEQVDASHyFSDEFQPLL Y11(Phospho)

4 NADGPVK

Z377

6 hypothetical protein Z3776 NP_289066.1 MEIyENENDQVEAIKR Y4(Phospho)

Z393

9 hypothetical protein Z3939 NP_289194.1 HVNQSyFR Y6(phospho)

Z513

7

hypothetical type three secretion system

protein NP_290285.1

yLLPKSGEIKPtHINDLFLNR

LnK

Y1(Phospho)T12(Phospho

)

Z513

7


protein NP_290286.1 LIEGYTyGEER Y7(Phospho)

Z589

7 hypothetical protein Z5897 NP_290917.1 TQQLyDSAIEYYIK Y5(Phospho)

zipA cell division protein NP_288974.1 SKRDDDSyDEDVEDDEGV

GEVR Y8(Phospho)

zipA cell division protein NP_288974.1 VNHAPANAQEHEAARPSPQ

HQyQPPYASAQPR Y22(Phospho)

Appendix III

List of unique phosphortyrosine sites identified combined from E. coli K12 and EHEC

O157:H7


accession Pepetide sequence

Protein

phosphosite

accB acetyl-CoA carboxylase biotin carboxyl

carrier protein subunit NP_289823.1

AAPAASFPVMQQAyAAPMMQQPAQSNAAAPATVPSMEAPAAAEISGHIVR

Y48

aceA isocitrate lyase NP_418439.1 LLAyNcSPSFNWQK Y316

aceB malate synthase A NP_418438.1 DAVNGTISyTNEAGK Y146

aceB malate synthase A NP_418438.1 DAVNGTISYTNEAGKIyQLKPNPAVLIcR Y154

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 EQVAyYKEDEK Y556

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 QIGIYSPNGQQyTPQDR Y546

aceE pyruvate dehydrogenase subunit E1 NP_285810.1 QIGIySPNGQQYTPQDR Y539

aceF dihydrolipoamide acetyltransferase NP_285811.1 yINIGVAVDTPNGLVVPVFK Y493

ackA acetate kinase NP_288870.1 YVEDNyATKEDAKR Y293

acpP acyl carrier protein NP_287228.1 ITTVQAAIDyINGHQA Y72


dehydrogenase NP_287484.1 AAySSGKPAIGVGAGNTPVVIDETADIKR Y203


dehydrogenase NP_287484.1 EYLPASyHEGSKNPVAR Y690


dehydrogenase NP_287484.1 FATHGGyLLQGK Y272


dehydrogenase NP_287484.1 ILINTPASQGGIGDLyNFK Y409


dehydrogenase NP_287484.1 NGALNAAIVGQPAyK Y302


dehydrogenase NP_287484.1 NHFASEYIYNAyKDEK Y80


dehydrogenase NP_287484.1 NHFASEyIYNAYKDEK Y75


dehydrogenase NP_287484.1 NHFASEYIyNAYKDEK Y77


dehydrogenase NP_287484.1 QTAFSQyDRPQAR Y766


dehydrogenase NP_287484.1 VSyFGQK Y384


dehydrogenase NP_287484.1 IyKFPK Y581


dehydrogenase NP_287484.1 LVAMGGIGHTSCLyTDQDNQPAR Y372

ahpC alkyl hydroperoxide reductase subunit C NP_286332.1 AAQyVASHPGEVcPAK Y157

alaC glutamate-pyruvate aminotransferase

AlaC, Z3644 NP_288949.1 LcTVAQRPDTHGySTSR Y70

alaS alanyl-tRNA synthetase NP_289243.1 EASGFGADyNAMIR Y446

alaS alanyl-tRNA synthetase NP_289243.1 GAMALFGEKyDERVR Y649

alaT aminotransferase AlaT NP_288864.1 NLPTAQGyCDSK Y68

aldB aldehyde dehydrogenase B NP_418045.4 MTNNPPSAQIKPGEyGFPLK Y15

appY DNA-binding global transcriptional

activator NP_415096.1 KLITSNSysINVVAQK Y201

aroC chorismate synthase NP_288903.1 DVFRPGHADYTyEQK Y111

aroG phospho-2-dehydro-3-deoxyheptonate

aldolase NP_286475.1 MNyQNDDLR Y3

asnB asparagine synthetase B NP_286388.1 AVGVHQSAyK Y553

asnB asparagine synthetase B NP_286388.1 DVIyHIETYDVTTIR Y314

asnB asparagine synthetase B NP_286388.1 LSIVDVNAGAQPLyNQQK Y64

asnB asparagine synthetase B NP_415200.1 EcFEAyLPASVAWR Y440

asnS asparaginyl-tRNA synthetase NP_286805.1 KFENPVyWGVDLSSEHER Y332

asnS asparaginyl-tRNA synthetase NP_286805.1 HSIEyLR Y120

aspA aspartate ammonia-lyase NP_290772.1 GEYQyLNPNDHVNK Y146

aspA aspartate ammonia-lyase NP_290772.1 GEyQYLNPNDHVNK Y144

aspA aspartate ammonia-lyase NP_418562.4 EVPADAyYGVHTLR Y22

aspC aromatic amino acid aminotransferase NP_286803.1 INLGIGVyKDETGKTPVLTSVK Y36

atpA F0F1 ATP synthase subunit alpha NP_290373.1 DSVGAVVMGPyADLAEGMK Y79

atpD F0F1 ATP synthase subunit beta NP_290371.1 AAPSyEELSNSQELLETGIK Y117

atpD F0F1 ATP synthase subunit beta NP_290371.1 MPSAVGyQPTLAEEMGVLQER Y268

atpD F0F1 ATP synthase subunit beta NP_290371.1 NIAIEHSGySVFAGVGER Y174

atpD F0F1 ATP synthase subunit beta NP_290371.1 VyDALEVQNGNER Y27

atpG F0F1 ATP synthase subunit gamma NP_290372.1 SWDYLyEPDPK Y208

bcp thioredoxin-dependent thiol peroxidase NP_289033.1 SFMGKTyDGIHR Y116

betA choline dehydrogenase, a flavoprotein NP_414845.1 STAGyFVANGMPVR Y544

bioB biotin synthase NP_286538.1 LANAGLDYYNHNLDTSPEFyGNIITTR Y161

bioB biotin synthase NP_286538.1 TGAcPEDcKycPQSSR Y59

bisC biotin sulfoxide reductase NP_290136.1 EAYGPASIFAGSyGWR Y77

carB carbamoyl phosphate synthase large

subunit NP_285727.1 LAVGyTLDELMNDITGGR Y330


protein NP_290260.1 IEEISSSDNKHyYAGR Y152


protein NP_290260.1 IEEISSSDNKHYyAGR Y153

cheZ phosphatase of chemotaxis regulator

CheY NP_288318.1 DRLYyVVQMTAQAAER Y57

cheZ phosphatase of chemotaxis regulator

CheY NP_416395.1 LyYVVQMTAQAAER Y56

chuX heme-binding protein involved in iron

acquisition NP_290084.1 HGyFNLR Y86

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGYVGyEEGGYLTEAVR Y660

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGyVGYEEGGYLTEAVR Y657

clpB protein disaggregation chaperone NP_289147.1 MSELQyGKIPELEKQLEAATQLEGK Y507

clpB protein disaggregation chaperone NP_289147.1 LVGAPPGYVGYEEGGyLTEAVRR Y665

clpP ATP-dependent Clp protease proteolytic

subunit NP_286179.1 VMIHQPLGGyQGQATDIEIHAR Y142

cnu oriC-binding nucleoid-associated protein NP_288061.1 LYDHLNyTLTDDQELINMYR Y28

codA cytosine deaminase NP_414871.1 TFALAQKyDR Y208

csrA RNA chaperone and carbon storage

regulator NP_289242.1 EVSVHREEIyQR Y48

cydB cytochrome d terminal oxidase

polypeptide subunit II NP_286462.1 NTHSLy Y379

cyoA cytochrome bo terminal oxidase subunit

II NP_414966.1 LGSQIyAmAGmQTR Y184

cysB transcriptional regulator of cystein

regulon NP_287924.1 YIVEVVNHNLNVSSTAEGLyTSQPGISK Y27

cysJ sulfite reductase, alpha subunit,

flavoprotein NP_417244.1 sRAPVAAPSqSVATGAVNEIHTSPySK Y231

cysU sulfate/thiosulfate transporter subunit NP_416919.1 tLLDALMDLPFALPTAVAGLtLASLFsVN

GFyGEWLAK Y125

dapD 2,3,4,5-tetrahydropyridine-2,6-

carboxylate N-succinyltransferase NP_285860.1 FADyDEAR Y93

dhaM dihydroxyacetone kinase subunite M-

specific, PTS-like enzyme NP_415716.4 ELSQQYQQLDDEyLQAR Y364

dhaM dihydroxyacetone kinase subunite M-

specific, PTS-like enzyme NP_415716.4 ELSQQyQQLDDEYLQAR Y357

dinI DNA damage-inducible protein I NP_287195.1 IQyAFPDNEGHVSVR Y31

dnaK molecular chaperone DnaK NP_285706.1 AKIELSSAQQTDVNLPyITADATGPK Y285

dnaK molecular chaperone DnaK NP_285706.1 VLENAEGDRTTPSIIAyTQDGETLVGQPA

KR Y42

dps DNA starvation/stationary phase

protection protein Dps NP_286576.1 SKATNLLyTR Y16

eae type III secretion system intimin

adherence protein NP_290259.1 MITHGcyTR Y7

efp elongation factor P NP_290780.1 ATyYSNDFR Y4

efp elongation factor P NP_290780.1 ATYySNDFR Y5

elaB conserved protein NP_416769.1 VSQASDSYYyR Y63

emrR transcriptional repressor MprA NP_289235.1 HEDFPyQEILLTR Y24

eno phosphopyruvate hydratase NP_289333.1 DAGyTAVISHR Y364

eno phosphopyruvate hydratase NP_289333.1 GMPLyEHIAELNGTPGK Y131

eno phosphopyruvate hydratase NP_289333.1 IEEALGEKAPyNGRK Y422

entE enterobactin synthase subunit E NP_286321.1 IIHTQGyPMcPDDEVWVADAEGNPLPQG

EVGR Y357

era GTP-binding protein Era NP_289123.1 FLGAELPySVTVEIER Y212

espA type III secretion system secreted protein

EspA NP_290256.1 SDVQSLQyR Y182


EspB NP_290254.1 QLAQSyQIQQAVFESQNK Y75


EspB NP_290254.1 SLENFQQGNLELyKQDVR Y272

espD type III secretion system secreted protein

EspD NP_290255.1 NSNEIyMDGQTK Y137


EspJ NP_288436.1 ITPENTPPMLLSyR Y50


EspJ NP_288436.1 TSySLTK Y22

espP type V secretion system secreted serine

protease, pO157 encoded YP_325580.1 QqALERyGVNYKGEK Y189


tyrosine kinase Etk NP_286918.1 ASTAYSYGYNYYGySYSEK Y720


tyrosine kinase Etk NP_286918.1 ASTAYSYGYNYYGYsySEKE Y722


tyrosine kinase Etk NP_286918.1 AsTAYSYGYNyYGYSYSEKE Y717


tyrosine kinase Etk NP_286918.1 AsTAYSYGYNYyGYSYSEKE Y718


tyrosine kinase Etk NP_286918.1 AsTAySYGYNYYGYsYSEKE Y711


tyrosine kinase Etk NP_286918.1 AsTAYSYGyNYYGYSYSEKE Y715


tyrosine kinase Etk NP_286918.1 ASTAYSyGYNYYGYSYSEKE Y713

etp phosphotyrosine-protein phosphatase NP_286919.2 EIPDPyRK Y121

fabG 3-ketoacyl-(acyl-carrier-protein)

reductase NP_287227.1 IITIGSVVGTMGNGGQANyAAAK Y151

fabI enoyl-(acyl carrier protein) reductase NP_287908.1 AIPNyNVMGLAK Y156

fbaA fructose-bisphosphate aldolase class II NP_289492.2 DSVSyGVVK Y281

fbaA fructose-bisphosphate aldolase, class II NP_417400.1 ANEAyLQGQLGNPKGEDQPNKK Y310

fbaB fructose-bisphosphate aldolase class I NP_416600.4 AINYGyTDDRVYSK Y254

fbp fructose-1,6-bisphosphatase I NP_418653.1 GGIYLyPSTASHPDGK Y259

fcI fucose synthetase NP_288539.1 GLENTYNWFLENQLQyRG Y319

fdhE formate dehydrogenase formation

protein NP_418327.1 FAALIAHAQEVVLyDHPLEMDLTAR Y69

fdx [2Fe-2S] ferredoxin NP_417020.1 VTDEDLVVEIPRyTINHAR Y103

feoA ferrous iron transport protein A NP_289948.1 MQyTPDTAWK Y3

fhuC iron-hydroxamate transporter ATP-

binding subunit NP_285847.1 MQEyTNHSDTTFALR Y4

fliD flagellar capping protein NP_288385.1 LSAyGtLKsALTTFQTAnTALSK Y47

folP dihydropteroate synthase NP_289751.2 TMQEAPKyDDVFAEVNR Y154

frdB fumarate reductase (anaerobic), Fe-S

subunit NP_418577.1 MAQLNSQNGVWScTFVGycSEVcPK Y210

frr ribosome recycling factor NP_285866.1 ASPSLLDGIVVEyYGTPTPLR Y44

frr ribosome recycling factor NP_285866.1 ASPSLLDGIVVEYyGTPTPLR Y45

fruR DNA-binding transcriptional regulator

FruR NP_285776.1 EHNyHPNAVAAGLR Y47

ftsA cell division protein FtsA NP_285790.1 VLHVIPQEYAIDyQEGIKNPVGLSGVR Y139

ftsK DNA translocase FtsK NP_286767.1 DDTWVDEDEyEDDEEYEDENHGKQHES

R Y217

ftsK DNA translocase FtsK NP_286767.1 DDTWVDEDEYEDDEEyEDENHGKQHES

R Y223

ftsK DNA translocase FtsK NP_286767.1 MDDDEEITyTAR Y280

ftsK DNA translocase FtsK NP_286767.1 yGEQYQHDVPVNAEDADAAAEAELAR Y663

ftsK DNA translocase FtsK NP_286767.1 YGEQyQHDVPVNAEDADAAAEAELAR Y667

ftsK DNA translocase at septal ring sorting

daughter chromsomes NP_415410.1 sQEyIEDKEVTLTK Y5

ftsZ cell division protein FtsZ NP_285791.1 QVQQPVMDRyQQHGMAPLTQEQKPVAK Y339

ftsZ cell division protein FtsZ NP_285791.1 VVNDNAPQTAKEPDyLDIPAFLRK Y371

fumA fumarase A = fumarate hydratase class I;

