PERFORM YOUR INTERNSHIP IN A LIFE SCIENCES COMPANY! · LOCATION INTERNSHIP: Turnhout INTERNSHIP: Internship Life Sciences Consultant ISMS mainly works for the health care industry

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STUDYING LIFE SCIENCES? READY FOR A NEW CHALLENGE?

PERFORM YOUR INTERNSHIP*

IN A LIFE SCIENCES COMPANY!

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STAGEPLAATSEN

OPINNO Stageplaatsen 2015‐2016 Pagina 1 van 16

COMPANY:

I.S.M.S.

ISMS helps you build the bridge between Life Science and Business.

Our multidisciplinary approach, combining science, communication, marketing and business, enables

us to handle the complexity of your Market Access project from pre‐launch to late lifecycle.

LOCATION INTERNSHIP:

Turnhout

INTERNSHIP:

Internship Life Sciences Consultant

ISMS mainly works for the health care industry for projects where there is both a scientific and a

business aspect. (such as communication materials to payers, price assessments, creation of value

dossiers…).

We aim at providing the student with following skills:

• Understanding of the health care industry in a broad sense (internal and external

stakeholders, business model, …)

• Ability to understand the needs of the health care industry in terms of how certain activities

can contribute to their success (e.g. price landscaping, unmet need assessment…)

• Ability to apply the learnings acquired during previous study to specific projects within ISMS

(creation value communication tools, communications, ….)

• Ability to reach a quality level in terms of analytics, accuracy, scientific methodology that

meets the standards of the top 10 pharmaceutical companies worldwide.

Further, ISMS will aim at creating a working environment were student feels comfortable, and

support above aims through day‐to‐day coaching as well as through systematic feedback on all

outputs realized.

METHODOLOGY AND/OR TECHNIQUES THAT WILL BE USED:

The Intern will be involved in a wide range of activities, from scientific communication to business

analytics. He/she will be trained to approach every challenge in a systematic and methodological

way. At ISMS, we use a range of proprietary techniques and methodologies, e.g.

• Communication excellence

• Value creation business analytics

• Barrier/Driver oriented marketing research

• State of the Art business Modelling

USE OF LABORATORY ANIMALS?

No

STAGEPLAATSEN


COMPANY:

MindBytes

MindBytes is composed of a multidisciplinary team of Software and Data Engineers, Science PhD’s,

and Communication Professionals that are dedicated to helping people and organizations change

their behavior and make better decisions.

We believe that the traditional way of learning results is inadequate in addressing the increasing

complexity of our environment. Our learning platforms that are interactive, team‐oriented, and

emotionally captivating have demonstrated to address this issue.

We aim at improving the lives of patients and caregivers with our SERES Serious Games, which are

based on sound scientific research and rigorous external validation by Universities and HealthCare

professionals,

We help creating responsive and hence competitive organizational behavior in business, healthcare,

and public sectors, by creating tailor‐made learning solutions, based on solid business insights.


Gent

INTERNSHIP:

Internship Creation Serious Games in Health Care

Description of the tasks:

‐ Areas Schizophrenia, Dementia and Depression

‐ Study impact of caregiving on patients and caregivers

‐ Use serious gaming to modify caregiver behavior

‐ Develop the game content based on science

‐ Interview experts to score and improve the game

‐ Search for reliable validation tools and pilot study

‐ Study games in caregivers and improve via feedback


‐ Identify evaluation criteria of the effectiveness of psychological intervention.

‐ Identify compounds which can affect the status of caregivers and patients.

‐ Compare their status across different studies.

‐ Discuss their limitation and bias.

‐ Contact doctors, patient and social organizations.

‐ Test the game in the target population and collect feedback from participants and doctors.

‐ Use additional questionnaires.


No

STAGEPLAATSEN


COMPANY:

Medanex Clinic

Medanex Clinic is a CRO specialized in preclinical and clinical in vivo research using large animals

(rabbit, sheep, goat, (mini)pig, llama and horse).

Our main activities are preclinical surgical studies and surgery training for medical device,

pharmaceutical and biotech companies. We also provide our technical expertise on a consultancy

basis.

Our in‐house equipment consists of state‐of‐the‐art operating theatres, intensive care units,

anesthetic equipment, fluoroscopy, ultrasonography and X‐ray. We also provide MRI, CT and

(histo)pathology services through experienced partners.

The animal facility is designed to ensure maximal animal welfare and is suited to house larger groups

of animals in non‐surgical studies or for long term follow‐up.

The team of veterinarians and animal caretakers, specialized in lab animal science and medical R&D,

is complemented by a pool of external experts in all relevant fields of preclinical animal testing.


Diest

INTERNSHIP:

The use of large animals for biomedical research

‐ assisting in surgical/medical procedures

‐ working in different projects

‐ general post operative care of large animals (replacement of

bandages/injections/preparation of animals prior to surgery)

‐ sampling

‐ assistance in anesthesia/ autopsy/ medical imaging


Basic veterinary care

Practical work with large laboratory animals


Yes

STAGEPLAATSEN


COMPANY:

European Centre for Clinical Research Training (ECCRT)

Our mission is to provide clinical research professionals with competencies to develop new therapies

for patients quicker & more efficient, without jeopardizing quality.

