Clinical Nutrition Supplements (2011) 6(S1), 23–204

Poster presentations

Critical care IPP001-SUN Outstanding abstractA RANDOMISED, DOUBLE-BLIND, CROSS-OVER STUDY OFTHE EFFECT OF 1 LITRE INFUSIONS OF BALANCED ANDUNBALANCED 6% HYDROXYETHYL STARCH SOLUTIONSON BLOOD VOLUME, SERUM BIOCHEMISTRY AND RENALBLOOD FLOW IN HEALTHY HUMAN SUBJECTSA.H. Chowdhury1, E.F. Cox2, S.T. Francis2, D.N. Lobo1.1Division of Gastrointestinal Surgery, NottinghamDigestive Diseases Centre NIHR Biomedical ResearchUnit, Nottingham University Hospitals, Queen’s MedicalCentre, 2Sir Peter Mansfield Magnetic ResonanceCentre, School of Physics and Astronomy, Universityof Nottingham, Nottingham, United Kingdom

Rationale: We compared the effects of infusion ofa ‘balanced’ preparation of 6% hydroxyethyl starch(potato-derived) [PlasmaVolume-Redibag (PVR) (BaxterHealthcare, UK)] with 6% hydroxyethyl starch (maize-derived) in 0.9% saline [Voluven (Fresenius Kabi, UK)] onblood volume and renal arterial blood flow using magneticresonance imaging (MRI).Methods: Twelve healthy men, who underwent weighingand blood sampling prior to baseline MRI, were ran-domised to receive 1 L infusions over 30 min of Voluvenor PVR. MRI scanning proceeded for 60 min. Othermeasurements were repeated at 30 and 60 min from thestart of the infusion and then hourly for 4 h. Blood volumecalculations were based on haematocrit. Cross-over stud-ies with the alternate colloid occurred 7 10 days later.Results: Both colloids produced equivalent changes inmean±SE body weight, blood volume and extravascularfluid volume (Table).

Time DBody weight(kg)

DBlood volume(ml)

DExtravascular fluid volume(ml)

Voluven PVR p Voluven PVR p Voluven PVR P

30min 0.8±0.04 0.8±0.02 1.00 602±58 530±66 0.45 231±81 304±72 0.514h 0.1±0.1 0.10±0.1 0.79 294±56 257±69 0.62 177.2±143.4 166±144 0.91

DRenal artery blood flow(cm/s)

DRenal volume(%)

DRenal perfusion(ml/100g/min)

7min 3.1±1.1 2.5±1.8 0.75 2.9±0.9 1.4±1.6 0.30 0.0±2.6 9.8±2.6 0.00528min 4.7±2.5 1.2±1.4 0.06 3.3±1.3 4.1±1.2 0.65 2.4±3.8 5.6±6.8 0.70

Mean peak serum chloride concentrations were 108mmol/l after Voluven and 106 mmol/l after PVR(p = 0.088). Changes in strong ion difference were similar(p = 0.219). The peak increase in renal perfusion was 4%after PVR infusion and 1% following Voluven (p = 0.226).Conclusion: There were no differences in the plasma ex-panding properties of potato- or maize-derived hydroxy-

ethyl starch. Similar blood volume expansion and hyper-chloraemia may explain the lack of difference in renalblood flow.Disclosure of Interest: A. Chowdhury Other: AHC has received atravel bursary from Baxter Health Care., E. Cox: None Declared,S. Francis: None Declared, D. Lobo Other: DNL has receivedresearch funding, speaker’s honoraria and travel bursaries fromFresenius Kabi, Baxter Health Care, BBraun and Nutricia ClinicalCare.

PP002-SUNENERGY REQUIREMENTS IN BRAIN INJURED CRITICALLYILL PATIENTSP. Koukiasa1, A. Kokkinis2, M. Bitzani1. 1ICU, G.Papanikolaou Hosp, Thessaloniki, 2Nutrition & DieticsDepartment, Technological Education Institute of Crete,Sitia, Greece

Rationale: Accurate determination of nutritional needsis essential to critically ill patients, in order to avoidcomplications related to over or under nutrition. Becauseof the heterogeneity in this patient population, thereare differences in energy requirements related to theunderlining disease. The aim this study was to estimatecaloric needs of critically ill patients with brain injury.Methods: The study was preformed in a 15 bed IntensiveCare Unit of a community hospital. During a 3 year period,Resting Energy Expenditure (REE) was prospectivelymeasured by Indirect Calorimetry (IC) in critically illpatients with brain injury. All patients had an ICU stay>3 days, were intubated and mechanically ventilated.For the majority of patients repeated measurements byIC were performed. Linear regression analysis was usedto test correlation between REE, APACHE II score andpatients age.Results: Forty three brain injured patients (28 men and15 women) were included in study, with a total number of149 measurements. Mean APACHE II score on admition was17.6±5 and mean age was 59.8±12. Mean REE measuredby IC was 1914±438.6 Kcal/24hrs, or 23.82±4.06 Kcal/kgBW. There was no significant correlation between REEand APACE II score on admition, or patient age (P= 0.6,r = 0.06 and P= 0.06, r = 0.28 respectively).Conclusion: According to the study results, brain in-jured patients are mildly hypermetabolic. Provision of23 Kcal/kgBW/d is needed, in order to meet theirmetabolic demands. The amount of energy required bythis group of patients is within the range recommendedby the ESPEN guidelines for critically ill patients.Disclosure of Interest: None Declared