QMU 3RD WEEK complete.docx

7/29/2019 QMU 3RD WEEK complete.docx

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QMU 3RD

WEEK

1. Misoprostol protects the GIT mucosa by:-

a. Increase uterine contraction

b. Releases aluminiumc. Increase mucus and bicarbonate ion

d. Coats the mucosa

2. All the statements are concerning sucralfate except:-

a. Should be given with magnesium carbonates

b. Forms gel to protect the mucosa

c. Stimulates mucus secretion

d. It does not cause systemic adverse effect

3. Which drugs is used against h. pylori:-

a. Sucralfate

b. Cimetidine

c. Misoprostol

d. Bismuth chelate

4. The side effects of h pylori eradication therapy include:-

a. Constipation

b. Other organism becomes more resistant

c. Liver failure

d. Kidney failure

5. In bismuth based drug regimen, the correct drug combination is :-a. Bismuth, amoxicillin, ppi, metronidazole

b. Bismuth, tetracycline, ppi, clarithromycin

c. Bismuth, tetracycline, ppi, metronidazole

d. Bismuth, tetracycline, sucralfate, omeprazole

6. Which of the following statements is true regarding gastric polyps?

a. It occurs in older persons.b. They are classified into 2 types; Inflammatory and Auto-Immune type


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d. It is formed of right large and left small lobes

13. Liver drained by portal lymph nodes then into the coeliac lymph nodes except..

a. Caudate lobe

b. Quadrate lobe

c. Superior surface

d. Bare area

e. Renal impression

14. Inferior surface shows the following features except...

a. Colic impression

b. Fissure for ligamentum teres

c. Fissure for ligamentum venosum

d. Duodenal impression

15. Porta hepatis..

a. Anteriorly bounded by Caudate lobe

b. Posteriorly bounded by Quadrate lobe

c. Anteriorly bounded by Quadrate lobe

Pharmacology

Anti emetic and prokinetic Drug

16. All of the following are true about anticholinergic drugs except :

a. Reduce the excitability of labyrinth receptors

b. Used to treat postoperative nausea

c. Useful in treating nausea caused by cancer chemotherapy

d. Its cause drowsiness, blurred vision

17. Which is true about Histamine-1receptor antagonist?

a. Used in narcotic-induced vomiting

b. Cause diarrhea and prolactin release

c. Efficient in treating nausea of pregnancy

d. Have prokinetic action.

18. All of these are true about Domperidone except:

a. One of Dopamine antagonist

b. Have prokinetic action

c. Its poorly crosses the blood brain barrier


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d. Have pyramidal side effect

19. All of these are true about therapeutic use of 5-HT antagonist except:

a. Acute vomiting induced

b. Pregnancy induce vomiting

c. Postoperative vomiting

d. Radiation induced vomiting

20. All of these are prokinetic drug except:

A. Motilin

B. Domperidone

C. Metoclopramide

D. Erythromycin

E. Benzodiazepine

21. Portal system is formed by veins draining the GIT and lower limbs. [T/F]

22. Portal vein ascends behind the 2nd

part of duodenum and in front of IVC before

entering the liver together with the hepatic artery and bile duct. [T/F]

23. Tributaries of the splenic vein are :-A. Splenic vein, short gastric vein, left gastroepiploic vein, right gastric vein

