RACE TO GROW NEW ORGANS

Chetan Shetty13043MBA-BT(II)PUMBA

Contents

1. Introduction

2. Main Theme

3. Success Story

4. Business Opportunity

5. Conclusion

Introduction• Some facts about people needing organ transplantation:

1. At present, out of the 1,50,000 patients requiring kidney

transplants across India every year, only 200 get kidneys

by way of donations from the deceased.

2. Organs a Living Donor May Give:

■ single kidney

■ segment of the liver

■ lobe of a lung

■ portion of the pancreas

■ portion of the intestine

3. All major religions support organ & tissue donation as an

unselfish act of charity

4. The need for donated organs and tissue continues to grow.

Over 100,000 men, women and children currently await life-

saving organ transplants

5. Sadly, an average of 18 people die each day due to a lack of

available organs

• To cope up with these growing demands it is necessary that

some alternate way be devised to fulfill them.

• Organ growing is one of the new advances in medicine that

would enable organ replacement.

• Human organs will be replaced internally or externally, using

a replacement organ that was “grown” using a tissue or a cell

from the patient himself

Main theme

Problems with organ donation:

1. The body will naturally react against tissue from someone

else.

2. This problem is called "rejection“.

3. Many patients have to be on drugs that suppress their

immune systems for the rest of their lives

Some simpler lab-grown organs already exist

A lab-engineered urine tube.

• Techniques vary, but they tend to have a similar strategy

1. Scan the patient's organ

2. Create a scaffold

3. Add cells

4. Put it in a bioreactor

Printing a prototype kidney

Success Story

• Luke Masella was born with a birth defect called Spina Bifida,

caused paralysis of bladder.

• Lost 25% of his body weight due to toxin build up.

• Luke and his parents opted for a very radical solution- a brand

new bladder.

• Tissue Engineering pioneer Anthony Atala

of Wake Forest Institute for Regenerative

Medicine made Luke his bladder.

• He created a scaffolding, harvested stem

cells from Luke’s original bladder, and

seeded the scaffolding with those cells.

• Two months later, Atala attached the

new bladder to Luke’s original

bladder, expanding it.

• Now a 20 year old sophomore at the

University of Connecticut, Luke

has a bladder and kidneys that

function normally.

Business Opportunity

• Tissue engineering shows different aspects of life saving

technology.

• All of these features require formidable inputs from different

backgrounds.

• Computer engineering, Mechanical Works, Biotechnologists all

need to come into play.

• For an organization to make this into a business, it would require

lots of investment in capital and labor.

• Some areas where business

can be developed are:

1. Printers.

2. 3D imaging

3. Blood supply vessels.

4. Building of body parts

outside the body.