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NIFA Funded Research on Chemicals, Mycotoxins, and
Nanoparticles in FoodsJodi P. Williams, PhD
National Program Leader, Food Safety
IRAC Workshop on Chemical Food Safety Risk Assessment
FDA Center for Food Safety and Applied Nutrition, College Park, MD
June 14th 2012
Director
Dr. Sonny Ramaswamy
INSTITUTE OF YOUTH AND COMMUNITY
DEVELOPMENT
INSTITUTE OF BIOENERGY, CLIMATE, and
ENVIRONMENT
INSTITUTE OF FOOD
PRODUCTION AND SUSTAINABILITY
INSTITUTE OF FOOD SAFETY AND
NUTRITION
Competitive Formula Funds
AFRI
SBIR
Challenge
NIFSI
HATCH
Special Research
Grants
Award Statistics
30 awards
> $4.6M
Acc. No. Title Location0211058 GORDON RESEARCH CONFERENCE ON MYCOTOXINS AND
PHYCOTOXINS GORDON RESEARCH CONFERENCES
0213695 RAPID ENZYME-BASED ASSAYS TO DETECT BANNED SUBSTANCES IN FOOD
BIOO SCIENTIFIC
0214332 FOOD SAFETY: FARM TO TABLE OKLAHOMA STATE UNIVERSITY0212075 THE FOOD ANIMAL RESIDUE AVOIDANCE DATABANK
(FARAD)/NC COMPONENT NORTH CAROLINA STATE UNIV
0212102 FOOD ANIMAL RESIDUE AVOIDANCE DATABANK UNIVERSITY OF FLORIDA0215579 NANOSCALE ANALYSIS OF CHEMICAL RESIDUES IN FOODS
USING WHISPERING-GALLERY MODE MINIATURE SENSORS RUTGERS UNIVERSITY
0222256 INTEGRATED STRATEGIES TO REDUCE FOODBORNE ILLNESS AND FOOD ALLERGIC REACTIONS ASSOCIATED WITH INDEPENDENTLY OPERATED RESTAURANTS
TEXAS WOMAN'S UNIVERSITY
0222716 FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD) UNIVERSITY OF FLORIDA
0222964 FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD) (PD-JIM RIVIERE)
NORTH CAROLINA STATE UNIV
0225913 ADVANCING FOOD ALLERGY EDUCATION FOR HOSPITALITY MANAGEMENT AND/OR DIETETICS STUDENTS USING STORYTELLING
Kansas State University
0229060 ACCUMULATION OF ENGINEERED NANOPARTICLES IN BELOWGROUND VEGETABLES: NUTRITIONAL BIOACCESSIBILITY AND DIETARY EXPOSURE RISKS
SOUTHERN ILLINOIS UNIV
0230865 FOOD ANIMAL RESIDUE AVOIDANCE DATABANK (FARAD) KANSAS STATE UNIV
0162162 LIPOSOME-AMPLIFIED BIOANALYSIS OF TOXIC CHEMICALS AND PATHOGENS
N Y AGRICULTURAL EXPT STATION
0170246 MYCOTOXINS IN CEREAL GRAINS UNIVERSITY OF GEORGIA0189368 ANALYTICAL METHODS DEVELOPMENT AND COMPOSITION
OF ORGANIC MINOR CONSTITUENTS IN FOOD AND WATER UNIVERSITY OF MAINE
0191214 UNDERSTANDING THE INTERSECTION BETWEEN CHEMISTRY, FOOD PROCESSING AND HUMAN HEALTH
UNIV OF CALIFORNIA
0201770 PESTICIDE RESIDUE ANALYSIS TO SUPPORT PESTICIDE REGISTRATION FOR USES ON MINOR CROPS
UNIV OF HAWAII
0203755 FOOD SAFETY POST HARVEST KANSAS STATE UNIV0205400 MICROBIOLOGICAL AND CHEMICAL SAFETY OF RAW FOODS
SOLD ON THE INTERNET MARKETS VIRGINIA STATE UNIVERSITY
0212399 ENHANCEMENT OF FOOD SAFETY BIOSENSOR SYSTEMS THROUGH NANOTECHNOLOGY
UNIV OF IDAHO
0223848 MYCOTOXINS: BIOSECURITY, FOOD SAFETY AND BIOFUELS BYPRODUCTS (NC129, NC1025)
UNIVERSITY OF ARKANSAS
0224052 MYCOTOXINS: BIOSECURITY, FOOD SAFETY AND BIOFUELS BYPRODUCTS (NC129, NC1025)
UNIVERSITY OF KENTUCKY
224220 EFFECTS OF FOOD PROCESSING ON FOOD ALLERGENS - ASSESSMENT AND IMPROVEMENT OF DETECTION METHODS
UNIVERSITY OF NEBRASKA
224261 CHARACTERIZATION AND COMPARISON OF CONFORMATIONAL AND LINEAR EPITOPES ON THE TREE NUT ALLERGENS AND THE EFFECTS OF FOOD PROCESSING
FLORIDA STATE UNIVERSITY
