DRUG CLASSIFICATION INDICATION CONTRAINDICATION SIDE EFFECTS NSG. RESPONSIBILITY

Citicoline CNS Stimulant CVD in acute & recovery phase, symptoms & signs of cerebral insufficiency

Parasympathetic hypertonia Gastrointestinal disorders •Somazine must not be administered along with medicaments containing meclophenoxate

Dopamine Inotropic, vasopressor To treat shock and correct hemodnamic imbalances, improve perfusion of vital organs, to increase cardiac output, and to correct hypotension.

Contraindicated in patient with uncorrected tachyarrhythmias, pheocromocytoma, or ventricular fibrillation.- Use cautiously in patients with occlusive vascular disease, cold injuries, diabetic endarteritis, and arterial embolism; in pregnant woman; with a history of sulfite sensitivity; and in those taking MAO inhibitor.

Side Effects:CNS: headache GI: nausea

During infusion, frequently monitor ECG, BP, cardiac output, CVP, pulmonary artery wedge pressure, pulse rate, urine output, and color and temperature of the limbs.

If diastolic pressure rises disproportionately, decrease perfusion rate and watch out carefully for further signs of vasoconstriction unless such action is desired.

Observe for adverse reaction.

Check for urine output.Hydralazine Hydrochloride

antihypertension For hypertensive patient tachycardia, palpitation, angina pectoris, severe headache, dizziness, weight gain, GI disturbances, pruritus, rashes, nausea and vomiting

Give oral drug with food to increase bioavailability(drug should be given in a consistent relationship ti ingestion of food for consistent response to therapy).

Drug may cause a syndrome resembling systemic lupus erythematosus (SLE). Arrange for CBC, LE cell preparations, and ANA titers before and periodically during prolonged therapy, even in the asymptomatic patient. Discontinue if blood dyscrasias occur. Reevaluate therapy if ANA or LE tests are positive.

Arrange for pyridoxine if patient develops symptoms of peripheral neuritis.

Monitor patient for orthostatic hypotension which is most marked in the morning and in hot weather, and with alcohol or exercise.

Isosorbide dinatrate  cardiovascular

agent; nitrate vasodilator

It is prescribed as a coronary vasodilator in the treatment of angina pectoris and congestive heart failure and esophageal spasm caused by GI reflux.

Closed-angle glaucoma, known hypersensitivity to this drug, concurrent use of drugs for erectile dysfunction, narrow-angle glaucoma, head trauma, or severe anemia prohibits its use.

fast, slow, pounding, or uneven heart rate;

worsening angina pain; blurred vision or dry mouth; nausea, vomiting, sweating, pale skin,

feeling like you might pass out; or blue-colored skin, tiredness, and

feeling...

Make position changes

slowly, particularly from

recumbent to upright

posture, and dangle feet

and ankles before

walking.

Lie down at the first

indication of light-

headedness or faintness.

Keep a record of anginal

attacks and the number of

sublingual tablets

required to provide relief.

Do not drink alcohol

because it may increase

possibility of light-

headedness and faintness.

Do not breast feed while

taking this drug without

consulting physician.

Atropine Sulfate  Anticholinergic - Antidote to overdosage with cholinergic substances (nerve gases, poisonous mushroom)- Pre-op medication to reduce salivary and resp. tract secretions.

Contraindicated in patients with glaucoma, pyloric stenosis or prostatic hypertrophy, except in doses ordinarily used for preanesthetic medication.

Can cause blurred vision, dilated pupils, dry mouth, palpitations urinary retention, tachycardia drowsiness, and confusion

monitor level of consciousness do not sit up or stand up

quickly advise patient to stay out of

bright light chew sugarless gums and

suck hard candies to avoid

mouth dryness use lubricating drops is

wearing contact lenses avoid extreme heat

Sodium Chloride Electrolyte supplement Hydrating solution; hyperosmolar diabetes

 Normal or elevated electrolyte levels (with 3% and 5% solutions)• Fluid retention

CV: edema (when given too rapidly or in excess), thrombophlebitis, heart failure exacerbation

Metabolic: fluid and electrolyte disturbances (such as hypernatremia and hyperphosphatemia), aggravation of existing metabolic acidosis (with excessive infusion)

Respiratory: pulmonary edema

Other: pain, swelling, local tenderness, abscess, or tissue necrosis at I.V. site

