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NEURONS, SYNAPSES AND SIGNALING
The neuron – structure and function• Conducts long distance electrical signals and short
distance chemical signals.
• Cell body – includes nucleus and other organelles
• Dendrites – highly branched extensions that receive signals from other neurons
• Axon – extension that transmits signals to other cells, can be long, branched at end
FIGURE 37.2
Dendrites
Nucleus
Stimulus
Axonhillock
Cellbody
Axon
Signaldirection
Presynapticcell
Synapse
Neurotransmitter
Synaptic terminals
Postsynaptic cell
Synapticterminals
• Synapse – junction between axon/dendrite
• Neurotransmitters – chemical messengers, pass information from transmitting neuron to receiving cell
• Glia cells – support cells in nervous system• Outnumber neurons• In brain• Nourish neurons, insulate axons, regulate the extracellular fluid
around surrounding neurons
Information processing• Sensory neuron – interneuron – motor neuron
• Central nervous system – brain and spinal cord
• Peripheral nervous system – nerves• Autonomic nervous system – involuntary actions
• Sympathetic – fight or flight• Parasympathetic – maintenance
Ion pumps and channels resting potential
• Inside of a cell is negatively charged relative to outside
• Membrane potential –charge difference between outside and inside of cell• attraction of opposite charges across the plasma membrane as
source of potential energy
• Resting potential – membrane potential for resting neuron
Resting potential• Potassium – K+ - greater inside of cell• Sodium – Na+ - greater outside of cell• Gradients are maintained by sodium potassium pump
• S/P Pump – 3 K+ out for 2 Na+ in• Existence of a voltage difference in resting neuron
• Ion channel – allows ions to move back and forth across the membrane and generates a membrane potential
• Net flow of each ion across the membrane since neither K+ or Na+ is at equilibrium
Figure 37.6
OUTSIDEOF CELL
INSIDEOF CELL
Key
Na
K
Sodium-potassiumpump
Potassiumchannel
Sodiumchannel
Action Potentials - axons• Neuron responds to stimulus – gated ion channels react
• Hyperpolarization – inside of membrane more negative due to opening K+ channel, which diffuse out, shifting membrane potential
• Depolarization – reduction in the magnitude of the membrane potential, usually involves gated Na+ channels opening and diffusing into the cell
• Action potential – massive change in membrane voltage
1
Figure 37.11
Key
Na
K
Actionpotential
Threshold
Resting potential
Time−100
−50
0
50
Mem
bra
ne
po
ten
tial
(mV
)
Rising phase of the action potential
Depolarization
Falling phase of the action potential
Resting state
Undershoot
Sodiumchannel
Potassiumchannel
Inactivation loop
OUTSIDE OF CELL
INSIDE OF CELL
1
5
43
2
15
42
3
Figure 37.12-3
Axon
Plasmamembrane
Cytosol
Actionpotential
Actionpotential
Actionpotential
K
K
K
K
Na
Na
Na
1
2
3
Evolutionary adaptations of axon• Wider axon – allows for less resistance to the flow of
currents
• Invertebrates differ from vertebrates• Vertebrate axons have narrow diameters but do conduct action
potentials at high speeds• Due to insulation – myelin sheath
• Myelin sheaths
in CNS – oligodendroglia
in PNS – schwann cells
Figure 37.13
Axon Myelinsheath
Schwanncell
Nodes ofRanvier Nucleus of
Schwann cell
Schwanncell
Node of Ranvier
Layers of myelin
Axon
0.1 m
Saltatory conduction• Myelinated axons have gaps – nodes of Ranvier
• where voltge-gated Na+ channels are located
• Action potentials occur at nodes and pass over myelinated sections – making conduction much faster
Figure 37.14
Cell body
Schwann cell
Depolarized region(node of Ranvier)
Myelinsheath
Axon
The synapse - communication• Electrical and chemical synapses• Most synapses are chemical synapses in the vertebrate
brain
• Release of neurotransmitters, held in vesicles, by the pre-synaptic neuron
• Neurotransmitter diffuses across the synaptic cleft, to the post synaptic membrane, which activates a specific receptor
Figure 37.15
Presynaptic cell Postsynaptic cell
Axon Synaptic vesiclecontaining neurotransmitter
Synapticcleft
Postsynapticmembrane
Ca2
K
Na
Ligand-gatedion channels
Voltage-gatedCa2 channel
Presynapticmembrane
1
2
3 4
Neurotransmitters• Acetylcholine – nervous system functions, muscle
stimulation, memory formation, learning• Glutamate – AA – in invertebrates, at neuromuscular
junction rather than acetylcholine• GABA – (gamma-aminobutyric acid) – inhibitory
synapses, increase permeability to Cl-, Valium reduces anxiety through binding to a site on a GABA receptor
• Norepinephrine - excitatory• Dopamine and serotonin – affect sleep, mood, attention
and learning, Parkinsons, depression• Endorphins – decreasing pain perception
Evolution of the nervous system in the Animal Kingdom
• Cnidaria – nerve net, contraction and expansion of gastrovascular cavity
