Slides: Allen J. Flynn, 2017 Charles P. Friedman, 2016, 2017

July 10 2018 @ MCBK

The Knowledge Grid:Modular Technology Intended to

Stimulate a CBK Infrastructure to Emerge

Allen J. Flynn, PharmD, PhDUniversity of Michiganajflynn@med.umich.edu

Agenda for Today

• What we have done to mobilize CBK

• Links between our work and the draft MCBK Manifesto

• Preview of the Knowledge Grid (KGrid) Demo

Learning Health Sciences

Agenda for Today

• What we have done to mobilize CBK

• Links between our work and the draft MCBK Manifesto

• Preview of the Knowledge Grid (KGrid) Demo

Learning Health Sciences

1. Developed the Knowledge Grid (KGrid)

A reference implementation of several highly modular, technical CBK infrastructure “building blocks”

We have done two main things to Mobilize CBK& Stimulate a CBK Infrastructure to Emerge

2. Spotlighted CBK and its many uses and users

KGrid: specification and development of several modular technical components

KNOWLEDGE OBJECTS CBK TOOLS

Library Activator

Instance ofCBK

PRE-PUB: Flynn, A.J., Adler-Milstein, J., Boisvert P., Gittlen, N., Lagoze, C., Meng, G., Seagull, F.J., Friedman, C.P., ScriptNumerate: A Data-to-Advice Pipeline using Compound Digital Objects to Augment the Interoperability of Computable Biomedical Knowledge. [Accepted for the American Medical Informatics Association Symposium 2018]

Flynn, A.J., Boisvert, P., Gittlen, N., Gross, C., Iott, B., Lagoze, C., Meng, G. and Friedman, C.P., 2018. Architecture and Initial Development of a Knowledge-as-a-Service Activator for Computable Knowledge Objects for Health. Studies in health technology and informatics, 247, pp.401-405.

Flynn, A.J., Friedman, C.P., Boisvert, P., Landis-Lewis, Z. and Lagoze, C., 2018. The Knowledge Object Reference Ontology (KORO): A formalism to support management and sharing of computable biomedical knowledge for learning health systems. Learning Health Systems, 2(2), p. e10054.

Flynn, A.J., Bahulekar, N., Boisvert, P., Lagoze, C., Meng, G., Rampton, J. and Friedman, C.P., 2017. Architecture and Initial Development of a Digital Library Platform for Computable Knowledge Objects for Health. Studies in health technology and informatics, 235, pp.496-500.

Flynn, A.J., Shi, W., Fischer, R. and Friedman, C.P., 2016, January. Digital Knowledge Objects and Digital Knowledge Object Clusters: Unit Holdings in a Learning Health System Knowledge Repository. In System Sciences (HICSS), 2016 49th Hawaii International Conference on (pp. 3308-3317). IEEE.

Spotlighting CBK & its many uses and users

Realized that CBK is Criticalto Learning Health Systems

MCBK2017

InvitationalMeeting

Began to List

CBK Usesand

Users

CBKPaper

MCBK2018Open

Meeting

CBK for Collecting, Extracting,

Filtering, andTransforming Data

CBK is used throughout the Learning Cycle

CBK for DecisionSupport

CBK for ResultsVisualization

CBK for CalculatingScores & Probabilities

CBK for MessageTailoring

CBK for DataAnalytics

CBK for Data Cleaning,Noise Reduction &

Validation

CBK for CalculatingScores & Probabilities

to Extend Data Sets

CBK to guide Interpretation of Results

Agenda for Today

• What we have done to mobilize CBK

• Links between our work and the draft MCBK Manifesto

• Preview of the Knowledge Grid (KGrid) Demo

Learning Health Sciences

II. ABOUT TIMING:Our work raises this question:Is NOW THE TIME to achieve breakthroughs in mobilizing CBK?

I. AN APPROACH: We argue for a sociotechnical infrastructure approach to mobilizing CBK with the goal of MAKING IT MUCH EASIER to manage and deploy it

Two links between our work and the CBK Manifesto

Learning Health Sciences

Mobilizing CBK:

A Manifesto

Agenda for Today

• What we have done to mobilize CBK

• Links between our work and the draft MCBK Manifesto

• Preview of the Knowledge Grid (KGrid) Demo

Learning Health Sciences

KGrid Demo

CBK in Knowledge

Objects (KOs)

DigitalLibrariesfor KOs

ActivatorsTo Quickly

DeployKOs

+ +

Clinical App

Means to

Potentially Make

CBKEasier to Manage

and Deploy

Digital Library to Archive, Manage & Share CBK

Standing on the shoulders of digital library giants

Shelf

Engine

Activator

KnowledgeObjects

Paylo

ads

eHealthApplications

EHRs&

Apps

Providers

&

Patients

“Activator” to Provide CBK Directly to Health IT Users

Open APIs

Metadata

Demo Client Apps that Draw On or Consume CBK

CBK for Genotypeto Phenotype

Mapping

CBK forConditional

Drug UseRecommendations