 Teach patient to recognize and immediately report serious adverse reactions, such as breathing problems or swelling.• Instruct patient to report pain, tenderness, or swelling at injection site.• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

Cordarone Adrenergic blocker Life-threatening ventricular arrhythmias

• Hypersensitivity to drug• Cardiogenic shock• Second- or third-degree AV block• Marked sinus bradycardia• Breastfeeding• Neonates

CNS: dizziness, fatigue, headache, insomnia, paresthesia, peripheral neuropathy, poor coordination, involuntary movements, tremor, sleep disturbances

CV: hypotension, heart failure, worsening arrhythmia, AV block, sinoatrial node dysfunction, bradycardia, asystole, cardiac arrest, cardiogenic shock, electromechanical dissociation, ventricular tachycardia

EENT: corneal microdeposits, corneal or macular degeneration, visual disturbances, dry eyes, eye discomfort, optic neuritis or neuropathy, scotoma, lens opacities, photophobia, visual halos, papilledema

Monitor patient closely. Drug may cause serious or life-threatening adverse reactions.

 Watch for slow onset of life-threatening arrhythmias, especially after giving loading dose.

Monitor ECG continuously during loading dose and when dosage is changed.

GI: nausea, vomiting, constipation, abdominal pain, abnormal salivation, anorexia

GU: decreased libido

Hematologic: coagulation abnormalities, thrombocytopenia

Hepatic: nonspecific hepatic disorders, hepatic dysfunction

Metabolic: hypothyroidism, hyperthyroidism

Respiratory: cough, adult respiratory distress syndrome, pulmonary inflammation or fibrosis, pulmonary edema

Skin: flushing, photosensitivity, toxic epidermal necrolysis

Other: abnormal taste and smell, edema, fever, Stevens-Johnson syndrome

Nicardipine AntianginalsChronic stable angina Patient who are

hypersensitive to nicardipine

Dizziness Headache Paresthesis Drowsiness Peripheral edema Palpitations Tachycardia Nausea Dry mouth Abdominal discomfort Rash Flushing

Patients with hepatic impairment should receive lower doseMonitor blood pressure.Allow atleast 3 days between dosage adjustment to achieve steady plasma levels.Advise patient to report immediately if experiencing chest pain

Diazepam Antiepileptic • Management of anxiety disorders• Acute alcohol withdrawal• Muscle relaxant• Treatment of tetanus• Antiepileptic: severe recurrent convulsive seizures. • Unlabeled use: Treatment of panic attacks

• Contraindicated with hypersensitivity to benzodiazepines; psychoses, acute narrow-angle glaucoma, shock, coma, acute alcoholic intoxication; pregnancy, lactation.

- CNS:1) dizziness2) drowsiness3) lethargy4) hangover5) headache6) depression- EENT:1) blurred vision- RESP:1) respiratory depression- CV:1) hypotension- GI:1) constipation2) diarrhea3) nausea4) vomiting- DERM:1) rashes- LOCAL:1) pain (IM)2) phlebitis (IV)3) venous thrombosis- MISC:1) physical & psychological depen-dence2)tolerance

• Take this drug exactly as prescribed. Do not stop taking this drug without consulting your health care provider.• Caregiver should learn to assess seizures, administer rectal form, and monitor patient.• You may experience these side effects: Drowsiness, dizziness , GI upset (take drug with food); dreams, difficulty concentrating, fatigue, nervousness, crying (reversible).• Report severe dizziness, weakness, drowsiness that persists, rash or skin lesions, palpitations, swelling of the ankles, visual or hearing disturbances, difficulty voiding.

Calcium Gluconate Electrolytes and replacement solutions

Hypocalcemia, hypocalcemic tetany, magnesium toxicity, hypoparathyroidism

Hypercalcemia, ventricular fibrillation, renal canaliculi

GI irritationhemorrhageconstipationvomiting thirstrenal canaliculihypercalcemiapolyuria

Use cautiously in patients with sarcoidosis and renal or cardiac disease and in digitalized patients.

monitor blood calcium level frequently.