The ECCRT is a professional clinical research training provider focussing on the transfer of

implementable knowledge in the day‐to‐day activities of our participants.

We are not just another training certification factory; we value the outcome of the training as being

the most important. Our aim is your goal: to get a real return on your training investment.


Brussel

INTERNSHIP:

Jr Clinical Researcher STAR Programme

In order for you to gain practical experience, we have 3 trainee ship episodes in this STAR

Programme, running over 1 full year.

The 3 trainee ship periods are each time in a different organisation: Starting in a hospital

environment, then in a pharmaceutical company and ending with a Clinical Research Organisation

(CRO). This allows the participant to get the complete overview of the clinical trial life cycle from the

point of view of all stake holders involved.


Hospital trainee ship: How is clinical research conducted in real life? How does it affect a patient?

What is the difference with the regular clinical practice

Pharmaceutical/Medical Device Company: How are Medicines/Medical Devices developed; Where

does Clinical Research fit in the complete development. Why is clinical research done differently

from normal clinical practice?

CRO: What activities need to be done in order to safeguard patients’ rights and well‐being and at the

same time make sure that quality of data obtained in a clinical study is guaranteed.


No

STAGEPLAATSEN


COMPANY:

Pharmavize NV

Pharmavize is a contract research organization developing prototypes of new medicines for testing in

clinical trials for various diseases. In order to assure the quality requirements (GMP) of these new

medicines, state of the art methods are needed to control the quality, stability and chemical purity of

these medicines. The analytical development service is focused on developing such methods, based

on the chromatographic behavior of the active compounds and the impurities that may be present.

The internship will focus on the method development of new medicines by liquid chromatography.


Mariakerke

INTERNSHIP:

Method development of new medicines


HPLC

Liquid chromatography

Other standard Lab techniques


No

STAGEPLAATSEN


COMPANY:

Millibeter

Millibeter kweekt sinds september 2012 met succes de zwarte wapenvlieg (Hermetia illucens), voor

wetenschappelijke en commerciële doeleinden.

De focus ligt op onderzoek en ontwikkeling rond de larven van deze vliegensoort, en hun vermogen

om organisch afval om te zetten in nieuwe grondstoffen. Doel is om uit de biomassa van de larven

nieuwe grondstoffen te puren, en deze duurzame grondstoffen te valoriseren.

Het bedrijf ontwikkelt ook de infrastructuur om binnenkort ook op een industriële schaal te kunnen

kweken en afval te verwerken.


Aartselaar

INTERNSHIP:

Verwerking van afval tot nieuwe grondstoffen met behulp van de Zwarte Wapenvlieg

De stage zal bestaan uit 3 delen: 1)dagdagelijkse taken en onderhoud, 2)assisteren bij een specifiek

lange termijn project of een onderdeel ervan en 3)een literatuurstudie. De stagiaire zal in functie van

afstudeerrichting en persoonlijke interesse ingeschakeld worden in een van de lopende lange termijn

projecten. Deze zijn af te stemmen met de academische en bedrijfs‐ promotor.


• Condities en omgevingsfactoren in kweekkamer opvolgen en optimaliseren

• Prepoppen en legsels van de zwarte wapenvlieg oogsten

• Bioconversie opvolgen

• Prototypes van kooien, kweekcellen, kweekbakken, etc. uittesten

• Voeder voor larven voorbehandelen en toedienen

• Invloed van voederregime op verdere verwerking van larven opvolgen

• Assisteren in chemisch labo bij extractieproeven, drogestofbepaling, gewichtsbepaling, etc.

• Meten van het effect van omgevingsfactoren op de lengte van verschillende larvale stadia.

Labotechnieken

∙ Chem‐labo:

Biomassa ontsluiting: alkalische voorbehandeling, zuurhydrolyse, etc.

Drogestofbepaling

NIR

Solvent extractie

Filtratie

∙ Bio‐labo:

Onderzoek naar verschillende larvenstadia van de zwarte wapenvlieg

Microfoto’s maken met binaire loep en bijbehorend fototoestel

STAGEPLAATSEN


Conversieratio bepalen voor de verschillende voederregimes: Omzettingsefficiëntie van

afvalbiomassa naar larvenbiomassa


Yes

STAGEPLAATSEN


COMPANY:

Genzyme A Sanofi Company

One of the world's leading biotechnology companies, Genzyme is dedicated to making a major

positive impact on the lives of people with serious diseases. With many established products and

services helping patients in approximately 100 countries, Genzyme is a leader in the effort to develop

and apply the most advanced technologies in the life sciences. The company's products and services

are focused on rare inherited disorders, kidney disease, orthopaedics, cancer, transplant and

immune disease, and diagnostic testing. In October 2001 Genzyme Corporation developed in Geel

Genzyme’s first biotherapeutics manufacturing facility in Europe, Genzyme Flanders. A perfusion

production line was build for the manufacturing of an enzyme replacement therapy for the

treatment of Pompe disease.


