Vol. 267, No. 33 The Journal of November 25, 1992

Biological Chemistry Copyright 0 1992 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St., Baltimore, MD 21202 U S A .

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CONTENTS*

MINIREVIEW The new enzymology of precursor processing endopro- teases. Donald F. Steiner, Steven P. Smeekens, Shinya Ohagi, and Shu Jin Chan

COMMUNICATIONS Cell adhesion or integrin clustering increases phos- phorylation of a focal adhesion-associated tyrosine ki-

Michael Schaller, and R. L. Juliano nase. Lori Kornberg, H. Shelton Earp, J . Thomas Parsons,

Expression of a transmembrane phosphotyrosine phos- phatase inhibits cellular response to platelet-derived growth factor and insulin-like growth factor-1. Robert A. Mooney, Gregory G. Freud, Barbara A. Way, and Kathy L. Bordwell

Protein tyrosine phosphatase-lC is rapidly phosphoryl- ated in tyrosine in macrophages in response to colony stimulating factor-1. Yee-Guide Yeung, Karen L. Berg, Fiona J . Pixley, Ruth Hogue Angeletti, and E. Richard Stanley

Interleukin-la induces the accumulation of cytosolic phospholipase Az and the, release of prostaglandin Ez in

De Witt human fibroblasts. Lth-Llng Lin, Alue Y . Lin, and David L.

Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus. Anastasia G. Daifotis, Eleanor C. Weir, Barbara E. Dreyer, and Arthur E. Broadus

Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. Richard Chao, Wasiuddin Khan, and Yusuf A. Hannun

A rise and fall in 1,2-diacylglycerol content signal hex-

seph Michaeli, Xavier Busquets, Irene Orlow, Anas Younes, amethylene bisacetamide-induced erythropoiesis. Jo-

Delors Colomer, Paul A. Marks, Richard A. Rifkind, and Rich- ard N. Kolesnick

Caffeine inhibits the agonist-evoked cytosolic Ca" sig- nal in mouse pancreatic acinar cells by blocking inositol trisphosphate production. Emil C. Toescu, Stephen C. O'Neill, Ole H. Petersen, and David A. Eisner

A human polyadenylation factor is a G protein @-sub- unit homologue. Yoshio Takagaki and James L. Manley

Transport of organic substrates via a volume-activated channel. Kiaran Kirk, J . Clive Ellory, and James D. Young

ARTICLES Botulinum neurotoxins are zinc proteins. Giampietro Schiavo, Ornella Rossetto, Annalisa Santucci, Bibhuti R. DasGupta, and Cesare Montecucco

Conformational studies of the interdomain linker pep- tides in the dihydrolipoyl acetyltransferase component

of Escherichia coli. James D. F. Green, Richard N . Perham, of the pyruvate dehydrogenase multienzyme complex

Stephen J . Ullrich, and Ettore Appella

Fatty acid ethyl ester synthase in rat adipose tissue and its relationship to carboxylesterase. Takahiro Tsujita and Hiromichi Okuda

protein. Interactions with fatty acids and its use in A fluorescently labeled intestinal fatty acid binding

monitoring free fatty acids. Gary V. Richieri, Ronald T. Ogata, and Alan M. Kleinfeld

23502 Regulation of integrin gene expression by substrate

erine Arnaud, Bjorn Steffensen, and Robert J. Klebe adherence. Dali Chen, Victoria Magnuson, Stuart Hill, Cath-

23507 Total metabolic flow of glycosphingolipid biosynthesis is regulated by UDP-G1cNAc:lactosylceramide 81-r 3N-acetylglucosaminyltransferase and CMP-NeuAc: lactosylceramide a2+3sialyltransferase in human he-

suru Nakamura, Atsuko Tsunoda, Kumi Sakoe, Jianguo Gu, matopoietic cell line HL-60 during differentiation. Mit-

Atsushi Nishikawa, Naoyuki Taniguchi, and Masaki Saito

23515 Sequence-specific interaction between SlF, a spinach

plastid-related genes. Duo-Xiu Zhou, You-Fang Li, Mireille nuclear factor, and a negative cia-element conserved in

Rocipon, and Regis Mache

23520 @-Adrenergic stimulation of cFOS via protein kinase A is mediated by CAMP regulatory element binding pro- tein (CREB)-dependent and tissue-specific CREB-in- dependent mechanisms in corticotrope cells. Anne-Laur-

Philippe Loeffler ence Boutillier, Fabrice Barthel, James L. Roberts, and Jean-

23527 Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by ex- ogenous sphingolipids. Kentaro Hanada, Masahiro Nishi- jima, Makoto Kim, Akira Hasegawa, Shuji Fujita, Tomoya Ogawa, and Yuzuru Akamatsu

23534 Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the struc- tures of the apoprotein and the protein with bound palmitate. James C. Sacchettini, Giovanna Scapin, Deshmukh Gopaul, and Jeffrey I. Gordon

23546 Feedback inhibition of phosphatidate phosphatase from spinach chloroplast envelope membranes by diacylglyc- erol. Agnes Malherbe, Maryse A. Block, Jacques Joyard, and Roland Douce

23554 A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP- binding protein in rabbit peritoneal neutrophils. Yasu- nori Kanaho, Katsunobu Takahashi, Urara Tomita, Taroh Iiri, Toshiaki Katada, Michio Vi, and Yoshinori Nozawa

23560 Ryanodine stabilizes multiple conformational states of

Buck, Ildiko Zimanyi, Jonathan J. Abramson, and Isaac N. the skeletal muscle calcium release channel. Edmond

Pessah

23568 Inhibition of ascorbic acid transport in human neutro- phils by glucose. Philip Washko and Mark Levine

23575 Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. Ulla G. Knaus, Paul G. Heyworth, B. Therese Kinsella, John T. Curnutte, and Gary M. Bokoch

23583 Spectral analysis of the protein-derived tyrosyl radi- cals from prostaglandin H synthase. Janice A. DeCray,

J . Marnett, Thomas E. Eling, and Ronald P. Mason Gunter Lassmann, John F. Curtis, Todd A. Kennedy, Lawrence

23589 In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells. Masazumi Matsumura, Yutaka Saito, Michael R. Jackson, Elizabeth S. Song, and Per A. Peterson

* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1992) J . Biol. Chem. 267, 13781-13789, and reprints may be obtained from the editorial office.

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Reducing sugars can induce the oxidative inactivation

Dauid McClure, Jr. of rhodanese. Paul M. Horowitz, Michael Butler, and G.