aerobic isozyme NP_288047.1 TPEGyASGSLGPTTAGR Y431

fumA fumarate hydratase (fumarase A),

aerobic Class I NP_416129.1 LASAKYyDELPTEGNEHGQAFR Y253

fumB anaerobic class I fumarate hydratase

(fumarase B) NP_418546.1 LASAHyYDELPTEGNEHGQAFR Y252

fur ferric uptake regulator NP_286398.1 LTNHSLYLyGHCAEGDCR Y130

fusA elongation factor G NP_289887.1 ILFyTGVNHK Y33

fxsA F exclusion of bacteriophage T7 NP_290773.2 MPGGGFSAGTGGGNTFDGEyQR Y140

gadB glutamate decarboxylase isozyme NP_287662.1 NWIDKEEyPQSAAIDLR Y90


dehydrogenase NP_288215.1 GANFDKyAGQDIVSNAScTTNcLAPLAK Y139


dehydrogenase NP_288215.1 LVSWyDNETGYSNK Y312


dehydrogenase A NP_416293.1 LVSWYDNETGySNK Y318

gatA galactitol-specific enzyme IIA

component of PTS NP_416597.1 SSAIyLLRPTNK Y74

gatB galactitol-specific enzyme IIB

component of PTS NP_416596.1 VNEIETyMDGVHLIcTTAK Y47

gatY D-tagatose 1,6-bisphosphate aldolase 2,

catalytic subunit NP_416599.2 NAFSQALKNyLTEHPEATDPR Y246


catalytic subunit NP_416599.2 NYLTEHPEATDPRDyLQSAK Y259


catalytic subunit NP_416599.2 QyHHPLAIHLDHHTK Y73

gatZ putative tagatose 6-phosphate kinase 1 NP_288597.1 KVLIEATSNQVNQFGGyTGMTPADFR Y56

