New Insights into Cancer Cachexia

PowerPoint PresentationNew Insights into Cancer Cachexia
Patients with pancreatic cancer have a high incidence of weight loss
Baracos et al., 2017, Nature Primer, In Press
Patients with
Patients with confirmed pancreatic adenocarcinoma (PDAC)
that are candidates for surgical resection (stage I and II)
Analyzing Serum Markers
SDF IL-15 TRAIL
TNF IL-17 TGFa
INFg LIF CD-40L
IL-1b MCP-1 FGF2
IL-4 G-CSF PDGFBB
IL-6 GM-CSF VEGF-A
IL-8 HGF MMP13
IL-10 RANKL Leptin
P = 0.13
P = 0.03 P = 0.17
Increases in MCP-1 associates with weight loss but not BMI
Talbert et al., 2017, JCSM, In Press
P=0.002P=0.19
NF-kB
NF-kB
GDF-15 is Elevated in Pancreatic Cancer
Wang et al., 2014, BMC Cancer
Elevated GDF-15 Associates with Poor Survival in Pancreatic Cancer
Ratnam et al., 2017, JCI
GDF-15 is a driver of cancer cachexia
Lerner et al., 2016, JCSM
RNA Seq Screen Between p65+/+ and p65-/- MEFs
Ratnam et al., 2017, JCI
GDF-15 Gene NF-kB binding site
Ratnam et al., 2017, JCI
NF-kB is a direct regulator of GDF-15 in pancreatic cancer
Ratnam et al., 2017, JCI
GDF-15 is required for the development of pancreatic cancer
KPC Control
KPC shGDF-15
NF-kBNF-kB
GDF-15
Mary Dillhoff, MD Carl Schmidt, MD Phil Hart, MDAngela Sarna
Priyani Rajasekera Nivi Ratnam