P S Y C H O L O G Y 4 0 5 - 4 2 0 M I N O R R E S E A R C H P R O B L E M S - S P E C I A L T O P I C S

F a l l S e m e s t e r 2 0 1 4 INSTRUCTOR & LABORATORY STAFFING: Kenneth J. Sufka, Ph.D., Professor of Psychology & Pharmacology/Research Professor, RIPS 311B Peabody Building, 915-7728, pysufka@olemiss.edu Stephen White, M.A., Graduate Research Assistant, swwhite1@olemiss.edu Hannah Harris, B.A., Graduate Research Assistant, hmharris@go.olemiss.edu Mary Jourdan, B.A., Graduate Research Assistant, mkjourd1@go.olemiss.edu Office: 101B Peabody Building, 915-5390 COURSE DESCRIPTIONS: Psy 405: Participate in small research projects under the direction of a faculty member. Psy 420: Independent study of topics of mutual interest to student and professor. MEETING TIMES: Seminar meetings are scheduled for Monday at 1:00 p.m. in 108 Peabody Building. Laboratory research times (6-9 hrs/week) are assigned depending upon the specific research project. In many cases, you will be required to work weekends. At other times during the term you may have the week off. Unless announced in advance, we will always meet for seminar. COURSE OBJECTIVES: This course is designed to provide exceptional students an opportunity to become involved in cutting edge neuroscience and psychopharmacology research. Over the course of the semester, you will learn many aspects of the research process. These include, among others, literature searches, reviews and presentations, experimental design and statistical analyses, animal care, and various animal experimental procedures from drug injections to brain extractions/dissections. This laboratory has many ongoing research projects and collaborations; your participation will help us meet these research obligations. RESEARCH PROJECTS: Animal model validation, stress and anxiety/depression; pain and analgesia (cancer models and migraine); drug discovery (botanical-derived products and synthetic chemistry); addiction. UNIVERSITY COMPLIANCE REQUIREMENTS FOR CONDUCTING ANIMAL RESEARCH:

To become familiar with the University of Mississippi Animal Care and Use program, go to the Animal Research web site at http://www.olemiss.edu/depts/research/compliance/animal/index.html

Prior to working with animals, students must: 1. Complete species-specific training for bird, rat and mouse 2. Complete Health & Safety training (biological, chemical, and pathogen) 3. Submit Occupational Health Evaluation and Occupational Health Risk Inventory 4. Read, sign and submit allergy forms 5. Obtain tetanus vaccine (provided free of charge) if you have not had one within the past 10 years 6. Attend ORSP-IACUC Ethics in Animal Research Seminar (to be scheduled later this term)

ATTENDANCE & RESEARCH INTEGRITY POLICY: Students are required to attend each and every seminar meeting and scheduled laboratory research assignment. If you have to miss a seminar meeting or laboratory research due to an illness or personal emergency, please notify one of us as soon as possible. Arriving late for or missing a scheduled lab will lead to an instructor-initiated drop. Any violation of university or federal animal welfare policies and laws or evidence of research misconduct will result in an F assigned for the course and a recommendation of expulsion and will be handled by university disciplinary procedures (see M-Book for details).

COURSE EXAMS AND GRADING: There are no exams for this course. Psy 405 and Psy 420 students begin this course with Z and A grades, respectively. Please do all the readings, participate in seminars, and show up for all lab assignments and your grade will remain the same. Should your grade slip because you cannot meet these obligations, I will provide extra lab and library assignments. COURSE READING MATERIALS: Selected articles from scientific journals and/or book chapters (partial reading list is detailed below) will be assigned throughout the term. You will need to be ready to discuss such material in a meaningful way with your colleagues in the laboratory. In many cases, you will be asked to provide oral presentations of such material; students conducting their own research project will be required to propose and defend such project to their lab colleagues. You will need a flash drive so we can provide these articles in PDF files. ANIMAL MODELING:

Willner P (1991). Behavioural models in psychopharmacology. In: Behavioral Models in Psychopharmacology: Theoretical, Industrial and Clinical Perspectives. Willner P (editor). Cambridge: Cambridge University Press; pp 3-18.

van der Stay, FJ (2006). Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy. Brain Research Reviews 52:131-159.