gatZ D-tagatose 1,6-bisphosphate aldolase 2,

subunit NP_416598.1 IRyYWPHSR Y351


subunit NP_416598.1 MVyEAHSTDYQTR Y254


subunit NP_416598.1 YyWPHSR Y352

gcvP glycine dehydrogenase NP_289471.1 NLFCSCVPISEyQ Y956

gdhA glutamate dehydrogenase NP_288194.1 MDQTySLESFLNHVQK Y5

glf UDP-galactopyranose mutase,

FAD/NAD(P)-binding NP_416540.1 VGDEPYyPVNDNK Y311

glf UDP-galactopyranose mutase,

FAD/NAD(P)-binding NP_416540.1 YYDMHQVISAALyQVK Y358

glgC glucose-1-phosphate adenylyltransferase NP_289975.1 MKGENWyR Y114

glmS glucosamine--fructose-6-phosphate

aminotransferase NP_290368.1 RQDIESNLQyDAGDKGIYR Y241

glnA glutamine synthetase NP_290495.1 GGyFPVPPVDSAQDIR Y180

glnA glutamine synthetase NP_290495.1 IHPGEAMDKNLyDLPPEEAK Y398

glnA glutamine synthetase NP_290495.1 LVPGyEAPVMLAYSAR Y327

glnA glutamine synthetase NP_290495.1 MTPHPVEFELYySV Y467

glnB regulatory protein P-II for glutamine

synthetase NP_289109.1 GAEymVDFLPK Y51

glnK nitrogen assimilation regulatory protein NP_414984.1 GAEySVNFLPK Y51

glnL nitrogen regulation protein NR(II)/NtrB

sensory histidin kinase NP_290494.1 tAFQLTLHGERyRLAAR Y277

glpD sn-glycerol-3-phosphate dehydrogenase,

aerobic, FAD/NAD(P)-binding NP_417884.1 yLEHYEFR Y55

glpG intramembrane serine protease GlpG NP_289967.1 YLAASWQAGHTGSGLHyR Y80

glpK glycerol kinase NP_290555.1 LINDAyDSEYFATK Y335

glpK glycerol kinase NP_418361.1 LINDAYDSEyFATK Y332

glpK glycerol kinase NP_418361.1 NTyGTGcFMLMNTGEK Y266

gltA type II citrate synthase NP_286436.1 QLYTGyEKR Y416

glyA serine hydroxymethyltransferase NP_289107.1 EMNIADyDAELWQAMEQEK Y11

glyA serine hydroxymethyltransferase NP_289107.1 MIIGGFSAySGVVDWAK Y177

glyA serine hydroxymethyltransferase NP_289107.1 VMQAQGSQLTNKyAEGYPGKR Y55

glyA serine hydroxymethyltransferase NP_289107.1 VMQAQGSQLTNKYAEGyPGKR Y59

glyS glycine tRNA synthetase, beta subunit NP_418016.1 DKLEPyFTEGR Y628

gmd GDP-mannose dehydratase NP_288540.1 ESTPFyPR Y152

gmd GDP-mannose dehydratase NP_288540.1 IDHIyQDPHGSNPNFHLHYGDLTDSSNLT

R Y48

gmd GDP-D-mannose dehydratase NP_288559.1 SPyAVAK Y157

gmk guanylate kinase NP_290228.1 TQPLyDTQVSVSHTTR Y31

gnd 6-phosphogluconate dehydrogenase NP_288534.1 DyFGAHTYK Y447

gpmA phosphoglyceromutase NP_286476.1 FTGWyDVDLSEK Y26

gpmA phosphoglyceromutase NP_286476.1 HyGALQGLNK Y92

gpt xanthine-guanine

phosphoribosyltransferase NP_285955.1 HVDTVcISSyDHDNQR Y63

greA transcription elongation factor GreA NP_289755.2 EHGDLKENAEyHAAR Y48

groEL Cpn60 chaperonin GroEL, large subunit

of GroESL NP_290776.1 GYLSPyFINKPETGAVELESPFILLADKK Y203

groEL Cpn60 chaperonin GroEL, large subunit

of GroESL NP_290776.1 QQIEEATSDyDREK Y360

groES Cpn10 chaperonin GroES, small subunit

of GroESL NP_290775.1 VGDIVIFNDGyGVKSEK Y71

grxB glutaredoxin 2 (Grx2) NP_415582.1 LYIYDHcPycLK Y11

grxD glutaredoxin-4 NP_416171.1 FAyVDILQNPDIR Y49

guaB inosine 5'-monophosphate

dehydrogenase NP_289062.1 GSSDRyFQSDNAADKLVPEGIEGR Y402


oxidoreductase NP_285800.1 HVGGVAEyR Y285


oxidoreductase NP_285800.1 SAcTyVGASR Y318

gyrB DNA gyrase subunit B NP_290332.1 SNSyDSSSIK Y5

hdhA 7-alpha-hydroxysteroid dehydrogenase NP_288055.1 NINMTSyASSK Y159

hemL glutamate-1-semialdehyde

aminotransferase NP_285850.1 SENLySAAR Y8

hemY putative protoheme IX biogenesis

protein NP_290430.1 LAEGDyQQVEK Y100

hha hemolysin expression-modulating

protein NP_286201.1 NKyELSDNELAVFYSAADHR Y33

hisC histidinol-phosphate aminotransferase NP_288526.1 NLTPyQSAR Y20

hisS histidyl-tRNA synthetase NP_289067.1 AGIEHGLLyNQEQR Y99


regulator H-NS NP_287482.1 LQQyREMLIADGIDPNELLNSLAAVK Y61


regulator H-NS NP_287482.1 YSyVDENGETK Y99

holE DNA polymerase III subunit theta NP_288279.1 LPyEPK Y71

hslU ATP-dependent protease ATP-binding

subunit HslU NP_290562.1 FTEVGyVGKEVDSIIR Y91

htpG heat shock protein Hsp90 NP_415006.1 ALSNPDLyEGDGELR Y57

ibpA heat shock protein IbpA NP_290325.1 TYLyQGIAER Y87

icd isocitrate dehydrogenase specific for

NADP+ NP_287350.1 TVTyDFER Y391

iha bifunctional enterobactin

receptor/adhesin protein NP_286713.1 DGQLGSLTGGyDR Y276

ihfB integration host factor subunit beta NP_286787.1 GFGSFSLHyR Y55

infA translation initiation factor IF-1 NP_286761.1 ILTGDKVTVELTPyDLSK Y60

infB translation initiation factor IF-2 NP_289744.1 AREVALyR Y656

infB translation initiation factor IF-2 NP_289744.1 MAEENKWTDNAEPTEDSSDyHVTTSQH

AR Y228

infB translation initiation factor IF-2 NP_289744.1 YYSVIyNLIDEVK Y772

infC translation initiation factor IF-3 NP_288152.1 IMDYGKFLyEK Y39

iscU scaffold protein for assembly and

transfer of iron-sulfur clusters NP_289086.1 AySEKVIDHYENPR Y3

iscU scaffold protein for assembly and

transfer of iron-sulfur clusters NP_289086.1 VIDHyENPR Y11

ispG 4-hydroxy-3-methylbut-2-en-1-yl

diphosphate synthase NP_289068.1 SGLyEDGVRK Y330

kdsA 2-dehydro-3-deoxyphosphooctonate

aldolase NP_287461.1 SSIHSyRGPGLEEGMK Y69

L706

6

hypothetical protein L7066 encoded by

pO157 YP_325626.1 QASAyFAK Y96

lon DNA-binding ATP-dependent protease

La NP_286181.1 SQREyYLNEQMK Y243

lpdA dihydrolipoamide dehydrogenase NP_285812.1 GISyETATFPWAASGR Y374

lpdA dihydrolipoamide dehydrogenase NP_285812.1 TQVVVLGAGPAGySAAFR Y19

lsrF putative autoinducer-2 (AI-2) aldolase NP_416034.1 IAAEMGAQIIKTyYVEK Y205

luxS S-ribosylhomocysteine lyase NP_417172.1 VQDQNQIPELNVyQcGTYQMHSLQEAQD

IAR Y126

maeB malic enzyme NP_289015.1 DLALAySPGVAAPcLEIEKDPLK Y39

manX PTS system, mannose-specific IIAB

component NP_288253.1 AAPTPAKPMGPNDyMVIGLAR Y161

manZ PTS system mannose-specific

transporter subunit IID NP_288255.1 YYGVAYGySK Y173

manZ PTS system mannose-specific

transporter subunit IID NP_288255.1 YYGVAyGYSK Y171

map methionine aminopeptidase NP_285862.1 GFHEEPQVLHyDSR Y186

map methionine aminopeptidase NP_285862.1 IcNDYIVNEQHAVSAcLGyHGYPK Y62

map methionine aminopeptidase NP_285862.1 IcNDYIVNEQHAVSAcLGYHGyPK Y65

metH B12-dependent methionine synthase NP_290646.1 IEQNYSGPTVyVQNASR Y856

mntH manganese transport protein MntH NP_288962.1 MTNyRVESSSGR Y4

mogA molybdenum cofactor biosynthesis

protein MogA NP_285701.1

ASSGVyQDKGIPALEEWLTSALTTPFELETR

Y20

mraY phospho-N-acetylmuramoyl-

pentapeptide-transferase NP_285783.1 MAPIHHHyELK Y328

mrcB penicillin-binding protein 1b NP_285845.1 RRYEDDDDYDDyDDYEDEEPmPR Y37

mrcB penicillin-binding protein 1b NP_285845.1 RRYEDDDDYDDYDDyEDEEPMPR Y40

mrcB penicillin-binding protein 1b NP_285845.1 RRyEDDDDYDDYDDYEDEEPMPR Y28

mreB cell wall structural complex MreBCD,

actin-like component MreB NP_417717.2 IKHEIGSAyPGDEVR Y226

mukB cell division protein MukB NP_286799.1 ELAyLSADDLR Y1140

nadR bifunctional DNA-binding

transcriptional repressor/ NMN

adenylyltransferase

NP_418807.4 TAIKQQGcTLQqVADASGMtKGyLSqLLN

AK Y31

nagD ribonucleotide monophosphatase NP_286389.1 GFyPAcGALcAGIEK Y153

nagD ribonucleotide monophosphatase NP_415201.1 AAyFVANGAR Y132

narX narX sensory histidine kinase NP_287470.1 MQSyRLLAAVPLSEK Y58

ndk nucleoside diphosphate kinase NP_289071.1 ADyADSLTENGTHGSDSVESAAR Y107

nfuA iron-sulfur cluster scaffold protein F NP_417873.1 DLTEHQRGEHSyY Y190

nrdB ribonucleotide-diphosphate reductase

subunit beta NP_288809.1 AyTTFSQTK Y3

nuoB NADH dehydrogenase subunit B NP_288861.1 RPLSWVVGDQGVyR Y193

nuoI NADH dehydrogenase subunit I NP_288855.1 MYPEEPVyLPPR Y39

nuoI NADH dehydrogenase subunit I NP_288855.1 QDLVYEKEDLLISGPGKYPEYNFyR Y151

ompA outer membrane protein A NP_286832.1 IGSDAyNQGLSER Y269

ompR osmolarity response regulator NP_289945.1 GREySAMER Y194

ompR osmolarity response regulator NP_289945.1 yLTEQGFqVRSVAnAEQMDR Y23

oppA oligopeptide ABC transporter substrate-

binding protein NP_415759.1 AQGNMPAyGYTPPYTDGAK Y341

osmY hyperosmotically inducible periplasmic

protein NP_418793.1

isKTLLAVMLTSAVATGSAyAEnnAqTTNESAGQKVDSSMNK

Y27

paaY putative transferase NP_289841.1 SSyNPDGNPLTIGEDVTVGHK Y146

pckA phosphoenolpyruvate carboxykinase NP_289943.1 MQLIGGTWyGGEMKK Y207

pdxB erythronate-4-phosphate dehydrogenase NP_416823.1 KVDIGTSHIAGyTLEGK Y258

pepB aminopeptidase B NP_289080.2 GITFDSGGySIK Y204

pepB aminopeptidase B NP_417018.4 AVDLISNVAGDRVTyR Y144

pepD aminoacyl-histidine dipeptidase

(peptidase D) NP_285954.1 IcSIPHPSyHEEQLAEYIVGWAK Y27

pepE peptidase E NP_290648.1 RSAVFIPFAGVTQTWDDyTAK Y49

per perosamine synthetase NP_288542.1 QyWHDVIGYNYR Y218

per perosamine synthetase NP_288542.1 YIPVyQPSLTGK Y7

pfkA 6-phosphofructokinase NP_290545.1 MVQLDRySVSDMINR Y56

pflB formate acetyltransferase 1 NP_286778.1 DAIPTQSVLTITSNVVyGK Y613

pflB formate acetyltransferase 1 NP_286778.1 LPFAyAK Y659

pflB formate acetyltransferase 1 NP_286778.1 THNQGVFDVyTPDILR Y153

pflB formate acetyltransferase 1 NP_286778.1 VSGyAVR Y736

pflB pyruvate formate lyase I NP_415423.1 SEPIKGDVLNyDEVMER Y473

pgi glucose-6-phosphate isomerase NP_290659.1 FAAyFQQGNMESNGK Y348

pgk phosphoglycerate kinase NP_289493.1 SLyEADLVDEAKR Y234

phoP DNA-binding response regulator in two-

component regulatory system with PhoQ NP_415648.1

ESWQDKVEVLSAGADDyVTKPFHIEEVM

AR Y98

plsB glycerol-3-phosphate acyltransferase NP_290675.2 VFTyYTPKEESIK Y94

plsB glycerol-3-phosphate acyltransferase NP_290675.2 VFTYyTPKEESIK Y95

pntB pyridine nucleotide transhydrogenase NP_288037.1 SMNTGyAGVQNPLFFK Y431

ppa inorganic pyrophosphatase NP_290858.1 AQIAHFFEHyKDLEK Y142

ppc phosphoenolpyruvate carboxylase NP_290593.1 MNEQySALR Y5

proA gamma-glutamyl phosphate reductase NP_285960.1 NIAySFLPALSK Y267

proP proline/glycine betaine transporter NP_290744.1 EILVEHyDNIEQK Y467

proQ RNA chaperone YP_026161.1 yLYGVKPGATR Y70

proQ RNA chaperone YP_026161.1 YLyGVKPGATR Y72

proS prolyl-tRNA synthetase NP_285888.1 VVAAAIEQNyDER Y460

proX glycine betaine transporter ligand

binding protein NP_417165.1 FyRExVFVnGAAQGYLIDKK Y104

prsA ribose-phosphate pyrophosphokinase NP_287453.1 IANRLyTSLGDAAVGR Y24

pspG phage shock protein G NP_290683.2 YQRyDR Y75

pta phosphate acetyltransferase NP_288871.1 HQFAQSLNyEIAK Y124

pta phosphate acetyltransferase NP_288871.1 VAMLSySTGTSGAGSDVEK Y591

ptr protease III NP_289373.1 EVLAyR Y690

ptsI PEP-protein phosphotransferase of PTS

system (enzyme I) NP_416911.1

HMTADAAAHEVIEGQASALEELDDEyLKER

Y122

purB adenylosuccinate lyase NP_287345.1 TARDEVILPyWR Y146


succinocarboxamide synthase NP_289029.1 QAELyRGK Y8


succinocarboxamide synthase NP_289029.1 TVySTENPDLLVLEFR Y16

purH

bifunctional

phosphoribosylaminoimidazolecarboxa

mide formyltransferase/IMP cyclohydrolase

NP_290638.1 ALSyNNIADTDAALEcVK Y262

purM phosphoribosylaminoimidazole

synthetase NP_289052.1 TDKTSLSyKDAGVDIDAGNALVGR Y9


PurR NP_288094.1 ELHySPSAVAR Y45


PurR NP_288094.1 SVADGPFRDyRR Y339

putP major sodium/proline symporter NP_287020.1 FAEADAHyHSAPPSR Y491

pykF pyruvate kinase NP_288110.1 LNFSHGDyAEHGQR Y40

pyrG CTP synthetase NP_417260.1 SQGLDDyIcKR Y259

rcsB transcriptional regulator RcsB NP_288797.1 ISAGGyGDKR Y146

rcsB transcriptional regulator RcsB NP_288797.1 LDAHVLITDLSMPGDKyGDGITLIK Y64

recA recombinase A NP_289246.1 IVEIyGPESSGK Y66

recT DNA recombinase NP_415865.1 nVQLIIGyRGmIDLAR Y121

rfaD ADP-L-glycero-D-mannoheptose-6-

epimerase NP_290202.1 AAGyDKPFK Y288

rfaF ADP-L-glycero-D-mannoheptose-6-

epimerase NP_290203.1 LITGyHK Y311

rfaF ADP-heptose:LPS heptosyltransferase II

WaaF NP_418077.1 KGDAAEGyHQSLIDITPQR Y323

rfbA dTDP-glucose pyrophosphorylase NP_416543.1 NNYGQYLyK Y286

rhlB ATP-dependent RNA helicase RhlB NP_290410.1 LGLAYGGDGyDKQLK Y124

rimJ ribosomal-protein-S5-alanine N-

acetyltransferase NP_287200.1 MFGyR Y4

rne ribonuclease E NP_287218.1 APAPEyVPEAPR Y1018

rne ribonuclease E NP_287218.1 EYFPANySAHGRPNIK Y82

rne ribonuclease E NP_287218.1 VRyEQSVAEETVVAPVAEETVAAEPIVQ

EAPAPR Y731

rpiA ribose-5-phosphate isomerase A NP_289482.1 LGGRPEyR Y156

rplB 50S ribosomal protein L2 NP_289878.1 LEyDPNR Y83

rplC 50S ribosomal protein L3 NP_289881.1 DLANDGyR Y45

rplE 50S ribosomal protein L5 NP_289869.1 AKLHDyYKDEVVK Y7

rplE 50S ribosomal protein L5 NP_289869.1 AKLHDYyKDEVVK Y8

rplE 50S ribosomal protein L5 NP_289869.1 EQIIFPEIDyDKVDR Y143

rplE 50S ribosomal protein L5 NP_289869.1 GNySMGVR Y128

rplE 50S ribosomal protein L5 NP_289869.1 IRQGyPIGcK Y83

rplF 50S ribosomal protein L6 NP_289866.1 DGyADGWAQAGTAR Y58

rplF 50S ribosomal protein L6 NP_289866.1 KLQLVGVGyR Y94

rplM 50S ribosomal protein L13 NP_289799.1 TDKVyYHHTGHIGGIK Y74

rplM 50S ribosomal protein L13 NP_289799.1 TDKVYyHHTGHIGGIK Y75

rplN 50S ribosomal subunit protein L14 NP_417769.1 yAGVGDIIKItIK Y32

rplO 50S ribosomal protein L15 NP_289862.1 RGFEGGQMPLyR Y58

rplQ 50S ribosomal protein L17 NP_289855.1 AGDNAPMAyIELVDR Y112

rplR 50S ribosomal protein L18 NP_289865.1 SGFQyHGR Y99

rplT 50S ribosomal protein L20 NP_288150.1 AGQyAYR Y45

rplT 50S ribosomal protein L20 NP_288150.1 GyYGAR Y24

rplU 50S ribosomal protein L21 NP_289760.1 MyAVFQSGGK Y2

rplV 50S ribosomal protein L22 NP_289876.1 KVSQALDILTyTNKK Y38

rplY 50S ribosomal protein L25 NP_288768.1 AQDVQRHPyKPK Y82

rpmE 50S ribosomal protein L31 NP_290567.1 DIHPKyEEITAScScGNVMK Y9

rpmE2

50S ribosomal protein L31 type B NP_286014.1 SHPFyTGK Y57

rpmF 50S ribosomal protein L32 NP_287223.1 HHITADGyYR Y48

rpmF 50S ribosomal protein L32 NP_287223.1 HHITADGYyR Y49

rpmG 50S ribosomal protein L33 NP_290216.1 LVSSAGTGHFyTTTK Y21


alpha NP_289856.1 IAyNVEAAR Y185


alpha NP_289856.1 LLVDAcySPVER Y177


beta NP_290618.1 IVIKVNEDEMyPGEAGIDIYNLTK Y742


beta NP_290618.1 MVySYTEK Y3


beta NP_290618.1 STGSySLVTQQPLGGK Y1251


beta NP_290618.1 SVFPIQSySGNSELQYVSYR Y62


beta' NP_290619.1 LIPAGTGYAyHQDR Y1365


beta' NP_290619.1 LIPAGTGyAYHQDR Y1363


beta' NP_290619.1 SVITVGPyLR Y360

rpsA 30S ribosomal subunit protein S1 NP_415431.1 HEAWITLEKAyEDAETVTGVINGK Y102

rpsF 30S ribosomal protein S6 NP_290830.1 RQLAyPINK Y49

rpsG 30S ribosomal protein S7 NP_289888.1 VGGSTyQVPVEVRPVRR Y85

rpsI 30S ribosomal protein S9 NP_289798.1 AENQYyGTGR Y7

rpsI 30S ribosomal protein S9 NP_289798.1 MAENQyYGTGR Y6

rpsJ 30S ribosomal protein S10 NP_289882.1 DQyEIR Y65

rpsN 30S ribosomal protein S14 NP_289868.1 RVALADKyFAK Y20

rpsP 30S ribosomal protein S16 NP_289162.1 KRPFyQVVVADSR Y17

rpsQ 30S ribosomal protein S17 NP_289872.1 FVKHPIyGK Y34

rpsR 30S ribosomal protein S18 NP_290832.1 YLSLLPyTDRHQ Y70

rpsU 30S ribosomal protein S21 NP_289640.1 EFyEKPTTER Y38

rrmJ 23S rRNA methyltransferase J NP_289753.1 WLQEHFSDKyVQQAQK Y22

sapC peptide transport permease protein NP_287896.1 PYDSVySEKRPPGTLR Y7

sbcB exonuclease I NP_288516.2 NFPGTLDyAEQQR Y421

secA preprotein translocase subunit SecA NP_285794.1 GVHVVTVNDyLAQR Y134

secA preprotein translocase subunit SecA NP_285794.1 KQLLEyDDVANDQR Y648

secF preprotein translocase subunit SecF NP_286148.1 AQEyTVEQLNHGR Y5

secY preprotein translocase subunit SecY NP_289861.1 ANLKGyGR Y441

secY preprotein translocase subunit SecY NP_289861.1 VyAAQSTHLPLK Y258

selD selenophosphate synthetase NP_288197.1 LTQySHGAGcGcK Y11

serC phosphoserine aminotransferase NP_286782.1 GQFAAVPLNILGDKTTADYVDAGyWAA

SAIK Y101

serS seryl-tRNA synthetase NP_286770.1 FAGDLFHTRPLEEEADTSNyALIPTAEVP

LTNLVR Y232

sgrR DNA-binding transcriptional dual

regulator NP_414611.1 LEEGCyYLLFDSR Y336

sgrR DNA-binding transcriptional dual

regulator NP_414611.1 VLyYRPLR Y126

slyX hypothetical protein NP_289895.1 ASQPSNIASQAEETPPPHy Y72

sms DNA repair protein RadA NP_291002.1 LSGyAGSAGVAK Y54

sspA stringent starvation protein A NP_289797.1 IIMEYLDERFPHPPLMPVyPVAR Y92

sucA 2-oxoglutarate dehydrogenase E1

component NP_286442.1 YAGRPASASPAVGyMSVHQK Y914

sucC succinyl-CoA synthetase subunit beta NP_286444.1 LVTyQTDANGQPVNQILVEAATDIAK Y84