Geel

INTERNSHIP:

Continuous improvement to control the microbial content during the manufacturing of a biological

product (enzyme replacement therapy for rare diseases)

The Microbiology group of the Cell Culture and Microbiology division of the Technology Department

at Genzyme Flanders focuses on adequate contamination control on the microbial entry points, risks

to the process and product. Microbial contamination is a potentially high risk that may impact

biologic product quality and safety. The recent cases of bacterial contamination of biologic products

suggest that thorough understanding of microbial control at certain process steps is required.

Further, because endotoxin is directly related to gram‐negative contamination, extensive

measurement must be conducted. Additionally, endotoxin itself may be harmful for patients when

part of a biologic product when it enters the blood. The cost of inadequate microbial control can be

enormous, possibly resulting in facility shut down, and therefore, thorough investigations must be

conducted, the root cause identified and reoccurrence prevented.


This project will evaluate findings and actions taken in order to identify cause of microbiological

contamination and identify future actions. Further, research‐tools to evaluate the microbiological

content concerning the manufacturing processes are available. The recent cases of bacterial

contamination on a particular process step suggest that thorough understanding of microbial control

at certain process steps is required and can also be applicable to other processes.


No

STAGEPLAATSEN


COMPANY:

GO4CURE LLC

GO4CURE is a novel online health information platform for patients, caregivers and physicians,

providing trustworthy information tailored to the user's profile and interests. GO4CURE focuses on

diseases with unmet medical needs, and keeps users up to date with the latest relevant healthcare

innovations, future treatments and clinical trials. GO4CURE provides direct access to cutting‐edge

medical research and medical innovators.


Gent

INTERNSHIP:

Development of an online health information platform for physicians and patients ‐ GO4CURE

The objective for the student is to assist in the development of the online platform for patients and

physicians, more specifically identifying and developing content for distinct disease areas: oncology,

auto‐immune diseases and neurodegenerative diseases. He or she will be involved in finalizing and

adjusting the business model and setting up collaborations with users (physicians, patients and

caregivers) and clients (industry, MHOs and medical care centers) as well as designing the

architecture and content presentation of the online platform.


‐ Medical database searches, using public or our own platform

‐ Writing knowledge summaries for specific user groups (physicians and patients)

‐ Map the different healthcare stakeholders that can benefit from GO4CURE

‐ Develop wireframes (back end and front end) to establish the optimal architecture of the

online platform

‐ Develop optimal communication tools and marketing strategies to attract users and clients

‐ Insight (and if able, contribute to) the development of state‐of‐the‐art algorithms

empowered by semantic technology, unlocking medical and scientific information from

medical databases


No

STAGEPLAATSEN


COMPANY:

I.S.M.S.

ISMS mainly works for the health care industry for projects where there is both a scientific and a

business aspect. (such as communication materials to payers, price assessments, creation of value

dossiers…).


Turnhout

INTERNSHIP:

Support market access evaluation (optimize pricing and reimbursement) by assessing unmet need,

definition of potential areas of differentiation and optimize development plan based on EU/US payer

requirements for customers developing new compounds

We aim at providing the student with following skills:

‐ Understanding of the health care industry in a broad sense (internal and external

stakeholders, business model, …)

‐ Ability to understand the needs of the health care industry in terms of how certain activities

can contribute to their success (e.g. price landscaping, unmet need assessment…)

‐ Ability to apply the learnings acquired during previous study to specific projects within ISMS

(creation value communication tools, communications, ….)

‐ Ability to reach a quality level in terms of analytics, accuracy, scientific methodology that

meets the standards of the top 10 pharmaceutical companies worldwide.

‐ Further, ISMS will aim at creating a working environment were student feels comfortable,

and support above aims through day‐to‐day coaching as well as through systematic feedback

on all outputs realized.


The Intern will be involved in a wide range of activities, from scientific communication to business

analytics. He/she will be trained to approach every challenge in a systematic and methodological

way. At ISMS, we use a range of proprietary techniques and methodologies, e.g.

‐ Communication excellence

‐ Value creation business analytics

‐ Barrier/Driver oriented marketing research

‐ State of the Art business Modeling


No

STAGEPLAATSEN


COMPANY:

Medanex Clinic

Large laboratory animal surgery and medicine. Medanex Clinic is a service facility for research groups

working with large laboratory animals (sheep, goats, pigs, minipigs and llamas).


Diest

INTERNSHIP:

Het gebruik van grote proefdieren in biomedisch onderzoek en training

Meewerken aan de dagelijkse activiteiten in een private proefdierfaciliteit voor preklinisch onderzoek

en training, zoals assisteren bij anesthesieën en chirurgische ingrepen, verzorgen van de dieren,

opstellen van protocols, data management, literatuuronderzoek.


‐ Anesthesie en chirurgie van grote proefdieren (schapen, geiten, varkens, konijnen en lama's)

‐ Klinisch onderzoek van grote proefdieren

‐ Dataverwerking

‐ Opstellen van protocollen vanuit verschillende invalshoeken: ethische matrix, statistiek,...