EPR kinetic studies of superoxide radicals generated during the autoxidation of l-methyl-4-phenyl-2,3-di- hydropyridinium, a bioactivated intermediate of Par- kinsonian-inducing neurotoxin 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine. Lun-Yi Zang and Hara P. Misra

Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells. Takao Kondo, Hiroshi Inui, Fumiko Konishi, and Tadashi Inagami

Effects of ecotropic murine retroviruses on the dual-

porter. Ha0 Wang, Esther Dechant, Michael Kauanaugh, R. function cell surface receptorbasic amino acid trans-

Alan North, and David Kabat

15-Hydroxyeicosatetraenoic acid (15-HETE) recep- tors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells. Becky M. Vonakis and Jack Y. Vanderhoek

amiloride with the organic cation-proton antiporter in Specific interaction of 5-(N-methyl-N-isobutyl)-

human placental brush-border membrane vesicles. Transport and binding. Puttur D. Prasad, Frederick H. Leibach, Virendra B. Mahesh, and Vadiuel Ganapathy

The mechanism of ATP inhibition of wild type and

Rong-Lan Zheng and Robert G. Kemp mutant phosphofructo-1-kinase from Escherichia coli.

by Cu(II)/HzOz. Conversion of proline residue to 2- Oxidative fragmentation of collagen and prolyl peptide

pyrrohdone. Yoji Kato, Koji Uchida, and Shunro Kawakishi

Coagulant properties of hybrid human/porcine factor VI11 molecules. Pete Lollar, Ernest T. Parker, and Philip J. Fay

The 48-kDa subunit of the mammalian oligosacchar- yltransferase complex is homologous to the essential yeast protein WBP1. Susana Silberstein, Daniel J. Kelleher, and Reid Gilmore

A novel pathway for the activation of phospholipase D by P,, purinergic receptors in BAC1.2FS macrophages. Chakib El-Moatassim and George R. Dubyak

The purification and characterization of arsenite oxi- dase from Alcaligenes faecalis, a molybdenum-contain- ing hydroxylase. Gretchen L. Anderson, Jeffrey Williams, and Russ Hille

The effects of stem I and loop A on the processing of 5 S rRNA from Drosophila melanogmter. Louis Leuinger, Vikram Vasisht, Vilma Greene, and Indera Arjun

Manganese(I1) oxidation by manganese peroxidase from the basidiomycete Phanerochaete chrysospor- ium. Kinetic mechanism and role of chelators. Hiroyuki Wariishi, Khadar Valli, and Michael H. Gold

The interaction of human factor VIIa with tissue factor. Sriram Krishnaswamy

Mutational mapping of the catalytic activities of human tyrosinase. Ram K. Tripathi, Vincent J. Hearing, Kazunori Urabe, Pilar Aroca, and Richard A. Spritz

Involvement of sequences near both amino and car- boxyl termini in the rapid intracellular degradation of tyrosine aminotransferase. Robert H. Stellwagen

Ligand binding characteristics of the major mistletoe

Lee lectin. Reiko T. Lee, Hans-Joachim Gabius, and Yuan Chuan

tional regulatory region. Constitutive and interferon- Structural constraints within a trimeric transcrip-

r-inducible expression of the HLA-DRA gene. Barbara J. Vilen, Joseph F. Penta, and Jenny P. - Y. Ting

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Mechanism of inhibition of the retroviral protease by a Rous sarcoma virus peptide substrate representing the cleavage site between the gag p2 and p10 proteins.

Irene T . Weber, Terry D. Copeland, and Alexander Wlodawer Craig E. Cameron, Bjorn Grinde, Joyce Jentoft, Jonathan Leis,

Cooperative interactions among subunits of a voltage- dependent potassium channel. Evidence from expres-

P. Kauanaugh, Jerrel Yakel, John P. Adelman, and R. Alan sion of concatenated cDNAs. Raymond S. Hurst, Michael

North

Effects of the amino-terminal regions of tropomyosin and troponin T on thin filament assembly. Kent A. Wil- ladsen, Carol A. Butters, Laura E. Hill, and Larry S. Tobacman

Isolation and sequencing of cDNAs and genomic DNAs encoding the a 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2. Yusuke Kamagata, Marie- Geneuieue Mattei, and Yoshifumi Ninomiya

Expression, purification, and physicochemical charac- terization of a recombinant Yersinia protein tyrosine phosphatase. Zhong- Yin Zhang, James C. Clemens, Heidi L. Schubert, Jeanne A. Stuckey, Mark W. F. Fischer, Daniel M. Hume, Mark A. Super, and Jack E. Dixon

In vivo phosphorylation of the yeast uracil permease. Christiane Volland, Catherine Garnier, and Rosine Haguen- auer-Tsapis

Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-

nus. Richard B. Presland, Paul V. Haydock, Philip Fleckman, 100-like calcium binding domain at the amino termi-

Wilas Nirunsuksiri, and Beuerly A. Dale

Purification, characterization, cloning, and expression of a glutamic acid-specific protease from Bacillus lich-

Kengo Kitadokoro, Takashi Fujiwara, Etsuo Nakamura, Hwo- eniformis ATCC 14580. Shinji Kakudo, Norihisa Kikuchi,

yuki Okamoto, Masaru Shin, Mikio Tamaki, Hiroshi Teraoka, Hiroshige Tsuzuki, and Nobw Yoshida

Casein kinase I1 phosphorylation of signal sequence receptor a and the associated membrane chaperone cal- nexin. Wei-Jia Ou, Dauid Y. Thomas, Alexander W. Bell, and John J. M. Bergeron

Progesterone blocks cholesterol translocation from ly-

din, Raymond R. O’Neill, Gene Carstea, Caluin F. Roff, Marc sosomes. Jean D. Butler, Joan Blanchette-Mackie, Ehud Gol-

C. Patterson, Shutish Patel, Marcella E. Comly, Adele Cooney, Marie T. Vanier, Roscoe 0. Brady, and Peter G. Pentcheu

Ovarian cancer al,3-~-fucosyltransferase. Differen- tiation of distinct catalytic species with the unique substrate, 3’-sulfo-N-acetyllactosamine in conjunction

Rakesh K. Jain, and Khushi L. Matta with other synthetic acceptors. E. V. Chandrasekaran,

Dramatic changes of sulfated proteoglycans composi- tion in a tumorigenic SV-40-transformed renal proxi- mal-tubule cell line. Brigitte Lelong, Remi Piedagnel, Fran- fois Chhtelet, Beatrice Baudouin, Paul E. C. Brenchley, Pierre J. Verroust, Roland Cassingena, Alain Vandewalle, and Pierre M. Ronco

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independ- ent mechanism. Sergio Grinstein, Michael Woodside, Claude Sardet, Jacques Pouyssegur, and Daniela Rotin

Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent in- terconversions of tetrameric and dimeric GLUT1. Dan- iel N. Hebert and Anthony Carruthers

Leishmania enriettii by gene cluster deletion. Maria A. Creation of null/+ mutants of the a-tubulin gene in

Curotto de Lafaille and Dyann F. Wirth

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Differential processing of osteopontin transcripts in rat kidney- and osteoblast-derived cell lines. Krishna Shgh, Ani1 B. Mukherjee, Michael W. De Vouge, and Band B. Mukherjee

Studies of the catalytic activities and substrate speci- ficities of Saccharomyces cerevisiae myristoyl-coen- zyme A:protein N-myristoyltransferase deletion mu- tants and human yeast Nmt chimeras in Escherichia coli and S. cerevisiae. David A. Rudnick, Robin L. Johnson, and Jeffrey I. Gordon

Regulation of phosphoinositide kinases in T cells. Evi- dence that phosphatidylinositol 3-kinase is not a sub- strate for T cell antigen receptor-regulated tyrosine

J. Fry, Michael D. Waterfield, and Doreen A. Cantrell kinases. Stephen G. Ward, Karin Reif, Steven L e y , Michael

Inhibition of Acanthamoeba myosin I heavy chain ki- nase by Ca2+-calmodulin. Hanna Brzeska, Dorota Kulesza- Lipka, and Edward D. Korn

The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities. Melya J . Hughes and Josef Jiricny

man brain. George Perides, Firoz Rahemtulla, William S. Isolation of a large aggregating proteoglycan from hu-

Lane, Richard A. Asher, and Amico Bignami

Immunoglobulin K gene enhancers synergistically acti- vate gene expression but independently determine chromatin structure. Veronica C. Blasquez, Michael A. Hale, Kenneth W. Trevorrow, and William T. Garrard