sucC succinyl-CoA synthetase, beta subunit NP_415256.1 YGLPAPVGyAcTTPR Y23

sufC cysteine desulfurase ATPase component NP_288116.1 SFIIVTHyQR Y204

surA peptidyl-prolyl cis-trans isomerase SurA NP_285750.1 LAyDGLNYNTYR Y120

talB transaldolase B NP_285700.1 KLSyTGEVK Y265

terC putative phage inhibition, colicin

resistance and tellurite resistance protein NP_286709.1 SGDDDDEIEDySQHLAYR Y164

thrS threonyl-tRNA synthetase NP_288153.1 TGHWDNyKDAMFTTSSENR Y313

tig Peptidyl-prolyl cis/trans isomerase

(trigger factor) NP_286178.1 GLIEEMASAyEDPKEVIEFYSK Y378

tnaA tryptophanase NP_290344.1 SyYALAESVK Y85

tnaA tryptophanase/L-cysteine desulfhydrase,

PLP-dependent NP_418164.4 AMySIAK Y214


PLP-dependent NP_418164.4 EAFDTGVRyDFK Y165


PLP-dependent NP_418164.4 ETyKYADMLAMSAK Y258


PLP-dependent NP_418164.4 ETYKyADMLAMSAK Y260


PLP-dependent NP_418164.4 FAENAyFIK Y236


PLP-dependent NP_418164.4 GLTFTyEPK Y456


PLP-dependent NP_418164.4 LLPHIPADQFPAqALAcELyK Y386


PLP-dependent NP_418164.4 MVAFSNyFFDTTQGHSQINGcTVR Y134


PLP-dependent NP_418164.4 NIFGyQYTIPTHQGR Y93


PLP-dependent NP_418164.4 NIFGYQyTIPTHQGR Y95


PLP-dependent NP_418164.4 SyYALAESVK Y80


PLP-dependent NP_418164.4 TLcVVQEGFPTyGGLEGGAMER Y307

topA DNA topoisomerase I NP_287925.1 LYEAGYITyMR Y319


potassium transporter NP_289851.1 AyYGGPLIGNALSTMR Y161


potassium transporter NP_289851.1 AYyGGPLIGNALSTMR Y162

tsf elongation factor Ts NP_285864.1 VAALEGDVLGSyQHGAR Y146

tuf elongation factor Tu NP_289886.1 GITINTSHVEyDTPTR Y70

tuf elongation factor Tu NP_289886.1 HYAHVDcPGHADyVK Y88

tuf elongation factor Tu NP_289886.1 HyAHVDcPGHADYVK Y77

tuf elongation factor Tu NP_290611.1 ELLSQyDFPGDDTPIVR Y161

tuf elongation factor Tu NP_290611.1 GYRPQFyFR Y332

tufB protein chain elongation factor EF-Tu

(duplicate of tufA) NP_418407.1 FESEVyILSKDEGGR Y310

tus DNA replication terminus site-binding NP_288045.1 ARyDLVDR Y4

protein

tyrB aromatic amino acid aminotransferase NP_290687.1 VDAyAGDPILTLMER Y8

udp uridine phosphorylase NP_290463.1 SIGATTHVGVTASSDTFYPGQERyDTYSG

R Y169

udp uridine phosphorylase NP_290463.1 YDTySGR Y172

ugpQ glycerophosphodiester

phosphodiesterase, cytosolic NP_417906.1 ILVyTVNKPQR Y213

upp uracil phosphoribosyltransferase NP_289051.2 NEETLEPVPyFQK Y113

upp uracil phosphoribosyltransferase NP_289051.2 ISVVGMyRNEETLEPVPYFQK Y102


function? NP_290066.1 AVSMARPyNAK Y30


function? NP_290066.1 VSLIHVDVNySDLYTGLIDVNLGDMQK Y43

uvrY DNA-binding response regulator in two-component regulatory system with BarA

NP_416424.1 VmQAGAAGyLSKGAAPQEVVSAIRSVyS

GQR Y101,Y119

vacB exoribonuclease R NP_290809.2 SQDPFQEREAEKyANPIPSR Y14

wbdP glycosyl transferase NP_288541.1 FNEQyYR Y80

wbdP glycosyl transferase NP_288541.1 FNEQYyR Y81

wbdP glycosyl transferase NP_288541.1 IyTEYNPDVYLVcTGATQDYR Y245

wbdP glycosyl transferase NP_288541.1 IYTEyNPDVYLVcTGATQDYR Y248

wbdP glycosyl transferase NP_288541.1 NHySLNDAMVK Y356

wbdP glycosyl transferase NP_288541.1 WFADySGNIAK Y209

wcaD putative colanic acid biosynthesis

protein NP_288562.1 yLIYSNSYVLNFIK Y151

wcaG putative UDP-galactose 4-epimerase NP_288548.1 VHSSGFVAPyTLSQGLDR Y304

wcaG putative UDP-galactose 4-epimerase NP_288548.1 TLQyEFVHAK Y316

wzc tyrosine kinase NP_288566.2 ASAyQDYGYYEYEYK Y705

wzc tyrosine kinase NP_288566.2 ASAYQDyGYYEYEYK Y708

wzc tyrosine kinase NP_288566.2 ASAYQDYGYYEyEYKSDAK Y713

wzc tyrosine kinase NP_288566.2 ASAYQDYGYYEYEyKSDAK Y715

wzc protein-tyrosine kinase NP_416564.4 ASAYQDYGyYEYEYK Y710

wzy O antigen polymerase NP_288545.1 LSRNENISyNcDL Y390

xasA acid sensitivity protein, putative

transporter NP_287663.1 ARSPHyIVMNDK Y503

xthA exonuclease III NP_416263.1 IIMAEIPSLLGNVTVINGyFPQGESR Y109

yaeH hypothetical protein NP_285859.1 KTVVADGVGQGyKEVQEISPNLR Y66

yaiB hypothetical protein NP_286120.1 LIDQVEGALyEVKPDASIPDDDTELLR Y57

yaiE hypothetical protein Z0487 NP_286129.1 MLQSNEyFSGK Y7

yajD hypothetical protein Z0511 NP_286151.1 EFVySNLR Y36

ybbN DnaK co-chaperone, thioredoxin-like

protein NP_415025.4 AIPTVyLFQNGQPVDGFQGPQPEEAIR Y82

ybeZ predicted protein with nucleoside

triphosphate hydrolase domain NP_286385.1 VLEQSAESVPEyGK Y118

ybfA hypothetical protein NP_286412.1 MELyR Y4

ybfA hypothetical protein Z0846 NP_286412.1 ATGDFy Y68

ybfA predicted protein NP_415228.1 EyPAWLIFLRR Y7

ybgI putative hydrolase-oxidase NP_286425.1 LNSAAISDyAPNGLQVEGK Y22

ybiI hypothetical protein NP_286567.1 DLQKPAYTGyNR Y77

ybiI hypothetical protein NP_286567.1 DLQKPAyTGYNR Y74

ybiO putative transport protein NP_286572.1 WLAKTITLSPHtQRNyPELQK Y412

ybiT fused predicted transporter subunits of

ABC superfamily: ATP-binding

components

NP_415341.1 DRIyALPEMSEEDGYKVADLEVK Y103

ybiT

fused predicted transporter subunits of

ABC superfamily: ATP-binding components

NP_415341.1 IYALPEMSEEDGyKVADLEVK Y114

ybiT

fused predicted transporter subunits of

ABC superfamily: ATP-binding components

NP_415341.1 YGEMDGySAEAR Y129

ybjC hypothetical protein NP_286616.1 LAPQLMNRPPQySR Y82

ycbB L,D-transpeptidase YcbB NP_286800.1 FQQAPGPRNSLGRyK Y496

ycfU outer membrane-specific lipoprotein

transporter subunit LolC NP_287250.1 AAATQPAEALRyE Y398

yciH translation initiation factor Sui1 NP_287915.1 LVySTETGRIDEPK Y11

ydaA universal stress protein UspE NP_287853.1 cDLLVIKPDQyQTPVELDDEEDD Y304

ydcH hypothetical protein NP_287734.1 KEGSDDRGyNAEVVR Y25

ydfG 3-hydroxy acid dehydrogenase NP_287611.1 NHGHIINIGSTAGSWPyAGGNVYGATK Y141

ydiA PEP synthetase regulatory protein NP_288137.1 THGLNPNNLNKyDAR Y126

ydiA PEP synthetase regulatory protein NP_288137.1 PLVFySIVLPEIR Y71

yebC hypothetical protein NP_288301.1 cGGNLGTDGSVAyLFSK Y132

yecN hypothetical protein NP_288306.2 VAyGDGGFSELQSAIR Y32

yeeF putative amino acid/amine transport

protein NP_288519.1 SFRNPVPQyEDVA Y450

yeeX conserved protein NP_416511.4 GDYEDRVDDyIIKNAELSK Y79

yejH predicted ATP-dependent DNA or RNA

helicase NP_416689.1

HGYLTPPERLDMPVVQyDFSRLqAQSNG

LFSEADLnR Y209

yejO putative ATP-binding component of a

transport system NP_288772.1 VNDDGKFNNDVAGTRGVyQAGIR Y796

yfgM conserved protein, UPF0070 family NP_417008.1 mEIyENENDQVEAVKR Y4

yfiD stress-induced alternate pyruvate

formate-lyase subunit NP_289137.1 AGyAEDEVVAVSK Y38

yfiD stress-induced alternate pyruvate

formate-lyase subunit NP_289137.1 LGDIEyR Y54

ygaG S-ribosylhomocysteinase LuxS NP_289238.1 VQDQNQIPELNVyQcGTYQMHSLQEAQD

IAR Y126

ygaG S-ribosylhomocysteinase LuxS NP_289238.1 VQDQNQIPELNVYQcGTyQMHSLQEAQD

IAR Y131

ygaU predicted protein NP_417151.1 QVYGNANLyNK Y121

ygdE putative RNA 2'-O-ribose

methyltransferase NP_289361.1 DAGVLANyETPK Y140

ygfB Hypothetical protein Z4246 NP_289477.2 NIAQLGYDEDEDQEELEmSLEEIIEyVR Y164

yggX hypothetical protein Z4307 NP_289534.1 EVHIEGyTPEDKK Y85

yhcB Conserved protein NP_289801.1 LAESEASNDQAPVQMPRDySEGASGLLR Y119

yhcB Conserved protein NP_289801.1 NKAELDEyREELVSHFAR Y50

yhcB Conserved protein NP_289801.1 QLyQHMAK Y76

yhcB Conserved protein NP_289801.1 QQQALQyELEK Y38

yhcB Conserved protein NP_289801.1 SAELLDTMAHDyR Y72

yheS putative ABC transporter ATP-binding

protein NP_289900.1 LAQQQAMyESQQER Y249

yhgI Iron-sulfur cluster scaffold protein NP_289954.1 DLTEHQRGEHSyY Y190

yhiQ predicted SAM-dependent

methyltransferase NP_417954.1

LqLIHAsSLtALTDITPRPQVVyLDPMFPHKQKSALVK

Y169

yhjE major facilitator superfamily (MFS) of

transporters protein NP_290103.1 M(ox)QAtATTLDHEQEytPINsR Y14

yibK tRNA methyltransferase NP_290189.1 AGLDyHEFTAVTR Y51

yibO phosphoglyceromutase NP_290195.1 VATyDLQPEMSSAELTEK Y368

yifE hypothetical protein NP_290396.1 RFHTLSGGKPQVEGAEDyTDSDD Y107

yihA GTP-binding protein required for normal

cell division, EngB in EHEC NP_418301.3 LVDLPGyGYAEVPEEMKR Y82

yihA ribosome biogenesis GTP-binding

protein YsxC NP_290489.2 LVDLPGYGyAEVPEEMKR Y84

yihI GAP-like protein that activates GTPase

activity of Der NP_290491.1 LGLSyDDDEEEEEDEKQEDMMR Y146

yjbQ hypothetical protein Z5655 NP_290689.1 TVPDNGNyEHDYEGADDMPSHIK Y77

yjgF hypothetical protein NP_290875.1 TIATENAPAAIGPyVQGVDLGNMIITSGQI

PVNPK Y30

yjiM predicted 2-hydroxyglutaryl-CoA

dehydratase NP_418755.4 TDKcPyFYFSDLVVGETTcDGK Y95

yjiM predicted 2-hydroxyglutaryl-CoA

dehydratase NP_418755.4 TDKcPYFyFSDLVVGETTcDGK Y97

yjiY predicted inner membrane protein NP_418774.2 LDPTRAtPAVINNDGLNyVPTnR Y82

yjjK

transporter subunits of ABC

superfamily: ATP- and membrane

binding components

NP_418808.1 RLDEVyALYADPDADFDKLAAEQGR Y108

ylaC hypothetical protein NP_286199.1 VcyNGEWYNTR Y112

yleA isopentenyl-adenosine A37 tRNA

methylthiolase MiaB NP_286386.1 TWGcQMNEyDSSK Y17

yqgF holliday junction resolvase-like protein NP_289521.1 SGLFEQGGyR Y113

yqiA esterase YqiA NP_289611.1 HIyDLK Y123

Z034

2

putative LysR-like transcriptional

regulator NP_285993.1 EMVVAsPsyLAANsTPVHPR Y172

Z036

7 unknown protein encoded in ISEc8 NP_286017.1 VyDPAVQRPLR Y85

Z112

1 hypothetical protein NP_286656.1 HLLyLSNEDKEK Y204

Z112

1 hypothetical protein NP_286656.1 YIYYFPNENSPFyTLK Y291

Z153

3 putative oxidoreductase NP_287037.1

AYADDFAEYNIQINGIAPGYyVsEMTAIIY

NNPKIK Y201

Z204

0 hypothetical protein Z2040 NP_287504.1 VNyFIKDLWDL Y69

Z359

4 hypothetical protein NP_288905.1 LIQEQVDASHyFSDEFQPLLNADGPVK Y57

Z3776

hypothetical protein Z3776 NP_289066.1 MEIyENENDQVEAIKR Y4

Z393

9 hypothetical protein Z3939 NP_289194.1 HVNQSyFR Y56

Z5137

hypothetical type three secretion system protein

NP_290285.1 yLLPKSGEIKPtHINDLFLNRLnK Y168

Z513

7


protein NP_290286.1 LIEGYTyGEER Y64

Z5897

hypothetical protein Z5897 NP_290917.1 TQQLyDSAIEYYIK Y458

zipA cell division protein NP_288974.1 SKRDDDSyDEDVEDDEGVGEVR Y53

zipA cell division protein NP_288974.1 VNHAPANAQEHEAARPSPQHQyQPPYAS

AQPR Y92

znuC zinc transporter subunit: ATP-binding

component of ABC superfamily NP_416372.1 GAEQLGIyR Y228

Appendix IV

List of phosphotyrosine sites motifs identified in E. coli

Protein

accession Protein name

Phospho Tyr

site Peptide sequence Motif

NP_290410.1 ATP-dependent RNA helicase RhlB 124 AYGGDGyDKQLKV GpYxxxxK

NP_290203.1 ADP-heptose:LPS heptosyltransferase II 311 IRLITGyHKVRKG GpYxxxxK

NP_416823.1 erythronate-4-phosphate dehydrogenase 258 TSHIAGyTLEGKA GpYxxxxK

NP_289534.1 hypothetical protein Z4307 85 EVHIEGyTPEDKK GpYxxxxK

NP_287223.1 50S ribosomal protein L32 48 HITADGyYRGRKV GpYxxxxK

NP_287484.1 bifunctional acetaldehyde-CoA/alcohol

dehydrogenase 272 FATHGGyLLQGKE GpYxxxxK

NP_289869.1 50S ribosomal protein L5 83 FKIRQGyPIGCKV GpYxxxxK

NP_290202.1 ADP-L-glycero-D-mannoheptose-6-epimerase 288 NLRAAGyDKPFKT GpYxxxxK

NP_285862.1 methionine aminopeptidase 62 VSACLGyHGYPKS GpYxxxxK

NP_289521.1 Holliday junction resolvase-like protein 113 LFEQGGyRALNKG GpYxxxxK

NP_286918.1 cryptic autophosphorylating protein tyrosine

kinase Etk 720 GYNYYGySYSEKE GpYxxxxK

NP_289866.1 50S ribosomal protein L6 94 QLVGVGyRAAVKG GpYxxxxK

NP_415716.4 fused predicted dihydroxyacetone-specific PTS

enzymes: HPr component/EI component 357 KELSQQyQQLDDE KxxxxxpY

NP_285845.1 penicillin-binding protein 1b 28 KVSRRRyEDDDDY KxxxxxpY

NP_416600.4 fructose-bisphosphate aldolase class I 254 KAINYGyTDDRVY KxxxxxpY

NP_289062.1 inosine 5'-monophosphate dehydrogenase 402 KGSSDRyFQSDNA KxxxxxpY

NP_289194.1 hypothetical protein Z3939 56 KHVNQSyFRYGDK KxxxxxpY

NP_288540.1 GDP-mannose dehydratase 152 KESTPFyPRSPYA KxxxxxpY

NP_289882.1 30S ribosomal protein S10 65 KDARDQyEIRTHL KxxxxxpY

NP_286919.2 phosphotyrosine-protein phosphatase 121 KEIPDPyRKSQDA KxxxxxpY

NP_290372.1 F0F1 ATP synthase subunit gamma 208 KSWDYLyEPDPKA KxxxxxpY

NP_286805.1 asparaginyl-tRNA synthetase 120 KRHSIEyLREVAH KxxxxxpY

NP_286576.1 DNA starvation/stationary phase protection

protein Dps 16 KATNLLyTRNDVS KxxxxxpY

NP_290495.1 glutamine synthetase 327 KRLVPGyEAPVML KxxxxxpY

NP_290567.1 50S ribosomal protein L31 9 KDIHPKyEEITAS KxxxxxpY

NP_286805.1 asparaginyl-tRNA synthetase 332 KFENPVyWGVDLS KxxxxxpY

NP_289799.1 50S ribosomal protein L13 74 KRTDKVyYHHTGH KxxxxxpY

NP_290255.1 secreted protein EspD 137 KNSNEIyMDGQTK KxxxxxpY

NP_286918.1 cryptic autophosphorylating protein tyrosine

kinase Etk 711 KRASTAySYGYNY KxxxxxpY

NP_289137.1 autonomous glycyl radical cofactor GrcA 54 KLGDIEyREVPVE KxxxxxpY

NP_290325.1 heat shock protein IbpA 87 KERTYLyQGIAER KxxxxxpY

NP_418546.1 anaerobic class I fumarate hydratase (fumarase

B) 252 KLASAHyYDELPT KxxxxxpY

NP_285812.1 dihydrolipoamide dehydrogenase 374 KEKGISyETATFP KxxxxxpY

NP_418808.1 fused predicted transporter subunits of ABC

superfamily: ATP-binding components 108 KRLDEVyALYADP KxxxxxpY

NP_286567.1 hypothetical protein Z1024 77 KPAYTGyNRRGSK KxxxxxpY

NP_418653.1 fructose-1,6-bisphosphatase I 259 KGGIYLyPSTASH KxxxxxpY

NP_290254.1 secreted protein EspB 75 KQLAQSyQIQQAV KxxxxxpY

NP_289801.1 cytochrome d ubiquinol oxidase subunit III 50 KAELDEyREELVS KxxxxxpY

NP_290430.1 putative protoheme IX biogenesis protein 100 KLAEGDyQQVEKL KxxxxxpY

NP_286476.1 phosphoglyceromutase 92 KLNERHyGALQGL KxxxxxpY

NP_418755.4 predicted 2-hydroxyglutaryl-CoA dehydratase 95 KTDKCPyFYFSDL KxxxxxpY

