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Contents

Preface ............................................................................................................................ v

Contributors .................................................................................................................. .xi

PART I. MOLECULAR MECHANISMS IN RHEUMATIC DISEASES

1 GeneticsPeter K. Gregersen ............................................................................................... 3

2 VirusesAndras Perl ......................................................................................................... 15

3 ApoptosisJohn D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou .......... 35

4 Humoral ResponseGary S. Gilkeson ................................................................................................ 59

5 T-Cell SignalingGary A. Koretzky and Erik J. Peterson ............................................................. 75

6 Adhesion and Costimulatory MoleculesVassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler .................. 87

7 Transcription FactorsHenry K. Wong ................................................................................................. 109

8 Immune ComplexesMark H. Wener ................................................................................................. 127

9 ComplementV. Michael Holers ............................................................................................. 145

10 Eicosanoids and Other Bioactive LipidsLeslie J. Crofford .............................................................................................. 161

11 CollagensSergio A. Jiménez ............................................................................................. 175

PART II. CELLULAR MECHANISMS IN RHEUMATIC DISEASES

12 T-LymphocytesNilamadhab Mishra and Gary M. Kammer ................................................... 199

13 B-LymphocytesRobert F. Ashman ............................................................................................ 213

14 Monocytes and MacrophagesJames M. K. Chan and Sharon M. Wahl ........................................................ 225

15 Polymorphonuclear CellsMichael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein ......... 243

16 SynoviocytesDavid E. Yocum ................................................................................................ 259

17 ChondrocytesTariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud .................. 267

18 Osteoblasts and OsteoclastsStavros C. Manolagas ..................................................................................... 279

19 Animal ModelsThomas J. Lang and Charles S. Via ............................................................... 293

PART III. PATHOGENESIS OF RHEUMATIC DISEASES

20 Systemic Lupus ErythematosusStamatis-Nick C. Liossis and George C. Tsokos ............................................ 311

21 Rheumatoid ArthritisRichard M. Pope and Harris Perlman ............................................................ 325

22 Inflammatory MyopathiesNorbert Goebels and Reinhard Hohlfeld ........................................................ 363

23 Systemic SclerosisTimothy M. Wright ........................................................................................... 375

24 VasculitisJörg J. Goronzy and Cornelia M. Weyand ..................................................... 385

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25 OsteoarthritisA. Robin Poole and Ginette Webb ................................................................... 401

26 OsteoporosisStavros C. Manolagas ...................................................................................... 413

27 Heritable Disorders of Connective TissuePetros Tsipouras ............................................................................................... 423

PART IV. MOLECULAR ASPECTS OF TREATMENT OF RHEUMATIC DISEASES

28 CorticosteroidsHenry K. Wong and George C. Tsokos ........................................................... 439

29 Cytotoxic DrugsDavid A. Fox and W. Joseph McCune ............................................................ 451

30 Complement InhibitorsSavvas C. Makrides .......................................................................................... 465

31 Cytokine Response ModifiersRichard E. Jones and Larry W. Moreland ..................................................... 477

32 Restoration of Immune ToleranceWoodruff Emlen ............................................................................................... 487

33 Metalloproteases and Their Modulation as Treatment in OsteoarthritisJohanne Martel-Pelletier, Ginette Tardif, Julio Fernandes,and Jean-Pierre Pelletier ................................................................................. 499

34 Gene TherapyRobert P. Kimberly ........................................................................................... 515

Index ........................................................................................................................... 525

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