Characterization of the phosphotransferase domain of casein kinase I1 by site-directed mutagenesis and expression in Escherichia coli. Rolf Jakobi and Jolinda A. Traugh

Identification of basic residues involved in activation and calmodulin binding of rabbit smooth muscle myosin light chain kinase. Daniel P. Fitzsimons, B. Paut Herring, James T . Stull, and Patrick J. Gallagher

Angiotensin I1 regulates tenascin gene expression in vascular smooth muscle cells. Behrooz G. Shurifi, David

A. Fagin W. LaFkur, Carlos J . Pirola, James S. Forrester, and James

Protein translocation in the endoplasmic reticulum. U1- traviolet light induces the noncovalent association of nascent peptides with translocon proteins. Lori Anderson and John B. Denny

Cross-linking of the erythrocyte (Na+,K*)-ATPase. Chemical cross-linkers induce a-subunit-band 3 heter- odimers and do not induce a-subunit homodimers. Dwight W. Martin and John R. S u c h

The phosphorylation of kinesin regulates its binding to synaptic vesicles. Reiko Sato-Yoshitake, Hiroshi Yorifuji, Masaki Inagaki, and Nobutaka Hirokawa

Human Mn-superoxide dismutase in pulmonary epithe- lial cells of transgenic mice confers protection from oxygen injury. Jonathan R. Wispi, Barbara B. Warner, Jean

James D. Crapo, Ling-Yi Chang, and Jeffrey A. Whitsett C. Clark, Chitta R. Dey, Jon Neuman, Stephun W. Glasser,

The carboxyl terminus of RAP30 is similar in sequence to Region 4 of bacterial sigma factors and is required for function. Karla Pfeil Garrett, Hiroaki Serizawa, Jeanene P. Hanley, John N. Bradsher, Akio Tsuboi, Naoko Arai, Tak- ashi Yokota, Ken-ichi Arai, Ronald C. Conaway, and Joan Weliky Conaway

Alzheimer j3A4-amyloid protein precursor in immuno- competent cells. Ursula Monr+ng, Gerhurd KGnig, Richard B. Banati, Hans Mechler, Chrzstran Czech, Jochen Gehrmann, Ursula Schreiter-Gasser, Colin L. Masters, and Konrad Beyreuther

Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natu- ral killer cell granule exocytosis. Adrian T. Tzng, Renee A. Schoon, Robert T. Abraham, and Paul J . Leibson

Identification of nuclear encoded precursor tRNAs within the mitochondrion of Trypanosoma brucei. Ka- thy Hancock, Allen J . LeBlanc, David Donze, and Stephen L. Hajduk

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A key role for a 145-kDa cytosolic protein in the stim- ulation of Caz+-dependent secretion by protein kinase C. Takamichi Nishizaki, Jane H. Walent, Judith A. Kowal- chyk, and Thomas F. J. Martin

Growth-associated glycosylation of transferrin se- creted by HepG2 cells. Timothy J. Hahn and Charles F. Goochee

Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells. Heidi Kiil Blomhoff, Erlend B. Smeland, Bjdrn Erikstein, Anne Marie Rasmussen, Bjdm Skrede, Cecilia Skjdnsberg, and Rune Blomhoff

Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines. Diana Linnekin, Gerald Evans, Dennis Michiel, and William L. Farrar

a 8-ketoacyl-acyl carrier protein synthase I isozyme Structure and expression of the Km12 gene encoding

from barley. Sakari Kauppinen

Electrophoretic studies on the assembly of the nitrogen- ase molybdenum-iron protein from the KZeiwieZZapneu- moniae nifD and nifK gene products. Theresa C. White, Georgianna S. Harris, and William H. Orme-Johnson

Promoter region of the human azA adrenergic receptor gene. Diane E. Handy and Haralambos Gavras

Selective tissue distribution of G protein y subunits, including a new form of the y subunits identified by cDNA cloning. James J . Cali, Eric A. Balcueva, Igor Ry- balkin, and Janet D. Robishaw

Cleavage of membrane-anchored growth factors in- volves distinct protease activities regulated through common mechanisms. A t a m i o Pandiella, Marcus W. Bos- enberg, Eric J . Huang, Peter Besmer, and Joan Massagui

Pseudomonas exotoxin A-epidermal growth factor (EGF) mutant chimeric protein as an indicator for iden- tifying amino acid residues important in EGF-receptor interaction. Her-Shyong Shiah, Tzong-Yueh Chen, Cht-Ming Chang, Judy T. Chow, Hsing-Jien Kung, and Jaulnng Hwang

K. Soma Sundaram and Meir Lev Purification and activation of brain sulfotransferase.

Factors determining the specificity of signal transduc- tion by guanine nucleotide-binding protein-coupled receptors. 111. Coupling of a2-adrenergic receptor sub- types in a cell type-specific manner. Emir D u x and Stephen M. Lanier

Interferon a induces rapid tyrosine phosphorylation of

Oscar R. Colamonici the a subunit of its receptor. Leonidas C. Platanias and

Interaction between the p21- GTPase activating pro- tein and the insulin receptor. Gijsbertus J . Pronk, Reni H. Medema, Boudewijn M. Th. Burgering, Robin Clark, Frank McCorrnick, and Johannes L. Bos

Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor- la gene family. Stephen Lee, Anne-Micfile Francoeur, Sha Liu, and Eugenla Wang

crosis factor-a receptor binding site and structure- Site-directed mutational analysis of human tumor ne-

and Mann-Jy Chen functional relationship. Xiang-Ming Zhang, Irene Weber,

Prolactin receptor triggering. Evidence for rapid ty-

A. Evans, Paul A. Kelly, and William L. Farrar rosine kinase activation. Hallgeir Rui, Julie Y. Djeu, Gerald

The human type VI collagen gene. mRNA and protein variants of the a3 chain generated by alternative splic- ing of an additional 5-end exon. Stefania Zanussi, Roberto Doliann, Daniela Segat, Paolo Bonnldo, and Alfonso Colombatti

Structure of the gene encoding dihydrolipoyl trans-

keto acid dehydrogenase complex and characterization acylase (E2) component of human branched chain a-

of an E2 pseudogene. Ktm s. Lau, W. Joseph Herring, Jacinta L. Chuang, Martha McKean, Dean J. Danner, Rody P. Cox, and David T. Chuang

Purification of Limulus polyphemus proclotting en- zyme. Robert I. Roth and Jack Levin

vii

24103 &Adrenergic agonists that down-regulate receptor mRNA up-regulate a M, 35,000 protein(s) that selec- tively binds to &adrenergic receptor mRNAs. J . David Port, Ling- Yan Huang, and Craig C. Malbon

24109 Regulation of ADP-ribosylation factor (ARF) expres- sion. Cross-species conservation of the developmental and tissue-specific alternative polyadenylation of ARF

gale, Eleni Kousuelari, Joel Moss, and Martha Vaughan 4 mRNA. Koichi Mishima, S. Russ Price, Maria S. Nightin-

24117 Purification and characterization of a soluble phospha- tidylinositol 4-kinase from the yeast Saccharomyces cereuisiae. Catherine A. Flanagan and Jeremy Thorner

24126 Deletion of the pro-al(1) N-propeptide affects secretion of type I collagen in Chinese hamster lung cells but not in Mov-13 mouse cells. Seung-Taek Lee, Seungbok Lee, Donna P. Peters, Guy G. Hoffman, Alex Stacey, and Daniel S. Greenspan

24134 Purification and characterization of the mouse mam- mary tumor virus protease expressed in Escherichia coli. Luis Mekndez-Arias, Matthew Young, and Stephen Oroszlan