224266 POST-HARVEST PROCESSING OF PEANUT AND WHEAT PRODUCTS TO REDUCE INHERENT ALLERGENS
NORTH CAROLINA A&T STATE UNIV
224342 PREVENTING FOOD PROTEIN ALLERGIC REACTIONS VIA CONJUGATION WITH POLYSACCHARIDES
UNIV OF WISCONSIN
Acc. No. Title Location
www.cris.nifa.usda.gov – Search by Accession Number
NANOTECHNOLOGY &REDUCING ALLERGENS AND IMPROVING FOOD QUALITY
AFRI Foundational Program
• Nanomaterials are increasingly incorporated into food ingredients
• Researchers at Ohio State University are proposing that engineered nanoparticles are modified by the environment of the gastro-intestinal(GI) tract.
• Evaluate the size, composition, surface charge, crystallinity, and
surface chemistry/physics of particles after modification affect their interactions with intestinal epithelial cells, influencing particle toxicity, bioavailability and tissue distribution.
Impact of the Physicochemical Properties of Engineered Nanomaterials on their Cellular Uptake and Potential Toxicity in
the Gastrointestinal Tract Environment
Dutta, P.K.; Rathman, J.; Waldman, J.; The Ohio State University, Columbus, and Chihae Yang, FDA (2010-05267)
Influence of Nanoparticle Characteristics on Fate, Bioavailability, and Toxicity of Food-Grade Nanoemulsions, Xiao, H.; McClements, D. J.; Decker, E. A.
University of Massachusetts Amherst (2010-05266)
Development In vitro In vivo
Develop nanoemulsions with beta-carotene encapsulated within.
Quantification of the factors impacting the bioavailability of beta-carotene in simulated gastrointestinal conditions.
Determine the bioavailability and safety of beta-carotene-nanoemulsions in Mongolian gerbils.
Post Harvest Processing of Peanut and Wheat Products to Reduce Inherent Allergens; Ahmedna, M;
North Carolina A&T State UniversityConfirm reduction in clinical trials – skin pricks
Evaluate sensory acceptability
FOOD SAFETY CHALLENGE AREA
AFRI
Risk Assessment And Intervention Strategies For The Emerging Food Safety Threat Of Ochratoxin
PD = Dr. Dojin Ryu Institution: Texas Woman's University
• Aspergillus are ubiquitous & toxigenic fungi that produce ochratoxin A (OTA), a possible human carcinogen.
• OTA has been found in a wide variety of agricultural commodities including cereal grains, nuts, dried fruits, spices, meat, milk, & many processed foods.
• Currently, no regulation for OTA in food has been set in the U.S.
Risk Assessment And Intervention Strategies For The Emerging Food Safety Threat Of Ochratoxin
PD = Dr. Dojin Ryu Institution: Texas Woman's UniversityOptimization & verification of methods for detecting and quantifying OTA in foods to obtain reliable data in different food matrices
Determination of OTA concentrations & presence of toxigenic fungi in foods with a comprehensive national survey
Risk assessment of foodborne OTA exposure (general public & high-risk populations, including infants)
Development of strategies to reduce OTA exposure from the food supply through examination of current postharvest practices
Nanoparticle Contamination of Agricultural Crop Species
PD = Dr. Jason White, Connecticut Agricultural Experiment Station (CAES)
• Nanomaterials (NM) are being incorporated into pesticides and fertilizers.
