Pathology

Prof. Dr. Osman A. Attallah

Visitor Prof of PathologyVisitor Prof. of PathologyDepartment of Patahology, Faculty of

Veterinary Medicine, Zagazig UniversityEgyptEgypt

Email: dr atallah o a@hotmail comEmail: [email protected]

Mobile: +2 - 0197434781

Systemic PathologySystemic Pathology

(1)Organ: IntestineA g

(rabbit)Stain:: H&E.Lesion:A

B A

Acutenecrotic enteritis.

Micro.:The intestinal mucosa sufferedcoagulative necrosis, particularly the upper layer(A) Hyperemic blood vessels and inflammatory

◌ABB(A). Hyperemic blood vessels and inflammatorycells (B) are seen in the deep layer of the mucosa.

(2)(2)Organ : Intestine.Stain : H & E.L ib Lesion :

Chronic catarrhalenteritis

b aa

enteritis

b

Micro.:Most of the columnar epithelial liningf h i i h d bl ll

b

of the intestine chnged to goblet cells(metaplasia).The nuclei of the goblet cells are ontheir basement membrane and excessive mucin

i t i th ti ( ) Th l i

a

exists in the upper portion (a).The laminapropria and the sbmucosa present congestedblood vessels and infiltration with lymphocytesand macrophages (b) The lumen of the intestineand macrophages (b) The lumen of the intestinecontains numerous dequamated epithelium.

(3)Organ: Intestine.b Organ: Intestine.Stain: H&E.Lesion:

a b

Lesion:

Acute catarrhalparasitic enteritisparasitic enteritis.

Micro: The epithelial covering of the villi ispartially desquamated.The mucosa presents

h i bl d l b id

b

numerous hyperemic blood vessels, besidesnumerous neutrophils (a).The parasite (3rd stagelarvae of Strongyloides westeri) (arrow) appearas bluish masses (b) in the intesinal lumen and

aas bluish masses (b) in the intesinal lumen andmucosa.

(4)Organ : :Intestine

(Rabbit)(Rabbit)Stain : H & E.Lesion :a

Chronic catarrhalenteritis.

bc d

Micro. : The epithelial lining of the intestinecontains the various developmental stages of Eimeria

abp g

(schizonts, merozoites, trophozoites and oocysts) (a),and numerous goblet cells (b). The lumen of theintestine contains numerous oocysts and necrotic

i h li ( ) Th i h i bl depithelium (c). The mucosa contains hyperemic bloodvessels besides numerous inflammatory cells (d).

(5)O I i (Chi k

bOrgan : Intestine (ChickenStain : H & E.Lesion : A t h h iAcute hemorrhagicenteritis (coccidiosis)

aa

b

ab

Micro The epithelial lining of the bottom of the crypts of LieberkuhnMicro. : The epithelial lining of the bottom of the crypts of Lieberkuhncontain the various developmental stages of Eimeria (a).The mucosacontains numerous congested blood-vessels, erythrocytaes and inflammatorycontains numerous congested blood vessels, erythrocytaes and inflammatorycells. Sloughed villi with oocysts (b) are seen in the intestinal lumen.

((66))Organ:Organ: Abomasum.Abomasum.

a

c Organ:Organ: Abomasum. Abomasum. Stain:Stain: H&E.H&E.Lesion:Lesion:Chronic ulcerativeChronic ulcerativeb

c

Chronic ulcerative Chronic ulcerative gastritisgastritis

b

b

Micro. : Ulceration (a) of the gastric mucosa,which shows hyperemic and thrombosed blood

l (b) b id i filt ti ith t hila

vessels (b) besides infiltration with neutrophils,lymphocytes and macrophages (c). c

bb

(7)

Organ : Peritoneum(Chick). St i H & E

ab Stain : H & E.

Lesion :

C i i

b

Chronic necrotic peritonitis.

Micro.: Focal thickening of the visceralperitone m (co ering the intestine) b fibro speritoneum (covering the intestine) by fibrousconnective tissue with caseated foci (a) surroundedwith macrophages and lymphocytes (b). Thefibrous connective tissue shows aggregation of

afibrous connective tissue shows aggregation ofgranulocytes b

(8)(8)Organ : Liver.Stain : H & E.Lesion:

aLesion:

Acute toxic infla-immation

(hepatitis)aa

Micro. : Diffuse cenrolobular necrosis infiltrated awith eosinophils, and partially replaced with blood(a). Few lymphocytes are seen in the portal tracts

a

(9)( )Organ : Liver.Stain : H & ELesion:

Chronic infecti-o sb ous

inflammation (hepatitis)

ab

(hepatitis).