24140 Effects of folate receptor expression following stable transfection into wild typeand methotrexate transport- deficient ZR-75-1 human breast cancer cells. Katharine H. Dixon, Timothy Mulli an, Koong-Nah Chung, Patrick C. Elwood, and Kenneth H. $wan

ADDITIONS AND CORRECTIONS 24148 Structure of triphosphonoglycosphingolipid containing

N-acetylgalactosamine 6-0-2-aminoethylphosphonate in the nervous system of Aplysia kurodai. Vol. .266 (1991) 9939-9943. Sachrko Abe, Sht eko Arakl, Mez Sa- take, Naoshi Fujiwara, Kazuo Kon, and ~ w u m u Ando

24148 Deoxycytidine deaminase-resistant stereoisomer is the active form of (2)-2’,3’-dideoxy-3’-thiacytidine in the inhibition of hepatitis B virus replication. Vol. 267

Doong, James Hua Zhou, J . Warren Beach. fak S. Jeong, (1992) 13938-13942. Chien-Neng Chan Shin-Lian

Chung K. Chu, Ching-hwa Tsai, and Yung-chi Cheng

24148 Signal transduction by the epidermal growth factor

serine phosphorylation site. Vol. 267 (1992) 16620- receptor is attenuated by the COOH-terminal domain

16626. Steven J . Theroux, Debra A. Latour, Krista Stanley, David L. Raden, and Roger J. Davis

xiii Cumulative author index. Numbers 1 through 33.

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Vol. 267, No. 33 The Journal of Biological Chemistry November 25,1992

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Indica

CONTENTS Arranged by

MINIREVIEW

teases. Donald F. Steiner, Steven P. Smeekens, Shinya Ohagi, The new enzymology of precursor processing endopro-

and Shu Jin Chan

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Total metabolic flow of glycosphingolipid biosynthesis is regulated by UDP-G1cNAc:lactosylceramide 81-r 3N-acetylglucosaminyltransferase and CMP-NeuAc: lactosylceramide a2+3sialyltransferase in human he- matopoietic cell line HL-60 during differentiation. Mit- suru Nakamura, Atsuko Tsunoda, Kumi Sakoe, Jianguo Gu, Atsushi Nishikawa, Naoyuki Taniguchi, and Masaki Saito

hamster ovary cells. Restoration of the growth of a Sphingolipids are essential for the growth of Chinese

mutant defective in sphingoid base biosynthesis by ex-

jima, Makato Kko, Akira Hasegawa, Shuji Fujita, Tomoya ogenous sphingolipids. Kentaro Hanada, Masahiro Nishi-

Ogawa, and Yuzuru Akamatsu

Ligand binding characteristics of the major mistletoe lectin. Reiko T. Lee, Hans-Joachim Gabius, and Yuan Chuan Lee

Progesterone blocks cholesterol translocation from ly- sosomes. Jean D. Butler, Joan Blanchette-Mackie, Ehud Gol- din, Raymond R. O’Neill, Gene Carstea, Calvin F. Roff, Marc

Marie T. Vanier, Roscoe 0. Brady, and Peter G. Pentcheu C. Patterson, Shutish Patel, Marcella E. Comly, Adele Cooney,

Ovarian cancer al,3-~-fucosyltransferase. Differen- tiation of distinct catalytic species with the unique substrate, 3’-sulfo-N-acetyllactosamine in conjunction with other synthetic acceptors. E. V. Chandrasekaran, Rakesh K. Jain, and Khushi L. Matta

Growth-associated glycosylation of transferrin se- creted by HepG2 cells. Timothy J. Hahn and Charles F. Goochee

a 8-ketoacyl-acyl carrier protein synthase I isozyme Structure and expression of the Kasl2 gene encoding

from barley. Sakari Kauppinen

N-acetylgalactosamine 6-0-2-aminoethylphosphonate Structure of triphosphonoglycosphingolipid containing

in the nervous system of Aplysia kurodai. Vol. 266 (1991) 9939-9943. Sachiko Abe, Shigeko Araki, Mei Sa- take, Naoshi Fujiwara, Kazuo Kon, and Susumu Ando

CELL BIOLOGY AND METABOLISM Cell adhesion or integrin clustering increases phos- phorylation of a focal adhesion-associated tyrosine ki-

Michael Schaller, and R. L. Juliano nase. Lori Kornberg, H. Shelton Earp, J. Thomas Parsons,

Expression of a transmembrane phosphotyrosine phos- phatase inhibits cellular response to platelet-derived

A. Mooney, Gregory G. Freund, Barbara A. Way, and Kathy L. growth factor and insulin-like growth factor-1. Robert

Bordwell

Protein tyrosine phosphatase- 1C is rapidly phosphoryl- ated in tyrosine in macrophages in response to colony stimulating factor-1. Yee-Guide Yeung, Karen L. Berg, Fiona J. Pixley, Ruth Hogue Angeletti, and E. Richard Stanley

phospholipase Az and the release of prostaglandin E2 in Interleukin-la induces the accumulation of cytosolic

De Witt human fibroblasts. Lih-Ling Lin, Alice Y . Lin, and David L.

gene expression in the rat uterus. Anastasia G. Dazfotzs, Stretch-induced parathyroid hormone-related peptide

Eleanor C. Weir, Barbara E. Dreyer, and Arthur E. Broadus

Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. Richard Chao, Wasiuddin Khan, and Yumf A. Hannun

ltes a Communication

Subject

-23463

-23467

23502

23554

23568

23609

23625

23664

23713

23789

23815

23862

23910

23916

23930

23937

23950

Categories

A rise and fall in 1,2-diacylglycerol content signal hex- amethylene bisacetamide-induced erythropoiesis. Jo- seph Michaeli, Xavier Busquets, Irene Orlow, Anas Younes, Delors Colomer, Paul A. Marks, Richard A. Rifkind, and Rich- ard N. Kolesnick

Caffeine inhibits the agonist-evoked cytosolic CaZ+ sig- nal in mouse pancreatic acinar cells by blocking inositol trisphosphate production. Emil C. Toescu, Stephen C. O’Neill, Ole H. Petersen, and David A. Eisner

Regulation of integrin gene expression by substrate

erine Arnaud, Bjorn Steffensen, and Robert J. Klebe adherence. Dali Chen, Victoria Magnuson, Stuart Hill, Cath-

phospholipase D via a pertussis toxin-sensitive GTP- A protein kinase C inhibitor, staurosporine, activates

binding protein in rabbit peritoneal neutrophils. Yasu- nori Kanaho, Katsunobu Takahashi, Urara Tomita, Taroh Iiri, Toshiaki Katada, Michio Vi, and Yoshinori Nozawa

Inhibition of ascorbic acid transport in human neutro- phils by glucose. Philip Washko and Mark Levine

Phospholipase D mimics platelet-derived growth factor as a competence factor in vascular smooth muscle cells.