Nalbuphine Hydrochloride

Opioid agonist-antagonist

Moderate to severe pain  Hypersensitivity to drug

CNS: dizziness, sedation, headache, vertigo

CV: hypertension, hypotension, tachycardia, bradycardia

 Instruct patient to change position slowly and carefully to avoid dizziness from sudden blood pressure decrease.• Tell patient to avoid

EENT: miosis

GI: nausea, vomiting, dry mouth

Respiratory: dyspnea, respiratory depression

Skin: sweating, clammy skin

Other: hypersensitivity reactions including anaphylaxis

CNS depressants (including alcohol, sedative-hypnotics, and some herbs) for at least 24 hours after taking nalbuphine.• Advise patient to consult prescriber before taking herbs. anticonvulsant drug

Furosemide Loop Diuretic acute pulmonary edemaedemahypertension

Anuria hepatic coma & precoma severe hypokalemia &/or

hyponatremia hypovolemia w/ or w/o

hypotensionHypersensitivity to furosemide or sulfonamides

vertigo, dizziness, headache, paresthesia, orthostatic hypotension, thrombophlebitis, abdominal pain, hypokalemia, anemiamuscle spasm

To prevent nocturia, give preparation in the morning and early in the afternoon

Watch for signs of hpokalemia

do not confuse with Torsemide or Lasix with Lonox

advise patient to take drug with food to prevent GI upset

inform patient of possible need for potassium or magnesium supplements

DigoxinCardiac Glycosides

V-fib, V-flutter, CHF, pulmonary edema, atrial fibrillation and or flutter, and paroxysmal atrial contractions

Contraindicated in patients hypersensitive to the drug or any of its components and in those with digitalis-induced toxicity, ventricular fibrillation, or ventricular tachycardia unless caused by heart failure.

Side Effects:CNS: agitation, dizziness, fatigue, generalized weakness, headache, malaise.GI: Nausea

Monitor K+, Mg++, ECG, liver/renal function tests, drug level (therapeutic level 0.5-2.0 mg/ml, toxicity is >2.0 mg/ml).

Before each dose assess apical pulse for full minute, record and report changes in rate or rhythm.

Withhold drug and contact provider if pulse is < 60/min. or >100 (adults) or <

110/minute (children) Weigh dailyMonitor I&O and signs of CHF

Phenobarbital CNS DRUGS- HYPNOTICS/ SEDATIVES

Short-term treatment of insomnia, long- term treatment of generalized toni-clonic seizures

Hypersensitivity to barbiturates, pregnancy, severe renal, hepatic, resp. impairment

PRECAUTION:Impaired renal, hepatic cardiac or resp. functionsADVERSE RXNDizziness, headache, hangover, confusion in elderly, GI disturbances, allergic reactions, sedation and depression may occur

>instruct pt. to avoid alcohol and other CNS depressant to prevent inc. depression> withdrawal insomnia may occur after short-term use, insomnia improves in 1-3 nights >on empty stomach, 30-60 mins before bedtime for expected sleeplessness>advice pt to change positions slowly to prevent orthostatic hypotension

Morphine Sulfate Analgesics (Opioid) Relief of moderate to severe pain not responsive to non-narcotic analgesics. Premed. Analgesic adjunct in general anesth esp in pain associated w/ cancer, MI & surgery. Alleviates anxiety associated w/ severe pain. Hypnotic for pain-related sleeplessness.

Lightheadedness, dizziness, sedation, nausea, vomiting, constipation & sweating.

Caution patient not to chew or crush controlled-release preparations.

Dilute and administer slowly IV to minimize likelihood of adverse effects.

Tell patient to lie down during IV administration.

Keep opioid antagonist and facilities for assisted or controlled respiration readily available during IV administration.

Use caution when injecting SC or IM into chilled areas or in patients with hypotension or in shock; impaired perfusion may delay absorption; with repeated doses, an excessive amount may be absorbed when circulation is restored.

Reassure patients that they are unlikely to become addicted; most patients

who receive opioids for medical reasons do not develop dependence syndromes.

Epinephrine Alpha-adrenergic agonist, Beta1and beta2-adrenergic agonist, Cardiac stimulant, Vasopressor, Bronchodilator

Acute asthmatic attacks, Advanced cardiac life support

Hypersensitivity drowsiness, headache, nervousness, tremors, cerebral hemorrhage, dizziness, weakness, vertigo, pain

Monitor heart rate. Use extreme caution when

calculating and preparing doses; epinephrine is a very potent drug;

Use minimal doses for minimal periods of time

Protect drug solutions from light, extreme heat, and freezing; do not use pink or brown solutions.

