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“Multiscale” data integration into a structure/function model of H/ACA guide RNAs in Archaea keywords: structural & RNA biology, phylogeny, transcriptomics, bioinformatics Fabrice Leclerc IGM - Orsay [email protected]

Multiscale data integration into a structure/function model of H/ACA guide RNAs in Archaea

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Mini-colloque: "Les multiples facettes de l'ARN" (2013).

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Page 1: Multiscale data integration into a structure/function model of H/ACA guide RNAs in Archaea

“Multiscale” data integration into a structure/function model of H/ACA guide RNAs in Archaea

keywords: structural & RNA biology, phylogeny, transcriptomics, bioinformatics

Fabrice Leclerc IGM - Orsay

[email protected]

Page 2: Multiscale data integration into a structure/function model of H/ACA guide RNAs in Archaea

Outline

✤ H/ACA guide RNAs: structure(s) & “old/new” function(s) (Eukaryotes)

✤ Archaea: H/ACA (Euryarchaea + Crenarchaea) & H/ACA-like (Crenarchaea): variations on the same theme ?

✤ Alternative function(s) in Archaea ?