NP_286332.1 alkyl hydroperoxide reductase subunit C 157 KIKAAQyVASHPG KxxxxxpY

NP_290491.1 hypothetical protein Z5402 146 QKLGLSyDDDEEE pYD

NP_415423.1 pyruvate formate lyase I 473 KGDVLNyDEVMER pYD

NP_418327.1 formate dehydrogenase formation protein 69 AQEVVLyDHPLEM pYD

NP_290495.1 glutamine synthetase 398 AMDKNLyDLPPEE pYD

NP_285862.1 methionine aminopeptidase 186 EPQVLHyDSRETN pYD

NP_288974.1 cell division protein ZipA 53 KRDDDSyDEDVED pYD

NP_290195.1 phosphoglyceromutase 368 SPKVATyDLQPEM pYD

NP_285860.1 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-

succinyltransferase 93 PMKFADyDEARFQ pYD

NP_416689.1 predicted ATP-dependent DNA or RNA

helicase 209 DMPVVQyDFSRLQ pYD

NP_289243.1 alanyl-tRNA synthetase 649 ALFGEKyDERVRV pYD

NP_285845.1 penicillin-binding protein 1b 37 DDDYDDyDDYEDE pYD

NP_290917.1 hypothetical protein Z5897 458 IRTQQLyDSAIEY pYD

NP_288215.1 glyceraldehyde-3-phosphate dehydrogenase 312 VKLVSWyDNETGY pYD

NP_289751.2 dihydropteroate synthase 154 MQEAPKyDDVFAE pYD

NP_287350.1 isocitrate dehydrogenase 391 NAKTVTyDFERLM pYD

NP_289107.1 serine hydroxymethyltransferase 11 EMNIADyDAELWQ pYD

NP_289886.1 elongation factor Tu 70 NTSHVEyDTPTRH pYD

NP_414871.1 cytosine deaminase 208 FALAQKyDRLIDV pYD

NP_285955.1 xanthine-guanine phosphoribosyltransferase 63 TVCISSyDHDNQR pYD

NP_290744.1 proline/glycine betaine transporter 467 EILVEHyDNIEQK pYD

NP_286476.1 phosphoglyceromutase 26 NRFTGWyDVDLSE pYD

NP_416129.1 fumarate hydratase (fumarase A), aerobic Class

I 253 LASAKYyDELPTE pYD


dehydrogenase 766 QTAFSQyDRPQAR pYD

NP_290611.1 elongation factor Tu 161 RELLSQyDFPGDD pYD

NP_285888.1 prolyl-tRNA synthetase 460 AAIEQNyDERGIV pYD

NP_285750.1 peptidyl-prolyl cis-trans isomerase SurA 120 MRSRLAyDGLNYN pYD

NP_290228.1 guanylate kinase 31 LKTQPLyDTQVSV pYD

NP_289878.1 50S ribosomal protein L2 83 VVERLEyDPNRSA pYD

NP_289869.1 50S ribosomal protein L5 143 IFPEIDyDKVDRV pYD

NP_285794.1 preprotein translocase subunit SecA 648 RKQLLEyDDVAND pYD

NP_290368.1 glucosamine--fructose-6-phosphate

aminotransferase 241 IESNLQyDAGDKG pYD

NP_288137.1 hypothetical protein Z2732 126 PNNLNKyDARIAA pYD

NP_286017.1 unknown protein encoded in ISEc8 85 TLTGRVyDPAVQR pYD

NP_289033.1 thioredoxin-dependent thiol peroxidase 116 SFMGKTyDGIHRI pYD

NP_290555.1 glycerol kinase 335 KLINDAyDSEYFA pYD

NP_290371.1 F0F1 ATP synthase subunit beta 27 DAVPRVyDALEVQ pYD

NP_290463.1 uridine phosphorylase 169 YPGQERyDTYSGR pYD

NP_286713.1 bifunctional enterobactin receptor/adhesin

protein 276 GSLTGGyDRTLRY pYD

NP_290648.1 peptidase E 49 TQTWDDyTAKTAA pYxxK

NP_415648.1 DNA-binding response regulator in two-

component regulatory system with PhoQ 98 SAGADDyVTKPFH pYxxK

NP_289868.1 30S ribosomal protein S14 20 VALADKyFAKRAE pYxxK

NP_288797.1 transcriptional regulator RcsB 146 KISAGGyGDKRLS pYxxK

NP_288870.1 acetate kinase 293 RYVEDNyATKEDA pYxxK

NP_289080.2 aminopeptidase B 204 TFDSGGySIKQTA pYxxK

YP_026161.1 regulator of ProP expression, post-translational 72 SSWRYLyGVKPGA pYxxK

NP_285783.1 phospho-N-acetylmuramoyl-pentapeptide-

transferase 328 APIHHHyELKGWP pYxxK

NP_286120.1 hypothetical protein Z0478 57 QVEGALyEVKPDA pYxxK

NP_287504.1 hypothetical protein Z2040 69 STIRVNyFIKDLW pYxxK


dehydrogenase 409 GGIGDLyNFKLAP pYxxK

NP_286014.1 50S ribosomal protein L31 type B 57 SKSHPFyTGKLRT pYxxK

NP_289107.1 serine hydroxymethyltransferase 59 NKYAEGyPGKRYY pYxxK

NP_290562.1 ATP-dependent protease ATP-binding subunit

HslU 91 KFTEVGyVGKEVD pYxxK

NP_290775.1 co-chaperonin GroES 71 VIFNDGyGVKSEK pYxxK

NP_288566.2 tyrosine kinase 713 DYGYYEyEYKSDA pYxxK

NP_417260.1 CTP synthetase 259 SQGLDDyICKRFS pYxxK

NP_418164.4 tryptophanase/L-cysteine desulfhydrase, PLP-

dependent 236 RFAENAyFIKQRE pYxxK

NP_415582.1 glutaredoxin 2 (Grx2) 11 IYDHCPyCLKARM pYxxK

NP_416540.1 UDP-galactopyranose mutase, FAD/NAD(P)-

binding 358 VISAALyQVKNIM pYxxK

NP_286656.1 hypothetical protein Z1121 291 NENSPFyTLKIDS pYxxK

YP_325626.1 hypothetical protein L7066 96 LRQASAyFAKAEF pYxxK

NP_285701.1 molybdenum cofactor biosynthesis protein

MogA 20 RASSGVyQDKGIP pYxxK

NP_416424.1 DNA-binding response regulator in two-

component regulatory system with BarA 101 QAGAAGyLSKGAA pYxxK

NP_288768.1 50S ribosomal protein L25 82 DVQRHPyKPKLQH pYxxK

NP_416769.1 conserved protein 63 ASDSYYyRAKQAV pYxxK

NP_289051.2 uracil phosphoribosyltransferase 113 TLEPVPyFQKLVS pYxxK

NP_416293.1 glyceraldehyde-3-phosphate dehydrogenase A 318 YDNETGySNKVLD pYxxK

NP_418438.1 malate synthase A 154 NEAGKIyQLKPNP pYxxK

NP_289029.1 phosphoribosylaminoimidazole-

succinocarboxamide synthase 8 QKQAELyRGKAKT pYxxK

NP_290675.2 glycerol-3-phosphate acyltransferase 95 PRVFTYyTPKEES pYxxK

NP_289611.1 esterase YqiA 123 LESRHIyDLKVMQ pYxxK

NP_290773.2 FxsA 140 NTFDGEyQRKDDD pYxxK

NP_416511.4 conserved protein, UPF0265 family 79 EDRVDDyIIKNAE pYxxK

NP_290066.1 universal stress protein; broad regulatory

function? 30 VSMARPyNAKVSL pYxxK

NP_287896.1 peptide transport permease protein 7 MPYDSVySEKRPP pYxxK

NP_288903.1 chorismate synthase 111 GHADYTyEQKYGL pYxxK

NP_289876.1 50S ribosomal protein L22 38 ALDILTyTNKKAA pYxxK


dependent 165 FDTGVRyDFKGNF pYxxK

NP_286778.1 formate acetyltransferase 1 613 ITSNVVyGKKTGN pYxxK


dependent 456 KGLTFTyEPKVLR pYxxK

NP_288436.1 hypothetical protein Z3071 22 NIQKTSySLTKME pYxxxK

NP_417018.4 aminopeptidase B 144 AGDRVTyRITKGE pYxxxK

NP_286386.1 (dimethylallyl)adenosine tRNA

methylthiotransferase 17 GCQMNEyDSSKMA pYxxxK

NP_290776.1 chaperonin GroEL 203 RGYLSPyFINKPE pYxxxK

NP_288255.1 PTS system mannose-specific transporter

subunit IID 171 RYYGVAyGYSKGI pYxxxK


dehydrogenase 581 DIRKRIyKFPKMG pYxxxK


dehydrogenase 384 QPARVSyFGQKMK pYxxxK

NP_288152.1 translation initiation factor IF-3 39 DYGKFLyEKSKSS pYxxxK

NP_289333.1 phosphopyruvate hydratase 422 LGEKAPyNGRKEI pYxxxK

NP_290675.2 glycerol-3-phosphate acyltransferase 94 GPRVFTyYTPKEE pYxxxK

NP_416543.1 glucose-1-phosphate thymidylyltransferase 286 NYGQYLyKMTKDS pYxxxK


dehydrogenase 80 EYIYNAyKDEKTC pYxxxK

NP_290830.1 30S ribosomal protein S6 49 GRRQLAyPINKLH pYxxxK

NP_288871.1 phosphate acetyltransferase 124 FAQSLNyEIAKTL pYxxxK


dehydrogenase 203 GMVKAAySSGKPA pYxxxK

NP_288301.1 hypothetical protein Z2916 132 TDGSVAyLFSKKG pYxxxK

NP_418361.1 glycerol kinase 332 DAYDSEyFATKVQ pYxxxK

NP_288559.1 GDP-D-mannose dehydratase 157 FYPRSPyAVAKLY pYxxxK

NP_289361.1 putative RNA 2'-O-ribose methyltransferase 140 AGVLANyETPKRP pYxxxK

NP_286388.1 asparagine synthetase B 64 AGAQPLyNQQKTH pYxxxK

NP_290216.1 50S ribosomal protein L33 21 AGTGHFyTTTKNK pYxxxK

NP_286761.1 translation initiation factor IF-1 60 TVELTPyDLSKGR pYxxxK

NP_286129.1 hypothetical protein Z0487 7 MLQSNEyFSGKVK pYxxxK

NP_286178.1 trigger factor 378 EEMASAyEDPKEV pYxxxK

NP_287227.1 3-ketoacyl-(acyl-carrier-protein) reductase 151 NGGQANyAAAKAG pYxxxK

NP_289492.2 fructose-bisphosphate aldolase 281 IKDSVSyGVVKMN pYxxxK

NP_418407.1 protein chain elongation factor EF-Tu

(duplicate of tufA) 310 KFESEVyILSKDE pYxxxK

NP_288385.1 flagellar capping protein 47 TAKLSAyGTLKSA pYxxxK

NP_288055.1 7-alpha-hydroxysteroid dehydrogenase 159 NINMTSyASSKAA pYxxxK


dependent 214 ANLKAMySIAKKY pYxxxK

NP_289801.1 cytochrome d ubiquinol oxidase subunit III 38 QQQALQyELEKNK pYxxxK

NP_290285.1 hypothetical protein Z5137 168 LWTIVKyLLPKSG pYxxxK

NP_289744.1 translation initiation factor IF-2 656 AREVALyRQGKFR pYxxxK

NP_417906.1 glycerophosphodiester phosphodiesterase,

cytosolic 213 GLRILVyTVNKPQ pYxxxK

NP_416034.1 putative autoinducer-2 (AI-2) aldolase 205 AQIIKTyYVEKGF pYxxxK


dehydrogenase 77 FASEYIyNAYKDE pYxxxK

NP_288864.1 aminotransferase AlaT 68 LPTAQGyCDSKGL pYxxxK

NP_290776.1 chaperonin GroEL 360 EEATSDyDREKLQ pYxxxK

NP_287223.1 50S ribosomal protein L32 49 ITADGYyRGRKVI pYxxxK

Appendix V

List of 192 phosphopeptides as upregulated and 92 as downregulated upon

TSLP stimulation

Gene

Symbol Protein name RefSeq ID Peptide Sequence Phosphosite

Raio of TSLP-

stimulation vs

unstimulated

Mean Std.

