-
7/28/2019 Oncology - Pancreatic Ca
1/35
..
-
7/28/2019 Oncology - Pancreatic Ca
2/35
232 ., 227 . 14900 , 14100 . 50 . - 0,97; 5- 3,8% 4,6% , -
5-20%.
, . .
30 .
-
7/28/2019 Oncology - Pancreatic Ca
3/35
(, )
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Kras p53 .
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7/28/2019 Oncology - Pancreatic Ca
4/35
, .
, , , , .
, , 40 , 3,3 (95% CI:1,388,1). 2 , 15
. () .
-
7/28/2019 Oncology - Pancreatic Ca
5/35
-75%
-18%
-7%
-
7/28/2019 Oncology - Pancreatic Ca
6/35
6 :
-
( ) ( )
-
7/28/2019 Oncology - Pancreatic Ca
7/35
:
:
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:
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7/28/2019 Oncology - Pancreatic Ca
8/35
0
1 , 2 .
2 , 2 .
3 12-., , ( , ,
, ( , , , , )
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7/28/2019 Oncology - Pancreatic Ca
9/35
Nx
N0
N1
N1a
N1b /
0
1
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7/28/2019 Oncology - Pancreatic Ca
10/35
1.
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- -
2. 3. 4. 5. -
6. - - -
7. 8.
9.
-
7/28/2019 Oncology - Pancreatic Ca
11/35
-
7/28/2019 Oncology - Pancreatic Ca
12/35
1.
2.
3.
4.
5.
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7/28/2019 Oncology - Pancreatic Ca
13/35
1. , .
2. . .
3. .
4. ( ) 70-80%.
-
7/28/2019 Oncology - Pancreatic Ca
14/35
().
CA-19-9 (sialyl-Lewis-aantigen), .
. ().
().
().
. .
-
7/28/2019 Oncology - Pancreatic Ca
15/35
.
. .
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7/28/2019 Oncology - Pancreatic Ca
16/35
.
.
-
7/28/2019 Oncology - Pancreatic Ca
17/35
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-- : , , .
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7/28/2019 Oncology - Pancreatic Ca
18/35
-
7/28/2019 Oncology - Pancreatic Ca
19/35
- -
12 . (W. Molnar, A.E.Stockum, 1974 .)
-
7/28/2019 Oncology - Pancreatic Ca
20/35
-
-
7/28/2019 Oncology - Pancreatic Ca
21/35
)
-
7/28/2019 Oncology - Pancreatic Ca
22/35
)
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7/28/2019 Oncology - Pancreatic Ca
23/35
. .
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7/28/2019 Oncology - Pancreatic Ca
24/35
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7/28/2019 Oncology - Pancreatic Ca
25/35
,
. ,
.
-
7/28/2019 Oncology - Pancreatic Ca
26/35
, .
:
,
,
, .
-
7/28/2019 Oncology - Pancreatic Ca
27/35
-
..
-
..
-
7/28/2019 Oncology - Pancreatic Ca
28/35
-
7/28/2019 Oncology - Pancreatic Ca
29/35
- , .
-
7/28/2019 Oncology - Pancreatic Ca
30/35
-
7/28/2019 Oncology - Pancreatic Ca
31/35
1
3
,
4
2 -
6
-
5
-
7
-
-
7/28/2019 Oncology - Pancreatic Ca
32/35
. .. , ..
-
7/28/2019 Oncology - Pancreatic Ca
33/35
.
, .
81%.
-
7/28/2019 Oncology - Pancreatic Ca
34/35
5- ( 750,1000, 1250, 1500 mg/m2). 7 12.8 .
(Gem+FU+LV) 11
. 21 . (Pister et al., 2003). 4 ., - 7-8 ., 1 .
-
7/28/2019 Oncology - Pancreatic Ca
35/35
36% 19% - 2 .
3 25% , 50%, 10 . 1- 3 59% 21%, 11% 4 .
4% 1 .