bMicro. : Focal coogulative necrosis (a) of thehepatic parenchyma (a) surrounded by a zone of

b

p p y ( ) yneutrophils, macrophages and lymphocytes (b). Thenecrotic areas are infiltrated with macrophagesand lymphocytes. a

b

(10)a (10)Organ : Liver (Mouse).Stain : H & E.bLesion:

Chronicc

Chronic Parasitic inflam-mation(hepatitis) ( p ).

a

b

Micro. :Schistosome-eggs (a) are surroundedb i hil l h d h (b)

b

by eosinophils, lymphocytes and macrophages (b).The hepatic cells reveal some degenerativechanges. The hepatic cells, adjacent to the

hi t ( ) h t h

a

cbschistosome worm (c), show pressure atrophy. b

(11)Organ : Liver.gStain : H & E.Lesion : a

Migratory tracks of C tiCysticercus tenuicollis.

Micro. : Focal replacement of the hepaticparenchyma with migratory tracks (a) Theparenchyma with migratory tracks (a). Thetracks are represented by crescent-icallylamellated fibrinous material, trapp- ing

erythrocytes and leukocytes. Macroph-erythrocytes and leukocytes. Macrophages, lymphocytes, eosinophils and siderocytesare surrounding the tracks and infiltratingthe portal tracts. The oncospheres are

a

the portal tracts. The oncospheres arerepresented by cavities lined with filamentouscells on an eosinophilic hyalinized layer.

(12)Organ : Liver.Stain : H & EStain : H & E.Lesion :

I di id li dIndividualized hepatic cells.

a

Micro. :Complete dissociation of thehepatic cords to appear as individual hepatichepatic cords to appear as individual hepaticcells with blood among them.The portal tracts (a) are intact. a

(13)Organ : Liver.Stain : H & E.a

bStain : H & E.Lesion :ChronicParasitic inflam

ab c Parasitic inflam.,

hepatitis,(Distomiasis)

Mi

(Distomiasis)

Micro. : The hepatic parenchyma isextensively replaced by hyperplastic adenomatousbile ducts (a) containing the

acbile ducts (a), containing theparasite (b). Such ducts are surrounded withexcessive fibrous tissue proliferationinfiltrated with macrophages, siderocytes, binfiltrated with macrophages, siderocytes,lymphocytes and eosinophils (c). Thrombosedblood vessel were encounteere

b

(14)A ( )Organ : Liver(Sheep)B

)

(Sheep) Stain : H&EL iLesion :

Cirrhosis.A

Micro : Extensive replacement of the hepaticcells with fibrous tissue (A). Lym-

A( ) y

phocytes and macrophages are present. Theregenerated hepatic cells formed soild noduleswithout the normal histologic arrangement of theh i l b l (B)

B

hepatic lobules (B).

(15)( )Organ: :Liver.Stain: H&Ea Stain: H&E.Lesion::a

Chronic eosinophilichepatitis.a

MiMi

p

MicroMicro:: TheThe portalportal tractstracts areare infiltratedinfiltrated withwithnumerousnumerous eosinophilseosinophils ,, besidesbesides somesomelymphocyteslymphocytes andand macrophagesmacrophages (a)(a)..lymphocyteslymphocytes andand macrophagesmacrophages (a)(a)..

16b

Organ: Liver (bile duct).Organ: Liver (bile duct).Stain: H&E.Lesion:a aChronic catarrhal colangitis.

a

MicroMicro ::TheThe wallwall ofof thethe bilebile--ductduct isis thickenedthickened bybyproliferatedproliferated fibrousfibrous tissuetissue infiltratedinfiltrated withwithl h tl h t dd ll llll ( )( ) E t iE t i

blymphocyteslymphocytes andand plasmaplasma cellscells (a)(a).. ExtensiveExtensivedesquamationdesquamation ofof thethe epithelialepithelial lininglining ofof thethe bilebileductduct (b)(b)..

a

(17)Organ : GallbladderOrgan : GallbladderStain:H&E. Lesion :b Lesion :

C ia

Chronic hemorrhagic

a

ulcerativecholecystitis.

a

Micro :Almost complete desq amation of

cholecystitis.

ab

Micro.:Almost complete desquamation ofthe epithelial lining with denuded laminapropria (a). The latter is infiltrated withl h t h i hil d

a

lymphocytes, macrophages, eosinophils andneutrophils. Numerous erythrocytes are present(b).

(18)aOrgan : Lung(Rabbit).St i H & EStain : H & E.Lesion :

Granulomatous a a

pneumonia (TB).

