OrganMatch Clinical Portal...Pathway type is TWL - Transplant waiting list for deceased organ donation, LDD - living directed donation and KPD - Kidney Paired Donation. Rows shaded

Table of Contents

ORGANMATCH CLINICAL PORTAL

User Guide

Page | 1 OrganMatch – Clinical Portal – User Guide Version 1 October 2020

Table of Contents

Abbreviations....................................................................................................................... 2

Search................................................................................................................................. 3

Pool Management ................................................................................................................ 4

Patient Match Profile ............................................................................................................ 6

Histocompatibility Profile....................................................................................................... 6

HLA Typing Profile ............................................................................................................. 6

Unacceptable Antigens and Acceptable Antigens ................................................................... 6

Assignment of Unacceptable Antigens (UA) and Use in matching algorithms .............................. 8

mPRA .............................................................................................................................. 8

Test Results ......................................................................................................................... 9

Enrolments for Transplant.....................................................................................................10

Enrolment Status .............................................................................................................10

Readiness........................................................................................................................10

Reports ..............................................................................................................................12

Notes and Attachments ........................................................................................................12

TWL Match History ..............................................................................................................13

Transplants .........................................................................................................................13

Transplant Events.............................................................................................................14

Notifications .......................................................................................................................15


Abbreviations

Abbreviation Description TWL Transplant Waiting List KPD Kidney Paired Donation UA Unacceptable antigen / Antigens used for exclusion AA Acceptable Antigens mPRA Calculated PRA used in matching HLA Human Leucocyte Antigens


Search To find a person in OrganMatch the following criteria can be used:

• last name • first name • date of birth • Hospital reference.

Click Search, from the left hand navigation.

Add the Search criteria information and then click Search.

Click on the patient record to view patient information


Pool Management

Pool management will list all the patients currently enrolled on a program.

Programs include - organ program and pathway.

Pathway type is TWL - Transplant waiting list for deceased organ donation, LDD - living directed donation and KPD - Kidney Paired Donation.

Rows shaded green indicate that the recipient is ready and not on hold.

Click on the patient to access the patient record.

• Click Pool Management, from the left hand navigation. • Click into a filter to bring up the Filter search box. • Click on the patient record to view patient information

Use the Export Excel function to export data on patients into an excel file. Data exported includes the following data.

Last Name Accept Increased Viral Risk - Date of consent Status

First Name Accept ABOi Reason

Date of Birth Accept ABOi - Date of consent Previous Transplant

OM Lab ABOi - ABOi values HLA Typing

National Reference State Urgency UA&AA - TWL cPRA

Hospital Reference National Urgency UA&AA - TWL - AB Screening

Date of Last Sample Paediatric Status for Matching UA&AA - TWL - Prev. Donor Mismatch

Organ Program Ready UA&AA - TWL - Other

Pathw ay Transplant Hospital Reference UA&AA - TWL - AA

ABO Transplant Provider UA&AA - Living Donor cPRA

Subtype Clinical Hospital UA&AA - Living Donor - AB Screening

Rhesus Clinical Hospital Reference UA&AA - Living Donor - Prev. Donor Mismatch

Waiting Time - days Clinical Provider UA&AA - Living Donor - Other

Dialysis for matching Accept HepBc Ab pos UA&AA - Living Donor - AA


Height (cm) Accept HepBc Ab pos - Date of consent Consolidated Antibodies

Weight (kg) Accept HepC Ab pos

Transplant Unit Accept HepC Ab pos - Date of consent

Transplant Hospital Reference Accept TRK

Transplant Provider Accept TRK - Date of consent

Clinical Hospital Accept Increased Viral Risk

Clinical Hospital Reference Accept Increased Viral Risk - Date of consent

Clinical Provider Accept ABOi

Accept HepBc Ab pos Accept ABOi - Date of consent Accept HepBc Ab pos - Date of consent ABOi - ABOi values

Accept HepC Ab pos State Urgency Accept HepC Ab pos - Date of consent National Urgency

Accept TRK Paediatric Status for Matching

Accept TRK - Date of consent Ready

Accept Increased Viral Risk


Patient Match Profile

The match profile contains all recipient information

• Find a patient in the system via search or pool management • Click on a patient to view the Match Profile

The following tabs will be shown

• Histocompatibility Profile • Test Results • Enrolments for transplant • Reports • Notes and Attachments • TWL match history • Transplants

Histocompatibility Profile

This section contains immunological data for the patient. HLA Typing and unacceptable antigens are used in the matching algorithms to find the best immunologically matched donor for the patient.

HLA Typing Profile

HLA typing of the patient is displayed .These HLA results are used in matching. For further details such as testing method, test date refer to patient report issued by the laboratory.

Unacceptable Antigens and Acceptable Antigens


This section provides details a tailored profile of HLA antigens that should be avoided when matching potential donors. Assignment of UA is performed by the laboratories in consultation with the transplant units.

In the details section, more information is provided on how the unacceptable antigens were defined.

An assessment of factors, such HLA antibodies, previous transplant mismatches are used when defining a list of HLA donor antigens would be considered unacceptable for an individual recipient.


