MOVEMENT OF MELANOSOMES

FORMATION OF MELANOSOMES

MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE)

HUMAN SKIN

MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS

MELANOBLASTS DIVIDE TO FORM MELANOCYTES

AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM

MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES

INACTIVE TYROSINASE DUE TO MUTATION

MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.

BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.

CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.

SO MISDIRECTED AT TRANS-GOLGI SYSTEM

MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.

LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.

LACK OF FUNCTIONAL TYROSINASE

LACK OF TRANSFER TO KERATINOCYTES

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