Nestler EJ, Hyman, SE (2010) Animal models of neuropsychiatric disorders. Nature Neuroscience, 13,1161-1169.

Parlee, MB, Bird, SJ (2000). Of mice and men (and women and children): scientific and ethical implications of animal models. Progress in Neuro-Psychopharmacology & Biological Psychiatry 24,1219-1227.

Miczek KA, De Wit H (2008) Challenges for translational psychopharmacology research-some basic principles. Psychopharmacology, 199, 291-301.

DEPRESSION MODELS:

Willner P (1991). Animal models of depression. In: Behavioral Models in Psychopharmacology: Theoretical, Industrial and Clinical Perspectives. Willner P (editor). Cambridge: Cambridge University Press; pp 91-125.

Matthews K, Christmas D, Swan J, Sorrell E (2005). Animal models of depression: navigating through the clinical fog. Neuroscience and Biobehavioral Reviews 29:503-513.

Morilak DA, Frazer, A (2005). What should animal models of depression model? Neuroscience and Biobehavioral Reviews 29:515-523.

McArthur R, Borsini F (2006). Animal models of depression in drug discovery: a historical perspective. Pharmacology, Biochemistry and Behavior 84:436-452.

Kalueff AV, Wheaton M, Murphy DL (2007). Whatʼs wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behavioral Brain Research 179:1-18.

Kalueff AV, LaPorte JL, Murphy DL, Sufka KJ (2008) Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research? Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32, 1172-1178.

Neumann ID, Wegener G, Homberg JR, Cohen H, Slattery DA, Zohar J, Olivier JDA, Mathe AA (2011) Animal models of depression and anxiety: what do they tell us about the human condition? Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35, 1357-1375.

Holtzheimer, P. E., & Mayberg, H. S. (2011). Stuck in a rut: rethinking depression and its treatment. Trends in Neurosciences, 34, 1-9.

Schmidt, MV (2011) Animal models for depression and the mismatch hypothesis of disease. Psychoneuroendocrinology, 36, 330-338.

Pryce CR, Seifritz E (2011) A translational research framework for enhanced validity of mouse models of psychopathological states in depression. Psychoneuroendocrinology, 36, 308-329.

Samuels BA, Leonardo ED, Gradient R, Williams A, Zhou J, David DJ et al., (2011). Modeling treatment-resistant depression. Neuropharmacol, 61, 408-13.

CHICK ANXIETY DEPRESSION MODEL: Feltenstein MW, Warnick JE, Guth AN, Sufka KJ (2004) The chick separation stress paradigm: a validation study. Pharmacology, Biochemistry and Behavior, 77, 221-226. Feltenstein MW, Sufka KJ (2005) Screening antidepressants in the chick separation stress paradigm, 181, 153-159. Warnick JE, Wicks WT, Sufka KJ (2006). Modeling anxiety-like states: pharmacological characterization of the chick separation stress paradigm. Behavioral Pharmacology, 17, 581-87.

Sufka KJ, Feltenstein MW, Warnick JE, Acevedo EO, Webb HE, Cartwright CM (2006) Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks. Behavioural Pharmacology, 17, 681-689.

Warnick JE, Huang C-J, Acevedo EO, Sufka KJ (2009) Modeling the anxiety-depression continuum in chicks. Journal of Psychopharmacology, 23, 143-156.

Sufka KJ, Warnick JE, Pulaski CN, Slauson SR, Kim YB, Rimoldi JM (2009) Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. Behavioural Pharmacology, 20, 146-154.

Hymel KA, Salmeto AL, Kim EH, Sufka KJ, (2010) Development and validation of the chick anxiety depression continuum model. In JE Warnick, AV Kalueff (Eds.), Translational Neuroscience and its Advancement of Animal Research: Advancement, Challenges, and Research Ethics, Nova Science Publishers, pp. 83-110. Salmeto AL, Hymel KA, Carpenter EC, Brilot BO, Bateson M, Sufka KJ, (2011) Cognitive bias in the chick anxiety-depression model. Brain Research, 1373, 124-130.

Kim EH, Sufka KJ (2011) The effects of environmental enrichment in the chick anxiety depression model. Behavioural Brain Research, 221, 276-281.

Hymel KA, Sufka KJ (2012) Pharmacological reversal of cognitive bias in the chick anxiety depression model. Neuropharmacology, 62, 161-166.