‐ Literatuursearch


Yes

STAGEPLAATSEN


COMPANY:

Millibeter

Renewable resources & chemicals from insect‐biomass: proteins & amino acids; fats and fatty acids;

chitin and chitin‐derivatives.


Aartselaar

INTERNSHIP:

Verwerking van organisch afval met behulp van de Zwarte Wapenvlieg

De stage zal bestaan uit 3 delen: dagdagelijkse taken en onderhoud, assisteren bij een specifiek lange

termijn project of een onderdeel ervan en een literatuurstudie. De stagiaire zal in functie van

afstudeerrichting en persoonlijke interesse ingeschakeld worden in een van de lopende lange termijn

projecten. Deze zijn af te stemmen met de academische en bedrijfs‐ promotor.

Mogelijke taken:

‐ Condities en omgevingsfactoren in kweekkamer opvolgen en optimaliseren

‐ Prepoppen en legsels van de zwarte wapenvlieg oogsten

‐ Prototypes van kooien, kweekcellen, kweekbakken, etc. uittesten

‐ Voeder voor larven voorbehandelen en toedienen

‐ Invloed van voederregime op verdere verwerking van larven opvolgen

‐ Assisteren in chemisch labo bij extractieproeven, drogestofbepaling, gewichtsbepaling, etc.

‐ Meten van het effect van temperatuur op de lengte van verschillende larvale stadia


Chem‐labo:

‐ Biomassa ontsluiting: alkalische voorbehandeling, zuurhydrolyse, etc.

‐ Drogestofbepaling

‐ NIR

‐ Solvent extractie

‐ Filtratie

Bio‐labo:

‐ Onderzoek naar verschillende larvenstadia van de zwarte wapenvlieg

‐ Microfoto’s maken met binaire loep en bijbehorend fototoestel

‐ Conversieratio bepalen voor de verschillende voederregimes: Omzettingsefficiëntie van

afvalbiomassa naar larvenbiomassa


STAGEPLAATSEN


COMPANY:

Pharmavize

You have a promising drug molecule and you are preparing for Pre‐clinical or Early Phase Clinical

Studies? You are looking for contractors who can characterize, formulate, GMP produce, label and

release your clinical trial material? PharmaVize is a reliable source that can meet your clinical supply

material needs. Their business is to develop and manage your clinical supply materials, from design

to delivery. PharmaVize offers an integrated service level that is tailored to the clients’ specific needs.


Mariakerke

INTERNSHIP:

Van capsuleren naar tabletteren

In vroeg klinische studies (gezonde vrijwilligers, kleine patient populaties) wordt uitvoerig gebruikt

gemaakt van poeder‐in‐capsule technologie. Voor latere klinische studies (grote patient populaties)

en commerciële geneesmiddelen is tabletteer technologie veelal de voorkeur.

De stage beoogt het uitwerken van een aantal formulatie‐concepten voor capsules en tabletten, die

een naadloze transfer van het capsule naar het tablet platform toelaten.


‐ Formulatietechnieken: Mengen, automatisch capsuleren en tabletteren (R&D labo‐schaal)

‐ Analytische technieken: Poeder karakterisatie, gehalte, hardheid, friabiliteit, dissolutie


No

STAGEPLAATSEN


COMPANY:

Adhoc Clinical

Adhoc Clinical is a privately owned CR0 rendering services to innovative pharma , biotech and

medical device companies.

We are experts in study start up and monitoring of your clinical trials/ clinical investigations.

Adhoc has operatational activities in Belgium, France and the Netherlands and has a large network

allowing easy access to resources and knowhow in most EU countries.


Ieper

INTERNSHIP:

Clinical trial start up activities

Learn how to :

‐ select study sites to perfom clinical trials

‐ submit trials for Ethical Committee review

‐ submit trials for Competent authority review

‐ negociate site clinical trial agreements

‐ ...


Learning objective will be reached by reading of our internal processess (SOP's), comprehensive

reading of rules and regulation, work with experienced staff


No

STAGEPLAATSEN


COMPANY:

ProDigest

ProDigest provides customized solutions to the operators in the market of food, functional food and

pharmaceutical industry. They offer services in the field of gastrointestinal transit, bioavailability and

metabolism of compounds based on the application of an extensive in vitro technology platform

including a dynamic simulation model of the gastrointestinal tract. This technology platform is

extended with expertise and access to animal trials and proof‐of‐concept human intervention

studies.


Zwijnaarde

INTERNSHIP:

Screening novel antibiotics in an in vitro gut model

The student will be involved in the development of an in vitro gut model that will be used to screen

novel antibiotics in treatment of artificially induced disease. The in vitro gut model is referred to as

the 'SHIME', which stands for 'Simulator of the Human Intestinal Microbial Ecosystem'. Focus will be

on in vitro activity and therapeutic efficacy of new agents in treatment of Clostridium difficile disease

and on their effects on the gut microbiota.


