DNA STRUCTURE

Daniela Rios CarmonaMOLECULAR BIOLOGY

Teacher: Lina María Martínez Sánchez

IntroductionDNA is a secuence of nucleotides that expresses into proteins that are necesary for life.Its correct structure determines wheater an organism is viable or not and the quality of life it’ll have.

1st news

July 17, 2015Under the leadership of Giulio Maria Pasinetti, MD, PhD, Saunders Family Chair and Professor of Neurology at the Icahn School of Medicine at Mount Sinai and Director of Biomedical Training in the Geriatric Research Education and Clinical Centers at J.J. Peters Bronx VA Medical Center

The study tries to bond type 2 diabetes and Alzaheimer’s disease to determine weather numer one is a probable cause of the condition and how genetics could help prevent it from happening in those patients.

Type 2 diabetesType 2 diabetes is a chronic disease in which there is a high level of glucose in the blood. Is the most common form of diabetes.The goal of treatment at first is to lower your high blood glucose levels. Long-term goals are to prevent problems from diabetes

Alzheimer’s diseaseIs the most common form of dementia among older people. Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. It begins slowly. Involving first the parts of the brain that control thought, memory and language.

Personal opinionThere should be more of this studys in wich genes that decode for specific sicknesses, like T2D and AD, are related and determined weather they are consecuences of one an other so we can start early treatments and prevent this diseases from really affecting our patients lifes.

2nd news

July 17, 2015Professor Andy Fraser and his team in the University of Toronto's Donnelly Centre.

The fact that they found how genetics influences the severity of any genetic disease opens up a hole new spectrum of ways to face any of this genetic conditons.

Genetic disordersA genetic disease is any disease that is caused by an abnormality in an individual's genome, the person's entire genetic makeup. The abnormality can range from minuscule to major, from a discrete mutation in a single base in the DNA of a single gene to a gross chromosome abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes.

For example:• Cystic fibrosis• sickle cell anemia• Marfan syndrome• Huntington’s disease• Hemochromatosis• Phenylketonuria• Neurofibromatosis• Haemophilia• Down syndrome

Personal opinionI found this study, personally, very important specially because of the prediction of the serverity of any of this genetic disorders.To tell a patient that they will somehow suffer from a disease no mather how severe it could seem but not being able to tell them how much it can affect them is giving them even more reasons to undergo and this is something we should try very hard to prevent.

Medical utility

This studys open doors for new terapeutic targets specially in the development of concomitant treatments for T2D and AD.

Whit this findings we could start making new terapeutic alternatives that might, in a future, modificate the genetic alterations that are causing the disease to endure patient’s lifes.

If we could one day determine human genome in every individual since the minute they are born we’ll be predicting their possible diseases. This with the point to start treating them in their specific conditions and prevent them from happening or from having complications.

Bibliography• http://www.medicinenet.com/genetic_disease/article.htm• http://www.nlm.nih.gov/bsd/pmresources.html• Lina María Martínez Sánchez, Natalia Vargas Grisales, Laura

Mejía Cardona, Felipe Osorio Ospina, Sergio Ramírez Pulgarín. Biología molecular. Octava edición.

• http://www.news-medical.net/news/20150717/New-research-reveals-how-DNA-influences-severity-of-any-genetic-disease.aspx

• http://www.news-medical.net/news/20150717/Type-2-diabetes-patients-with-specific-genetic-markers-at-higher-risk-of-developing-