Dev

2010007H12Rik

hypothetical protein LOC69871

NP_081518.1 APEPEPGLDLSLSPSPLPEsPKAR

S20 0.61 NA

2410004B

18Rik

hypothetical protein

LOC66421 NP_079831.1

LLPEGEETVEsDDDKDE

R S11 4.93 4.20

4921513D23Rik

limkain-b1 NP_001074623.1 NTGVTEPLyR Y9 1.80 NA

6430527

G18Rik

enhanced at puberty

protein 1 NP_665835.1

AHGCFQDGRsPGPPPPV

GVK S10 6.16 NA

Add1 alpha-adducin isoform 3 | alpha-adducin isoform 2 |

alpha-adducin isoform 1

NP_001095914.1 | NP_038485.1 |

NP_001019629.2

AAVVTsPPPTTAPHKER S6 2.85 NA



NP_001095914.1 | NP_038485.1 |

NP_001019629.2

AAVVTSPPPtTAPHKER T10 2.85 NA



NP_001095914.1 | NP_038485.1 |

NP_001019629.2

AAVVTSPPPTtAPHKER T11 2.85 NA

Add3

gamma-adducin isoform

b | gamma-adducin

isoform a

NP_001157572.1 |

NP_001157571.1

SSDTSPAVVTTPPPPsMP

HKER S16 1.70 NA

Add3


b | gamma-adducin isoform a

NP_001157572.1 |

NP_001157571.1

SPERTEEVLSPDGsPSKs

PSK S14,S18 0.58 NA

Add3


b | gamma-adducin

isoform a

NP_001157572.1 | NP_001157571.1

SPERTEEVLSPDGSPsKSPSK

S16 0.57 NA

Agfg1

arf-GAP domain and FG

repeats-containing protein

1

NP_034602.1 SLLGESAPALHLNKGtPsQSPVVGR

T16,S18 0.43 NA

Agfg1 arf-GAP domain and FG repeats-containing protein

1

NP_034602.1 SLLGESAPALHLNKGtP

SQsPVVGR T16,S20 0.43 NA

Ahctf1 protein ELYS NP_080651.2 SGFRTtPLAsPsLSPGR T6,S10,S12 3.16 NA

Ahctf1 protein ELYS NP_080651.2 TTPLAsPSLsPGR S6,S10 1.81 NA

Akap13 A kinase (PRKA) anchor


ISAASEEEAVGNGAAtP

K T16 1.84 NA

Akap13 A kinase (PRKA) anchor protein 13

NP_083608.1 SAMEDVTVADAsPATAEPR

S12 1.61 0.00

Akt1

RAC-alpha

serine/threonine-protein kinase isoform 2 | RAC-

alpha serine/threonine-

protein kinase isoform 1

NP_001159366.1 |

NP_033782.1

SGSPsDNSGAEEMEVSL

AKPK S5 0.66 NA

Apex1 DNA-(apurinic or

apyrimidinic site) lyase NP_033817.1 AAADDGEEPKsEPETK S11 0.54 NA

Appl1 DCC-interacting protein

13-alpha NP_660256.1

VNQSALEAVTPsPSFQQ

R S12 0.35 0.30

Arhgap21

rho GTPase-activating

protein 21 isoform 2 | rho

GTPase-activating protein

21 isoform 1

NP_001074833.3 |

NP_001121556.2 KGsSSEVFSDAAR S3 1.93 NA

Atf2

cyclic AMP-dependent

transcription factor ATF-2

isoform 1

NP_001020264.1 NDsVIVADQtPtPTR S3,T10,T12 2.70 NA

Atf2


transcription factor ATF-2

isoform 2 | cyclic AMP-dependent transcription

factor ATF-2 isoform 1

NP_033845.1 |

NP_001020264.1 NDsVIVADQtPtPTR S13 1.62 NA

Atf2


transcription factor ATF-2 isoform 1

NP_001020264.1 NDSVIVADQtPtPTR T10,T12 1.53 0.31

Atf7 cyclic AMP-dependent

transcription factor ATF-7 NP_666177.1 tDSVIIADQtPtPTR T1,T10,T12 1.94 NA

Atf7 cyclic AMP-dependent transcription factor ATF-7

NP_666177.1 TDSVIIADQtPtPTR T10,T12 1.82 0.04

Atrx transcriptional regulator

ATRX NP_033556.2

LHDFLAHSSEESEETCSs

PR S18 3.79 NA

AW555464

hypothetical protein LOC217882

NP_001019773.2 GAsPVtPSTtPPPPTDPQLTK

S3,T6,T10 0.53 NA

B230219

D22Rik


LOC78521 NP_851795.1 VVHGLQETSGEVKPPsE S16 0.62 0.14

Bod1l biorientation of chromosomes in cell

division 1-like

NP_001074891.1 RLsVLGR S3 2.50 0.01

Bod1l biorientation of chromosomes in cell

division 1-like

NP_001074891.1 SLtSSDDAESSEPER T3 1.72 0.19

Bod1l

biorientation of

chromosomes in cell division 1-like

NP_001074891.1 sLTSSDDAESSEPER S1 1.66 0.17

Brd4 bromodomain-containing

protein 4 isoform 1 NP_065254.3 IHsPIIR S3 1.68 NA

Btk tyrosine-protein kinase BTK

NP_038510.2 YVLDDEyTSSVGSKFPVR

Y7 2.79 0.23

Cad

carbamoyl-phosphate

synthetase 2, aspartate transcarbamylase, and

dihydroorotase

NP_076014.1 IHRAsDPGLPAEEPK S5 2.40 NA

Cad

carbamoyl-phosphate synthetase 2, aspartate

transcarbamylase, and

dihydroorotase

NP_076014.1 IHRAsDPGLPAEEPKEKP

PR S5 1.60 NA

Calm2 calmodulin NP_031615.1 VFDKDGNGyISAAELR Y9 1.81 0.14

Camsap1 calmodulin-regulated spectrin-associated

protein 1

NP_001108548.1 APVHFVEPLsPTGVPGH

R S10 2.38 NA

Casc5 protein CASC5 NP_083893.2 RVsFADTIK S3 2.51 NA

Cd3eap

DNA-directed RNA

polymerase I subunit RPA34

NP_665821.1 TALGNLGVsVK S9 0.62 NA

Cd84 SLAM family member 5

precursor NP_038517.1 NAQPTESRIyDEIPQSK Y10 2.46 0.01

Cd84 SLAM family member 5 precursor

NP_038517.1 KTVyAVVSR Y4 1.63 NA

Cdca8 borealin NP_080836.3 RLsHDFVTPAMSR S3 1.64 0.20

Cdv3

protein CDV3 isoform d |

protein CDV3 isoform c |

protein CDV3 isoform b | protein CDV3 isoform a

NP_001127899.1 | NP_001127898.1 |

NP_787027.1 | NP_780774.1

KTPQGPPEIySDTQFPSL

QSTAK Y10 3.07 0.16

Cep135 centrosomal protein of

135 kDa NP_950197.1 IVsEQLQR S3 0.01 0.00

Chchd3

coiled-coil-helix-coiled-coil-helix domain-

containing protein 3,

mitochondrial precursor

NP_079612.1 YsSVYGASVSDEDLK S2 0.65 NA

Chd8 chromodomain-helicase-

DNA-binding protein 8 NP_963999.2 LTsQDYEVR S3 1.64 NA

Chek1 serine/threonine-protein

kinase Chk1 NP_031717.2 AtSGGMSESSSGFSK T2 1.80 NA

Cic

protein capicua homolog

isoform c | protein

capicua homolog isoform b | protein capicua

homolog isoform a

NP_001103602.1 |

NP_001103601.1 | NP_082158.2

KVFsPVIR S4 1.79 NA

Clasp2

CLIP-associating protein

2 isoform b | CLIP-associating protein 2

isoform a | CLIP-

associating protein 2 c

NP_001075429.1 | NP_083909.2 |

NP_001107819.1

ASLLHSMPLHSsPR S12 3.14 NA

Clec4a3 dendritic cell inhibitory

receptor 3 NP_694877.2 ysQLLEEKMIIK Y1,S2 0.01 NA

Clptm1l

cleft lip and palate

transmembrane protein 1-

like protein

NP_666159.1 fERtVNVsVPKK T4,S8 0.09 NA

Crtc2 CREB-regulated transcription coactivator 2

NP_083157.1 RVPLsPLSLPAGPADAR S5 2.79 0.24

Crtc2 CREB-regulated

transcription coactivator 2 NP_083157.1

LPPYPySPPSLVIPTHPPt

PK Y6,T19 2.28 NA

Crtc2 CREB-regulated transcription coactivator 2

NP_083157.1 LPPYPYsPPSLVIPTHPPtPK

S7,T19 2.28 NA

Csf2rb

cytokine receptor

common subunit beta precursor

NP_031806.3

VPSGSPALGPPGFEDYV

ELPPSVsQAAKSPPGHPAPPVASsPTVIPGEPR

S24,S41 3.41 NA

Csnk1d

casein kinase I isoform

delta isoform 2 | casein

kinase I isoform delta isoform 1

NP_082150.1 | NP_620690.1 LRGTQEVAPPTPLTPTS

HTANTsPRPVSGMER S23 0.65 NA

Ctnnd1

catenin delta-1 isoform 4

| catenin delta-1 isoform 2 | catenin delta-1

isoform 1

NP_001078922.1 |

NP_001078917.1 |

NP_031641.2

LNGPQDHNHLLySTIPR Y12 2.91 0.01

Ctnnd1

catenin delta-1 isoform 4

| catenin delta-1 isoform 3 | catenin delta-1

isoform 2 | catenin delta-1 isoform 1

NP_001078922.1 |

NP_001078918.1 |

NP_001078917.1 | NP_031641.2

VGGsSVDLHR S4 1.90 NA

Dag1 dystroglycan precursor NP_034147.1 LTLEDQAtFIKK T8 0.19 NA

Dapp1

dual adapter for

phosphotyrosine and 3-

phosphotyrosine and 3-phosphoinositide

NP_036062.1 EVEEPCIyESVR Y8 8.53 0.49

Dbnl

drebrin-like protein

isoform 3 | drebrin-like

protein isoform 2 | drebrin-like protein

isoform 1

NP_001139781.1 |

NP_038838.1 | NP_001139780.1

LRsPFLQK S3 2.38 0.38

Ddx55

ATP-dependent RNA helicase DDX55 isoform

2 | ATP-dependent RNA

helicase DDX55 isoform 1

NP_001177724.1 | NP_080685.2

KKDEGsDIDDEDMEELLNDTR

S6 0.58 NA

Dido1

death-inducer obliterator

1 isoform 3 | death-

inducer obliterator 1 isoform 2

NP_780760.2 | NP_808520.2 LGPVsPAPSQPNSQIR S5 1.76 NA

Dlg1 disks large homolog 1 NP_031888.2 EQMMNSSVSSGSGsLR S14 0.56 NA

Dnahc7b dynein, axonemal, heavy

chain 7B NP_001153858.1

FDSSGIYFVPPsGDHKsY

INytK

S12,S17,Y2

1,T22 0.01 NA

Dner delta and Notch-like epidermal growth factor-

related receptor precursor

NP_690879.1 LVSFEVPQNtSVK T10 0.01 NA

Dner

delta and Notch-like

epidermal growth factor-related receptor precursor

NP_690879.1 LVSFEVPQNTsVK S11 0.01 NA

Dock10 dedicator of cytokinesis

protein 10 NP_780500.2 ASLAsLDsNPSTTEK S5,S8 0.53 NA


protein 2 NP_203538.2 IKEEMSKDQPDYGVySR Y15 1.95 NA



LTPFHSPSPLQSTALsPP

PLtPK S16,T21 1.50 NA

Dok2 docking protein 2 NP_034201.1 SGSPCMEENELySSSTT

GLCK Y12 1.67 NA

Edc4 enhancer of mRNA-

decapping protein 4 NP_853625.1

tRSPDVISSASTALSQDIP

EIASEALSR T1 0.01 NA

Eef2 elongation factor 2 NP_031933.1 EDLyLKPIQR Y4 0.01 NA

Eif2s2 eukaryotic translation initiation factor 2 subunit

2

NP_080306.1 sGDEMIFDPTMsKK S1,S12 0.45 0.06

Epb4.1l2 band 4.1-like protein 2 NP_038539.2 SyNLVVAK Y2 0.62 NA

Epb4.1l2 band 4.1-like protein 2 NP_038539.2 sYNLVVAK S1 0.60 0.04

Eprs bifunctional aminoacyl-

tRNA synthetase NP_084011.1 GFFICDQPYEPVSPYsCR S16 3.90 NA

Eprs bifunctional aminoacyl-

tRNA synthetase NP_084011.1 GFFICDQPYEPVSPySCR Y15 3.48 0.60

Etv3 ETS translocation variant

3 NP_036181.3 SsGVVPQsAPPVPTASSR S2,S8 1.92 NA

Fam120a

constitutive coactivator

of PPAR-gamma-like

protein 1

NP_001028440.2 NLTEQNSySNIPHEGK Y8 100.00 NA

Fam63a

hypothetical protein LOC75007 isoform 2 |


LOC75007 isoform 1

NP_598619.2 | NP_955769.1 VETAEVCSRPQELPQsP

R S16 1.90 NA

Fap seprase NP_032012.1 SKKyPLLIQVyGGPCSQS

VK Y4,Y11 0.63 NA

Fcer1g

high affinity

immunoglobulin epsilon receptor subunit gamma

precursor

NP_034315.1 EKADAVyTGLNTR Y7 3.58 0.13

Fcer1g

high affinity immunoglobulin epsilon

receptor subunit gamma

precursor

NP_034315.1 ADAVyTGLNTR Y5 3.23 NA

Fes tyrosine-protein kinase Fes/Fps

NP_034324.2 ISDFGMSREEADGIyAASAGLR

Y15 12.58 NA

Flcn folliculin NP_666130.1 VRAHsPAEGASSESSSP

GPK S5 0.67 0.01

Flcn folliculin NP_666130.1 AHsPAEGASSESSSPGPK S3 0.57 NA

Fyn|Lck|S

rc|Yes1

tyrosine-protein kinase Fyn isoform b | tyrosine-

protein kinase Fyn

isoform a | proto-

oncogene tyrosine-protein

kinase Yes | proto-

oncogene tyrosine-protein kinase LCK isoform b |

proto-oncogene tyrosine-

protein kinase LCK isoform a | neuronal

proto-oncogene tyrosine-

protein kinase Src isoform 2 | neuronal proto-


kinase Src isoform 1

NP_032080.2 |

NP_001116365.1 | NP_033561.1 | NP_034823.1 |

NP_001155904.1 |

NP_001020566.1 | NP_033297.2

LIEDNEyTAR Y7 2.24 1.59

Fyn|Src|Y

es1

tyrosine-protein kinase

Fyn isoform b | tyrosine-

protein kinase Fyn isoform a | proto-


kinase Yes | neuronal proto-oncogene tyrosine-

protein kinase Src isoform

2 | neuronal proto-oncogene tyrosine-protein

kinase Src isoform 1

NP_032080.2 |

NP_001116365.1 |

NP_033561.1 | NP_001020566.1 |

NP_033297.2

LIEDNEyTARQGAK Y7 3.58 0.28

Gatad2b transcriptional repressor p66-beta

NP_647465.1 VSSPLPsPSAMSDAANSQAAAK

S7 2.69 NA

Gatad2b transcriptional repressor

p66-beta NP_647465.1

VsSPLPsPSAMSDAANS

QAAAK S2,S7 2.30 NA

Gatad2b transcriptional repressor p66-beta

NP_647465.1 VSsPLPSPSAMSDAANSQAAAK

S3 0.57 0.05

Gatad2b transcriptional repressor

p66-beta NP_647465.1

VsSPLPSPSAMSDAANS

QAAAK S2 0.56 0.03

Gpr126 G-protein coupled receptor 126 precursor

NP_001002268.1 SISIPELKAFtLCFEASK T11 0.01 NA

Gpsm3 G-protein-signaling

modulator 3 NP_598877.1

LLEDKEQLySTILSHQC

QR Y9 5.82 0.46

Hbq1a|Hb

q1b|Hpse2|Ush2a

Usherin precursor | heparanase-2 |

hemoglobin, theta T2 |

hemoglobin, theta T1

NP_067383.3 | NP_001074726.1 |

NP_778165.1 |

NP_001029153.1

LVtLAR T3 0.01 NA

Hcfc1 host cell factor 1 NP_032250.2 VASsPVMVSNPATR S4 2.14 0.33

Hcfc1 host cell factor 1 NP_032250.2 VAsSPVMVSNPATR S3 1.91 NA

Hck


HCK isoform p56Hck | tyrosine-protein kinase

HCK isoform p59Hck

NP_001165588.1 | NP_034537.2

IIEDNEyTAR Y7 2.24 1.59

Hemgn hemogen NP_444379.1 MCHDVARPEVLsPK S12 100.00 NA

Hn1l

hematological and

neurological expressed 1-like protein

NP_945175.1 MFQGADSQAGKsGSR S12 0.51 0.11

Hpd

4-