Techniques will include:

‐ Gas chromatographic analyses of extracted short chain fatty acids

‐ Ammonium analyses in complex samples

‐ Real‐time PCR

‐ Culturing bacteria under anaerobic conditions (both in liquid and solid media)

‐ Safe handling of pathogenic bacteria

‐ HPLC analyses to monitor antibiotic concentrations in complex matrices


No

STAGEPLAATSEN


COMPANY:

Novosanis

Novosanis is a medical device company and spin‐off from the University of Antwerp. Novosanis

currently has two medical devices in development, a device suited for intradermal injection of e.g.

vaccines and a device suited for guaranteed collection of first‐void urine for a better detection of

sexually transmitted infections and cancer.


Antwerpen

INTERNSHIP:

Ontwikkeling van Medical Devices

As an intern, you will contribute to the technical and/or clinical development of medical devices and

of mapping of all the technical and clinical aspects necessary for regulatory authorities.


‐ Overview state of the art through literature surveys and patent searches

‐ Technical verification using imaging technology in skin samples, next to modeling and

simulation work, mechanical testing and small technical set‐ups to assess needles, reservoirs,

…

‐ (Pre)Clinical validation in animal models and healthy volunteers

‐ Compliance with ISO13485


SCRIPTIEPLAATSEN

OPINNO Scriptieplaatsen 2015‐2016 Pagina 1 van 15

COMPANY:

I.S.M.S.

ISMS helps you build the bridge between Life Science and Business.

Our multidisciplinary approach, combining science, communication, marketing and business, enables

us to handle the complexity of your Market Access project from pre‐launch to late lifecycle.


Turnhout

INTERNSHIP:

Apply Settings Simulation Model to Determine Cost effectiness in a Complex Mental Health

Environment

Application of ISMS developed settings model to show an overview of the patient flow through the

pathway and simulate the pathway by changing key parameters in the tool. The patient flow can be

combined with the costs and utilities to calculate (incremental) costs and incremental cost‐

effectiveness ratios (ICER) for each of the parameters.


At ISMS, we use a range of proprietary techniques and methodologies, e.g.

• Communication excellence

• Value creation business analytics

• Barrier/Driver oriented marketing research

• State of the Art business Modelling


No

SCRIPTIEPLAATSEN


COMPANY:

MindBytes

MindBytes is composed of a multidisciplinary team of Software and Data Engineers, Science PhD’s,

and Communication Professionals that are dedicated to helping people and organizations change

their behavior and make better decisions.

We believe that the traditional way of learning results is inadequate in addressing the increasing

complexity of our environment. Our learning platforms that are interactive, team‐oriented, and

emotionally captivating have demonstrated to address this issue.

We aim at improving the lives of patients and caregivers with our SERES Serious Games, which are

based on sound scientific research and rigorous external validation by Universities and HealthCare

professionals,

We help creating responsive and hence competitive organizational behavior in business, healthcare,

and public sectors, by creating tailor‐made learning solutions, based on solid business insights.


Gent

INTERNSHIP:

Serious gaming as a novel technology‐driven intervention for children with mental disease

To develop a prototype of serious games for groups of informal caregivers of children with mental

illnesses, which provides virtual caregiving experience by disclosing interlinks between caregivers’

actions and their possible consequences.


1) Literature study in two steps: a) in scientific databases via PsycInfo, MEDLINE and EMBASE; b) on

governmental and HONcoded websites. Included data were related to caregiver burden, caregiver

coping and patient quality of life; excluded publications were about professional caregivers or an

irrelevant disease.

2) The main learning and game elements were developed based on available software SERES

(MindBytes), using the theoretical game model of the Serious Games Institute (UK) and behavioral

oriented learning approach.

3) A structured interview to collect expert opinion about the game content.

4) Gameplay and discussion in a focus group of six experienced informal caregivers.


No

SCRIPTIEPLAATSEN


COMPANY:

Pharmavize NV

Pharmavize is a contract research organization developing prototypes of new medicines for testing in

clinical trials for various diseases. In order to assure the quality requirements (GMP) of these new

medicines, state of the art methods are needed to control the quality, stability and chemical purity of

these medicines. The analytical development service is focused on developing such methods, based

on the chromatographic behavior of the active compounds and the impurities that may be present.

The internship will focus on the method development of new medicines by liquid chromatography.


Mariakerke

INTERNSHIP:

Biorelevante analyse van lipide‐gebaseerde geneesmiddelafgitesystemen

Zeer veel hedendaagse geneesmiddelkandidaten hebben een te lage wateroplosbaarheid om na

orale inname in voldoende mate geabsorbeerd te worden. Hierdoor is de gewenste therapeutische

respons vaak laag en variabel. Een vaak gebruikte manier om de opname van slecht waterloplosbare

geneesmiddelen te verhogen, bestaat erin om het geneesmiddel in te nemen als een oplossing in een

lipide. Ondanks de bewezen werkzaamheid van deze zogenaamde ‘lipidegebaseerde systemen’, is de

manier waarop deze systemen werkzaam zijn in vivo zeer complex. Het is dan ook zeer uitdagend om

via in vitro testen het in vivo effect te voorspellen. Binnen Pharmavize wordt er sedert enkele jaren

gewerkt aan de ontwikkeling van in vitro testen die toelaten om de in vivo performantie van

lipidegebaseerde testen te voorspellen. Het gebruik van deze biorelevante in vitro testen laat toe om

het aantal (dure) dierproeven te verminderen, en zorgt er ook voor dat Pharmavize de selectie van

de juiste formulering kan onderbouwen met wetenschappelijke argumenten. Het onderzoekswerk

dat kadert binnen deze scriptie, is erop gericht om de huidige in vitro testprocedures voor

lipidegebaseerde systemen binnen Pharmavize verder te verfijnen, om ze zo wetenschappelijk

correcter, gebruiksvriendelijker en kosten‐efficiënter te maken.