Inagami Takao Kondo, Hiroshi Inui, Fumiko Konishi, and Tadashi

tors. Involvement in the 15-HETE-induced stimulation 15-Hydroxyeicosatetraenoic acid (15-HETE) recep-

of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells. Becky M. Vonakis and Jack Y. Vanderhoek

A novel pathway for the activation of phospholipase D by Pz. purinergic receptors in BAC1.2F5 macrophages. Chakib El-Moatassim and George R. Dubyak

Involvement of sequences near both amino and car- boxyl termini in the rapid intracellular degradation of tyrosine aminotransferase. Robert H. Stellwagen

Casein kinase I1 phosphorylation of signal sequence receptor a and the associated membrane chaperone cal-

John J. M. Bergeron nexin. Wei-Jia Ou, Dauid Y. Thomas, Alexander W. Bell, and

Dramatic changes of sulfated proteoglycans composi- tion in a tumorigenic SV-40-transformed renal proxi- mal-tubule cell line. Brigitte Lelong, RBmi Piedagnel, Fran-

J. Verroust, Roland Cassingina, Alain Vandewalle, and Pierre p i s Chirtelet, Beatrice Baudouin, Paul E. C. Brenchley, Pierre

M. Ronco

Regulation of phosphoinositide kinases in T cells. Evi- dence that phosphatidylinositol 3-kinase is not a sub- strate for T cell antigen receptor-regulated tyrosine kinases. Stephen G. Ward, Karin Reif, Steven Ley, Michael J. Fry, Michael D. Waterfield, and Doreen A. Cantrell

Angiotensin I1 regulates tenascin gene expression in vascular smooth muscle cells. Behrooz G. Sharifi, Dauid W. LaFleur, Carlos J . Pzrola, James S. Forrester, and James A. Fagin

traviolet light induces the noncovalent association of Protein translocation in the endoplasmic reticulum. U1-

nascent peptides with translocon proteins. Lori Anderson and John B. Denny

The phosphorylation of kinesin regulates its binding to synaptic vesicles. Reiko Sato- Yoshitake, Hiroshi Yorifuji, Masaki Inagaki, and Nobutakn Hirokawa

Human Mn-superoxide dismutase in pulmonary epithe- lial cells of transgenic mice confers protection from oxygen injury. Jonathan R. Wispe, Barbara B. Warner, Jean C. Clark, Chitta R. Dey,, Jon Neuman, Stephan W. Glasser, James D. Crapo, Ling- Yz Chang, and Jeffrey A. Whltsett

Alzheimer oA4-amyloid protein precursor in immuno- competent cells. Ursula Monning, Gerhard Konig, Richard B. Banati, Hans Mechler, Chrlstian Czech, Jochen Gehrmann,

Beyreuther Ursula Schreiter-Gasser, Colin L. Masters, and Konrad

Vll l ...

ix

23957 Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natu- ral killer cell granule exocytosis. Adrian T. Ting, Renee A. Schoon, Robert T. Abraham, and Paul J . Leibson

23972 A key role for a 145-kDa cytosolic protein in the stim- ulation of Caz+-dependent secretion by protein kinase C. Takamichi Nkhizaki, Jane H. Walent, Judith A. Kowal- chyk, and Thomas F. J. Martin

23988 Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells. Heidi

Marie Rasmussen, Bjern Skrede, Cecilia Skjmsberg, and Rune Kiil Blomhoff, Erlend B. Smeland, Bj@m Erikstein, Anne

Blomhoff

24028 Cleavage of membrane-anchored growth factors in- volves distinct protease activities regulated through common mechanisms. Atanasio Pandiella, Marcus W. Bos- enberg, Eric J. Huang, Peter Besmer, and Joan Massague

24045 Factors determining the specificity of signal transduc- tion by guanine nucleotide-binding protein-coupled receptors. 111. Coupling of az-adrenergic receptor sub- types in a cell type-specific manner. Emir Duzic and Stephen M. Lunier

24058 Interaction between the p21‘” GTPase activating pro-

Medema, Boudewijn M. Th. Burgering, Robin Clark, Frank tein and the insulin receptor. Gijsbertus J . Prank, Rent! H.

McCormick, and Johannes L. Bos

24076 Prolactin receptor triggering. Evidence for rapid ty-

A. Euans, Paul A. Kelly, and William L. Farrar rosine kinase activation. Hallgeir Rui, Julie Y . Djeu, Gerald

24117 Purification and characterization of a soluble phospha- tidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. Catherine A. Flanagan and Jeremy Thorner

24126 Deletion of the pro-al(1) N-propeptide affects secretion of type I collagen in Chinese hamster lung cells but not

Donna P. Peters, Guy G. Hoffman, Alex Stacey, and Daniel S. in Mov-13 mouse cells. Seung-Taek Lee, Seungbok Lee,

Greenspan

24140 Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-

H. Dixon, Timothy Mulligan, Koong-Nah Chung, Patrick C. deficient ZR-75-1 human breast cancer cells. Katharine

Elwood, and Kenneth H. Cowan

24148 Deoxycytidine deaminase-resistant stereoisomer is the active form of (f)-2’,3’-dideoxy-3’-thiacytidine in the inhibition of hepatitis B virus replication. Vol. 267

Doong, James Hua Zhou, J. Warren Beach, Lak S. Jeong, (1992) 13938-13942. Chien-Neng Chang, Shin-Lian

Chung K. Chu, Ching-hwa Tsai, and Yung-chi Cheng

24148 Signal transduction by the epidermal growth factor

serine phosphorylation site. Vol. 267 (1992) 16620- receptor is attenuated by the COOH-terminal domain

16626. Steven J. Theroux, Debra A. Lutour, Krista Stanley, Dauid L. Raden, and Roger J. Davis

ENZYMOLOGY 23479 Botulinum neurotoxins are zinc proteins. Giampietro

DasGupta, and Cesare Montecucco Schiauo, Ornella Rossetto, Annalisa Santucci, Bibhuti R.

23489 Fatty acid ethyl ester synthase in rat adipose tissue and

Hiromichi Okuda its relationship to carboxylesterase. Talzohiro Tsujita and

23546 Feedback inhibition of phosphatidate phosphatase from spinach chloroplast envelope membranes by diacylglyc- erol. Agnes Malherbe, Maryse A. Block, Jacques Joyard, and Roland Douce

23583 Spectral analysis of the protein-derived tyrosyl radi- cals from prostaglandin H synthase. Janice A. DeGray,

J. Marnett, Thomas E. Eling, and Ronald P. Mason Gunter Lassmann, John F. Curtis, Todd A. Kennedy, Lawrence

23617 Effects of ecotropic murine retroviruses on the dual-

porter. Ha0 Wang, Esther Dechant, Michael Kauanaugh, R. function cell surface receptorbasic amino acid trans-

Alan North, and Dautd Kabat

23640

23674

23688

23696

23759

23782

23894

23903

23993

24041

24097

24134

-23475

23560

23601

23632

23767

23823

23829

The mechanism of ATP inhibition of wild type and

Rong-Lan Zheng and Robert G. Kemp mutant phosphofructo-1-kinase from Escherichia coli.

