-
7/30/2019 Profile Analiza SWOT
1/6
Main contactDr. LUIS MENENDEZ-ARIASOrganisation name: Centro de
Biologa Molecular Severo Ochoa (CSIC-UAM)
http://www.cbm.uam.esDepartment/Unit: Virology and
MicrobiologyAddress: c/ Nicols Cabrera, 128049 Madrid Spain
Main organisationCentro de Biologa Molecular Severo Ochoa
(CSIC-UAM)Address: c/ Nicols Cabrera, 128049 Madrid Spain
ExpertiseFavourite themeFP7-PEOPLE, FP7-HEALTH,
FP7-INCOExpertise descriptionResearch in the laboratory of Dr.
Menendez-Arias is mainly devoted tounderstanding structure-activity
relationships in human immunodeficiencyvirus type 1 (HIV-1) reverse
transcriptase (RT), elucidating mechanisms ofHIV-1 resistance to
antiretroviral drugs, and understanding HIV replicationfitness. The
group has experience in the characterization of viral enzymesand is
potentially interested in the purification and characterization of
viralpolymerases. Molecular biology techniques (e.g. cloning,
site-directedmutagenesis, RT-PCR amplifications, etc...) and
protein expression andpurification are commonly used in the lab of
the group leader. In addition,the lab has a strong background in
using more specialized methods inenzymology, such as
pre-steady-state kinetics of nucleotide incorporation.We would be
interested in collaborating in projects dealing with
thecharacterization of viral polymerases and eventually
identification of potentialantiviral drugs.Expertise categories
Medicine, Health, Biotechnology, Life sciences, Medical
biotechnology,Coordination, Cooperation, Scientific researchSkills
and competencesDr. Luis Menndez-Arias is a Research Professor of
the Consejo Superior deInvestigaciones Cientficas (CSIC, Spanish
National Research Council) andGroup Leader at the CBMSO, where he
has been working since 1994. Hisresearch is mainly devoted to
understanding structure-activity relationshipsin human
immunodeficiency virus type 1 (HIV-1) reverse transcriptase
(RT),
http://www.cbm.uam.es/https://cordis.europa.eu/partners/web/lmenendezarias/profile?p_p_id=3&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&p_p_col_id=public-column-2&p_p_col_count=2&_3_orgName=Centro+de+Biolog%C3%ADa+Molecular+Severo+Ochoa+(CSIC-UAM)&_3_struts_action=%2Fsearch%2Fsearch&_3_searchtype=advSearchhttps://cordis.europa.eu/partners/web/lmenendezarias/profile?p_p_id=3&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&p_p_col_id=public-column-2&p_p_col_count=2&_3_orgName=Centro+de+Biolog%C3%ADa+Molecular+Severo+Ochoa+(CSIC-UAM)&_3_struts_action=%2Fsearch%2Fsearch&_3_searchtype=advSearchhttp://www.cbm.uam.es/
-
7/30/2019 Profile Analiza SWOT
2/6
elucidating mechanisms of HIV-1 resistance to antiretroviral
drugs, andunderstanding HIV replication fitness. Dr. Menndez-Arias
graduated fromthe Complutense University of Madrid, Spain in
Biology in 1984, and obtainedhis Ph.D. in 1989 at the Department of
Biochemistry and Molecular Biology ofthe Faculties of Biology and
Chemistry of the same university. Between 1990
and 1994, he was trained as a postdoctoral fellow in the
Frederick CancerResearch and Development Center, Frederick,
Maryland, USA, where heconducted studies on the biochemical
properties of retroviral proteases andtheir implications in virus
maturation and antiviral therapy. He has published86 papers listed
in PubMed (his h index is 26).At present, he is Academic Editor of
the journals Sequencing and PLoS ONE,and member of the Editorial
Boards of Antiviral Research, Antiviral Therapy,Virus Research,
Viruses and World Journal of Virology. He also served asguest
editor for special issues of the journals Virus Research
(Retroviralreverse transcription, co-edited with Dr. B. Berkhout
and published in 2008)and Viruses (Retroviral enzymes, published in
2010). At present, Dr.Menndez-Arias leads a group of 6 people with
two post-docs and two Ph.D.students, as well as a visiting Masters
degree student from the University ofParma. He is also involved in
teaching activities of Master degrees at themajor universities of
Madrid.Research infrastructure of the organisationThe Centro de
Biologa Molecular Severo Ochoa is a biological researchcentre
founded in 1975 as a joint venture of the Universidad Autnoma
deMadrid (UAM) and the Consejo Superior de Investigaciones
Cientficas (CSIC,Spanish National Research Council). Research at
CBMSO covers a widevariety of topics in molecular biology. At
present, the institute is housed in
new facilities inaugurated in January 2008. The Institute
employs more than600 people (about 100 senior scientists/permanent
staff). The CBMSO isorganized in five research departments
(Cellular Biology and Immunology,Virology and Microbiology, Genome
Function and Dynamics, MolecularNeurobiology and Development and
Differentiation) and has a number ofcore facilities that constitute
the Technical Department. As of January 2012,there were 74 group
leaders in the institute, 16 of them junior principalinvestigators.