Various formualtion technologies for galenic forms

Basic analytical tasks

Basic Laboratory tasks


No

SCRIPTIEPLAATSEN


COMPANY:

P95, Consultancy

Consultancy and services in Epidemiology and Pharmacovigilance.


Heverlee

INTERNSHIP:

Development of data flow for a Common Data Model implementation to combine large health care

databases.

The project will involve systems analyses and programming in SQL, data integration, and testing using

(e.g. CPRD, EMIS, TESSY datasets).


Database schema development. Data flow diagrams, systems analyses and costumer requirements

assessment.

SQL (MySQL) programming and optimization for large databases (>100GB).

Development and implementation of data conversion and transfer procedures, quality validation and

monitoring routines.

Nice to have but not required: programming data visualization techniques.


No

SCRIPTIEPLAATSEN


COMPANY:

GO4CURE LLC

GO4CURE is a novel online health information platform for patients, caregivers and physicians,

providing trustworthy information tailored to the user's profile and interests. GO4CURE focuses on

diseases with unmet medical needs, and keeps users up to date with the latest relevant healthcare

innovations, future treatments and clinical trials. GO4CURE provides direct access to cutting‐edge

medical research and medical innovators.


Gent

INTERNSHIP:

Development of an online health information platform for physicians and patients

The objective for the student is to assist in the development of a novel online health information

platform GO4CURE for patients and physicians.

The need for education and continuous updates on cutting‐edge medical breakthroughs is a major

challenge for physicians. Patients are looking for more trustworthy information, validated by the

medical community.

GO4CURE tackles these challenges and unlocks medical innovations to different users. GO4CURE’s

powerful search engines provide only relevant and carefully selected, trustworthy information.

GO4CURE provides access to medical experts to discuss clinical trials and new & future treatments.

You will be closely involved in all aspects to develop the online platform.


‐ Medical database searches, using public availaibe or our own platform

‐ Writing knowledge summaries for specific user groups (physicians and patients) ‐ ENG & NL ‐ for

distinct disease areas: oncology, auto‐immune diseases and neurodegenerative diseases.

‐ Develop strategies to set up partnerships with different healthcare stakeholders that benefit from

GO4CURE

‐ Oversight of the development of the back end and front end of the online platform by our

technology partners

‐ Analysis of the use of apps and other online tools to reinforce the platform

‐ Develop optimal communication tools and marketing strategies to attract users and clients

‐ Insight (and if able, contribute to) the development of state‐of‐the‐art algorithms empowered by

semantic technology, unlocking medical and scientific information from medical databases

SCRIPTIEPLAATSEN


‐ Finalizing and adjusting the business model and assist in setting up collaborations with users

(physicians, patients and caregivers) and clients (industry, MHOs and medical care centers)


No

SCRIPTIEPLAATSEN


COMPANY:

Pharmavize

You have a promising drug molecule and you are preparing for Pre‐clinical or Early Phase Clinical

Studies? You are looking for contractors who can characterize, formulate, GMP produce, label and

release your clinical trial material? PharmaVize is a reliable source that can meet your clinical supply

material needs. Their business is to develop and manage your clinical supply materials, from design

to delivery. PharmaVize offers an integrated service level that is tailored to the clients’ specific needs.


Mariakerke

INTERNSHIP:

Formulatietechnieken voor slecht wateroplosbare molecules

Meer en meer nieuwe pharmaceutisch actieve small molecules hebben een slechte

wateroplosbaarheid en beperkte biologische beschikbaarheid. Dit gegeven is een uitdaging voor de

formulatie‐ontwikkelaars die deze moeilijk oplosbare geneesmiddelen dienen te formuleren in een

geneesmiddel. De scriptie beoogt het toepassen van een aantal formulatietechnieken (bvb

nanosuspensies, solid dispersions, lipids) op concrete case‐studies. De bekomen formulatie‐

concepten zullen hoofdzakelijk aan de hand van dissolutietesten met elkaar vergeleken worden.