Assignment of Unacceptable Antigens (UA) and Use in matching algorithms

Unacceptable antigens or Antigens used for exclusion that are assigned in OrganMatch will

• TWL UA will potentially exclude the patient from progressing through to the matching algorithms and are therefore patients will be ineligible to be offered a kidney from any deceased organ donor with those antigens.

• Living Donor UA will exclude KPD patients from being eligible to be offered a kidney from a live donor on the KPD with those HLA antigens

Acceptable Antigens are used in specific cases, for example if the patient has an allele specific antibody. There are three types of Unacceptable antigens in Organ Match

• Antibody sourced - as a result of HLA antibody test results • Previous donor mismatch • Other - HLA antigens added from other sources such as those to avoid high eplet loads.

mPRA

Match calculated panel-reactive antibody. Provides an estimate of the percentage of deceased organ donors that will be incompatible for a recipient based on the antigens assigned as unacceptable for a recipient. The mPRA represents the HLA antigen frequency in the population, based on a pool of donors from the Australian population. If more than one HLA antigen is unacceptable, the mPRA is the total frequency of the HLA antigens.


Test Results

HLA antibody results and non HLA antibody results are viewable.

To Export test results to an excel file , click on Export Test Results

Click on the result to view more information about the test result


Enrolments for Transplant Current and historical enrolments can be viewed. Click on the row to see more information about the enrolment. These are individuals for each Organ Program.

Enrolment Status

Status indicates if a patient is available for transplant.

Status can be updated by the hospital transplant coordinators, if they have been provided access to do this.

Readiness

A patient’s readiness indicates if OrganMatch criteria for matching has been met.

Program Pathway Criteria Kidney TWL • HLA A, B, DRB1

• OM Lab • Transplant Hospital • ABO final and ABO confirmed • Unacceptable Antigens authorised • Dialysis state date

Kidney LDD • HLA A, B, DRB1 • OM Lab

Kidney KPD • HLA A, B, C, DRB1, DQB1, DQA1, DPB1 • OM Lab • Transplant Hospital • ABO final and ABO confirmed • Unacceptable Antigens authorised • Luminex Single Antigen Bead – Class I and Class II – tested

Lung Heart Liver

TWL • HLA A, B, DRB1 • OM Lab • Transplant Hospital • ABO final and ABO confirmed


Enrolment Information Generic information in all enrolments include

• View History Status – see all changes to the enrolment status

• Providers Clinical and transplant units linked to the recipients Hospital reference – details of hospital MRN or UR numbers

Willing to accept This section displays information on additional acceptance criteria for the recipient for patients on Kidney TWL.

• Accept HepBc Ab pos (KPD only) - recipient consented to receive as Hep B core Ab positive

donor • Accept HepC Ab pos (TWL only) - Patients are consented to receive HCV Virus Antibody

positive/PCR positive (HCV Ab+ve / PCR+ve) and who are willing to consent to receive kidneys from HCV AB+ve donors

• Accept Increased Viral Risk Donor (TWL only) - These patients have been consented to receive donors with increased Viral Risk

• Accept TRK (TWL only) - Tumor Resected Kidney - only applicable for states that have these programs

• Accept ABOi TWL - Currently this is only applicable for blood group A or B patients that can accept Blood group AB deceased organ donors. KPD - indicates which ABO incompatible donors can be accepted.


Reports

Reports that have been issued by the laboratory (from April 2nd 2019) can be viewed and downloaded from this section

Notes and Attachments Attachments and notes can be added to a recipient record

To add a note

• Click Add Note • Add a title and detail of Note

• Click on Attachment and add a document ( PDF/Excel/Word) . For example Enrolment forms, ABO results, consent forms could be attached .

• Click Save When a note is added, a notification will be sent to the laboratory, indicating that a note has been added to the recipient record. Notes can be replied to by selecting reply . A notification will be sent to the lab if you reply to the note. This is a useful alternative to emailing the laboratory .


TWL Match History This section displays the matching history with deceased organ donors. Kidney ranks are displayed

If algorithm assessment is Yes, this means the recipient was eligible to pass through to matching. You will be able to see the matching outcome and the rank and score of the recipient with the donor. If the algorithm assessment is No - the patient has been excluded for matching - usually due to Unacceptable antigens or blood group incompatibility. Click on the blue arrow – to view further details of the match.

Transplants

Transplant information can be viewed.

Clicking on the transplant row, will take you to the Transplant event.


Transplant Events

The transplant event will show you information on the patient in relation to their donor. This includes information that was provided to the transplant unit at the time of the offer and also post-transplant information.


Notifications

Notifications will alert the provider to updates on recipient records. Notifications are sent when the following updates are made to a recipient record: • Change of status • Change to enrolment criteria eg: Recipient is willing to accept Increased Viral Risk Donor • New reports available • Ending an enrolment

In the person record, the banner displays a bell icon which indicates the number of notifications for the person.

To delete notification

Click on the bell icon

The notification will display

Click on the check box and click delete

The notification will be deleted from the system

For Bulk deletions

From the notification screens tick the delete box, and all the notifications on the screen, will be ticked. Select delete to remove all notifications shown.

Documents

OrganMatch Clinical Portal...Pathway type is TWL - Transplant waiting list for deceased organ donation, LDD - living directed donation and KPD - Kidney Paired Donation. Rows shaded