The purification and characterization of arsenite oxi- dase from Alcaligenes faecalis, a molybdenum-contain-

and Rws Hille ing hydroxylase. Gretchen L. Anderson, Jeffrey Williams,

Manganese(I1) oxidation by manganese peroxidase from the basidiomycete Phanerochaete chrysospor- ium. Kinetic mechanism and role of chelators. Hiroyuki Wariishi, Khadar Valli, and Michael H. Gold

The interaction of human factor VIIa with tissue factor. Sriram Krishnaswamy

Expression, purification, and physicochemical charac- terization of a recombinant Yersinia protein tyrosine phosphatase. Zhong-Yin Zhang, James C. Clemens, Heidi L. Schubert, Jeanne A . Stuckey, Mark W. F. Fischer, Daniel M. Hume, Mark A. Saper, and Jack E. Dixon

Purification, characterization, cloning, and expression of a glutamic acid-specific protease from Bacillus lich- eniformis ATCC 14580. Shinji Kakudo, Norihisa Kikuchi, Kengo Kitadokoro, Takashi Fujiwara, Etsuo Nakamura, Hiro- yuki Okamoto, Masaru Shin, Mikio Tamaki, Hiroshi Teraoka, Hiroshige Tsuzuki, and Nobuo Yoshida

Characterization of the phosphotransferase domain of casein kinase I1 by site-directed mutagenesis and expression in Escherichia coli. Rolf Jakobi and Jolinda A. Traugh

Identification of basic residues involved in activation and calmodulin binding of rabbit smooth muscle myosin

James T. Stull, and Patricia J. Gallagher light chain kinase. Daniel P. Fitzsimons, B. Paul Herring,

Characterization of a 97-kDa phosphotyrosylprotein

Euans, Dennis Michiel, and William L. Farrar regulated by multiple cytokines. Diana Linnekin, Gerald

Purification and activation of brain sulfotransferase. K. Soma Sundaram and Meir Leu

Purification of Limulus polyphemus proclotting en- zyme. Robert I. Roth and Jack Leuin

Purification and characterization of the mouse mam- mary tumor virus protease expressed in Escherichia coli. Luis Menendez-Arias, Matthew Young, and Stephen Oroszlan

MEMBRANES AND BIOENERGETICS Transport of organic substrates via a volume-activated channel. Kiaran Kirk, J. Cliue Ellory, and James D. Young

Ryanodine stabilizes multiple conformational states of

Buck, Ildiko Zimanyi, Jonathan J . Abramson, and Isaac N. the skeletal muscle calcium release channel. Edmond

Pessah

EPR kinetic studies of superoxide radicals generated during the autoxidation of l-methyl-4-phenyl-2,3-di- hydropyridinium, a bioactivated intermediate of Par- kinsonian-inducing neurotoxin 1-methyl-4-phenyl-

Misra 1,2,3,6-tetrahydropyridine. Lun-Yi Zang and Hara P.

Specific interaction of 5-(N-methyl-N-isobutyl)-

human placental brush-border membrane vesicles. amiloride with the organic cation-proton antiporter in

Transport and binding. Puttur D. Prasad, Frederick H. Leibach, Virendra B. Mahesh, and Vadiuel Ganapathy

In uivo phosphorylation of the yeast uracil permease.

auer-Tsupis Christiane Volland, Catherine Gamier, and Rosine Haguen-

Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independ- ent mechanism. Sergio Grinstein, Michael Woodside, Claude Sardet, Jacques Pouyssegur, and Daniela Rotin

Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent in- terconversions of tetrameric and dimeric GLUT1. Dan- iel N. Hebert and Anthony Carruthers

Indicates a Communication

X

23922 Cross-linking of the erythrocyte (Na+,K*)-ATPase. Chemical cross-linkers induce a-subunit-band 3 heter- odimers and do not induce a-subunit homodimers. Dwight W. Martin and John R. Sachs

24103 &Adrenergic agonists that down-regulate receptor

tively binds to &adrenergic receptor mRNAs. J. Davzd mRNA up-regulate a M. 35,000 protein@) that selec-

Port, Ling- Yan Huang, and Craig C. Malbon

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

023471 A human polyadenylation factor is a G protein &sub- unit homologue. Yoshio Takagaki and James L. Manley

23515 Sequence-specific interaction between SlF, a spinach nuclear factor, and a negative cis-element conserved in plastid-related genes. Dao-Xiu Zhou, You-Fang Li, Mireille Rocipon, and Rigis M a c h

23520 @-Adrenergic stimulation of cFOS via protein kinase A is mediated by CAMP regulatory element binding pro- tein (CREB)-dependent and tissue-specific CREB-in-

ence Boutillier, Fabrice Barthel, James L. Roberts, and Jean- dependent mechanisms in corticotrope cells. Anne-Luur-

Philippe Loeffler

23658 The 48-kDa subunit of the mammalian oligosacchar- yltransferase complex is homologous to the essential yeast protein WBP1. Susana Silberstein, Daniel J . Kelleher, and Reid Gilmore

23683 The effects of stem I and loop A on the processing of 5 S rRNA from Drosophila melanogaater. Louis Levinger, Vikram Vasisht, Vilma Greene, and Indera Arjun

23707 Mutational mapping of the catalytic activities of human tyrosinase. Ram K. Tripathi, Vincent J. Hearing, Kazunori Urabe, Pilar Aroca, and Richard A. Spritz

23728 Structural constraints within a trimeric transcrip- tional regulatory region. Constitutive and interferon- y-inducible expression of the HLA-DRA gene. Barbara J . Vilen, Joseph F. Penta, and Jenny P.-Y. Ting

23753 Isolation and sequencing of cDNAs and genomic DNAs encoding the a4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2. Yusuke Kamagata, Marie- Genevieve Mattei, and Yoshifumi Ninomiya

23772 Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S - 100-like calcium binding domain at the amino termi- nus. Richard B. Presland, Paul V. Haydock, Philip Fleckman, Wilas Nirunsuksiri, and Beverly A. Dale

23839 Creation of null/+ mutants of the a-tubulin gene in Leishmania enriettii by gene cluster deletion. Maria A. Curotto de Lafaille and Dyann F. Wirth

23847 Differential processing of osteopontin transcripts in rat

Ani1 B. Mukherjee, Michael W. De Vouge, and Barid B. kidney- and osteoblast-derived cell lines. Krishna Singh,

Mukherjee

23876 The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities. Melya J . Hughes and Josef Jiricny

23888 Immunoglobulin K gene enhancers synergistically acti- vate gene expression but independently determine chromatin structure. Veronica C. Blosquez, Michael A. Hale, Kenneth W. Treuorrow, and William T. Garrard

23942 The carboxyl terminus of RAP30 is similar in sequence to Region 4 of bacterial sigma factors and is required for function. Karla Pfeil Garrett, Hiroaki Serizawa, Jeanene P. Hanky, John N. Bradsher, Akio Tsuboi, Naoko Arai, Tak- ashz Yokota, Ken-ichi Arai, Ronald C. Conaway, and Joan Weliky Conuway

23963 Identification of nuclear encoded precursor tRNAs within the mitochondrion of fiypanosoma brucei. Ka- thy Hancock, Allen J. LeBlanc, David Donze, and Stephen L. Hajduk

24007

24017

24023

24064

24082

24090

24109

23484

23495

23534

23575

23589

23596

23646

23652

23735

23742

Electrophoretic studies on the assembly of the nitrogen- ase molybdenum-iron protein from the Klebeiellapneu- moniae nifD and nifK gene products. Theresa C. White, Geogiannu S. Harris, and William H. Orme-Johnson

Promoter region of the human azA adrenergic receptor gene. Diane E. Handy and Haralambos Gavras

including a new form of the y subunits identified by Selective tissue distribution of G protein y subunits,

cDNA cloning. James J . Cali, Eric A. Balcueva, Igor Ry- balkin, and Janet D. Robishaw

Tissue-specific expression in mammalian brain, heart, and muscle of S1, a member of the elongation factor-

Liu, and Eugenia Wang l a gene family. Stephen Lee, Anne-Michile Francoeur, Sha

The human type VI collagen gene. mRNA and protein variants of the a3 chain generated by alternative splic-

Doliana, Daniela Segat, Paoln Bonaldo, and Alfonso Colombatti ing of an additional 5-end exon. Stefania Zanussi, Roberto