Analytische technieken: Dissolutie, particle size distributie, rheology, poeder characterisatie

Formulatietechnieken: Nano‐milling, melt‐extrusie, sproeidrogen, capsuleren, tabletteren


No

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COMPANY:

Pro‐C‐epT

Pro‐C‐epT is een innovatief Belgisch KMO bedrijf dat zich sinds 20 jaar gespecializeerd heeft in de

bouw en ontwikkeling van R&D apparatuur, zowel voor de farmaceutische, biotechnnologische,

voedings en scheikundige industrie. De klemtoon bij de bouw van de apparatuur ligt vooral op het

ontwikkelen van nieuwe formulaties op kleine schaal waarbij rekening wordt gehouden met de

mogelijkheid om op te schalen naar industriële processen. Een sterke data acquisitie in « real‐time »

en onder de vorm van een Excel batch rapport tijdens het proces, staat hierbij centraal.

Qua processen heeft ProCepT een gamma process ontwikkelingsapparatuur voor agglomeratie,

coaten, mengen, filtreren en drogen. Zie meer onder www.procept.be.


Zelzate

INTERNSHIP:

Scaling of a spray dryer / congealer

In de groep van droogapparatuur bevindt zich de « 4M8‐TriX Spray Dryer » sproeidroger/koeler, op

de markt sinds 2006, die wordt gebruikt om met zeer kleine hoeveelheden (vanaf 0,5 ml) de eerste

sproeidroog en koel experimenten uit te voeren.

Sproeidrogen is veruit de meest gebruikte techniek om substanties in oplossing (water of organische

solventen), via verneveling in een warme luchtstroom, om te vormen tot een gedroogd poeder. De

nevel van vloeistofdruppels, met een grote oppervlakte/massa verhouding, laat toe om snel en

evenredig het water te verdampen in de warme luchtstroom. Toepassingen vind men in Pharma,

Biotec, Food en Fine Chemical industry

Eén van de grote voordelen van het sproeidroog proces is de accurate en flexible controle over de

fysische poedereigenschappen (deeltjesgrootte en morfologie, densiteit, vochtgehalte, specifiek

opppervlak…). De controle over deze poedereigenschappen zijn oa. afhankelijk van de formulatie en

enkele verschillende krititische proces parameters zoals :

Luchtinlaat : temperatuur, debiet.

Oplossing van de substantie : temperatuur, debiet, concentratie‐viscositeit.

Sproeikop : type (bi‐fluid, mono dispers, ultrasonic,…), debiet, opening.

Recent heeft PorCepT een sproeidroger /koeler gebouwd met een 5 meter droogkamer om een

grotere verblijftijd te geven aan de druppels, waardoor er grotere deeltjes gemaakt kunnen worden

dan in de 1,6 meter uitvoering.

ProCepT wenst met een thesis student een vergelijkende studie te doen van verschillende

formulaties die gedroogd en gekoeld worden in de 1,6 en de 5 meter proceskamer. De deeltjes

worden statistisch geanalyseerd met een Laser Diffractie Toestel op grootte en op vorm. Het

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vochtgehalte van de deeltjes wordt eveneens geanalyseerd. Er wordt gebruik gemaakt van data

analyse software om relaties tussen de procesparmaters te bepalen.


Sproeidrogen / Sproeikoelen Laser Diffractie en beeld analyse voor gemaakte poeder deeltjes, LOD

balans,mDSC, Dissolutie


No

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COMPANY:

Multiplicom

Multiplicom develops, manufactures and commercializes molecular diagnostic assays, provided as

kits, which enable personalized medicine.

Multiplicom's diagnostic products enable medical genetics‐ and clinical laboratories to meet an

increasing demand for molecular diagnostic testing, driven by the scientific evidence that links

genetic information to health and disease. Our assays are simple, fast, accurate and flexible.

Our molecular diagnostic assays allow the:

determination of whether an individual has an increased genetic risk to develop a disease;

early detection of congenital genetic defects; and

identification of mutations that allow physicians to prescribe the most effective drugs for their

patients.

Multiplicom's History:

Founded in 2011 as a spin‐off from the University of Antwerp and VIB, Multiplicom achieved end of

2012 its first CE‐IVD‐certification for the BRCA MASTR Dx assay for breast and ovarian cancer

predisposition. It was the first company in Europe achieving a BRCA CE‐IVD certification and it

continues to develop and market quality controlled MPS‐based assays. Therefore, it enables clinical

laboratories to diagnose patients with a genetic disease or predisposition, steer cancer therapy, and

identify congenital defects early in pregnancy.


Niel

INTERNSHIP:

Development of cell free DNA based diagnostic assays

Cell free DNA (cfDNA) is a relative new class of DNA that is more and more used to developed

diagnostic tests in the oncology field. The advantage of cfDNA is that it can be obtained in a non

invasive way (simple phlebotomy), which is especially interesting in the development of diagnostic

and prognostic cancer tests.

However, given the physical properties of cfDNA, eg. Short DNA fragments (50‐200bp), short half life

time, relatively low cfDNA concentrations, etc. It is challenging to use cfDNA as input DNA source for

the development of diagnostic tests.

Nevertheless, targeted multiple PCR is the ideal technology to developed cfDNA based diagnostic

tests and has the potential to lead to highly competitive tests.