Shake the suspension for injection well before withdrawing the dose.

Phenytoin  anticonvulsant drug It is prescribed as an anticonvulsant for the treatment and prevention of tonic-clonic seizures, complex partial seizures, and seizures resulting from head trauma or surgery.

hypersensitivity to this drug

ataxia, nystagmus, hypersensitivity reactions, and gingival hyperplasia

• Assess blood pressure, ECG, and heart rate, especially during I.V. loading dose. Watch for adverse reactions.• Monitor phenytoin blood level; therapeutic range is 10 to 20 mcg/ml.• Evaluate CBC and kidney and liver function tests.• Closely monitor prothrombin time and Internationalized Normal Ratio in patients receiving warfarin concurrently.• Monitor drug efficacy.

Sodium Bicarbonate  Alkalizing Agent, Buffer, Antacid, electrolyte

o Hyperacidityo Peptic ulcero Hyperkalemia

Contraindicated in patients with metabolic or respiratory alkalosis;

GI: Gastric distention, belching, flatulence.Metabolic: metabolic alkalosis, hypernatremia, hypokalemia,

Monitor urinary pH, calcium, electrolytes and phosphate levels.

o Tricyclic antidepressant OD

o Shock associated with severe diarrhea, dehydration, uncontrolled DM

Reflux esophagitis

patients who are losing chlorides from vomiting or continuous GI suction; patients taking diuretics known to produce hypochloremia alkalosis; and patients with hypocalcemia in which alkalosis may produce tetany, hypertension, seizures, or heart failure. Oral sodium bicarbonate is contraindicated in patients with acute ingestion of strong mineral acids.

hyperosmolarity (with overdose).Other: Pain and irritation at injection site.

Record amount and consistency of stools. Clients on low-sodium diets should evaluate sodium contents of antacids.

Aminophylline

Dobutamine Andrenergics Increased cardiac output in short-term treat ment of cardiac decompensation caused by depressed contractility, such as during refractory heart failure; adjunctive therapy in cardiac surgery

Contra indicated in patients hypersensitive to drug and in those with idiopathic hypertrophic subaortic stenosisUse cautiously in patients with history of hypertension because drug may increase pressor responseUse cautiously in patients with history of sulfite sensitivity

Increased heart rate, hypertension,Angina, phlebitis, nonspecific chest pain, palpitations, hypotension, nausea, vomiting, shortness of breath, hypersensitivity reactions

Before starting dobutamine therapy: (1) give a plasma volume expander to correct hypovolemia (2) give cardiac glycoside

Continuously monitor ECG, blood pressure, pulmonary artery wedge pressure, cardiac output and urine output

Monitor Electrolyte levels. Drug may lower potassium level

Do not confuse with Dopamine

Tell patient to report adverse reactions promptly, especially labored breathing and drug-induced headache

Instruct patient to report discomfort at IV insertion site

Oxacillin 

Ceftriaxone 3rd generation Cephalosporin

Lower Respiratory Tract Infection Patients who are hypersensitive to cephalosporins or penicillins

fever, dizziness, headache, chills, thrombocytosis, nausea and vomiting

- Administer the drug slowly

via IVTT

- Assess for presence of

phlebitis and pain upon

administration of drug, as

well as other side and adverse

effects

- Assess for consistency of

stoolsCefuroxime cephalosporin

Cefazolin First generation cephalosphorins

•Treatment of:Skin & skin structure infections; pneumonia; urinary tract infections; bone & joint infections

Hypersensitivity to cephalosphorins. Serious hypersensitivity to penicillin.

• CNS:

Seizures (high doses)

• GI:

Pseudomembranous colitis, diarrhea,

nausea, vomiting, cramps

• GU:

Interstitial nephritis

• DERM:

Rashes, urticaria

• HEMAT:

Blood dyscrasias, hemolytic anemia

• LOCAL:

Pain at IM site, phlebitis at IV site

• MISC:

Allergic reactions including Anaphylaxis

and Serum sickness, superinfection

• Assess patient for infection at beginning and during therapy.• Before initiating therapy, obtain a history to determine previous use of and reactions to penicillins or cephalosphorins. • Obtain specimens for culture and sensitivity before initiating therapy.• Observe patient for signs and symptoms of anaphylaxis.• Monitor site for thrombophlebitis.• Instruct patient to report signs of superinfection and allergy.

