188 therapy and she was unevenful recovery for six years. This is a prolong survival case of eight year in surgical treated case of squamous cell carcinoma of the trachea ever found in this part of the world. International Survey on Attitudes in the Comtrol of Lung Cancer. Stanley, K. WHO, Geneva, Switzerland, and H. Hansen, Finsen Institute, Copenhagen, Denmark. One hundred and sixty members of the International Association for the Study of Lung Cancer (IASLC) from 28 countries responded to a joint WHO/IASLC question- naire on issues in the control of lung cancer. Nearly all respondents (97%) felt that at least 80% of all cases of lung cancer are caused by tobacco; 65% agreed that the risk of lung cancer is increased among those highly exposed to cigarette smoke (passive smoking) and 94% stated that greater attential should be given to tobacco control programmes. In contradiction to a WHO consensus finding, 59% felt that radiological and/or cytological screening should be recommen- ded as a routine policy for high risk groups of asymptomatic individuals. Chemotherapy was felt to be beneficial for patients with small cell carcinoma (SCC) by 94%; the most frequently reported chemotherapy regimen was CAV (cyclophospha- mide, doxorubicin and vincristine). For SCC patients, 70% stated that radiotherapy to the primary tumour was beneficial and 54% stated that prophylactic cranial irra- diation was of value. For patients with unresectable non-small cell carcinoma (NSCC) 44% felt that chemotherapy provided benefit beyond supportive care; teh corresponding figure for radiotherapy to the primary tumour was 73%. Con- siderable regional variation was seen in therapeutic approaches, especially for patients with NSCC. Reduced ~scle Protein Synthesis Rate in the Development of Cachexia in L~g Cancer Pat ient ~. 1 Souha~i , R.L., Finn ,3G., Woodward 2, C.J., Emery , P.W., Halliday , D. i. Department of Radiotherapy and Oncology, University College Hospital, London WCI. 2. Depart- ment of Nutrition, Queen Elizabeth College, London W8. 3. Clinical Research Centre, Harrow, Middlesex. We have measured the rate of protein synthesis in vivo in skeletal muscle and in the whole body of cancer patients and healthy adults, using tracer infusion of stable isotope labelled leucine. All stu- dies were performed in the fed state. Muscle protein synthesis rate in 6 lung cancer patients (4 small cell, 1 squamous cell, 1 undifferentiated) who had recently lost 3-13 kg body weight, was 0.030+0.006 (mean + S.E.). Since this is considerably lower than ~he rate in normal controls, depressed protein synthesis is likely to be a major cause of the exten- sive muscle wasting seen in cancer cachexia (Emery et al. (1984) Brit. Med. J. 289: 584). However, there was no significant difference between the cachectic cancer patients and controls in the rate of protein synthesis in the whole body, indicating an increase in the rate of protein synthesis in non-muscle tissue of cancer patients - preliminary results on 3 patients with small cell lung cancer who had not lost weight prior to the study suggest that muscle protein synthesis rate (0.029+ 0.00 4%/hr) is reduced at an early stage in the development of the disease, before the appearance of overt signs of cachexia.

Reduced muscle protein synthesis rate in the development of cachexia in lung cancer patients

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Page 1: Reduced muscle protein synthesis rate in the development of cachexia in lung cancer patients

188

therapy and she was unevenful recovery for six years.

This is a prolong survival case of eight

year in surgical treated case of squamous cell carcinoma of the trachea ever found in this part of the world.

International Survey on Attitudes in the Comtrol of Lung Cancer. Stanley, K. WHO, Geneva, Switzerland, and H. Hansen, Finsen Institute, Copenhagen, Denmark.

One hundred and sixty members of the International Association for the Study of Lung Cancer (IASLC) from 28 countries responded to a joint WHO/IASLC question- naire on issues in the control of lung cancer. Nearly all respondents (97%) felt that at least 80% of all cases of lung cancer are caused by tobacco; 65% agreed that the risk of lung cancer is increased among those highly exposed to cigarette smoke (passive smoking) and 94% stated that greater attential should be given to tobacco control programmes.

In contradiction to a WHO consensus finding, 59% felt that radiological and/or cytological screening should be recommen- ded as a routine policy for high risk groups of asymptomatic individuals.

Chemotherapy was felt to be beneficial for patients with small cell carcinoma (SCC) by 94%; the most frequently reported chemotherapy regimen was CAV (cyclophospha- mide, doxorubicin and vincristine). For SCC patients, 70% stated that radiotherapy to the primary tumour was beneficial and 54% stated that prophylactic cranial irra- diation was of value.

For patients with unresectable non-small cell carcinoma (NSCC) 44% felt that chemotherapy provided benefit beyond supportive care; teh corresponding figure for radiotherapy to the primary tumour was 73%. Con- siderable regional variation was seen in therapeutic approaches, especially for patients with NSCC.

Reduced ~scle Protein Synthesis Rate in the Development of Cachexia in L~g Cancer

Pat ient ~. 1 Souha~i , R.L., Finn ,3G., Woodward 2, C.J., Emery , P.W., Halliday , D. i. Department of Radiotherapy and Oncology, University College Hospital, London WCI. 2. Depart- ment of Nutrition, Queen Elizabeth College, London W8. 3. Clinical Research Centre, Harrow, Middlesex.

We have measured the rate of protein synthesis in vivo in skeletal muscle and in the whole body of cancer patients and healthy adults, using tracer infusion of stable isotope labelled leucine. All stu- dies were performed in the fed state. Muscle protein synthesis rate in 6 lung

cancer patients (4 small cell, 1 squamous cell,

1 undifferentiated) who had recently lost 3-13 kg body weight, was 0.030+0.006 (mean + S.E.).

Since this is considerably lower than ~he rate in normal controls, depressed protein synthesis is likely to be a major cause of the exten- sive muscle wasting seen in cancer cachexia (Emery et al. (1984) Brit. Med. J. 289: 584). However, there was no significant difference between the cachectic cancer patients and controls in the rate of protein synthesis in the whole body, indicating an increase in the rate of protein synthesis in non-muscle tissue of cancer patients - preliminary results on 3 patients with small cell lung cancer who had not lost weight prior to the study suggest that muscle protein synthesis rate (0.029+ 0.00 4%/hr) is reduced at an early stage in the development of the disease, before the appearance of overt signs of cachexia.