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A non exhaustive list of methods and technologies:

cfDNA isolation from plasma

optimising multiplex PCR tests

generating libraries for NGS sequencing

NGS data analysis

evaluate non NGS read out systems for rapid test development


No

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COMPANY:

Adhoc Clinical

Adhoc Clinical is a privately owned CR0 rendering services to innovative pharma , biotech and

medical device companies.

We are experts in study start up and monitoring of your clinical trials/ clinical investigations.

Adhoc has operatational activities in Belgium, France and the Netherlands and has a large network

allowing easy access to resources and knowhow in most EU countries.


Ieper

INTERNSHIP:

Clinical trials

Clinical trials : study start up and study monitoring


Student will be involved in all kinds of studies (interventional vs non interventional / prospective vs

retrospective studies) /prior to marketing authorisation vs post marketing autorisation


No

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COMPANY:

BioMARIC NV

Besides its own research and development programs to identify new markers for infectious diseases,

BioMARIC offers a full range of servicing activities dedicated to facilitate technical development of

various diagnostic assays.


Zwijnaarde

INTERNSHIP:

Production optimization of a recominant virus protein for use in diagnostics

Sexually Transmitted Infections remain a major global public health issue. The World Health

Organization (WHO) estimates that worldwide, 448 million new cases are diagnosed. About 35

million people are infected with HIV and 130‐150 million with Hepatitis C. Therefore, it is crucial to

have quick and reliable diagnostic tests to identify infections in early state to prevent the spread of

these diseases.

BioMARIC focuses on the development of accurate and quick diagnostic tests to detect for example

HIV, which can be used at the point of care. In the proposed project, the production of a

recombinant virus protein is optimized for use in such a diagnostic test.

The gene coding for a virus protein is cloned and expressed in E. coli, the resulting protein is purified

and formulated. In this project, not only the fermentation is optimized, but also the purification and

the formulation aiming a high production efficiency, a high product quality and a long term stability.


Fermentation: MTP, shake flasks, bioreactor (batch, fed‐batch), …

Purification, affinity‐ and size exclusion chromatography, dialysis

Analysis: SDS‐page, western‐blot, Determination of concentration

Formulation: Analytical chromatography, DSF , ...

Functionality: ELISA


No

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COMPANY:

Novosanis

Novosanis is a medical device company and spin‐off from the University of Antwerp. Novosanis

currently has two medical devices in development, a device suited for intradermal injection of e.g.

vaccines and a device suited for guaranteed collection of first‐void urine for a better detection of

sexually transmitted infections and cancer.


Antwerpen

INTERNSHIP:

Development of a medical device suited for intradermal injections of lyophilized biologicals and

vaccines

Research goals (depending on background focus on technical or clinical)

State of the art intradermal devices & lyophilized drugs

Technical development and technical verification

(Pre)Clinical validation

Preparation files for regulatory authorities (CE label, FAGG, EMA, FDA)

Methods (depending on background focus on technical or clinical)

Overview state of the art through literature surveys and patent searches

Technical verification using imaging technology in skin samples, next modeling and

simulation work, mechanical testing and small technical set‐ups to assess needles, reservoirs,

…

(Pre)Clinical validation in animal models and healthy volunteers

Compliance with ISO13485



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LET OP! DE VOLGENDE INTERNSHIP KOMT PAS MIDDEN 2016 ON LINE:

COMPANY:

Bio Base Europe Pilot Plant

De Bio Base Europe Pilot Plant is een open en onafhankelijke piloot infrastructuur in de Gentse

zeehaven, waar industrie, kmo's en onderzoeksinstellingen hun innovatieve projecten vanuit het labo

naar industriële schaal kunnen brengen. De Bio Base Europe Pilot Plant is ook partner in meerdere

lange termijn projecten (IWT,Era‐IB, FP7, ...).


Desteldonk

INTERNSHIP:

Ontwikkeling van biogebaseerde producten en/of processen

De thesisstudent zal in functie van afstudeer richting ingeschakeld worden in een van de lange

termijn projecten af te stemmen met de academische promotor.

Typische onderwerpen:

Fermentatieve productie en bijhorende downstreamprocessing van biosurfactantia

Fermentatieve productie en bijhorende downstreamprocessing van chito oligomeren

Fermentatieve productie van biosolventen gekoppeld aan in situ product recovery

Fermentatieve productie van glucosyltransferases en vervolgens glycosyleringsreacties

Biomassa ontsluiting gevolgd door enzymatische versuikering en fermentatie tot

hernieuwbare chemicaliën


Biomassa ontsluiting: alkalische voorbehandeling, zure hydrolyses, enzymatische hydrolyse,

...

Analytische technieken zoals GC‐FID, HPLC‐RI, HPLC‐UV, HPLC ELSD fotospectrometrie,

microscopie

Microbiologische technieken: uitplaten, inocolum bereiding, fermentatie

Downstream processing: cell disruptie, membraanfiltratie, centrifugatie, solvent extractie,

preparatieve chromatografie, ...


No

Documents

PERFORM YOUR INTERNSHIP IN A LIFE SCIENCES COMPANY! · LOCATION INTERNSHIP: Turnhout INTERNSHIP: Internship Life Sciences Consultant ISMS mainly works for the health care industry