hydroxyphenylpyruvate

dioxygenase

NP_032303.1 KKsQIQEyVDYNGGAGVQHIALK

S3,Y8 0.01 NA

Hsh2d

hematopoietic SH2

domain-containing

protein

NP_922935.1 NLRSLPQtSQRVK T8 0.01 NA

Hsp90aa1 heat shock protein HSP 90-alpha

NP_034610.1 LVTSPCCIVTSTyGWTANMER

Y13 1.80 0.15

Icam2 intercellular adhesion

molecule 2 precursor NP_034624.1 TGTyGVLAAWRR Y4 3.34 NA

Icam2 intercellular adhesion molecule 2 precursor

NP_034624.1 TGTyGVLAAWR Y4 3.26 NA

Inppl1

phosphatidylinositol-

3,4,5-trisphosphate 5-phosphatase 2

NP_034697.2 NSFNNPAyYVLEGVPH

QLLPLEPPSLAR Y8 6.63 0.08

Irs2 insulin receptor substrate

2 NP_001074681.1

SGGPNSCKSDDyMPMS

PTSVSAPK Y12 0.40 NA

Itgb3 integrin beta-3 precursor NP_058060.2 AKWDTANNPLyKEATSTFTNITYR

Y11 3.66 NA

Itsn2 intersectin-2 isoform 2 |

intersectin-2 isoform 1

NP_035495.2 |

NP_001185897.1 GEPEALyAAVTK Y7 2.04 0.09

Jak2 tyrosine-protein kinase

JAK2 NP_032439.2

REVGDyGQLHKTEVLL

K Y6 1.56 0.07

Junb transcription factor jun-B NP_032442.1 LIVPNSNGVITTtPtPPGQ

YFYPR T13,T15 3.75 NA

Kdm3b lysine-specific demethylase 3B

NP_001074725.1 RFsLDER S3 3.45 NA

Larp4b la-related protein 4B NP_766173.1 NLsTDASTNTVPVVGPR S3 4.52 NA

Larp4b la-related protein 4B NP_766173.1 NGFRPLDMNLyTQQR Y11 2.06 NA

Lass4 LAG1 longevity

assurance homolog 4 NP_080334.3

SDVEEPDssDDEPVSEGP

QLK S8,S9 0.64 NA

Lbp lipopolysaccharide-

binding protein precursor NP_032515.2 LGVVtNVFASLtFNNSK T5,T12 0.01 NA

Lcp1 plastin-2 NP_032905.2 VDTDGNGyISCNELNDL

FK Y8 2.83 NA

Lcp1 plastin-2 NP_032905.2 ARGsVsDEEMMELR S4,S6 1.99 NA

Lcp1 plastin-2 NP_032905.2 ARGsVSDEEMMELR S4 1.70 0.34

Lcp1 plastin-2 NP_032905.2 GsVSDEEMMELR S2 1.67 0.24

Lcp1 plastin-2 NP_032905.2 ARGSVsDEEMMELR S6 1.59 0.84

Ldlrap1 low density lipoprotein receptor adapter protein 1

NP_663529.2 ALIRsPSLAK S5 2.71 NA

Lmna prelamin-A/C isoform C |

prelamin-A/C isoform A

NP_001104572.1 |

NP_001002011.2 SGAQASSTPLsPTR S11 1.66 0.17

Lmna prelamin-A/C isoform C | prelamin-A/C isoform A

NP_001104572.1 | NP_001002011.2

SGAQASStPLsPTR T8,S11 1.61 NA

Lmnb1 lamin-B1 NP_034851.2 AsAPATPLsPTRLSR S2,S9 2.16 NA

Lpp lipoma-preferred partner

homolog isoform 1 NP_001139424.1

STGEPLGHVPARMETtH

SFGNPSIsVStQQPPKK

T16,S25,T2

8 0.01 NA

Lrrfip1 leucine-rich repeat flightless-interacting

protein 1 isoform 1

NP_001104781.1 AENQRPAEDSALsPGPL

AGAK S13 2.34 0.75

Lsm11 U7 snRNA-associated Sm-like protein LSm11

NP_082461.1 AGsPAsPPSPR S3,S6 0.57 NA

Lyn


Lyn isoform B | tyrosine-

protein kinase Lyn isoform A

NP_034877.2 |

NP_001104566.1 VIEDNEyTAR Y7 8.16 4.10

Lyn tyrosine-protein kinase


NP_034877.2 |

NP_001104566.1 VIEDNEYtAREGAK T8 8.04 NA

protein kinase Lyn

isoform A

Lyn



protein kinase Lyn isoform A

NP_034877.2 |

NP_001104566.1 VIEDNEyTAREGAK Y7 7.91 0.22

Madd

MAP kinase-activating

death domain protein

isoform 9 | MAP kinase-activating death domain

protein isoform 7 | MAP

kinase-activating death domain protein isoform 6

| MAP kinase-activating

death domain protein isoform 5 | MAP kinase-

activating death domain

protein isoform 4 | MAP kinase-activating death

domain protein isoform 3

| MAP kinase-activating death domain protein

isoform 2 | MAP kinase-

activating death domain protein isoform 13 | MAP

kinase-activating death domain protein isoform

12 | MAP kinase-

activating death domain protein isoform 11 | MAP

kinase-activating death

domain protein isoform 10 | MAP kinase-

activating death domain

protein isoform 1

NP_663502.3 |

NP_001171200.1 |

NP_001171199.1 |

NP_001171198.1 |

NP_001171197.1 | NP_001171196.1 |

NP_001171195.1 |

NP_001171193.1 | NP_001171192.1 |

NP_001171191.1 |

NP_001171190.1 | NP_001171194.1

ATLsDSEIETNSATSAIF

GK S4 5.23 NA

Map2k1|Map2k2

dual specificity mitogen-activated protein kinase

kinase 2 | dual specificity

mitogen-activated protein kinase kinase 1

NP_075627.2 | NP_032953.1 LCDFGVSGQLIDSMANsFVGTR

S17 3.63 0.59

Mapk1 mitogen-activated protein

kinase 1 NP_036079.1

VADPDHDHTGFLtEyVA

TR T13,Y15 68.32

30.0

3

Mapk1 mitogen-activated protein kinase 1

NP_036079.1 VADPDHDHTGFLTEyVATR

Y15 51.59 44.3

3



VADPDHDHTGFLtEYV

ATR T13 14.91 NA


NP_038899.1 QADSEMTGyVVTR Y9 2.77 NA



IADPEHDHTGFLTEYVA

tR T18 100.00 NA


NP_036082.1 IADPEHDHTGFLtEyVATR

T13,Y15 67.19 46.4

0



IADPEHDHTGFLTEyVA

TR Y15 34.45

38.1

5

Mapk8|Mapk10

mitogen-activated protein

kinase 8 | mitogen-

activated protein kinase 10 isoform 2 | mitogen-

activated protein kinase

10 isoform 1

NP_057909.1 |

NP_001075036.1 |

NP_033184.2

TAGTSFMMtPyVVTR T9,Y11 2.82 0.79

Mapk9

mitogen-activated protein kinase 9 isoform beta2 |


kinase 9 isoform beta1 | mitogen-activated protein

kinase 9 isoform alpha2 |

mitogen-activated protein kinase 9 isoform alpha1

NP_001157143.1 |

NP_058657.1 | NP_997575.2 |

NP_001157144.1

TACTNFMMtPyVVTR T9,Y11 2.66 0.37

Mapk9


kinase 9 isoform beta2 | mitogen-activated protein

kinase 9 isoform beta1 |

mitogen-activated protein kinase 9 isoform alpha2 |


NP_001157143.1 |

NP_058657.1 | NP_997575.2 |

NP_001157144.1

TACTNFMMTPyVVTR Y11 1.59 0.38

kinase 9 isoform alpha1

Mavs mitochondrial antiviral-

signaling protein NP_659137.1 VTTGGNQTGPNSsIR S13 0.61 0.00

Mdc1 mediator of DNA damage checkpoint

protein 1

NP_001010833.2 IRIEsQNSR S5 4.80 0.20

Med24 mediator of RNA polymerase II

transcription subunit 24

NP_035999.2 LLsSSDDDANILSsPTDR S3,S14 1.70 0.05

Med24

mediator of RNA

polymerase II transcription subunit 24

NP_035999.2 LLSSSDDDANILSsPTDR S14 0.48 0.21

Micall1 MICAL-like protein 1 NP_803412.1 APsAsPLAIHASR S3,S5 0.33 NA

Mki67 antigen KI-67 NP_001074586.2 RAsRDSFCADPDGEGQ

DTK S3 1.75 NA

Mprip

myosin phosphatase Rho-interacting protein

isoform 2 | myosin

phosphatase Rho-interacting protein

isoform 1

NP_036157.2 | NP_957697.1 VRVESGyFSLEK Y7 1.60 NA

Mtdh protein LYRIC NP_080278.3 KREEAAPPtPAPDDLAQ

LK T9 1.99 0.01

Mtmr10 myotubularin-related

protein 10 NP_766330.2 SGPLEACyAELDQSR Y8 2.98 NA

Naglu alpha-N-

acetylglucosaminidase NP_038820.2

ALADESGLDtysLSGGG

GVPVLVRGSTGVAAAAGLHR

T10,Y11,S1

2 0.01 NA

Nav1 neuron navigator 1 NP_775613.2 GQLTNIVsPTAATTPR S8 4.20 NA

Ncapd2 condensin complex

subunit 1 NP_666283.1

LQPLTsVDSDNDFVTPK

PR S6 4.50 0.71

Ncapd2 condensin complex subunit 1

NP_666283.1 LQPLTsVDsDNDFVTPKPR

S6,S9 1.55 NA

Ncoa3 nuclear receptor

coactivator 3 NP_032705.2 AVsLDsPVSVGSGPPVK S3,S6 2.48 NA

Nedd4l

E3 ubiquitin-protein ligase NEDD4-like

isoform 2 | E3 ubiquitin-

protein ligase NEDD4-like isoform 1

NP_114087.2 | NP_001107858.1

SLSsPTVTLSAPLEGAK S4 0.67 NA

Nedd4l

E3 ubiquitin-protein

ligase NEDD4-like isoform 2 | E3 ubiquitin-

protein ligase NEDD4-

like isoform 1

NP_114087.2 |

NP_001107858.1 SLsSPTVTLSAPLEGAK S3 0.67 0.02

Nedd4l

E3 ubiquitin-protein ligase NEDD4-like

isoform 2 | E3 ubiquitin-

protein ligase NEDD4-like isoform 1

NP_114087.2 |

NP_001107858.1 sLSSPTVTLSAPLEGAK S1 0.67 0.01

Nedd4l

E3 ubiquitin-protein

ligase NEDD4-like isoform 2 | E3 ubiquitin-

protein ligase NEDD4-

like isoform 1

NP_114087.2 |

NP_001107858.1 tSPQELSEEVSR T1 0.63 NA

Nsdhl

sterol-4-alpha-

carboxylate 3-

dehydrogenase, decarboxylating

NP_035071.3 MEQAVHGEsK S9 0.45 NA

Numa1 nuclear mitotic apparatus

protein 1 NP_598708.3 RVSSEtHQGPGTPESK T6 100.00 NA

Nup153 nucleoporin 153 NP_786925.2 RIPSAVSSPLNsPLDR S12 100.00 NA

Optn optineurin NP_862896.1 HGARTsDSDQQTYLFQ

R S6 7.89 NA

Optn optineurin NP_862896.1 NCPtPTRTDPISLSNCTE

DAR T4 7.50 NA

Oxtr oxytocin receptor NP_001074616.1 LVKYLQVVGMFAstYLL

LLMsLDR

S13,T14,S2

1 100.00 NA

Oxtr oxytocin receptor NP_001074616.1 LVKYLQVVGMFAStyLL

LLMsLDR

T14,Y15,S2

1 100.00 0.00

Pabpc1 polyadenylate-binding NP_032800.2 QAHLTNQyMQR Y8 1.52 0.15

protein 1

Pag1

phosphoprotein

associated with glycosphingolipid-

enriched microdomains 1

NP_444412.2 ESDyESIGDLQQCR Y4 2.30 NA

Pag1

phosphoprotein

associated with glycosphingolipid-


NP_444412.2 SSSSCNDLyATVK Y9 2.02 NA

Pag1

phosphoprotein associated with

glycosphingolipid-


NP_444412.2

SREEDPTLTEEEISAMyS

SVNKPGQSAHKPGPCMK

Y17 0.45 NA

Pak1ip1 p21-activated protein kinase-interacting protein

1

NP_080826.2 SDVSGDSKQPTKGNsPV

TAK S15 0.55 NA

Pank1 pantothenate kinase 1 isoform 1

NP_001107811.1 RAPRPGsTEVPAAAR S7 7.34 NA

Pcnp PEST proteolytic signal-

containing nuclear protein NP_001019793.1 DTPTSAGPNsFNKGK S10 0.60 0.05

Pcnp PEST proteolytic signal-containing nuclear protein

NP_001019793.1 DTPTSAGPNsFNK S10 0.58 NA

Pdlim5

PDZ and LIM domain

protein 5 isoform ENH4 |

PDZ and LIM domain protein 5 isoform ENH3b

| PDZ and LIM domain protein 5 isoform ENH3a

| PDZ and LIM domain

protein 5 isoform ENH2 | PDZ and LIM domain

protein 5 isoform ENH1e

| PDZ and LIM domain protein 5 isoform ENH1d


protein 5 isoform ENH1c | PDZ and LIM domain

protein 5 isoform ENH1b

| PDZ and LIM domain protein 5 isoform ENH1

NP_001177782.1 |

NP_072048.2 | NP_001177786.1 |

NP_062783.2 |

NP_001177781.1 | NP_001177785.1 |

NP_001177784.1 |

NP_001177783.1 | NP_062782.2

NTEFyHIPTHSDASK Y5 2.28 0.34

Pdlim5

PDZ and LIM domain

protein 5 isoform ENH1e

| PDZ and LIM domain protein 5 isoform ENH1d


protein 5 isoform ENH1c | PDZ and LIM domain

protein 5 isoform ENH1b


protein 5 isoform ENH1

NP_001177781.1 |

NP_001177785.1 | NP_001177784.1 |

NP_001177783.1 |

NP_062782.2

SAAAFKPVGSTsVK S12 0.47 0.06

Pds5a sister chromatid cohesion

protein PDS5 homolog A NP_001074790.1 IIsVTPVKNIDTVK S3 0.62 NA

Phf14 PHD finger protein 14 isoform 2 | PHD finger

protein 14 isoform 1

NP_083680.2 | NP_001161854.1

NSADDEELtNDsLTLSQSK

T9,S12 0.64 NA

Phldb1 pleckstrin homology-like domain family B member

1

NP_705765.3 RALsPLPAR S4 2.50 NA

Pi4k2a phosphatidylinositol 4-kinase type 2-alpha

NP_663476.1 VAAAAGSGPsPPCSPGHDRER

S10 0.41 0.07

Picalm

phosphatidylinositol-

binding clathrin assembly

protein

NP_666306.2 SGQSLTDRITAAQHsVTGSAVSK

S15 0.59 NA

Pik3ca

phosphatidylinositol-4,5-

bisphosphate 3-kinase

catalytic subunit alpha isoform

NP_032865.2 LCVLEyQGK Y6 100.00 NA

Pik3ca

phosphatidylinositol-4,5-

bisphosphate 3-kinase

catalytic subunit alpha isoform

NP_032865.2 LCVLEyQGKYILK Y6 100.00 NA

Pin4

peptidyl-prolyl cis-trans

isomerase NIMA-interacting 4

NP_081457.1 FGyHIIMVEGR Y3 100.00 NA

Plec

plectin isoform 1hij |

plectin isoform 1g | plectin isoform 1f |

plectin isoform 1e |

plectin isoform 1d | plectin isoform

1c2alpha3alpha | plectin

isoform 1c | plectin isoform 1b2alpha |

plectin isoform 1b |

plectin isoform 1a | plectin isoform 12alpha |

plectin isoform 1

NP_001157675.1 |

NP_958795.2 | NP_958787.2 |

NP_958788.2 | NP_958792.2 | NP_001157014.1 |

NP_035247.2 |

NP_001157021.1 | NP_958793.2 | NP_958796.2 |

NP_001157012.1 |

NP_958791.2

AVTGYKDPySGK Y9 7.75 NA

Plek pleckstrin NP_062422.1 sIRLPETIDLGALYLSMKDPEK

S1 0.55 0.09

Plek pleckstrin NP_062422.1 SIRLPEtIDLGALYLSMK

DPEK T7 0.51 NA

Poldip3 polymerase delta-interacting protein 3

NP_848742.1 sPAAFTSPPIGTVTPALK S1 0.62 0.00

Ppfia1 liprin-alpha-1 isoform B |

liprin-alpha-1 isoform A

NP_001028491.1 |

NP_001182015.1 VTSSMsSPSMQPK S6 0.66 NA

Ppp1r11 protein phosphatase 1 regulatory subunit 11