B. Splenic vein, short gastric vein, pancreatic vein, paraumbilical vein

C. Splenic vein, short gastric vein, left gastroepiploic vein, pancreatic vein, inferior

mesenteric vein

D. Splenic vein, left gastroepiploic vein, cystic vein, right gastroepiploic vein

24. Inferior mesenteric vein gives 3 tributaries, left, middle and right colic vein. [T/F]

25. There are ____ sites of portosystemic anastomosis.

26. Which of the following is false regarding the liver :

a. Has both endocrine and exocrine functions

b. It is a simple branched tubular gland

c. A thin connective tissue capsule surrounded the liver

d. The capsule is thicker at the hilum

27. By electron microscope, the hepatocytes show:


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a. Few free ribosomes

b. Smooth endoplasmic reticulum is rudimentary

c. Short microvilli projecting from vascular side\

d. Attached to the neighbouring hepatocytes by desmosomes

28. All the following describing the hepatic blood sinusoids except :

a. Have large diameter and lack of continuous basal lamina

b. Lining by endothelial cells and Kupffer cells

c. Endothelial cells have numerous fenestrae which lack of diaphragm

d. Kupffer cells show many vacuoles, lysosomes, phagosomes and few

mitochondria

29. The space of Disse contains

i. Reticular fibers

ii. Long, numerous microvilli from hepatocytes

iii. Processes of Ito cells

a. I and II

b. II and III

c. I and III

d. All the above

30. All of the following is true regarding the gall bladder except :

a. Hollow, pear shaped organ

b. Its mucosa is highly folded, lined by simple columnar cells

c. Lamina propria near the cystic duct contain serous secreting glands

d. Its musculosa consists of smooth muscle fibers, collagen and elastic fibers

31. In hypovolemia, what is the main liver function to correct homeostasis?

A. Blood reservoir

b. Secrete erythropoietin

c. Produce RBC

d. Destroy RBC

32. At which semester does the liver function as a producer of RBC?

A. 1st

b. 2nd

c. 3rd


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33. RBC is destroyed in the liver. Which cell destroys RBC?

A. Hepatocyte

b. Endothelial cell

c. Lymphocyte

d. Kupffer

34. What is the function of mucin-like substance (component of bile)

A. Protection

b. Nutrition

c. Waste product

35. The following are constituent of bile except?

A. Water

b. Lecithin

c. Albumin

d. Alkaline phosphatase

36. The body of pancreas is related posteriorly to the formation of portal vein. [T/F]

37. The head of pancreas is supplied by the superior and inferior pancreatico-duodenal

arteries. [T/F]

38. The ampulla of Vater opens into the third part of duodenum. [T/F]

39. The head is related posteriorly to the IVC, renal veins and common bile duct. [T/F]

40. The uncinate process and lower part of the head drain into the main pancreatic

duct. [T/F]

41. Which organelle is responsible for the basophilic staining of peripheral pancreatic

acini ?

A. Mintochondria

B. Zymogen granules

C. Rough endoplasmic reticulum

D. Smooth endoplasmic reticulum


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42. What is the functional unit of the liver?

A. Portal lobule

B. Liver acinus

C. Classical hepatic lobule

D. Portal tract

43. The secretory acini of the parotid gland is purely of mucous type. [T/F]

44. All the cells below are present in the neck region of fundic gland EXCEPT :-

A. Oxyntic cell

B. Stem cell

C. Mucous neck cell

D. Entero-endocrine cell

45. The most numerous lingual papillae present in the tongue is

A. Fungiform

B. Filiform

C. Circumvallate

D. Folliate

46. All of the following are not true about bile salts EXCEPT:-

a. Hepatocytes synthesize about 0.2-0.4mg bile salts per day

b. Lithocholate is relatively insoluble

c. Lithocholate is mostly excreted in urine

d. 90% of bile salts enter the colon and converted into salts of deoxycholic acid and

lithocholic acid

47. Functions of bile salts:-

a. Activate lipase enzyme

b. Facilitate water soluble vitamins and carotenes

c. Ability to dissolve soluble fatty acid in water

d. Direct antiseptic effect

48. Factors that control bile secretion :-

I. Bile pigments are the most powerful choleretics

II. Secretin increasing its water and bicarbonate content

III. Parasympathetic stimulation decrease bile secretion


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IV. Increase intrahepatic vascular pressure will stop bile secretion

