Embed Size (px)
Citation preview
101. Project Title �UNDERSTANDING THE ROLE OF SYNTHESIS AND EVALUATION OF THE ANTICANCER ACTIVITIES OF NEW RESVERATRIK DERIVATIVES�
102. Broad Subject: Life Sciences
103. Sub Area: Animal Sciences
104. Duration in months: 36 months
105. Total cost: 47, 66,400
106. FE Component:
107. Project Category: Basic Research
111. Principal Inv.: Dr. Chitta Suresh Kumar
112. Designation: Professor
113. Department: Biochemistry
114 Institute Name: Sri Krishnadevaraya University
115. Address: Bioinformatics Facility (BIF),
Dept. of Biochemistry,
Sri Krishnadeavaraya University,
Anantapur-515 003, A.P., India
116. Date of Birth: 20-07-1964, Age: 44 Years Sex (M)
117. Telephone: 08554-255644, e-mail: [email protected]
118. Co-Investigator: Dr. Manavathi Bramanandam
119. Designation : Assistant Professor
120. Department : Dept. of Biochemistry
121. Institute Name University of Hyderabad
122. Address
Department of Biochemistry
University of Hyderabad
Hyderabad-500046
Phone : +91-40-23134578
Mobile: 9966085638
Fax :+91-40-23010145
123. Date of Birth: April 12th, 1975 Sex (M/F) M
124.Telephone +919966085638 Fax 91-40-23010145
E-mail [email protected]
Project Title... �UNDERSTANDING THE ROLE OF SYNTHESIS AND EVALUATION OF THE ANTICANCER ACTIVITIES OF NEW RESVERATRIK DERIVATIVES�.
Registration No.............................................(to be filled by DST) Principal and investigator ...Prof. Chitta Suresh Kumar
Institution I)..Sri Krishnadevaraya University...............................
191. Project summary (maximum 150 words)
The project work is an out come of recent research progress in transcriptional
regulation of cancer related genes. Oncogenic activation of transcription factors is a
key event in the establishment and progression of human cancer. All cancer cells
acquire similar sets of functional capacities such as: independence from
mitogenic/proliferative regulatory signals; loss of sensitivity to ��anti-growth�� signals,
evasion of apoptosis, neo-angiogenic conversion, release from senescence, and
acquisition of invasiveness, and metastasis. There are now 17 known signal
transduction pathways, plus at least two stress-response pathways; all of these
appear to be highly conserved in nematodes, flies and all vertebrates. Ultimately,
transcription factors participate at the ends of all 19 pathways�by causing the up- or
down-regulation of specific genes. All primary and modifier genes leading to cancer
participate in one or another of these pathways. The focus of our research on
investigation of the molecular action of Resveratrol (RVSL) and its pharmacophore
synthesized RVSL derivatives on transcriptional factors. Its inhibition may be useful
as a method of either preventing carcinogenesis, or for increase in the effectiveness
of chemotherapy
192. Key words (maximum 6)
Resveratrol, trascrioptional factors, CADD, NF-kBt, U937, HUT-78 cells