Loria MJ, White SW, Robbins SA, Salmeto AL, Hymel KA, Murthy SN, Manda P, Sufka KJ (2013) Brain-derived neurotrophic factor response in vulnerable and resilient genetic lines in the chick anxiety-depression model. Behavioural Brain Research, 245, 29-33.

Hymel KA, Loria MJ, Salmeto AL, White SW, Sufka KJ. (2013). Strain vulnerability and resiliency in the chick anxiety depression model. Physiology and Behavior, 113, 63-67.

GLUTAMATE AND DEPRESSION:

Skolnick P, Popik P, Trullas R (2009) Glutamate-based antidepressants: 20 years on. Trends in Pharmacological Sciences, 30, 563-569.

Hashimoto K (2009) Emerging role of glutamate in the pathophysiology of major depressive disorder. Brain Research Reviews, 61, 105-123.

Li N, Lee B, Liu RJ, Banasr M, Dwyer J, Iwata M, Li XY, Aghajanian G, Duman R (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science, 329, 959-964.

Cryan, J, O’Leary O, (2010) Invited Commentary: A glutamate pathway to faster-acting antidepressants. Science, 329, 913-914.

Barbon A, Caracciolo C, Orlandi C, Musazzi L, Mallei A, La Via L, Bonini D, Mora C, Tardito D, Gennarelli M, Racagni G, Popoli M, Barlati S. (2011) Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels. Neurochemistry International 59, 896-905.

Mackowiak M, O'Neill J, Kicks C, Bleakman D, Skolnick P, (2002). An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology, 43, 1-10.

Li X, Tizzano J, Griffey K, Clay M, Lindstrom T, Skolnick P. (2001). Antidepressant-like actions of an AMPA receptor potentiator (LY392098). Neuropharmacology, 40, 1028-1033.

BDNF AND DEPRESSION:

Duman RS, Aghajanian GK (2012) Synaptic dysfunction in depression: Potential therapeutic targets. Science, 338, 68-72.

Eisch AJ, Petrik D (2012) Depression and hippocampal neurogenesis: A road to remission? Science, 338, 72-75.

Berton O, Hahn C-G, Thase ME (2012) Are we getting closer to translational models for major depression? Science, 338, 75-79.

Southwick SM, Charney DS (2012) The Science of resilience: Implications for the prevention and treatment of depression. Science, 338, 79-82.

Santos AR, Comprido D, Duarte CB, (2010) Regulation of local translation at the synapse by BDNF. Progress in Neurobiology, 92, 505-516.

Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, Reus VI, Nelson JC, Epel ES, Mellon SH (2011) Serum BDNF levels before treatment predict SSRI response in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 1623-1630.

Chourbaji S, Brandwein C, Gass P, (2011) Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice. Neuroscience and Behavioral Reviews, 35, 599-611.

Meng Q, Li N, Han X, Shao F, Wang W, (2011) Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology, 650, 229-232.

Shirayama Y, Chen Ac-H, Nakagawa S, Russell DS, Duman RS (2002) Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. The Journal of Neuroscience, 22, 3251-3261.

COGNITIVE BIAS & ENDOPHENOTYPING:

Kalueff AV, Murphy DL. (2007) The importance of cognitive phenotypes in experimental modeling of animal anxiety and depression. Neural Plasticity, 2007, 1-7.

Bateson M, Matheson SM, (2007) Performance on a categorization task suggests that removal of environmental enrichment induces ‘pessimism’ in captive European starlings (Sturnus vulgaris). Animal Welfare 16, 33–36.

Burman OHP, Parker RMA, Paul ES, Medl MT. (2009). Anxiety-induced cognitive bias in non-human animals. Physiology & Behavior, 98, 345-350.

ANHEDONIA AND DEPRESSION

Treadway MT, Zahn DH (2011) Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neuroscience and Biobehavioral Reviews, 35, 537-555.

Der-Avakian A, Markou A (2012) The neurobiology of anhedonia and other reward-related deficits. Trends in Neuroscience, 35, 68-77.

ENVIRONMENTAL ENRICHMENT:

Emma L. Burrows EL, McOmish CE, Hannan AJ (2011) Gene–environment interactions and construct validity in preclinical models of psychiatric disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 1376-1382.