Structure of the gene encoding dihydrolipoyl trans- acylase (E2) component of human branched chain a- keto acid dehydrogenase complex and characterization of a n E 2 pseudogene. Kim S. Lay W. Joseph Herring, Jacinta L. Chuang, Martha McKean, Dean J . Dunner, Rody P. Cox, and David T . Chuang

Regulation of ADP-ribosylation factor (ARF) expres- sion. Cross-species conservation of the developmental and tissue-specific alternative polyadenylation of ARF 4 mRNA. Koichi Mishima, S. Russ Price, Maria S. Nightin- gale, Eleni Kowuelari, Joel Moss, and Martha Vaughan

PROTEIN CHEMISTRY AND STRUCTURE Conformational studies of the interdomain linker pep- tides in the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase multienzyme complex of Escherichia coli. James D. F. Green, Richard N. Perham, Stephen J . Ullrich, and Ettore Appella

A fluorescently labeled intestinal fatty acid binding protein. Interactions with fatty acids and its use in monitoring free fatty acids. Gary V. Richieri, Ronald T. Ogata, and Alan M. Kkinfeld

Refinement of the structure of Escherichia coli-derived rat intestinal atty acid binding protein with bound oleate to 1.75-6 resolution. Correlation with the struc- tures of the apoprotein and the protein with bound palmitate. James C. Sacchettini, Gwvanna Scapin, Deshmukh Gopaul, and Jeffrey I. Gordon

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. Ulla G. Knaw, Paul G. Heyworth, B. Therese Kinsella, John T. Curnutte, and Gary M. Bokoch

In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaater cells. Masazumi Matsumura, Yutaka Saito, Michael R. Jackson, Elizabeth S. Song, and Per A. Peterson

Reducing sugars can induce the oxidative inactivation of rhodanese. Paul M. Horowitz, Michael Butler, and G. David McClure, Jr.

Oxidative fragmentation of collagen and prolyl peptide by Cu!II)/H20z. Conversion of proline residue to 2- pyrrolldone. Yoji Kato, Koji Uchrda, and Shunro Kawakishi

Coagulant properties of hybrid human/porcine factor VI11 molecules. Pete Lollar, Ernest T. Parker, and Philip J . Fay

Mechanism of inhibition of the retroviral protease by a Rous sarcoma virus peptide substrate representing the cleavage site between the gag p2 and p10 proteins. Craig E. Cameron, Bjorn Grinde, Joyce Jentoft, Jonathan Lels, Irene T. Weber, Terry D. Copeland, and Alexander Wlodawer

Cooperative interactions among subunits of a voltage- dependent potassium channel. Evidence from expres- sion of concatenated cDNAs. Raymond s. Hurst, Michael P. Kavanaugh, Jerrel Yakel, John P. Adelmun, and R. Alan North

Indicates a Communication

xi

23746 Effects of the amino-terminal regions of tropomyosin and tro onin T on thin filament assembly. Kent A. Wil- ludsen, &ol A. Butters, Laura E. Hill, and Larry S. Tobacman

23852 Studies of the catalytic activities and substrate speci- ficities of Saccharomyces cerevisiae myristoyl-coen- zyme A: rotein N-myristoyltransferase deletlon mu- tants an8 human yeast N,mt chimeras in .Escherichia coli and S. cerevisrae. Davzd A. Rudnzck, Robzn L. Johnson, and Jeffrey I. Gordon

23870 Inhibition of Acanthamoeh myosin I heavy chain ki- nase by Caz+-calmodulin. Hanna Brzeska, Dorota Kulesza- Lipka, and Edward D. Korn

23883 Isolation of a large aggregating proteoglycan fr0.m hu-

Lane, Richard A. Asher, and Amzco Bignami man brain. George Pendes, F!roz Rahemtullu, Wzlham S.

24034 Pseudomonas exotoxin A-epidermal growth factor (EGF) mutant chimeric protein as an indicator for iden- tifying amino acid residues important in EGF-receptor interaction. Her-Shyong Shiah, Tzong- Yueh Chen, Chi-Ming Chang, Judy T. Chow, Hsing-Jien Kung, and Jaulang Hwang

24053 Interferon a induces rapid tyrosine phosphorylation of the a subunit of its receptor. Leonidas C. Platanias and Oscar R. Colamonici

24069 Site-directed mutational analysis qf human tumor ne- crosis factor-a receptor binding site and structure- functional relationship. Xiang-Ming Zhang, Irene Weber, and Mann-Jy Chen

Ahe, Sachiko, 24148 Abraham, Robert T., 23957 Ahramson, Jonathan J.,

Adelman, John P., 23742 Akamatsu, Yuzuru, 23527 Anderson, Gretchen L., 23674 Anderson, Lori, 23916 Ando, Susumu, 24148 Angeletti, Ruth Hogue, 23447 Appella, Ettore, 23484

Arai, Naoko, 23942 Arai, Ken-ichi, 23942

Araki, Shigeko, 24148 Arjun, Indera, 23683 Arnaud, Catherine, 23502 Aroca, Pilar, 23707 Asher, Richard A., 23883

Balcueva, Eric A., 24023 Banati, Richard B., 23950 Barthel, Fahrice, 23520

Beach, J. Warren, 24148 Baudouin, Beatrice, 23815

Bell, Alexander W., 23789 Berg, Karen L., 23447 Bergeron, John J. M., 23789 Besmer, Peter, 24028 Beyreuther, Konrad, 23950 Bignami, Amico, 23883 Blanchette-Mackie, Joan,

Blasquez, Veronica C., 23888 Block, Maryse A,, 23546 Blomhoff, Heidi Kiil, 23988 Blomhoff, Rune, 23988 Bokoch, Gary M., 23575 Bonaldo, Paolo, 24082 Bordwell, Kathy L., 23443 Bos, Johannes L., 24058 Bosenberg, Marcus W., 24028 Boutillier, Anne-Laurence,

Bradsher, John N., 23942 Brady, Roscoe O., 23797 Brenchley, Paul E. C., 23815 Broadus, Arthur E., 23455 Brzeska, Hanna, 23870 Buck, Edmond, 23560 Burgering, Boudewijn M.

Busquets, Xavier, 23463

Butler, Michael, 23596 Butler, Jean D., 23797

Butters, Carol A,, 23746

Cali, James J., 24023

Cantrell, Doreen A,, 23862 Cameron, Craig E., 23735

Carruthers, Anthony, 23829 Carstea, Gene, 23797

Chan, Shu Jin, 23435 Cassingbna, Roland, 23815

Chandrasekaran, E. V., 23806

23560

23797

23520

Th., 24058

Chang, Chien-Neng, 24148 Chang, Chi-Ming, 24034 Chang, Ling-Yi, 23937

Chltelet, Frangois, 23815 Chao, Richard, 23459

Chen, Dali, 23502 Chen, Mann-Jy, 24069 Chen, Tzong-Yueh, 24034 Cheng, Yung-chi, 24148 Chow, Judy T., 24034 Chu, Chung K., 24148

Chuang, Jacinta L., 24090 Chuang, David T., 24090

Chung, Koong-Nah, 24140 Clark, Jean C., 23937 Clark, Robin, 24058 Clemens, James C., 23759 Colamonici, Oscar R., 24053 Colombatti, Alfonso, 24082 Colomer, Delors, 23463 Comly, Marcella E., 23797 Conaway, Joan Weliky,

Conaway, Ronald C., 23942 Cooney, Adele, 23797 Copeland, Terry D., 23735 Cowan, Kenneth H., 24140 Cox, Rody P., 24090 Crapo, James D., 23937 Curnutte, John T., 23575 Curotto de Lafaille. Maria A,.