Micro : Tubercle nodules (a) are scattered

( )

Micro. : Tubercle nodules (a) are scatteredthroughout the pulmonary tissue.

Each nodule consists of central aggregation ofmacrophages or caseated centers surroun ded

aamacrophages or caseated centers surrounded

with macrophages., lymphocytes and fibrous tissue.a

(19)a

(19)Organ : Lung.St i H & E

a

bb

Stain : H & E.Lesion :

b

b

Bronchiolectasia.c

b

Micro :Th b hi l t i lMicro.:The bronchioles are extensivelydistended with debri and inflammatory cells withintheir lumina (a). Degeneration and necrosis are

i th ll f b hi l t th ith

c

seen in the walls of many bronchioles together withleukocytic infiltration (b). The epithelial lining ofthe affected bronchioles frequently showedsq amo s metaplasia Collapsed s rro nding al eoli

csquamous metaplasia.Collapsed surrounding alveoli(c). b

(20)Organ : Lung (Guinea-pig).

C

Stain : H & E.Lesion:AB

Chronic C o cLymphocyticbronchiolitis

Micro.:Extensive replacement of thebronchiolar wall with lymphocytes and macro-

bronchiolitis

BC

y p yphages (A).Squamous metaplasia of the epththeliallining of the bronchioles (B) Granulocytes are seenin the lumens of theb hi l (C)

B

Abronchioles (C). A

(21)(21)Organ: Lung (sheep).Stain: H&E.L i

BLesion:

ParasiticA

Parasiticpneumonia(Mullerius

ill i )capillaries).B

Micro.: The larvae (A) are see in the air-vesicles surrounded by eosinophilic and

Bvesicles, surrounded by eosinophilic andlymphocytic infiltration with fibrous tissueproliferation. Chronic focal alveolar emphysema (B)is seen.

A

is seen.

(22)Organ : Lung :(Young chicks)

a(Young chicks)Stain : H & E.Lesion :

Mycoticpneumonia

ap

a

Micro.: The pulmonary tissue ist i l l d b t d d l ( ) aextensively replaced by caseated nodules (a)

surrounded with macrophages and fibrous tissue.a

a

(23)(23)Organ : Lung A

))

( Adult chickens).

Stain : H & EStain : H & ELesion :

Aspergillosis.

Micro. : Focal replacement of thel ti ith i

Apulmonary tissue with caseous necrosis.Mycelia (A) of the Aspergillus fumigatus areseen.

(24) B

Organ : Lung (Camel).

( )A

B

C g g ( )Stain : H & E.Lesion :

H d tid tD

Hydatid cyst.

EE

Micro.:Scolices (A) are surrounded withb d l i i ti f th l

AB

Cbroad capsule originating from the germ layer(B).The germ layer is surrounded with laminatedwall (C) without nuclei followed by a thickfibro s connecti e tiss e la er (D) The adjacent Efibrous connective tissue layer (D).The adjacentalveoli (E) are collapsed DE

(25)Orga : Lung(guinea pig)

A(guinea pig).Stain : H & E.Lesion :

Larva migrans.

Micro : L (A) f i iMicro. : Larva (A) of ascaris is seenin the pulmonary tissue with orwithout inflammation. Focal replace -ment Ap

of the pulmonary tissue with gra-nulomatous nodules. The latter consists ofcentral larva surrounded with eosi- nophilicd b i i d ith i hil d f ll d

A

debris, mixed with eosinophils and followedby a zone of macrophages and giant cells.

(26)Organ : Lung(Dog).Stain : H & EStain : H & E.Lesion :

PentastomiasisA Pentastomiasis(Linguatulaserrata).

A

serrata).A

Micro.:The arthropode, with transve- rselyAstriated cuticle (A), locally destroyed

the pulmonary tissue Numerous eosinophils andmacrophages surrounded the arthropode, filled the

A

p g pair-sacs and infiltrated the int- eralveolar septa,hyperemia and hemorrhage are seen.

(27)Organ : Lung.Stain : H & E.Stain : H & E.Lesion :

Acute serofibri-))

Acute serofibrinous pneumonia.

Micro.:Almost all the air-vesicles are filledith fib i d t t i iwith serofibrinous exudate containing numerous

neutrophils.Hyperemic pulmonary tissue.

C

(28)Organ :Lung.g gStain :H & E.Lesion :

ABChronic supp-Urative

i

AB

pneumonia.