• Planarian – cephalization – eye spot, nerves, nerve cords, simple CNS
• Insects – ganglia –clusters of neurons, brain, ventral nerve cord
• Vertebrates – CNS – brain and spinal cord• PNS - nerves
FIGURE 38.2
(a) Hydra (cnidarian)
Spinalcord(dorsalnervecord)
Brain
(b) Planarian (flatworm)
(c) Insect (arthropod) (d) Salamander (vertebrate)
Sensoryganglia
Brain
Nervecords
Eyespot
Transversenerve
Segmentalganglia
Brain
Nerve net
Ventralnerve cord
Glia cells• Nourish, support and regulate the functioning of neurons
• Astrocytes – hold blood vessels close, aid in nourishment
• Oligodendroglia – make myelin sheath in CNS
• Microglia – phagocytic,
CNS - PNS• Gray matter – consists mainly of cell bodies and dendrites
• White matter – consists of myelinated axon bundles
• Brain – consists of 100 billion neurons
Figure 38.4
Spinal cord
Central nervoussystem (CNS)
Peripheral nervoussystem (PNS)
Cranialnerves
Spinalnerves
GangliaoutsideCNS
Brain
Figure 38.5
Afferent neurons
Sensoryreceptors
Internaland external
stimuli
Autonomicnervous system
Motorsystem
Control ofskeletal muscle
Sympatheticdivision
Entericdivision
Control of smooth muscles,cardiac muscles, glands
Parasympatheticdivision
Efferent neurons
Peripheral Nervous System
Central Nervous System
(information processing)
Figure 38.6b
Medullaoblongata
Embryonic brain regions Brain structures in child and adult
Forebrain
Hindbrain
Midbrain
Telencephalon
Myelencephalon
Metencephalon
Forebrain
Hindbrain
Midbrain
Diencephalon
Cerebrum (includes cerebral cortex,white matter, basal nuclei)
Medulla oblongata (part of brainstem)
Pons (part of brainstem), cerebellum
Midbrain (part of brainstem)
Diencephalon (thalamus,hypothalamus, epithalamus)
Telencephalon
Myelencephalon
Metencephalon
Diencephalon
Mesencephalon
Mesencephalon
Embryo at 1 month Embryo at 5 weeks
Spinalcord
Child
Diencephalon
Midbrain
CerebellumSpinal cord
Pons
Cerebrum
Brain region functions• Cerebrum – skeletal muscle contraction, center for
learning, emotion, memory and perception
• Cerebellum – coordinates movement and balance, learning and remembering motor skills.
• Diencephalon –• thalmus – input center for sensory information• Hypothalmus- thermostat, biological clock
• Regulates pituitary gland therefor regulates hunger and thirst, fight or flight, role in sexual and mating behaviors.
The brain stem• Midbrain – receives sensory information, coordinates
visual reflexes
• Pons and Medulla – 2 way conduction from spinal cord to brain• Helps to coordinate large scale body movements, control several
automatic, homoestatic functions: breathing, heart and blood vessel activity, swallowing, vomiting and digestion.
Figure 38.6d
Diencephalon
ThalamusPineal glandHypothalamus
Pituitary gland
Spinal cord
Brainstem
Midbrain
Medullaoblongata
Pons
Emotions – Limbic system• Biological clock regulation –
• Typically regulated by cycles of light and dark• Coordinated by a group of neurons n the hypothalmus in
conjunction with sensory information from the eyes.
• Brain reward system and drug addition• Drugs alter the transmission of signals in the synaptic pathway
formed by neurons.• Mouse party
Use imaging of the brain to understand the brain
Positron emission tomagraphy (PET)
Magnetic resonance imaging (MRI)
Figure 38.8
Thalamus
Hypothalamus
Amygdala
Olfactorybulb
Hippocampus
Cerebral Cortex• Controls
• Language and speech – Broca’s area and Wernicke’s area• Both in left side of brain…
Left side of brain is also more adept at math and logical operations
Right side – recognition of faces and patterns, spatial relations and nonverbal thinking.
Frontal lobe – decision making
Figure 38.11
Frontal lobe
Temporal lobeOccipital lobe
Parietal lobe
Cerebellum
Motor cortex (controlof skeletal muscles)
Somatosensory cortex (sense of touch)
Wernicke’s area(comprehending language)
Auditory cortex(hearing)
Broca’s area(forming speech)
Prefrontal cortex(decisionmaking,planning)
Sensory association cortex (integrationof sensoryinformation)
Visual association cortex (combiningimages and objectrecognition)
Visual cortex(processing visualstimuli and patternrecognition)
Evolution of cognition in Vertebrates• Perception and reasoning that constitute knowledge
• Human evolution…larger cranial capacity
• Hypothesis – evolution of a highly convoluted cerebral cortex• Primates, and cetaceans (whales and dolphins)• Birds – lack convoluted cortex but have organization of clustered
neurons in top layer of brain, the pallium
Senses• Sensory receptor – sensory transduction - transmission –
perception
• Types of sensory receptors• Mechanoreceptors – pressure, touch, stretch, motion and sound• Electromagnetic - light, electricity and magnetism• Thermoreceptors – heat and cold• Pain – extreme pressure or temp• Chemoreceptors – solute concentration, smell, taste