Omeprazole Antisecretory drug Short-term treatment of active duodenal cancer

Short-term treatment of active benign gastric ulcer

Eradication of Helicobacter Pylori

First-line therapy for treatment of

Contraindicated with hypersensitivity to omeprazole or its

components.

Use cautiously with pregnancy, lactation.

CNS; headache, dizziness, asthenia, vertigo, insomnia, apathy, anxiety, paresthesias, dream abnormalities

Dermatologic: rash, inflammation, urticaria, pruritus, alopecia, dry skin

GI: diarrhea, abdominal pain, nausea, vomiting, constipation, dry mouth, tongue

Assessment:1. History :hypersensitivity to

omeprazole or any of its components; pregnancy,

lactation2. Physical: skin lesions; reflexes; urinary output; abdominal examination; respiratory auscultation

heartburn or symptoms of GERD. atrophy

Respiratory: URI symptoms, cough, epistaxis

Interventions:1. Administer before meals.2. Administer antacids with,

if needed.3. Have regular medical

follow-up visits.4. Report severe headache, worsening of symptoms,

fever, chills.Ceftazidine

Sodium Sulfate

Isordil 

Cloridine tab

Paracetamol tab Analgesics (Non-Opioid) & Antipyretics

Pyrexia of unknown origin. Fever & pain

Hematological, skin & other allergic reactions

Use liquid form for children and patients who have difficulty swallowing.

In children, don’t exceed five doses in 24 hours.

Advise patient that drug is only for short term use and to consult the physician if giving to children for longer than 5 days or adults for longer than 10 days.

Advise patient or caregiver that many over the counter products contain acetaminophen; be aware of this when calculating total dailydose.

Warn patient that high doses or unsupervised long term use can cause liver damage.

Hydrocortisone

Hyoscine-NobutylbromideSodium Chloride 

Isosorbide Dinitrite 

Gentamicin Sulfate

Didofenal

Dilantil

Ciprofloxacin

Chloramphenicol

Chlorphenamine

Ampicillin

Atropine Sulfate

Vit. K Phytomenadione 

Aqua-Mephyton, Vitamin K

Anticoagulant-induced prothrombin deficiency caused by coumarin or indanedione derivatives;

Prophylaxis and therapy of hemorrhagic disease of the newborn;

hypoprothrombinemia due to anti-bacterial therapy;

hypoprothrombinemia secondary to factors limiting absorption or synthesis of vitamin K, e.g., obstructive jaundice, biliary fistula, sprue, ulcerative coilitis, celiac disease, intestinal resection, cystic fibrosis of the pancreas, and regional enteritis;

other drug-induced hypoprothrombinemia.

Hypersensitivity to any component of this medication

Transient"flushing sensations" and "peculiar" sensations of taste have been observed, as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis.

Pain, swelling, and tenderness at the injection site may occur.

Tramadol  Analgesic Decreased pain.• Assess type, location, and

intensity of pain before and

2-3 hr (peak) after

administration.

• Assess BP & RR before and

periodically during

administration.

• Assess bowel function

routinely.

• Assess previous analgesic

history.

• Encourage patient to cough

and breathe deeply every 2 hr

to prevent atelactasis and

pneumonia.

Terbutaline SO4 

Sodium Chloride 

Ranitidine Histamine2 Antagonists Treatment and prevention of heartburn, acid indigestion, and sour stomach.

Hypersensitivity, Cross-sensitivity may occur; some oral liquids contain alcohol and should be avoided in patients with known intolerance.

• CNS:

Confusion, dizziness, drowsiness,

hallucinations, headache

• CV:

Arrhythmias

• GI:

Altered taste, black tongue, constipation,

dark stools, diarrhea, drug-induced

hepatitis, nausea

• GU:

Decreased sperm count, impotence

• ENDO:

Gynecomastia

• HEMAT:

Agranulocytosis, Aplastic Anemia,

neutropenia, thrombocytopenia

 • Assess patient for epigastric or abdominal pain and frank or occult blood in the stool, emesis, or gastric aspirate.• Nurse should know that it may cause false-positive results for urine protein; test with sulfosalicylic acid.• Inform patient that it may cause drowsiness or dizziness.• Inform patient that increased fluid and fiber intake may minimize constipation.• Inform patient that medication may temporarily cause stools and tongue to appear gray black.