Micro.: Focal replacement of the pulmonarytissue with abscesses (A) surrounded with fibrous

C( )

tissue capsuleinfiltrated with lympocytes and macrophages (B).The bronchioles (C) are filled with neutrophils, A( ) p ,and blood vessels are hyperemic. AB

(29)Organ : Lung.Stain : H & E.Stain : H & E.Lesion :

Chronic intersA

Chronic inters-titial

pneumoniapneumonia

Micro :Th i t l l t (A) d lMicro.:The interalveolarsepta(A) and pleuraare thickened with fibrinous exudate, inflitrated withlymphocytes and plasma cells. Various stages of

i i h l l b l

Apneumonia are seen in the pulmonary lobules.

B

B

(30)( )

AOrgan : Lung (Rat).Stain : H & E.Lesion:

B

Aspirated blood.B

BB

Mi AB

Micro.: The normal constituents of blood are seen in the bronchioles (A) and air-vesicles (B)

AB

(B).B

AA

(31)

A

(31)Organ : Testis(Buck)(Buck)Stain : H & E.Lesion :

Spermatostasis.A

Micro.: Some semininiferous tubules areoverdistended with sperms (A) causing pressure A

3131overdistended with sperms (A) causing pressureatrophy and necrosis of its epithelium The retained.sperms are frequently necrotic and calcified. Manyseminiferous tubules are lined by one or two layers

A

seminiferous tubules are lined by one or two layersof germ cells (B).

(32)Organ : Testis (Dog).Stain : H & E.Lesion :

Seminoma.

Micro.:Large polyhedral or round discretecells with large hyperchromatic nuclei andprominent nucleoli are occluding the lumina ofthe seminiferous tubules.

(33)Organ : Testis (Buck)Organ : Testis (Buck)Stain : H & E.Lesion:

Arrestedspermato-

igenesis.

Micro.:The seminiferous tubules arewidely separated by edema. They are lined withy p y yspermatogonia, primary and , secondaryspermatocytes besides Sertoli cells.The lumina ofsome tubules contain desquamated and necrotic

llgerm cells.

(34)Organ : Prepuce

PrepucePrepuce

(

g pStain : H & E.Lesion :

(Chronic serousposthitis.

Micro.: Papillary projections of the mucosawith hyperplastic mucosal lymph follicles Thewith hyperplastic mucosal lymph follicles. Themucosa is infiltrated with macrophages,plasmacells and lymphocytes.

A

(35)Organ : Uterus.Stain : H & E

AStain : H & E.Lesion :

MiliaryA

Miliary tuberculousendometritis.

Micro.:Numerous young tuberculousy gnodules(A) are scattered throughout theendometrium.Each tubercle nodule usuallyconsists of central caseation necrosis followed by A

Ay

macrophages and giant cells of the Langhan'stype and finally lymphocytes and fibrous tissue.

A

(36)Organ : Uterus (Sheep)Stain : H & E


Chronic cysticA

Chronic cysticcatarrhalendometritis.endometritis.

Micro. : Numerous cystic uterine glands(A) li d b fl tt d ith li E i(A) are lined by flattened epithelium.Excessivefibrous tissue proliferation infiltrated withlymphocyte, plasma cells and macrophagesamong the c stic terine glands

A Aamong the cystic uterine glands.

(37)Organ: Uterus (ewe).S i &Stain : H&E.Lesion:

Ch i ti

AB

Chronic necroticendometritis

.Micro.:About 1/3 of the luminal laminapropria is replaced b necrotic debris mi ed

ABpropria is replaced by necrotic debris, mixed

with macrophages, lymphocytes and plasma cells(A). Some uterine glands are cystic and containeosinophilic debris (B)

BB

eosinophilic debris (B).

(38)Organ : Udder (Cattle).Stain : H & E.L i

ALesion :

Chronic diffuselobulartuberculousmastitismastitis.

Micro.:Diffuse infiltration and/orreplacement of the affected lobules withmacrophages, giant cells of the Langhan's type(A), lymphocytes, plasma cells and fibrousi lif i i h i l f h

Atissue proliferation without involvement of theinterlobular septa.

A A

(39)Organ : Udder (Cattle)Organ : Udder (Cattle)Stain : H & E.Lesion :BChronic serousmastitis.

Micro. : Acini of some lobules are cystic (A)with flattened epithelium. Fibrous tissue

Bp

proliferation, infiltrated with lymphocytes andplasma cells, is seen among the acini. Hyperplasticepithelial lining of the lactiferous ducts (B). B

Bp g ( )

(40)Organ : Choriong(Intercotyledonary zone).Stain : H & E.Lesion:

Adventitial placentation.placentation.

iMicro.:Newly formed placentome-likestructure with absence of thrombosis.

(41)(41)Organ : Kidney (Cattle).Stain : H & E.Lesion :Lesion :

Acutetisuppurative

Nephritis(embolic(embolicnephritis).