One of the general strengths of the CBMSO is the researchsupport
services with competitive core equipment and technical
expertise.These include a modern animal facility, optical and
confocal microscopy,proteomics, bioinformatics and genomics (in
this latter case, our centre leadsthe core facility for Madrid, at
the UAM Scientific Park). In addition, we haveaccess within the
institute to other specialized equipment and facilities,relevant
for the execution of the proposed project: cell and virus
culturefacilities (BSL2 and BSL3 labs), flow cytometry, electron
microscopy andradioactivity labs with appropriate equipment and
legal requirements.Additional support services include microbial
fermentation, peptide synthesis,
-
7/30/2019 Profile Analiza SWOT
3/6
graphic design, photography, computing services, library and
administrativeservices (purchasing, personnel, institutional
relations, cultural office, etc).
My LINK
Projects
No projects provided
Results
No results provided
Publications
No publications provided
News
No news provided
Other linksNo other links provided
My LibraryEmpty
-
7/30/2019 Profile Analiza SWOT
4/6
Main contactDr Simone GiannecchiniOrganisation name: University
of FlorenceDepartment/Unit: Experimental and clinic
medicineAddress: viale Morgagni 4850134 Florence Toscany ItalyTel:
39-055-4598524Fax: 39-055-4598924
Main organisationUniversity of FlorenceDepartment: Public
HealthPosition in organisation: full time researcherAddress: viale
morgagni 48
50134 Florence Toscany ItalyFavourite themeFP7-HEALTHExpertise
descriptionHe has 15-years experience in cellular and molecular
biology applied to thestudy of pathogenesis of viruses infections
and their prevention. His maininterest is focused on the molecular
mechanism of the immunopathogenesisof infection by viruses and on
the antiviral development.Main research topics:Human Polyomavirus
JCV: the interest of his research is focused on thestudy of
molecular mechanisms of viral and cellular factors that may
beinvolved in the reactivation of JCV in immunosuppressed patients
and thatcan determine the beginning of the development of
progressive multifocalleukoencephalopathy. In particular, he has
studied the reactivation of JCV inpatients with
immunomediated-diseases treated with the monoclonalantibody
infliximab, monoclonal anti-TNFalpha used in clinical therapy.
Inthese studies the correlation between the expression levels of
cellularmicroRNAs and reactivation of JCV in the blood of the
patients wasexamined. Recently, he has activated collaborations in
order to study thereplicative activity of molecular clones of JCV
carrying archetype or PML-prototype genomic structures.
