AuthorsC2TN members: Pedro Santos3,* (C2TN contract), Sandra Cabo Verde3 (C2TN contract), Maria Helena Casimiro3 (C2TN contract), Luís M. Ferreira3, Fernanda Margaça3, António Falcão3

Students: Joana Madureira3 (PhD), Alexandra P. Rodrigues3

(PhD) * Email of corresponding author: psantos@ctn.tecnico.ulisboa.pt

Research group(s) Collaborations

KeywordsRadiation technologies Biomedical applications

Advanced materials Food safety

Wastewater treatment

Funding

Radiation for Material, Environmental and Heath Sciences Research at IRIS

Thematic StrandAdvanced Materials

Thematic StrandEnvironment & Cultural Heritage

Thematic StrandRadiopharmaceutical Sciences

& Health Physics

Good homogeneity of dose distribution across samples

Reproducibility of irradiation experiments

Broad range of dose rates (up to 1,2 kGy/h)

PRECISA22 – 60Co Irradiator

LINAC – Linear electron accelerator

Ionizing Radiation Facility - IRIS

Beam profile obtained withirradiated FWT-60 radiochromicdosimeters (60 cm from the beamexit; relative absorbed doses)

10 MeV

8‐12 MeV

4 s

10‐150 Hz

Electron beam

Photon beam (tungsten target)

Pulse width

Pulse repetition frequency

1 – simulation lamp2 – electron (pre-scatter)3 – (not used)4 – high energy target (photons)5 – low energy target (photons)

http://c2tn.tecnico.ulisboa.ptRADIATION FOR SCIENCE AND SOCIETY

C2TN/IST acknowledgesFundação para a Ciência e a Tecnologia for

financial support under the projectUID/Multi/04349/2013

Non-thermal post-harvest treatment that controls spoilageand foodborne pathogenic microorganisms withoutsignificantly affecting organoleptic attributes. Someimprovements on bioactive content, such as an increase inantioxidant activity, were observed after irradiation.

Food post-harvest irradiation treatment

Extraction of mushrooms valuable compounds through gamma and electron beam irradiation

Effect on bioactive composition and levelof trapped radicals (EPR spectrometry) of irradiated dried spices

Alternative treatment to increase chestnutsshelf-life without affecting the biochemicalprofile and nutritional value.

Microbial inactivation by ionizing radiation duringstorage time and sensory attributes for cherry tomatoes

Infusions of irradiated dried aromatic plants: higher phenolic content, preservation of antimicrobial properties.

Fiber optics as real-time dosimeters

Radiation induced absorption and recovery in a multimodesílica FOD

Low cost dosimeters for personal dosimetry and radiation processing: • in-vivo and real-time dose delivery monitoring in complex oncologic treatments• real-time insight about radiation exposure and facility safety conditions

Contracts with private sector

Active pharmaceutical ingredients (bulk or formulated):evaluation of gamma radiation as a sterilization method (foreither 15 or 25 kGy) and determination of the compoundsradiation resistance (maximum dose).

Irradiation of photonic components to simulate radiationresistance in outer space environment.

Wastewater treatment

Ionizing radiation applied to agro-industrial wastewaters as a complementary treatment to reduce levels of biorecalcitrantcompounds.

Cork boiling wastewater

Radiation effect on the toxicityand antioxidant activity.

Degradation of model recalcitrant compounds by gammaradiation in different conditions (pH and air/N2O saturatedfor ROS yields) and final stable oxidation productsidentification.

Municipal wastewater

Degradation pathway of gammairradiated aqueous solutions ofclofibric acid, a pharmaceuticallyactive drug metabolite foundpersistent in municipal wastewaters.

Hybrid materials for cultural heritage preservation

Preparation of PDMS based ormosils by ionizing radiation to be used alone or as additives for anefficient preservation of Roman mosaics (Conimbriga) and other stone based ancient structures.Promising biocide activity (fungus) will be improved and enlarged to other target microorganisms.

Enteric Virus inactivation

A 4-log reduction of Human Adenovirus titer in municipalwastewater can be reached by using gamma irradiation at adose of 6 kGy as a single treatment process without addingany chemicals, with the added benefit of increasing the waterquality. But, on fresh fruits this virus presented higherradioresistance.

This technology may be an effective tool to guarantee the reduction of viral pathogensand to contribute to public health and sustainable water supplies.

Further studies will be conducted with electron beam irradiation on virussuspensions to deepen the inactivation patterns of enteric virus by ionizing radiation.

Chitosan-Based Matrices for tissue regenerationSingle step chitosan based 3D matrices preparation and sterilization assisted by -radiation forbiocompatible and biodegradable skin scaffolds.

Cellular viability (Human Fetal Foreskin Fibroblasts):• Cells adhered and proliferated in all irradiated matrices (non cytotoxic)• Low Mw chitosan based matrices and presence of gelatin lead to higher cellular proliferation

CIMO-IPB, Bragança, Portugal

LAQV/DQ/DCR-FCT-UNL, Caparica, Portugal

CQE-IST-UL, Lisboa, Portugal

cE3c-FC-UL, Lisboa, Portugal

CICECO-UA, Aveiro, Portugal

MM&Ruins of Conimbriga, Coimbra, Portugal

1 RS | Radiopharmaceutical Sciences Group2 RPS | Radiation Protection and Safety Group3 REI | Radiation, Elements and Isotopes Group4 NET | Nuclear Engineering and Techniques Group5 QEf | f-element Chemistry Group6 SS | Solid State Group