Micro. : Focally scattered infla- mmatoryll i l t hil th h t th tcells, mainly neutrophils, throughout the cortex.

Areas of liquefactive and coagulative necroses couldbe seen.

(42)O Kid (C l )A Organ : Kidney (Cattle).Stain : H & E.Lesion :

A

Pyelonephritis.

Micro :S ti d l hi AMicro.:Suppuration and sloughingof the renal papillae. Scattered focal sup-purative areas, particularly in the medulla (A).

A

(43)Organ : Kidney.Organ : Kidney.Stain : H & E.Lesion:

Chronic non-suppurative

h itinephritis(lymphocyticnephritis)nephritis).

Micro. : Diffuse replacement of the renalparenchyma with lymphocytes and plasma cells.The adjacent renal tubules suffered atrophy withthickened and hyalinized basement membrane.Di i ti f th l ith li iDissociation of the renal epithelium, in somelocations, to form syncytium.

(44)Organ : Kidneyg y(Rabbit).Stain : H & E.Lesion :

Hydronephrosis.

Micro. : Atrophy Of the renal paren-chyma with cystic dilatation of the renal tubu leschyma with cystic dilatation of the renal tubules and excessive fibrous tissue proliferation.

(45)Organ :Kidney.Stain :H & E.

BStain :H & E.Lesion:

Ckronic lymph-B

Ckronic lymphocytic cysticnephritisA pA

.Micro: Diffuse replacement of the renalh ith fib ti i filt t d ith Bparenchyma with fibrous tissue infiltrated with

lymphocytes and plasma cells (A). Cystic dilatationof the renal tubules (B). AB

BA

(46)A (46)Organ : Urinarybladder(Sodium chlordeB (Sodium chlordetoxicosis) of a puppy.

Stain : H & E.Stain : H & E.Lesion :

EosinophilicEosinophiliccystitis.

Micro. : Desquamated epithelium (A) with congestion and hemorrhage (B) in the Mucosa

ABcongestion and hemorrhage (B) in the Mucosa,

besides eosinophilic infiltrationB

(47)A

B (47)Organ : Urinarybladder

B

(Sodium chloride toxi-cosis of sheep).Stain : H & E.

iLesion:

Desquamationqand hemorrhage.

Micro. : Desquamated epithelium (A) with mucosal congestion and hemorrhage (B). B

A

(48)Organ : Brain (Cow).S i &

A


E h lA Encephalo-malacia.

A

MiA

A A

Micro.: The necrotic nervous tissue is replaced by cavities (A) surrounded byfibrous astrocytesfibrous astrocytes.

(49)(49)Organ : Brain(Hippocampusof dog)

Aof dog).Stain : H & E.Lesion :

Intracytoplasmicinclusion bodyy(Negri body).

MiA

Micro. :Large oval or rounded eosinophilicintracytoplasmic inclusion bodies (Negri bodies)are seen in the large neurons (A) they are ofare seen in the large neurons (A), they are ofvariable numbers and sizes.

(50)A (50)Organ : Cerebellum(Cow).St i H & E

A


I t t l iIntracytoplasmicinclusion body(Negri body)(Negri body).

Micro. : Large oval or rounded eosin-ophilic intracytoplamic inclusion bodies (A) areophilic intracytoplamic inclusion bodies (A) are seen inside the Purkingiecells, they are of variable numbers and sizes.

A

(51)Organ : Braing

(Sheep).Stain : H & E.Lesion :

B

Satellitosis andneuronophagiaA neuronophagia.

Micro. : Numerous microglia (A) are seenMicro. : Numerous microglia (A) are seen around the degenerated neurons (satellitosis).Other neurons are being pha-gocytized (B) by the microglia (neuropha- gia)gocytized (B) by the microglia (neuropha- gia).

(52)Organ : Brain.Stain : H & E

◌A Stain : H & E.

Lesion:

Hemorrhagic

A

Hemorrhagicmeningo-encphalitis.p

B

Micro.: The meninges and underlying brain tissue show hyperemia and leuk-

ti i filt ti i d ithA

ocytic infiltration, mixed with numerous erythrocytes (A). Encephalomalacia is evi-dent (B).

B

53)(53)Organ : Brain (choroidplexus)A p )Stain : H & E.Lesion :

Chronic eosino-philic choroiditis.

Micro. : The choroid plexus is highlyinfiltrated with neutrophils eosinophils Ainfiltrated with neutrophils, eosinophils,macrophages and lymphocy-tes (A). Hyperemic capillaries and partialdestruction of the choroidal epithelial covering

A

destruction of the choroidal epithelial coveringare evident.