Kazlaukus V, Pagnussant N, Mioranzza S, Kalinine E, Nunes F, Pettenuzzo L, Souza DO, Portela LV, Porciuncula LO, Lara DR (2011) Enriched environment effects on behavior, memory and BDNF levels in low and high exploratory mice. Physiology and Behavior, 102, 475-480.

DʼAndrea I, Gracci F, Alleva E, Branchi I (2010) Early social enrichment provided by communal nest increases resilience to depression-like behavior more in female than male mice. Behavioural Brain Research, 215, 71-76.

Jones RB, Carmichael NL, Rayner E (2000) Pecking preferences and pre-dispositions in domestic chicks: implications for the development of environmental enrichment devices. Applied Animal Behavior Science, 69, 291-312.

Cirulli F, Berry A, Bonsignore LT, Capone F, DʼAndrea I, Aloe L, Branchi I, Alleva E (2010). Early life influences on emotional reactivity: Evidence that social enrichment has greater effects than handling on anxiety-like behaviors, neuroendocrine response to stress and central BDNF levels. Neuroscience and Biobehavioral Reviews, 34, 808-820.

PAIN AND ANALGESIA MODELS:

Mao J (2012) Current challenges in translational pain research. Trends in Pharmacological Sciences 33:568-573.

Mogil JS (2009) Animal models of pain: Progress and challenges. Nature Reviews Neuroscience 10:283-294.

Mogil JS, Davis KD, Derbyshire SW (2010) The necessity of animal models in pain research. Pain 151:12-17.

Sufka KJ (2011) Translational challenges and analgesic screening assays. Pain, 152, 1942-1943. Sufka KJ (1994) Conditioned place preference paradigm: a novel approach for analgesic drug

assessment against chronic pain. Pain, 58, 355-366 Sufka KJ, Roach JT (1996) Stimulus properties and antinociceptive effects of bradykinin B1 and B2

receptor antagonists in rats. Pain, 66, 99-103. Rutten K, De Vry J, Robens A, Tzschentke TM, van der Kam EL (2011) Dissociation of rewarding,

anti-aversive and anti-nociceptive effects of different classes of anti-nociceptives in the rat. European Journal of Pain 15:299-305.

Bannon AW, Malmberg AB; Models of nociception: hot plate, tail flick, and formalin tests in rodents. Current Protocols in Neuroscience, 2007, Ch. 8.

McCurdy CR, Sufka KJ, Smith GH, Warnick JE, Nieto MJ (2006) Antinociceptive profile of Salvinorin A, a structurally unique kappa opioid receptor agonist. Pharmacology Biochemistry and Behavior, 83, 109-113.

CANNABINOIDS AND CANCER-RELATED PAIN:

Saghafi, N., Lam, D. K., & Schmidt, B. L. (2011). Cannabinoids attenuate cancer pain and proliferation in a mouse model. Neuroscience Letters, 488(3), 247-251.

Park HJ, Stokes JA, Pirie E, Skahen J, Shtaerman Y, Yaksh TL (2013) Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: The effects of gabapentin, ketorolac, and etanercept. Anesthesiology and Analgesia, 116, 224-231.

Guindon J, Lai Y, Takacs SM, Bradshaw HB, Hohmann AG (2013) Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological Research, 67, 94-109.

ANIMAL MODELS OF MIGRAINE:

Greco R, Tassorelli C, Mangione AS, Smeraldi A, Allena M, Sandrini G, Nappi G, Nappi RE. (2013) Effect of sex and estrogens on neuronal activation in an animal model of migraine. Headache, 53, 288-296.

Costa A, Smeraldi A, Tassorelli C, Greco R, Nappi G. (2005) Effects of acute and chronic restraint stress on nitroglycerin-induced hyperalgesia in rats. Neuroscience Letters, 383, 7-11.

Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. (2014) Characterization of a novel model of chronic migraine. Pain, 155, 269-274.

NOTA BENE: • This is an extraordinary opportunity to be involved in psychopharmacology research projects. These

studies reflect a tremendous investment from the scientists involved. Treat this experience and those people leading projects with commitment, conscientiousness and respect. In most instances, you will be

reporting directly to a Research Technician or Graduate Research Assistants who are assigned to keep the laboratory running in a most efficient and productive capacity.