Influenza virus: he has performed its activities in studies on
mechanisms ofpathogenesis of avian and human influenza viruses. In
particular, the studieshave been projected to clarify the molecular
mechanisms allow theinterspecies transmission of avian influenza
virus correlating changes in theviral genome with phenotypic
changes in their behaviour of changing thehost. In addition,
another object of his interest are studies of anti-influenzavirus
drugs. He has been involved on the investigation of the molecular
basisof resistance to neuraminidase inhibitors such as oseltamivir
and zanamivir
https://cordis.europa.eu/partners/web/sgiannecchini/profile?p_p_id=3&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&p_p_col_id=public-column-2&p_p_col_count=2&_3_orgName=University+of+Florence&_3_struts_action=%2Fsearch%2Fsearch&_3_searchtype=advSearchhttps://cordis.europa.eu/partners/web/sgiannecchini/profile?p_p_id=3&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&p_p_col_id=public-column-2&p_p_col_count=2&_3_orgName=University+of+Florence&_3_struts_action=%2Fsearch%2Fsearch&_3_searchtype=advSearch
-
7/30/2019 Profile Analiza SWOT
5/6
and the development of new antiviral. He demonstrated that
nucleic acid-based molecules reproducing the packaging sequences of
polymerase genescan be attractive new antiviral for the influenza
virus. Several of his researchstudies have been done in
collaboration with National or Internationalresearch groups
(Istituto Superior di Sanit, Istituto zooprofilattico delle
venezie, Roslin Institute of Edinburg).Expertise
categoriesMedicine, Health, Biotechnology, Life sciencesSkills and
competencesPresent position: Researcher in MED/07, Faculty of
Medicine, University ofFlorence
EducationDegree in Biological Sciences in 1993, University of
Pisa.Professional qualification to Biologist in 1995, University of
Pisa.PhD in "Immunobiology of Virus" in 1998, University of
Pisa.Master in E-Medicine in 2006, University of Florence.From 2004
to 2006 time-dependent researcher, University of Florence.
Scholarships, patents and awardsTwo-years post PhD fellowship in
1998, University of Pisa.ANLAIDS Scholarships in 2000 entitled to
professor G.B. Rossi.Fellowships of the Istituto Superiore di Sanit
in 2002.Patent Oligopeptides and their use in the pharmacological
treatment of theFIV in the cat, HIPPOCAMPE S. A. (MYMETICS SA)
deposited in France in2001.
Award scientific entitled to Prof. Giovan Battista Rossi as a
"Best YoungItalian Researcher for AIDS Studies" in 2002.
He also participates actively in the virological surveillance of
influenza,collaborating on this purpose to the national influenza
center at the IstitutoSuperiore di Sanit, in the virology
laboratory of the Department of PublicHealth who is the reference
laboratory of the Tuscany region for thisactivity.He is member of
society such as the Italian Society of Virology, the ItalianSociety
of Medical Virology, the Italian Society of Microbiology, and
theEuropean Society of Virology, and referee for several
international journals.He is the author of 37 publications in
extenso in journals with good impactfactor and a number of
communications to national and international.
Teaching activitiesUniversity lecturer of Microbiology and
Clinical Microbiology in the three-year course of Dietician, of
Phycical Therapy and Obstetrics at the Universityof Florence.
-
7/30/2019 Profile Analiza SWOT
6/6
University lecturer of Microbiology and Clinical Virology,
Microbiology andHygiene, Microbiology in the University three-year
degree course ofBiotechnology, University of Florence.University
lecturer of Applicative and experimental microbiology,Application
of molecular virology, and Biotechnologies in microbiology, in
the University master course of Biotechnology, University of
Florence.Member of the teaching Committee of the PhD in Basic and
clinic virology atthe University of Pisa.Research infrastructure of
the organisationThe operative unit (OU) GIANNECCHINI has stable and
strong researchinteractive collaborations with several researchers
from differentinternational laboratories recognized of high
importance. The infrastructureof the OU, located in the Department
of Public Health, University of Florence,are composed of cellular
and molecular biology laboratories includinglaboratory of recently
set up of biosafety level 3. All research activities arecarried out
with instruments available in the department and is composedmainly
by thermocycler real-time PCR, Wester blot apparatus,
thermostatsand other equipment to propagate cell cultures in
vitro.
My LINK
Projects
No projects provided
Results
No results provided
Publications
No publications provided
News
No news provided
Other links
No other links provided
My LibraryEmpty
![Analiza SWOT[1]](https://img.dokumen.tips/doc/110x75/55cf9961550346d0339d10cd/analiza-swot1.jpg)