(54)Organ: Brain (meninges)Stain : H & EStain : H & E.Lesion:

ChronicA

Chroniceosinophilicmeningitis.

Bg

AMicro. :The meningeal covering of thecerebellum is thickened with macrophages,

Ap g ,

lymphocytes, eosinophils and neutrophils,,besides caseous necrosis (A). Oncospheres ofCoenuris cerebralis (B) are surrounded with

i d b iB

necrotic debris.Malacia of the adjacent brain tissue is evident.

(55)(55)Organ : Brain(Meninges)Stain : H & E.ALesion :

OsseousOsseousmetaplasia.

Micro.:Bone spicule with bone marrow (A) Ac o.: o e sp cu e w bo e ow ( )in the meninges.

(56)Organ : Sciatic nerve(Chi k )A B (Chicken).Stain : H & ELesion:

A B

Neural leukosisB

AA

B

Micro. : Numerous lymphocytes (A) are seen among, and replacing the degenerated

fib (B)

A

nerve fibers (B).

(57)Organ : Heart (Myocar-g ( y

dium). cow.Stain : H & E.Lesion :A

Sarcocystosis.A

B

Micro.: Sarcocysts, containing a greatnumber of banana shaped bradyzoites (A), areseen inside the muscle fibers (B) withoutevidence of inflammation.

ABB

(58)Organ : Heart (Myocar-

di ) t kdium), turkey.Stain : H & E.Lesion :

Granulomatousmyocarditisy(Fowl –typhoid).

Micro.: Focal replacement of the myocardium with numerous macroph-y pages and small lymphocytes.

(59)(59)Organ : Heart (Pericar-

dium), cow.St i H & E


Ch i

B

ChronicfibrinouspericarditisC pericarditis.

C

C

Micro. : Extensive replacement of the

CA

ppericardium with fibrinous exudate containingnumerous neutrophils and bacterial colonies (A).Granulation tissue (B) is seen extending between

B( ) g

the exudate and the underlying muscle (C ).

(60)Organ : Heart(Myocardium) buffalo

AC(Myocardium) buffalo.


B

Lesion :

Fistulous tract.

Micro.: The tract is lined with basoph- ilicbacterial colonies (A) lying on necrotic muscle fibers( ) y g(B).Leukocytes are seen among the necrotic musclefibers, besides hyperemic capillaries. Partialreplacement of the adjacent muscle fibers withfib bl t (C)

BCfibroblasts (C).

A

(61)(61)Organ : Heart (Myo-

cardium).St i H & EB Stain : H & E.Lesion :

Ch iA

B

Chronic non-suppurativemyocarditis

Bmyocarditis.

◌◌◌◌◌◌◌◌:Micro.: Congested myocardium which isfocally replaced by fibrous tissue infiltrated with

◌◌◌◌◌◌◌◌

focally replaced by fibrous tissue infiltrated withround cells (A). Coagulative necrosis of theinvolved muscle fibers (B); but the Purkingie cellswere relatively resist-

AB

were relatively resistant.

(62)Organ : Heart (Myo-cardium of guinea Pig).cardium of guinea Pig).


Parasitic myocarditis (N i

A

(Neoascaris-vitulorum larvae)

Micro : F l l t f th di

larvae).

Micro. : Focal replacement of the cardiacmuscle fibers with parasitic larvae (A) surroundedwith eosinophils besides round

d l i l l i( h l lA

and oval vesicular nuclei(perhaps sarcolemmalnuclei) together with Anitschkow myocytes (mostlyderived from the smooth muscle of the media ofth ll t i l ) Th l i f th dithe small arterioles). The nuclei of the cardiacmuscle fibers are moderately hypertrophic andvesicular.

(63)(63)Organ : Heart(Myocardium)Stain : H & E


MyocardialB

Myocardialedema andhyalineydegeneration.

Micro. : Widely searated muscle fiberswith clear spaces (A) Some

Awith clear spaces (A).Somemuscle fibers are more eosinophilic with darkly-stained nuclei, and hyperchromatic interstitial

B

stained nuclei, and hyperchromatic interstitialnuclei (B).

(64)A

(64)Organ : Heart (Myo-

cardium).B

)Stain : H & E.Lesion :

Hyperemia andhemorrhage

(klebsiella)(klebsiella).

Micro. : Hyperemic blood vessels (A) and AA B

extravasated blood (B) among the muscle fibers.Large vesicular nuclei of the muscle fiberswhich are widely separated from each other.y p

(65)Organ : Heart

(squab)AB (squab).Stain : H&E.Lesion :

AB

Cardiac myo-malacia.

