DEPARTMENT PHARMAKOLOGIE UND TOXIKOLOGIE

LMU MÜNCHEN

Postdoc position in pharmacology

and endolysosomal patch clampíng

at the LMU Munich, Germany

We are looking for PhD graduates with focus on

patch clamp electrophysiology/ion channels who

are interested in a Postdoctoral position at the

LMU Munich with a particular focus on

endolysosomal ion channels, i.e. TRPML cation

channels (mucolipins) and two-pore channels

(TPCs). We are looking for candidates with high

intrinsic motivation and a drive for scientific

innovation and discovery. The candidate would ideally have experience in molecular biological techniques in addition

to a strong background in patch-clamp electrophysiology and imaging techniques. The LMU is one of the top ranked

German universities with close ties to several Max-Planck institutes, Helmholtz institutes and other research

institutions. Apply today for a research position in a vibrant and lively city famous for its Oktoberfest and great outdoor

opportunities such as hiking and skiing! And benefit from one of the best research environments in Germany!

Selected publications:

-Scotto Rosato, A. et al. (2019) TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway. Nature Commun, 10:5630 -Goodridge, J. et al. (2019) TRPML1-mediated modulation of dense-core granules determines functional potential in NK cells. Nature Commun, 10:514 -Villella, V.R. et al. (2019) A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J, pii: e100101 -Plesch, E. et al. (2018) Selective agonist of TRPML2 reveals direct role in cytokine release from innate immune cells. eLIFE 7.pii: e39720 -Chao, Y.-K. et al. (2017) TPC2 polymorphisms associated with a human hair pigmentation phenotype result in gain of channel function by independent mechanisms. PNAS 114:E8595-E860 -Chen, C.-C. et al. (2017) Patch clamp technique to characterize ion channels in individual intact endolysosomes. Nature Protoc, 12:1639-1658 -Ruas, M. et al. (2015) Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. EMBO J, 34:1743-1758 -Sakurai, Y. et al. (2015) Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment, Science, 347:995-998 -Grimm, C. et al. (2014) High susceptibility to fatty liver disease in two-pore channel 2-deficient mice. Nature Commun, 5:4699 -Chen, C.-C. et al. (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nature Commun, 5:4681 -Aneiros, E. et al. (2011) Biophysical and molecular basis of TRPV1 proton gating. EMBO J, 30:994-1002 -Grimm, C. et al. (2007) A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. PNAS, 104:19583-19588

If you believe you fit this description then please send a brief letter of motivation, a short CV highlighting your academic and research accomplishments as well as copies of academic certificates and have 3 recommendation letters sent to christian.grimm@med.uni-muenchen.de Univ.-Prof. Dr. Dr. Christian Michael Grimm Professor for Molecular Pharmacology Department of Pharmacology and Toxicology Medical Faculty Ludwig-Maximilian-University (LMU) Munich Nussbaumstr. 26 80336 Munich Tel.: +49(0)89/2180-73811 Mobile: +49(0)157/34011173 Fax: +49(0)89/2180-73817