• LOCAL:

Pain at IM site

• MISC:

Hypersensitivity reactions, vasculitis

Potassium Chloride

Penicillin G ANTI-INFECTIVES-Penicillins

Metochlopromide  GASTROINTESTINAL DRUGS- ANTI-FLATULENTS

Gastrointestinal motility, nausea, vomiting of central and peripheral origin assoc. with surgery

GI hemorrhage, epileptics, hypersensitivity, lactation, pts. With breast cancer

PRECAUTION:Activities requiring mental alertness, elderly, lactation

ADVERSE RXNRestlessness, drowsiness, fatigue, insomnia, headache, dizziness, nausea

>give 30 mins before meals and at bed time> assess mental status during treatment>tell pt. To avoid driving & other hazardous activities for at least 2 hrs>advice pt. to avoid alcohol and other CNS depressant that enhance sedating properties of this drug

Nitroglycerine Patch Anti-Anginal Drugs of angina pectoris due to coronary artery disease

Headache. Transient episodes of lightheadedness. Infrequently, hypotension. Syncope, crescendo angina, rebound HTN, allergic & anaphylactoid reactions. Rarely severe, application site irritation

Administer transdermal systems to skin site free of hair and not subject to much movement. Shave areas that have a lot of hair. Do not apply to distal extremities. Change sites slightly to decrease the chance of local irritation and sensitization. Remove transdermal system before attempting defibrillation or cardioversion.

To use transdermal systems, you may need to shave an area for application. Apply to a slightly different area each day. Use care if changing brands; each system has a different concentration.

Nicardepine Calcium Antagonists Hypertensive emergencies or urgencies, peri-op & post-op HTN, hypertensive states of NPO patients.

Peripheral edema, headache, tachycardia, palpitations, localized thrombophlebitis & hypotension.

Patients with hepatic impairment should receive lower dose.

Monitor blood pressure.Allow atleast 3 days between dosage adjustment to achieve steady plasma levels.

Advise patient to report immediately if experiencing chest pain

Ketorolac Nonopioid Analagesics Short term management of pain - Hypersensitivity- Cross-sensitivity with other NSAIDs may exist¨Pre- or perioperative use- Known alcohol intoleranceUse cautiously in:1) History of GI bleeding2) Renal impair-ment (dosage reduction may be required)3) Cardiovascular disease

- CNS:1) drowsiness2) abnormal thinking3) dizziness4) euphoria5) headache-- RESP:1) asthma2) dyspnea- CV:1) edema2) pallor3) vasodilation- GI:1) GI Bleeding2) abnormal taste3) diarrhea4) dry mouth5) dyspepsia6) GI pain7) nausea- GU:1) oliguria2) renal toxicity3) urinary frequency- DERM:1) pruritis2) purpura3) sweating4) urticaria- HEMAT:1) prolonged bleeding time- LOCAL:

- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Assess for rhinitis, asthma, and urticaria.- Assess pain (note type, location, and intensity) prior to and 1-2 hr following administration.- Ketorolac therapy should always be given initially by the IM or IV route. Oral therapy should be used only as a continuation of parenteral therapy.- Caution patient to avoid concurrent use of alcohol, aspirin, NSAIDs, acetaminophen, or other OTC medications without consulting health care professional.- Advise patient to consult if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headche, or influenza-like syndromes (chills,fever,muscles aches, pain) occur.- Effectiveness of therapy can

1) injection site pain- NEURO:1) paresthesia- MISC:1) allergic reaction, anaphylaxis

be demonstrated by decrease in severity of pain. Patients who do not respond to one NSAIDs may respond to another.

Dexamethasone Corticosteroids Inflammation of corticosteroid-responsive dermatoses

Patient had an allergic reaction previously.Have an active peptic ulcerHave an active herpes simplex fungal or mycobacterial infection ot the eye, ear infection

Active tuberculosisHave psychoneurosis or psychosis

Increased appetiteWeight gainWater retentionIncreased WBCHypokalemiaSkin rashDizzinessInsomiaHeadache

Stop drug and notify doctor if patient develops signs of systemic absorption.Before applying, gently wash skin to prevent damage to skin rub medication gently.Treatment should be continued for a few days after clearing of lesions to prevent recurrence