Micro.: Focal disappearance of the musclefibers (A) which were partially replaced by( ) p y p y

round cells, particularly macropha-ges. Collapsed saecolemmal sheathes are evident(B).

AB

( )

(66)(66)Organ : Artery.Stain : H & E.Lesion :

ALesion :

Chronici hili

BeosinophilicarteritisA.

Micro. : Adventitia is highly infiltra-ted with eosinophils macrophages plasma cells Ated with eosinophils,macrophages, plasma cells and lymphocytes (A). Focal replacement of the media with aggregations of eosinophils, surrounding foreign remnants (B)

BA

surrounding foreign remnants (B).

(67)Organ : Artery(Tail of buffalo)(Tail of buffalo)Stain : H & E.Lesion :

Chroniclymphocytic

Ay p y

endarteritis.

B

Mi

B

Micro. : Intema is Highly infiltrated with lymphocytes (A).Tunica media showsnumerous capillaries (B). Anumerous capillaries (B). A

B

(68)Organ : ArteryOrgan : Artery(Tail of buffalo)Stain : H & E.Lesion :

ALesion :

Thrombosis

MiMicro. : Recent thrombus (A) is seen.Dry gangrene is evident. A

(69)A ( )Organ : Lung (Musculararterioles). Guinea pig.Stain : H & E.

A

Lesion :

Medial hypertro-Medial hypertrophy (andhyperplasia).

A

Micro. : Luminal narrowng or obst- ruction.Marked thickening of the media by enlarged and

A

Marked thickening of the media by enlarged andproliferated smooth muscle cells (A).

(70)Organ : Lung(Arterioles)(Arterioles).Guinea pig.Stain : H & E.Lesion :Lesion :

Periarteritis.

Micro. : Perivascular aggregation of leukocytes with infiltration of the vascular wallleukocytes with infiltration of the vascular wall.

(71)Organ : Aorta (Cattle).Stain : H & EStain : H & E.Lesion :

Caseation andCaseation and calcification.

Micro.: Irregular eosinophilic (caseation)and basophilic (calcification) masses of variablep ( )sizes are seen in theintema and media.

(72)Organ : Aorta (Cattle).Stain :von kossaStain :von kossaLesion:

Caseation andCaseation andcalcification.

Nicro: The calcified areas are stained black.

A

(73)Organ : Lymph node.B g y pStain : H & E.Lesion :

Ch iB Chronic serouslymphadenitis.

B

B

B

MicroMicro.. ::TheThe capsulecapsule isis edematousedematous andand infiltratedinfiltratedA

ppwithwith lymphocytslymphocyts (A)(A).. DepletedDepleted lymphlymph folliclesfollicles ofoflymphocyteslymphocytes (B)(B) inin thethe presencepresence ofof hyperplastichyperplastichistiocytes,histiocytes, particularlyparticularly inin thethe medullamedulla withwithh ih i h hh h dd dd hilihili

B

٧٤

hyperemia,hyperemia, hemorrhage,hemorrhage, edemaedema andand neutrophilicneutrophilicinfiltrationinfiltration..

B

(74)Organ :Lymph node.Stain : H & E.S : & .Lesion :

Chronic eosin-Chronic eosinophiliclymphadenitis.

Micro.: Focal replacement of the lymphoidtissue with eosinophils mixed with neutrophilstissue with eosinophils mixed with neutrophilsand macrophages, particularly in medulla.Hyperemic blood-vessels are seen.

(75)Organ : Lymph node

(Cattle).( )Stain : H & E.Lesion :

A Granulomatouslymphadenitis.

A

B

Micro.: Focal replacement ofthe lymphoid tissue with caseous necrosis (A)

A

the lymphoid tissue with caseous necrosis (A)surrounded with palisading macrophages (B)and giant cells (Langhans‘type).

AAB


(Cattle)A (Cattle).Stain : H & E.Lesion :

A

Chronic suppu−rativerativelymphadenitis.

A

Micro.: Focal replacement of the lymphoidMicro.: Focal replacement of the lymphoidtissue by neutrophils (A) surrounded withmacrophages giant cells and extensive fibroustiss e proliferationtissue proliferation

A

(77)Organ : Lymph nodeA g y p(Baffalo).Stain : H & E.Lesion :B Chronic hemorrh-agic lymphadenitis.

B B

Micro.:Extensive replacement of thelymphoid tissue with hemolyzed blood (A),and Alymphoid tissue with hemolyzed blood (A),andareas of caseous and fibrinoid necrosis (B)surrounded with neutrophils, eosinophils and

A

macrophages. Periarteritis, hyalinized arterialwalls and thrombosis are encountered. B

B


(Baffalo)(Baffalo).St ain : H & E.Lesion :AChronic necroticlymphadenitis.

