RESULT

Patient CharacteristicsFactors No. Of patients Percentage Age<60 tahun 22 73,3 %≥60 tahun 8 26,7 %SexMale 16 53,3 %Female 14 46,7 %

Age

<60 ≥60

0

2

4

6

8

10

12

14

16

HIF-1α (+)

HIF-1α (-)

HIF-1α (+) HIF-1α (-)

Sex

Male

Female

0 2 4 6 8 10 12 14

HIF-1α (+) 2HIF-1α (+)

Association between HIF-1α and Patient Characteristics

FactorsHIF-1α (+) HIF-1α (-)

Exact Sig. (2-sided)

Exact Sig. (1-sided)n (%) n (%)

Age

<60 6 20,0% 16 53,3%1,000 0,645

≥60 2 6,7% 6 20,0%

Sex

Male 3 10,0% 13 43,3%0,417 0,263

Female 5 16,7% 9 30,0%

Variable Characteristics

69%

26%

5%

DifferentiationWell Moderate Poor

positive (+)71%

negative (-)29%

Expression of Hypoxia Inducible Factor (HIF) -1α.

Staining of Immunohistochemistry of HIF-1α

Positive expression

Immunohistochemical staining of HIF-1α in well differentiated colon adenocarcinomas

Immunohistochemical staining of HIF-1α in moderatelydifferentiated colon adenocarcinomas

Immunohistochemical staining of HIF-1α in poorlydifferentiated colon adenocarcinomas

Negative expression

Relation of expression of HIF-1α and Differentiation Grade incolorectal cancer

Well Moderate Poor0

2

4

6

8

10

12

14

16

18

HIF - 1α (+) HIF - 1α (-)

Factor

HIF - 1α (+) HIF - 1α (-)Asymp. Sig. (2-sided)n % n %

Differentiation Grade

Well 2 10,5 % 17 89,5 %

0,081Moderate 3 42,9 % 4 57,1 %

Poor 3 75 % 1 25 %

Discussion

(Semenza, 2003)

Conclusion

Statistical analyses showed no significant difference between the expression of Hypoxia Inducible Factor (HIF) 1-α on the degree of differentiation in colorectal cancer tumors with p = 0.081.

Positive expression of HIF-1-α most founded in moderate and poor differentiation with each totaling 3 slides.