DRUG REACTIONS MMR vaccine, autism and mD: no link in Finnish study Results of a Finnish study do not support the hypothesis that measles, mumps and rubella (MMR) vaccine causes autism or inflammatory bowel disease (IBD). The 14-year study involved children who received live MMR vaccine at the age of 14-18 months, then again at the age of 6 years, and adults in nursing schools and defence forces who received MMR vaccine as part of a long-term vaccination project in Finland. Approximately 3 million vaccine doses were delivered during the study period. GIeffeds Overall, 31 children developed gastrointestinal (GI) signs or symptoms after MMR vaccination; these lasted for 24 hours and occurred after the first dose of MMR vaccine in 30 of the children. GI symptoms occurred from 20 hours to 15 days after MMR vaccination and generally resolved within a week. The most common GI symptom was diarrhoea with or without vomiting (17 children), followed by gingivostomatitis (7), vomiting alone (5) and abdominal pain (2). eNS signs and symptoms included febrile seizures (5 children), headache (2) and ataxia (1). Autistic-spectrum disorders were not seen in any patient. Peltola H. Patja a. Leinikki P, Valle M, Davidkin I. et aI . No evidence for measles. mumps. and rubeUa vaccine-associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet 351: 1327. 2 May 1998 80067 1403 1173-83241'9811136-000211$01 .00° LImited 111N. All rlghta.--v.cl 21 Inpharma-II Mey 1898 No. 1136

MMR vaccine, autism and IBD

Download PDF Report

View
213
Download
0

Embed Size (px)

Citation preview

DRUG REACTIONS

MMR vaccine, autism and mD: no link in Finnish study

Results of a Finnish study do not support the hypothesis that measles, mumps and rubella (MMR) vaccine causes autism or inflammatory bowel disease (IBD).

The 14-year study involved children who received live MMR vaccine at the age of 14-18 months, then again at the age of 6 years, and adults in nursing schools and defence forces who received MMR vaccine as part of a long-term vaccination project in Finland. Approximately 3 million vaccine doses were delivered during the study period.

GIeffeds Overall, 31 children developed gastrointestinal (GI)

signs or symptoms after MMR vaccination; these lasted for ~ 24 hours and occurred after the first dose of MMR vaccine in 30 of the children. GI symptoms occurred from 20 hours to 15 days after MMR vaccination and generally resolved within a week.

The most common GI symptom was diarrhoea with or without vomiting (17 children), followed by gingivostomatitis (7), vomiting alone (5) and abdominal pain (2). eNS signs and symptoms included febrile seizures (5 children), headache (2) and ataxia (1). Autistic-spectrum disorders were not seen in any patient. Peltola H. Patj a a. Leinikki P, Valle M, Davidkin I. et aI. No evidence for measles.

mumps. and rubeUa vaccine-associated inflammatory bowel disease or autism in

a 14-year prospective study. Lancet 351: 1327. 2 May 1998 80067 1403

1173-83241'9811136-000211$01 .00° Ad"Int8met~1 LImited 111N. All rlghta.--v.cl

Inpharma-II Mey 1898 No. 1136