Micro. : Focal replacement of the lymphd ith t d t i l (A) d d ithnode with caseated material (A) surrounded with

fibrous tissue infiltrated with macrophages andlymphocytes (B).

AB

lymphocytes (B).


AA

g y p(Guinea pig).


Parasitic nodule.

Micro. : Larva of Neoascaris vitulorum (A) i d d b thi k fib ti A(A) is surrounded by a thick fibrous tissue cap-sule infiltrated with few eosinophils. It partially replaced the lymphoid tissue.

A

replaced the lymphoid tissue.

(80)Organ : Lymph node.Stain : H & EStain : H & E.Lesion :

Diffuse caseationDiffuse caseation necrosis.

Micro. :Diffuse replacement of the lymphnode with granular eosinophilic and basophilicdebris.

(81)Organ : Lymph nodeOrgan : Lymph node.Stain : H & E.Lesion :

Lipidosis.

Micro. : Focal replacement of thel h id ti ith i l l d d llymphoid tissue with irregularly rounded clearvcuoles. Fat necrosis is seen in some vacuoles.

A

(82)Organ : Bursa ofOrgan : Bursa ofFabricius.Stain : H & E.Lesion :Lesion :

Chronic catarrhal bursitis

Micro :

bursitis

. Micro.: Extensive destruction of the B-lymphocytes (A), partcularly at the center of the lymph follicles which frequently extended to involve the whole follicle to be replaced by histiocytes Desquamation of the epithelial lininghistiocytes. Desquamation of the epithelial lining (B) is evident. The stroma is hyperemic hemorrhagic and shows histiocytic proliferation

(83)Organ : Spleen-Dog.

Ag p g


Caninenodular hyperplasia

(splenoma)(splenoma).

Micro. : Increased number of lymphocy-t hi h f d l ith t di ti ttes which formed large masses without distinct central arteries (A). Such lymphoid masses part-ially replaced the adjacent red pulp.

Aially replaced the adjacent red pulp.

(84)Organ : Spleen DogOrgan : Spleen-Dog.Stain : H & E.Lesion :

Hematoma.A

Micro.: Subcapsular hemorrhage (A) hi h h l d d iwhich appears hemolyzed and pressing

on the surrounding tissue. A

(85)

(85)(85)

Organ: Liver (Guineapig)

S i H & E

)OrA


E t d ll

gan

Extramedullaryhemopoiesis

.

Micro. : Aggregations of dark basophilic nuclei,of variable sizes,in the hepatic sinusoids (A). Megakaryocytes are seen.

A

( 6)(86) Orga : Chin of a horseStain : H & ELesion:

ChronicChronic Eosinophilicmyositis.y

Micro. : Numerous eosinophils withsome neutrophils and fibrous tissue focallyreplaced the chin muscles The affected musclesreplaced the chin muscles.The affected musclessuffered coagulative and caseous necrosis.

(87) Organ : Skeletal

muscle (Rat)muscle. (Rat)Stain : H & E.Lesion :

Chronic fibrinous myositisy(klebsiella).

Micro. : Extensive replacementof the musclefibers with macrophages, lymphocytes and somefibers with macrophages, lymphocytes and someneutrophils,together with fibrin network Thrombos-ed blood vessels.are seen. Fragmentation, of theremaining muscle fibers, is found.g ,

(88)(88) Organ : Skeletal muscle

(Duck)B ( )Stain : H & E.Lesion :

Chronic necroticmyositis (Vit. E.deficiency)A deficiency).

Micro. : Extensive replacement of theskeletal muscles with fibrous connective tissueinfiltrated with heterophils and macrophages(A). Hyaline degeneration (B) and Zenker’snecrosis of some muscle fibers are evident. A

B

A

(89)(89)Organ : Skeletal

muscle A (Chicken).Stain : H & E.Lesion :

A

Lesion :

Hemorrhage (Newcastle disease)(Newcastle disease).

Micro. : Extravasated blood (A) among the muscle fibers . Notice the avian nucleated erythrocytes. A

(90)Organ : Skeletal muscle.Stain : H & EStain : H & E.Lesion :

ChronicChronic Suppurativemyositis.y

Micro. : Numerous neutrophils are surro-unding and invading the skeletal muscles.The involved muscles lost their nuclei and bec-

ame more eosinophilic and fragmentedame more eosinophilic and fragmented.Interstitial-cells seem to proliferate togetherwith macrophages.

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Pathology