23942

Curtis, John F., 23583 Czech, Christian, 23950

23839

Daifotis, Anastasia G., 23455 Dale, Beverly A,, 23772 Danner, Dean J., 24090

Davis, Roger J., 24148 DasGupta, Bibhuti R., 23479

DeGray, Janice A,, 23583 Dechant, Esther, 23617

Denny, John B., 23916 De Vouge, Michael W., 23847 DeWitt, David L., 23451 Dey, Chitta R., 23937 Dixon, Jack E., 23759 Dixon, Katharine H., 24140 Djeu, Julie Y., 24076 Doliana, Roberto, 24082 Donze, David, 23963 Doong, Shin-Lian, 24148 Douce, Roland, 23546 Dreyer, Barbara E., 23455 Duhyak, George R., 23664 Duzic, Emir, 24045

Earp, H. Shelton, 23439 Eisner, David A,, 23467 Eling, Thomas E., 23583 Ellory, J. Clive, 23475 El-Moatassim, Chakih, 23664 Elwood. Patrick C.. 24140 Erikstein, Bjbrn, 23988

AUTHOR INDEX

Evans, Gerald, 23993 Evans, Gerald A,, 24076 Fagin, James A,, 23910 Farrar, William L., 23993,

Fay, Philip J., 23652 Fischer, Mark W. F., 23759

Flanagan, Catherine A,, Fitzsimons, Daniel P., 23903

Fleckman, Philip, 23772 Forrester, James S., 23910 Francoeur, Anne-Michele,

Freund, Gregory G., 23443 Fry, Michael J., 23862 Fujita, Shuji, 23527

Fujiwara, Takashi, 23782 Fujiwara, Naoshi, 24148

Gabius, Hans-Joachim, 23722 Gallagher, Patricia J., 23903 Ganapathy, Vadivel, 23632 Garnier, Catherine, 23767

Garrett, Karla Pfeil, 23942 Garrard, William T., 23888

Gehrmann, Jochen, 23950 Gavras, Haralamhos, 24017

Gilmore, Reid, 23658 Glasser, Stephan W., 23937 Gold, Michael H., 23688 Goldin, Ehud, 23797 Goochee, Charles F., 23982 Gopaul, Deshmukh, 23534 Gordon, Jeffrey I., 23534,

Green, James D. F., 23484 Greene, Vilma, 23683 Greenspan, Daniel S., 24126 Grinde, Bjorn, 23735 Grinstein, Sergio, 23823 Gu, Jianguo, 23507 Haguenauer-Tsapis, Rosine,

Hahn, Timothy J., 23982 Hajduk, Stephen L., 23963 Hale, Michael A,, 23888 Hanada, Kentaro, 23527 Hancock, Kathy, 23963 Handy, Diane E., 24017 Hanley, Jeanene P., 23942 Hannun, Yusuf A,, 23459

Hasegawa, Akira, 23527 Harris, Georgianna S., 24007

Haydock, Paul V., 23772 Hearing, Vincent J., 23707 Hebert, Daniel N., 23829 Herring, B. Paul, 23903 Herring, W. Joseph, 24090 Heyworth, Paul G., 23575 Hill, Laura E., 23746 Hill, Stuart, 23502

24076

24117

24064

23852

23767

Hille, Russ, 23674 Hirokawa, Nobutaka, 23930 Hoffman, Guy G., 24126 Horowitz, Paul M., 23596 Huang, Eric J., 24028 Huang, Ling-Yan, 24103 Hughes, Melya J., 23876 Hume, Daniel M., 23759 Hurst, Raymond S., 23742 Hwang, Jaulang, 24034 Iiri, Taroh, 23554 Inagaki, Masaki, 23930 Inagami, Tadashi, 23609 Inui, Hiroshi, 23609

Jackson, Michael R., 23589 Jain, Rakesh K., 23806 Jakohi, Rolf, 23894

Jeong, Lak S., 24148 Jentoft, Joyce, 23735

Jiricny, Josef, 23876 Johnson, Robin L., 23852 Joyard, Jacques, 23546 Juliano, R. L., 23439

Kakudo, Shinji, 23782 Kahat, David, 23617

Kanaho, Yasunori, 23554 Kamagata, Yusuke, 23753

Kato, Yoji, 23646 Katada, Toshiaki, 23554

Kauppinen, Sakari, 23999 Kavanaugh, Michael, 23617 Kavanaugh, Michael P.,

Kawakishi, Shunro, 23646 Kelleher, Daniel J., 23658 Kelly, Paul A,, 24076 Kemp, Robert G., 23640 Kennedy, Todd A,, 23583 Khan, Wasiuddin, 23459 Kikuchi, Norihisa, 23782 Kinsella, B. Therese, 23575

Kiso, Makoto, 23527 Kirk, Kiaran, 23475

Kitadokoro, Kengo, 23782 Klehe, Robert J., 23502 Kleinfeld, Alan M., 23495 Knaus, Ulla G., 23575

Kon, Kazuo, 24148 Kolesnick, Richard N., 23463

Konig, Gerhard, 23950 Kondo, Takao, 23609

Korn, Edward D., 23870 Konishi, Fumiko, 23609

Kornherg, Lori, 23439 Kousvelari, Eleni, 24109 Kowalchyk, Judith A,, 23972 Krishnaswamy, Sriram,

Kulesza-Lipka, Dorota, 23870 Kung, Hsing-Jien, 24034

LaFleur, David W., 23910

23742

23696

Lane, William S., 23883 Lanier, Stephen M., 24045 Lassmann, Gunter, 23583 Latour, Debra A,, 24148 Lau, Kim S., 24090 LeBlanc, Allen J., 23963 Lee, Reiko T., 23722

Lee, Seung-Taek, 24126 Lee, Seunghok, 24126

Lee, Stephen, 24064 Lee, Yuan Chuan, 23722 Leibach, Frederick H., 23632 Leibson, Paul J., 23957 Leis, Jonathan, 23735 Lelong, Brigitte, 23815

Levin, Jack, 24097 Lev, Meir, 24041

Levinger, Louis, 23683 Levine, Mark, 23568

Ley, Steven, 23862 Li, You-Fang, 23515 Lin, Alice Y., 23451 Lin, Lih-Ling, 23451 Linnekin, Diana, 23993 Liu, Sha, 24064 Loeffler, Jean-Philippe,

Lollar, Pete, 23652 Mache, Regis, 23515 Magnuson, Victoria, 23502 Mahesh, Virendra B., 23632

Malherbe, Agnes, 23546 Malbon, Craig C., 24103

Manley, James L., 23471 Marks, Paul A,, 23463

Martin, Dwight W., 23922 Marnett, Lawrence J., 23583

Mason, Ronald P., 23583 Martin, Thomas F. J., 23972

Masters, Colin L., 23950 Massague, Joan, 24028

Matsumura, Masazumi,

Matta, Khushi L., 23806 Mattei, Marie-Genevieve,

McClure, G. David, Jr., 23596 McCormick, Frank, 24058 McKean, Martha, 24090 Mechler, Hans, 23950 Medema, Rene H., 24058 Menendez-Arias, Luis, 24134 Michaeli, Joseph, 23463 Michiel, Dennis, 23993 Mishima, Koichi, 24109 Misra, Hara P.. 23601 Monning, Ursula, 23950 Montecucco, Cesare, 23479 Mooney, Robert A,, 23443

Mukherjee, Ani1 R.. 23847 Moss, Joel, 24109

Mukherjee, Barid R.. ? : W 7

23520

23589

23753