260 Book Reviews

cation channels; gap junctions; changes in membrane ca- pacitance; protein secretion; mutant cell lines; use of NMR; network thermodynamics]; salivary glands; lacrimal glands; exocrine pancreas; endocrine pancreas; gastric musosa; liver; epididymus; salt glands; cystic fibrosis epithelia [defect in the phosphorylation of a regulatory domain in the chloride channels]. The chapters are well written and pre- sented, making this volume a very useful account of the subject.

Cell Culture Techniques in Heart and Vessel Research-- Edited by H. M. Pn, Eg. 362pp. 1990. Springer, Berlin. DM 176.

If you want to know how to culture cardiomyocytes (embry- onic and adult), endothelial cells (micro and macrovascular) from heart, aorta, lungs or brain, smooth muscle cells, or pericytes, then this volume will be useful to you. Techniques such as the use of growth factors and attachment substrates, cultures on permeable filter membranes, microcarrier cul- tures, and co-cultures are described. There are sufficient practical details to enable the systems described to be set up. The book will also be useful to those already working in the field since it provides useful tips and hints that you may not already know.

Molecular Cell Biology. 2nd edition--J. DARNELL, H. LODISH and D. BALTIMORE. 1105 pp. 1990. Scientific American/ W. H. Freeman, New York.

The first edition appeared in 1986. This new edition has full colour illustrations, has been brought up to date, and many explanations are more clearly and simply expressed. As readers of the previous edition will appreciate, the book achieves a very high standard in the ground that it covers, its levels of explanation and illustration, and its up-to-date information. For example a protein kinesin binds to vesicles and carries them towards the + end of microtubules; another protein MAP1C carries vesicles towards the - e n d of microtubules; so explaining the anterograde and retro- grade transport of vesicles along nerve axons. Many such new explanations are available in this text and most people will learn much from reading this new edition. In addition to cell structure and function, gene expression, replication and expression, there are chapters on cell secretion and transport, cell signalling, hormones, nerve function, cellular movement, cancer, immunity, and the evolution of cells. Get this book for the library or buy one for yourself.

Experimental; its chemistry; mode of action; pharmacoki- netics; gastrointestinal ulcerogenicity; protection against myocardial ischaemia; neutrophil migration; immunochem- istry; (2) Therapeutic action; osteoarthritis; gout and urate elimination; analgesic effects; use in post operative trauma; rheumatoid arthritis; haematological reactions; tolerance. A useful retrospective and prospective survey of a widely used drug.

The Physiology of Excitable Cells. 3rd Edition--By D. J. AmLEY, 508 pp. 1989. Cambridge University Press, Cambridge. Cloth $90. Paperback $34.50.

The two earfier editions were published in 1971 and 1979. In this new edition all the material has been brought up to date, and emphasis has been given to the measurements of patch clamp currents flowing through single membrane channels, and the application of recombinant DNA methods for determining the structure of membrane pro- teins. The main topics dealt with are: electrophysiology of the cell; ionic theory of nerve conduction; voltage gated channels; neuromuscular transmission; nicotinic ACh recep- tor; synapses between neurons; neurotransmitters and their receptors; mechanics and energetics of muscle; contractile mechanism of muscle; activation of muscle contraction; comparative physiology of muscle; electric organs of fish; organization of sensory receptors; variety of sense organs; vertebrate photoreceptors. The text is well written and the illustrations are clear and detailed. The book is at advanced undergraduate/postgraduate level and most workers in the field will find it a useful and up to date book.

Smlium-Cnicium Exchange--Edited by T. J. A. ALLEN, D. NOaLE and H. REUTER. 332 pp. 1989. Oxford University Press, Oxford. $36.95.

This book is dedicated to the memory of Peter Baker who played a key role in the discovery and study of sodium-calcium exchange (E). The chapters deal with E in intact cells; E in plasma membrane vesicles; E in secretory vesicles; E in the heart; numerical probes of E; molecular biochemistry of E; electrogenic E; E in smooth muscle; E in non-vascular smooth muscle; comparisons of E as measured by isotopes and measurement of internal calcium; E in photoreceptors; E in sodium transporting epithelia. There is now great appreciation of the role of calcium in cells and the control of the internal calcium concentration. This book provides an excellent summary of this important topic.

Dietary Tanins; Consequences and Rem~ies---Edited by D. K. SALUNKHE, J. K. CHAVAN and S. S. KADAM. 200 pp. 1990. CRC Press, Boca Raton, FL. $124.95.

The Regulation of Sodium and Chloride Bniance--Edited by D. W. SELDIN and G. GIEmSCH. 532 pp. 1990. Raven Press, New York. $69.

The tanins and other phenolic compounds present in foods can act as anti-nutrients, especially in those countries where these plant materials form a major part of the diet. This book deals with the structure, classification and synthesis of plant phenolics; occurrence, nature and composition [sor- ghum, millet, barley, legumes, fruit and vegetables]; methods of tanin analysis; nutritional consequences of dietary tannins [growth, digestion, protein absorption, en- zyme inhibition]; removal and detoxification of tannins; tannin in crop production. Although phenols can have antibacterial, antioxidant and flavour inducing effects, their deleterious effects are well described in the present volume.

Azapropazoue; 20 years of Clinical Use---Edited by K. D. RAINSFORD. 295 pp. 1989. Kluwer Academic Publishers, Dordrecht, Holland. D.FI 140 $66.

Azapropazone (A) a pyrazolone benzotriazine is a non-ster- oidal anti-inflammatory drug (NSAID) widely used in the treatment of arthritic conditions. The book deals with (1)

This 0cok has two main sections. (1) Normal Sodium Chlori4e balance, distribution of NaCI across cell mem- branch,; regulation of NaC1 within extracellular space; mech- anisms of segmental NaC1 rcabsorption; glomerulotubular balance and regulation of NaCI by intrarenal hemodynam- ic~; "egulation of NaC1 and blood pressure by the renin s)st.'m; the pathology of the renin system in disease. (2) A at.ormal NaC1 balance. Diagnosis of disturbances; normal and e.dematous states; edema of congestive heart failure; eoema in nephrotic syndrome; edema of cirrhosis and its treatment; idiopathic edema of women; salt overload; salt wastage and depletion; hyponatremia; sodium handling in hypertensive states; diuretics, primary and secondary effects; diuretics, applied pharmacokinetics and drug resistance. Normally the kidney responds to the extracellular volume (ECV), but under pathological conditions (cirrhosis with ascites, congestive heart failure, nephrotic syndrome) the ECV expands as the arterial blood volume shrinks but the kidney responds not to the total ECV but some component in the arterial blood. The kidney behaves as if the ECV