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Page 1: paper #1

© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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© 1996 Nature Publishing Group http://www.nature.com/naturemedicine

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