• NM impacts on agricultural plants and potential trophic transfer is unknown.
• This project will quantitatively characterize the effects of NMs on crops, focusing on processes relevant to human risk. The research team has hypothesized that agricultural crops accumulate and are physiologically impacted by NMs in a toxicologically significant fashion with regard to subsequent human exposure.
Nanoparticle Contamination of Agricultural Crop SpeciesPD = Jason White, Connecticut Agricultural Experiment Station (CAES)
Determine the uptake, translocation, and toxicity of NMs in crops
Determine the impact of environmental conditions on NM uptake, translocation, and toxicity in crops
Determine the potential trophic transfer of NMs
Quantify the facilitated uptake of pesticides through NM-chemical interactions
Development of Rapid and Versatile Detection Systems for the Detection of Toxins and
Chemicals on Fresh Produce and NutsPD = Theodore Labuza; University of Minnesota
• Develop two detection systems based on surface-enhanced Raman spectroscopy (SERS) and nanoparticle (NP) aggregation assays
• Can be used for routine, in-the-field detection of toxins and chemicals on fresh produce and nuts.
• Toxins and chemicals of interest include commercially available pesticides, herbicides, cyanide, Shiga toxin and many others.
Development of Rapid and Versatile Detection Systems for the Detection of Toxins and Chemicals on Fresh Produce and Nuts
PD = Theodore Labuza; University of Minnesota
Develop rapid versatile (lab-based and hand-held) SERS protocols for detecting toxins and chemicals, including pesticides on fresh produce and nuts
Develop NP aggregation assay for multiplex detection of toxins and chemicals, including pesticides on fresh produce and nuts
ACQUISITION OF A LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY TO
ENHANCE RESEARCH ON TOXINS IN FRESH FOOD CROPS
(Equipment Grant)
PD = Simsek, Senay; Institution: North Dakota State University
A LCMS system, will be used for the analysis of toxins and other chemicals from fresh crops.
The instrumentation and data generated also will be incorporated into the education and training of students.
NIFSI & HATCH
Formula Funds/Competitive Funds
Helping Childbearing Women Make Informed Decisions Regarding Seafood Consumption
Provided with effective educational materials, childbearing aged women will consume seafood which provides nutrients that will support a healthy
pregnancy while lowering the risks of exposure to pollutants in seafood.
Validate the use of thermal decomposition (gold) amalgamation-atomic absorption spectrophotometry for the rapid measurement
of total mercury in fish using a fish fin or biopsy plug without having to sacrifice the fish.
To survey for mercury and omega-3 fatty acids in commercially important fish species across 5
regions in the US.
Develop and compare two educational communication vehicles to change the behavior
of pregnant women.
HIGHER EDUCATION CHALLENGE GRANT
Education Programs
Advancing Food Allergy Education for Hospitality Management and /or Dietetics Students using Storytelling; Kwon, J.; Kansas State University
Improve Student Retention of allergy prevention and management information
Improve the capacity of faculty to provide effective and updated allergy prevention instruction
Summer Internships to increase the number and diversity of students engaged in food allergy/safety research
SBIR
Sequential Injection Enzymatic Assay for Melamine Detection in Food
Develop a highly sensitive, reproducible, and rapid direct enzymatic sequential injection instrument
Detect 200 ppb in milk based samples
Food contaminated with mycotoxins can sometimes cause fatal acute illness and is associated with increased cancer risk from long-term exposure.
To demonstrate the feasibility of using colorimetric indicator based
cartridge to indicate the presence of trace quantities of trichothecene
mycotoxins in grains and in aqueous solutions.
Develop a simple battery operated handheld system utilizing micro-cartridges without antibodies or enzymes for rapid detection of
tricothecene mycotoxins in grains, other field crops and water.
Rapid Detection of Mycotoxins
Program Contacts• AFRI Programs – Jodi Williams (
[email protected]) , Isabel Walls ([email protected]), Jeanette Thurston, ([email protected]), Ram Rao ([email protected])
• Nanotechnology Programs – Hongda Chen [email protected]
• Small Business Innovation Research Programs – Jodi Williams