a. I and II

b. I,II and IV

c. II and III

d. II and IV

49. Micelles :

a. Formed of cylindrical water-insoluble disk

b. Contain fatty acids, phospholipids, and cholesterol only

c. Provide mechanism for their transport to enterocytes

d. Dissolved in liver

50. Cholagogues are

I. Gall bladder evacuants

II. Stimulants for bile secretion

III. Relax sphincter of Oddi

IV. MgSO4 is not a true cholagogues

a. I and III

b. II, III, and IV

c. I and IV

d. I,III, and IV

e. III and IV

51. Enterically transmitted hepatitis virus are

A. HAV and HEV

B. HBV, HCV, HDV

C. HAV only

D. HBV and HDV

52. HAV causes severe chronicity in all age and mostly end by death [T/F]

53. Virus particles of HAV are found in saliva and transmitted by air. [T/F]

54. Anti-HAV IgG rises 3-6 weeks later and and gives passive immunity. [T/F]

55. Detection of anti-HAV IgM are used to confirm the diagnosis of acute hepatitis A.

[T/F]


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56. The normal concentration of bile pigments are :-

a. 0.20.8 g/100ml plasma

b. 0.20.8 mg/dL plasma

c. 0.02

0.08 mg/dL plasma

d. 0.020.08 g/100ml plasma

57. All of the following are about the bile pigments EXCEPT :-

a. Bilirubin is the end product of hemoglobin and myoglobin metabolism

b. It has digestive function

c. The bilirubin combines with the albumin to form water insoluble compound called

haembilirubin

d. Cholebilrubin is catalyzed by glucoronyl transferase enzyme in the liver

58. Which one of the following is true regarding jaundice

a. bluish discoloration of the skin, sclera and mucous membrane.

b. detected clinically when the serum of bilirubin is between 0.8-2mg/100ml

c. in hemolytic jaundice, the color of the urine is found to be dark brown

d. there are three types of jaundice discovered until now

59. What are the possible causes of post hepatic jaundice?

a. Excessive hemolysis of the RBC

b. Disturbance of the intracellular protein conjugation

c. Stone in the lumen of the bile duct that leads to its complete obstruction

d. Mild obstruction of intrahepatic canaliculi

60. Regarding the fate of stercobilinogen :-

a. Urobilinogen is responsible for the normal color of the urine

b. 2/3 of the total amount of stercobilinogen is reabsorbed by the enterohepatic

circulation

c. In the feces, of stercobilinogen is lost in the oxidized form

d. The brown color of stool, is caused by the oxidized form of stercobilinogen that

occur in the intestinal lumen or after exposure to the atmosphere.


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ANSWER & REFERENCES

1. C ; page 70

2. A ; page 71

3. D ; page 71

4. B ; page 72

5. C ; page 72

6. B ; page 32

7. B ; page 32

8. C ; page 36

9. D ; page 37

10. A ; page 37

11. B ; page 97

12. B ; page 93

13. C ; page 94

14. C ; page 94

15. C ; page 95

16. C ; page 74

17. C ; page 75

18. D ; page 75

19. B ; page 76

20. E ; page 78

21. False ; page 90

22. False ; page 90

23. C ; page 91


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24. False ; page 91

25. Six ; page 92

26. B ; page 132

27. D ; page 134

28. D ; page 134

29. D ; page 135

30. C ; page 138

31. B ; reference prof

32. A ; ref pg 42

33. D ; ref pg 42

34. A ; ref prof

35. C ; pg 44

36. False ; Pg 100 ; the neck of pancreas

37. True ; pg 101

38. False ; pg 101 ; the second part of duodenum

39. True ; pg 99

40. False ; pg 101 ; drain to the accessory duct

41. C ; page 131

42. B ; page 136

43. False ; page 130

44. D ; page 113

45. D ; page 106

46. B ; page 45

47. A ; page 45-47


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48. D ; page 47

49. C ; page 46

50. D ; page 49

51. A ; page 61

52. False ; page 61

53. False ; page 61

54. False ; page 61

55. True ; page 62

56. B ; page 50

57. B ; page 50

58. D ; page 53

59. C ; page 53

60. D ; page 51

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QMU 3RD WEEK complete.docx