1. :

2. : PLOS One

Nature

3. :

4.

1.

lncRNA

lncRNA

X Xist RNA

hnRNP U lncRNA

hnRNP U cre

hnRNP U Xist RNA

hnRNP U Xist RNA X

X

hnRNP U

lncRNA hnRNP U

hnRNP U lncRNA

50% 3 4

2004 Brinkmann Zychlinsky

Neutrophil Extracellular Traps NETs

NETs

HL-60

NETs

NETs

2015

5th Jan News Letter http://nucleosome.kyushu-u.ac.jp

No.

11

DNA

DNA

HPLC

UV UV

(Sci.Rep.,4:4950|2014 )

HPLC

2.

PLOS One

DNA binding properties of the actin-related protein Arp8 and its role in DNA repair. Osakabe A, Takahashi Y, Murakami H, Otawa K, Tachiwana H, Oma Y, Nishijima H, Shibahara KI, Kurumizaka H, Harata M. Published: October 09, 2014 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0108354

DNA DNA

DNA

DNA

DNA

ATP

DNA

DNA

INO80

Actin-related-protein: Arp 15

DNA

INO80

Arp8 DNA

Arp8 DNA

DNA Arp8

Arp8 Arp8

DNA DNA DNA

Arp8 ATP ATP Arp8

DNA ATP Arp8 DNA

Arp8 DNA ATP

Arp8

Nalm-6 B Arp8 DNA

DNA

DNA Arp8 DNA

DNA INO80 INO80

DNA

INO80 Arp8 DNA

INO80

Nature

ONLINE Nature Reviews Molecular Cell Biology

Regulation of RNA polymerase II activation by histone acetylation in single living cells Stasevich TJ, Hayashi-Takanaka Y, Sato Y, Maehara K, Ohkawa Y, Sakata-Sogawa K, Tokunaga M, Nagase T, Nozaki N, McNally JG, Kimura H. Nature. 2014 Dec 11;516(7530):272-275 http://www.nature.com/nature/journal/v516/n7530/full/nature13714.html

RNA

II RNAP2

Fab-based live endogenous

modification labeling; FabLEM

RNAP2

H3

27 H3K27ac

RNAP2

H3K27ac

ChIP-seq

H3K27ac

RNAP2

3.

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice. Chihiro Horigome, Yukako Oma, Tatsunori Konishi, Roger Schmid, Isabella Marcomini, Michael Hauer,

Vincent Dion, Masahiko Harata and Susan M. Gasser

Mol Cell. 2014 Aug 21;55(4):626-39

DNA

DNA DNA double strand break: DSB

DSB

(Dion et al. 2012, Nat Cell Biol; Mine-Hattab and Rothstein 2012, Nat Cell Biol; Seeber et al. 2013, Genes

Dev) DSB Nup84

SUN Mps3 (Nagai et al. 2008, Science; Oza et al. 2009,

Gens Dev; Kalocsay et al. 2009 Mol Cell; Oza et al. 2010, Cell Cycle) DSB

DSB

SWR1 INO80 DSB

DSB Mps3 G1

Mps3 INO80 Rad51 SWR1

Htz1 DSB Mps3

Mps3 DSB uSCR

Mps3 DSB

SUMO Slx5/Slx8

SUMO FMI

HO

150 2014

CCD

nucleolus organizer region: NOR

DNA

4.

DNA http://nucleosome.kyushu-u.ac.jp/outreach/20150112.html

1 DNA

DNA

DNA

2 DNA

3 DNA

DNA

130

X

Chromatin Structure, Dynamics, and Function http://www.knt-ec.net/2015/iscsdf/ http://nucleosome.kyushu-u.ac.jp/activities/20150823.html

Invited speakers:

Frederic Berger (GMI, Austria)

Kerstin Bystricky (Univ. Toulouse, France)

Philippe Collas (Univ. Oslo, Norway)

Roland Foisner (MFPL, Austria)

Peter Fraser (Babraham Inst., UK)

Martin W. Hetzer (Salk Inst., USA)

Anthony Imbalzano (Univ. Mass, USA)

Joachim Lingner (EPFL, Switzerland)

Michael Guy Poirier (Ohio State Univ., USA)

Kannanganattu V. Prasanth (Univ. Illinois, USA)

Maria-Elena Torres-Padilla (IGBMC, France)

Paul A. Wade (NIEHS, NIH, USA

編集後記：寒さが身に沁みる今日この頃ですが、いかがお過ごしでしょうか。私は年末年始も容赦なく宿題がてんこ盛りの中、いつの

間にか年が明けていて焦りました。みなさま風邪などひかれないよう、ご自愛ください。今年もどうぞよろしくお願いします。

HiKi

2015 1 12 ( ) 13:00 17:30 ( 12:30)

2015 8 23-26

間違い探し

左右の絵で違うところはどこでしょう？

答えは本研究領域のホームページで！

http://nucleosome.kyushu-u.ac.jp/index.html