NP_083908.1 CCCIyEKPR Y5 3.34 NA

Ppp1r12a protein phosphatase 1

regulatory subunit 12A NP_082168.1 RLAsTSDIEEKENR S4 44.40 NA

Ppp1r12a protein phosphatase 1 regulatory subunit 12A

NP_082168.1 RSTQGVtLTDLQEAEKTIGR

T7 0.32 0.12

Ppp1r12a|Ppp1r12b

protein phosphatase 1

regulatory subunit 12B | protein phosphatase 1

regulatory subunit 12A

NP_001074776.1 | NP_082168.1

RStQGVTLTDLQEAEK T3 0.50 NA

Ppp1r12c protein phosphatase 1

regulatory subunit 12C NP_084110.2

ALNGVSsPVSSNPKsPVL

PEEAPFSR S7,S15 2.94 NA

Ppp1r12c protein phosphatase 1

regulatory subunit 12C NP_084110.2 RStQGVTLTDLK T3 0.39 NA

Prkca protein kinase C alpha

type NP_035231.2 STLNPQWNEsFTFK S10 0.65 NA


type NP_035231.2

ADVYPANDsTAsQDVA

NR S9,S12 0.65 NA


type NP_035231.2

ADVYPANDSTAsQDVA

NR S12 0.59 0.08


type NP_035231.2

ADVYPANDsTASQDVA

NR S9 0.53 NA

Pspc1 paraspeckle component 1 NP_079958.3 GAINMGDAFsPAPAGTQ

GPPPMMGMNMNNR S10 1.55 NA

Ptpn11

tyrosine-protein

phosphatase non-receptor

type 11 isoform b | tyrosine-protein


type 11 isoform a

NP_001103462.1 | NP_035332.1

KGHEyTNIK Y5 13.36 NA

Ptpn11

tyrosine-protein phosphatase non-receptor

type 11 isoform b | tyrosine-protein


type 11 isoform a

NP_001103462.1 | NP_035332.1

GHEyTNIK Y4 6.81 NA

Ptpn18 tyrosine-protein phosphatase non-receptor

type 18

NP_035336.2 GASAGTGPGPRAPTSTD

TPIySQVAPR Y21 1.70 0.08

Ptpn18 tyrosine-protein phosphatase non-receptor

type 18

NP_035336.2 APTSTDTPIySQVAPR Y10 1.62 0.05

Ptpn6

tyrosine-protein


type 6 isoform b |

tyrosine-protein

phosphatase non-receptor type 6 isoform a

NP_001071173.1 |

NP_038573.2 GQESEyGNITYPPAVR Y6 6.43 0.29

Ptpn6

tyrosine-protein

phosphatase non-receptor type 6 isoform b |

tyrosine-protein


NP_001071173.1 |

NP_038573.2 HKEEVyENVHSK Y6 2.47 0.11

type 6 isoform a

Ptpn7

tyrosine-protein

phosphatase non-receptor type 7

NP_796055.1 SLGTVEPICSVNtPR T13 1.90 NA

Puf60

poly(U)-binding-splicing

factor PUF60 isoform c |

poly(U)-binding-splicing factor PUF60 isoform b |

poly(U)-binding-splicing

factor PUF60 isoform a

NP_001158072.1 | NP_598452.2 | NP_082640.2

AVTPPMPLLTPAtPGGLPPAAAVAAAAATAK

T13 2.25 NA

Pum1

pumilio homolog 1

isoform 3 | pumilio

homolog 1 isoform 2 | pumilio homolog 1

isoform 1

NP_001153076.1 |

NP_001153075.1 | NP_109647.2

RPGQSFHVNSEVNSVLs

PR S17 2.38 0.01

Pxn paxillin isoform beta |

paxillin isoform alpha NP_598676.2 | NP_035353.1 AGEEEHVySFPNKQK Y8 0.65 0.12

Rbm39 RNA-binding protein 39 NP_573505.2 IGLPHsIK S6 0.60 0.04

Rbm7 RNA-binding protein 7 NP_659197.2 SFsSPEDYQR S3 1.78 NA

Rfc1 replication factor C subunit 1

NP_035388.2 LTLLKNsPMK S7 0.58 NA

Rgs18 regulator of G-protein

signaling 18 NP_075019.1 SRSFtYNDFQDVK T5 0.54 NA

Rgs18 regulator of G-protein signaling 18

NP_075019.1 NRLsLLLQRPDFHGETQASR

S4 0.10 NA

Rlim E3 ubiquitin-protein

ligase RLIM NP_035406.3 RLsVENMESSSQR S3 1.95 0.25

Rnf168 E3 ubiquitin-protein ligase RNF168

NP_081631.2 RLsEPGELRR S3 1.63 NA

Rpap1

RNA polymerase II-

associated protein 1

isoform 2 | RNA

polymerase II-associated

protein 1 isoform 1

NP_001157173.1 |

NP_796268.3

ASDtPSGPPAADTVGVA

MR T4 1.96 NA

Rpl4 60S ribosomal protein L4 NP_077174.1 KLDELyGTWR Y6 2.85 NA

Rpl7 60S ribosomal protein L7 NP_035421.2 FGIICMEDLIHEIyTVGKR

Y14 100.00 NA

Rps20 40S ribosomal protein

S20 NP_080423.1 DtGKTPVEPEVAIHR T2 2.39 NA

Rps6kb2 ribosomal protein S6 kinase beta-2

NP_067460.1 LyLILECLSGGELFtHLER

Y2,T15 0.09 0.01

Scaf11

splicing factor,

arginine/serine-rich 2,

interacting protein

NP_082424.2 ETVVESQSSQsPsPK S11,S13 0.57 NA

Scrib protein scribble homolog NP_598850.1 MKsLEQDALR S3 0.58 0.04

Sel1l3 protein sel-1 homolog 3 NP_766298.2 LyyERCtEVQDIISSYAA

TVQVGGERR Y2,Y3,T7 0.45 NA

Sema4b semaphorin-4B precursor NP_038687.2 VRLGsEIRDSVV S5 2.04 0.32

Sept1 septin-1 NP_059489.2 MDKEyVGFAALPNQLH

R Y5 3.39 NA

Sept2 septin-2 a NP_035021.1 QQPTQFINPETPGyVGFANLPNQVHR

Y14 100.00 0.00

Serbp1

plasminogen activator

inhibitor 1 RNA-binding

protein isoform 4 | plasminogen activator



inhibitor 1 RNA-binding protein isoform 2 |


inhibitor 1 RNA-binding protein isoform 1

NP_001107038.1 |

NP_001107037.1 | NP_001107036.1 |

NP_080090.2

tDKSSASAPDVDDPEAFPALA

T1 1.72 NA

Serbp1





protein isoform 3 |

NP_001107038.1 |

NP_001107037.1 | NP_001107036.1 |

NP_080090.2

TDKsSASAPDVDDPEAFPALA

S4 1.64 0.13





Serbp1





NP_001107037.1 |

NP_080090.2 SSFSHySGLK Y6 1.57 NA

Sf3b2 splicing factor 3b,

subunit 2 NP_084385.2

GFEEEHKDsDDDssDDE

QEKKPEAPK S9,S13,S14 0.61 0.02

Shank3 SH3 and multiple ankyrin repeat domains protein 3

NP_067398.2 RAPsTTLTLR S4 1.60 0.07

Shc1

SHC-transforming

protein 1 isoform b |

SHC-transforming protein 1 isoform a

NP_035498.2 |

NP_001106802.1 ELFDDPSyVNIQNLDK Y8 3.51 NA

Sin3a

paired amphipathic helix

protein Sin3a isoform 2 | paired amphipathic helix

protein Sin3a isoform 1

NP_001103820.1 | NP_035508.2

HSGTGAtPPVK T7 0.47 NA

Skap2 src kinase-associated

phosphoprotein 2 NP_061243.1

SQPIDDEIyEELPEEEED

TASVK Y9 5.96 0.70

Snapin SNARE-associated

protein Snapin NP_598615.1

AAAGSAAVsGAGtPVA

GPTGR S9,T13 0.55 NA

Sos1 son of sevenless homolog 1

NP_033257.2 IPESETESTAsAPNsPR S11,S15 0.39 NA

Sp110 sp110 nuclear body

protein NP_780606.3 ATAQPIIEILDEQPsPSPR S15 1.97 NA

Spna2

spectrin alpha chain,

brain isoform 3 | spectrin

alpha chain, brain isoform

2 | spectrin alpha chain, brain isoform 1

NP_001171139.1 |

NP_001171138.1 |

NP_001070022.1

KLDPAQSAsRENLLEEQGSIALR

S9 0.51 0.01

Spna2

spectrin alpha chain,

brain isoform 3 | spectrin

alpha chain, brain isoform 2 | spectrin alpha chain,

brain isoform 1

NP_001171139.1 |

NP_001171138.1 | NP_001070022.1

KLDPAQsASRENLLEEQ

GSIALR S7 0.35 0.29

Spopl speckle-type POZ protein-like isoform b

NP_001159470.1 QVSVVQDsVNVsGHTStNTLK

S8,S12,T17 0.01 NA

Spred1

sprouty-related, EVH1

domain-containing

protein 1

NP_277059.1 HVsFQDEDEIVR S3 0.45 0.01

Srrm2 serine/arginine repetitive

matrix protein 2 NP_780438.2 TPAAAAAMNLAsPR S12 2.08 0.08

Srsf11

splicing factor,

arginine/serine-rich 11 isoform 3 | splicing

factor, arginine/serine-rich 11 isoform 2 |

splicing factor,

arginine/serine-rich 11 isoform 1

NP_081265.1 |

NP_001087221.1 |

NP_001087222.1

LNHVAAGLVsPSLK S10 2.32 0.26

Stambpl1 AMSH-like protease NP_083958.3 SDGSNFANYsPPVNR S10 0.43 NA

Stat3

signal transducer and

activator of transcription

3 isoform 3 | signal transducer and activator

of transcription 3 isoform

1

NP_035616.1 | NP_998824.1 YCRPESQEHPEADPGSAAPyLK

Y20 100.00 NA

Stat5a

signal transducer and

activator of transcription

5A isoform 1

NP_035618.1 AVDGyVKPQIK Y5 35.04 36.0

3

Stat5b signal transducer and activator of transcription

5B

NP_001107035.1 AADGyVKPQIK Y5 36.13 38.0

8

Stk10 serine/threonine-protein

kinase 10 NP_033314.2 LSEEAEPRPTtPSK T11 2.54 NA

Stmn1 stathmin NP_062615.1 RASGQAFELILsPR S12 20.43 0.00

Stmn1 stathmin NP_062615.1 ELEKRAsGQAFELILSPR S7 3.65 NA

Stmn1 stathmin NP_062615.1 RAsGQAFELILsPR S3,S12 3.07 0.73

Sub1

activated RNA

polymerase II

transcriptional coactivator p15

NP_035424.1 ELVSSSSSGsDsDSEVEK S10,S12 0.49 NA

Sub1

activated RNA

polymerase II transcriptional coactivator

p15

NP_035424.1 ELVSSSSSGSDsDSEVEK S12 0.44 0.09

Sub1

activated RNA

polymerase II transcriptional coactivator

p15

NP_035424.1 ELVSSSSSGsDsDsEVEK S10,S12,S1

4 0.37 NA

Supt3h transcription initiation

protein SPT3 homolog NP_848767.1

sTAACGVEAHSDAIQPC

HIR S1 2.39 NA

Tagln2|Ta

gln3

transgelin-3 | transgelin-

2 NP_062728.1 | NP_848713.1 GASQAGMTGyGMPR Y10 4.26 NA

Tbc1d1 TBC1 domain family member 1

NP_062610.2 RANTLSHFPVECPAPPEPAQsSPGVSQR

S21 0.65 NA

Tcfeb

transcription factor EB

isoform b | transcription

factor EB isoform a

NP_001155194.1 | NP_035679.3

FAAHVSPAQGsPKPAPAAsPGVR

S11,S19 0.65 NA

Tcfeb

transcription factor EB

isoform b | transcription

factor EB isoform a

NP_001155194.1 | NP_035679.3

FAAHVsPAQGsPKPAPAAsPGVR

S6,S11,S19 0.57 NA

Tec

tyrosine-protein kinase Tec isoform b | tyrosine-

protein kinase Tec isoform a

NP_001106932.1 |

NP_001106931.1

YVLDDQyTSSSGAKFPV

K Y7 2.11 0.11

Tec


Tec isoform b | tyrosine-

protein kinase Tec isoform a

NP_001106932.1 |

NP_001106931.1 YVLDDQyTSSSGAK Y7 2.00 0.00

Tex2 testis-expressed sequence

2 protein NP_938034.2 TAPSsPLtSPSDTR S5,T8 1.52 NA

Thoc5 THO complex subunit 5 homolog

NP_766026.1 RRPtLGVQLDDK T4 3.67 NA

Tjap1 tight junction-associated

protein 1 NP_083027.1 AFVDRtPPPAAVVQR T6 1.92 NA

Tln1 talin-1 NP_035732.2 KSTVLQQQyNR Y9 6.63 4.73

Tmem41b transmembrane protein 41B

NP_705745.3 VADRsPTEMLHSTPAGDR

S5 2.18 NA

Tmem63a transmembrane protein

63A NP_659043.1 TALSPQQQQTyGAIR Y11 4.17 NA

Tnni2 troponin I, fast skeletal muscle

NP_033431.1 SVMLQIAAtELEK T9 0.01 NA

Tnpo3 transportin-3 NP_796270.2 wLENSLKGLPKETtVGA

VtVtHK

T14,T19,T2

1 0.01 NA

Tpd52l2 tumor protein D54 NP_079758.2 VVGGRENGSDNLPPsPGSGDQTLPDHAPF

S15 1.61 NA

Tsga10 testis-specific gene 10

protein NP_997111.1

QENQALsKKLNDtHNEL

SDIK S7,T13 0.25 NA

Ube2o ubiquitin-conjugating enzyme E2 O

NP_776116.2 NMTVEQLLTGSPtSPTVEPEKPTR

T13 2.01 0.51

Ube2o ubiquitin-conjugating

enzyme E2 O NP_776116.2

NMTVEQLLTGSPTsPTV

EPEKPTR S14 1.91 0.65

Vasp vasodilator-stimulated phosphoprotein

NP_033525.2 SSSSVTTSEAHPStPCSSDDSDLER

T14 2.45 NA

Wdr33 WD repeat domain 33

isoform 1 NP_083142.2 sSSLQGMDMASLPPR S1 1.89 NA

Wdr33 WD repeat domain 33 isoform 1

NP_083142.2 SsSLQGMDMASLPPR S2 1.89 NA


isoform 1 NP_083142.2 SSsLQGMDMASLPPR S3 1.89 NA

Wdr36 WD repeat domain 36 isoform 3

NP_659112.2 QTAFQIsSLISCLGERCLNN

S7 100.00 NA


isoform 3 NP_659112.2

QTAFQISsLISCLGERCL

NN S8 100.00 NA

Whsc1l1 histone-lysine N-methyltransferase NSD3

isoform 2 | histone-lysine

NP_001074738.1 |

NP_001001735.1

RPRSVLNSQPEQtNAGE

VASSQSSTDLRR T13 0.01 NA

N-methyltransferase

NSD3 isoform 1

Whsc2 negative elongation

factor A NP_036044.1

EASRPPEEPSAPsPTLPT

QFK S13 1.64 NA

Wipf1 WAS/WASL-interacting

protein family member 1 NP_694778.1 NLSLTSSAPPLPsPGR S13 2.01 0.10

Wiz protein Wiz isoform 2 |

protein Wiz isoform 1 NP_035847.2 | NP_997603.3

KLPPPPGSPLGHsPtAsPP

PTAR

S13,T15,S1

7 3.54 NA

Wiz protein Wiz isoform 2 |

protein Wiz isoform 1 NP_035847.2 | NP_997603.3 KAPLTLAGsPTPK S9 1.88 NA

Xdh xanthine

dehydrogenase/oxidase NP_035853.2

SVAsIGGNIITAsPIsDLN

PVLMAsR

S4,S13,S16,

S25 0.01 NA

Xkrx XK-related protein 2 NP_899142.2 tLEItsRLVILVLFsATLK T1,T5,S6,S1

5 0.01 NA

Zc3hav1

zinc finger CCCH-type

antiviral protein 1 isoform

2 | zinc finger CCCH-type antiviral protein 1

isoform 1

NP_083140.1 | NP_082697.1 SAVTGGKEAVySGVQS

LR Y11 2.30 NA

Zfp295

zinc finger protein 295

isoform 3 | zinc finger protein 295 isoform 2 |

zinc finger protein 295

isoform 1

NP_001075154.1 | NP_001075153.1 |

NP_780637.2

LGLVVPSGGPAsANQSI

DR S12 3.90 NA

Zzef1

zinc finger ZZ-type and

EF-hand domain-

containing protein 1

NP_001039001.1 LRLLsFR S5 6.05 NA

Documents

References - shodhganga.inflibnet.ac.inshodhganga.inflibnet.ac.in/bitstream/10603/47648/... · References 1. Garavelli, J.S. (2004) The RESID Database of Protein Modifications as