2018 ANNUALCancer Treatment-Related Adverse Events SYMPOSIUM

OCTOBER 26-27, 2018ZUCKERMAN RESEARCH CENTER NEW YORK

Memorial Sloan Kettering Cancer Center

Focus on Immunotherapies

Systemic anticancer therapies including cytotoxic chemotherapies, targeted therapies, and immunotherapies have resulted in improvements in patient survival. Despite this remarkable success, the majority of patients will develop toxicities of various organ systems, which may impact overall health and activities of daily living, resulting in inconsistent antineoplastic therapy, all of which may affect clinical outcome. Therefore, prevention and management of untoward events is critical for the maintenance of quality of life and the optimization of anticancer therapies.

Target Audience

The target audience includes MDs, PAs, NPs, RNs, Pharmacists, and other professionals involved in the care of cancer patients. Educational Objectives

• Recognize the clinical presentation, impact on quality of life, and grading of treatment-related adverse events in cancer patients

• Understand mechanisms and interventions to prevent and treat acute and chronic adverse events in cancer patients and survivors

• Discuss procedures and clinical tools to assess treatment-related toxicities in cancer patients

2018 MSK ANNUALCancer Treatment-Related Adverse Events SYMPOSIUM

SYMPOSIUM HIGHLIGHTS

• Therapy-related adverse events will affect the majority of patients, resulting in increased cost, inconsistent dosing, and decreased quality of life.

• With increased survival and patients living longer on therapy, adverse events affecting quality of life and clinical outcome command attention.

• This symposium provides up to date information on adverse event mechanisms and management, from specialists in the most commonly affected organ systems.

• Practical strategies to maintain patients’ quality of life and dose intensity will be highlighted for the most frequently occurring events.

mskcc.org/AdverseEvents

Mario E. Lacouture, MDMember, Memorial HospitalDermatology Service

Robin Mendelsohn, MDClinical Director, Gastroenterology, Hepatology and Nutrition ServiceCo-director, Center for Young Onset Colorectal CancerFellowship Director, Clinical Nutrition FellowshipMemorial Sloan Kettering Cancer CenterAssistant Professor of Clinical Medicine, Weill Cornell Medical Center

Friday, October 268:30 am Registration & Breakfast

Cytotoxic and Targeted Therapies Session IMODERATOR: Robin Mendelsohn, MD

9:00 am Welcome and Introduction: Importance of Adverse Events

Mario E. Lacouture, MD

9:15 am Treatment-Related Adverse Event Research Florian Scotte, MD, PhD

9:45 am Adverse Event Triage and Acute Evaluations Kathryn Ciccolini, AGANCP-BC, NP

10:00 am Nausea and Vomiting Mark Kris, MD

10:25 am Diarrhea and Constipation Robin Mendelsohn, MD

10:50 am Break

11:15 am Nephrotoxicities Joannie Lefebvre, MD, FRCPC

11:40 am VTE and Treatment-Related Coagulopathies Gerald A. Soff, MD

12:10 pm Panel Discussion All Faculty

12:30 pm Lunch

Cytotoxic and Targeted Therapies Session IIMODERATOR: Mario E. Lacouture, MD

1:15 pm Hypersensitivity Reactions Mariana Castells, MD, PhD

1:45 pm Cardiac Toxicities Anthony Yu, MD

2:15 pm Chemotherapy Induced Peripheral Neuropathy Charles Loprinzi, MD

2:45 am Ocular Toxicities Korey Jaben, MD

3:15 pm Break

3:45 pm Sexual Dysfunction Shari B. Goldfarb, MD

4:05 pm Treatment-Related Psychiatric and Cognitive Disorders

Mehak Sharma, MD

4:35 pm Dermatologic Toxicities from Cytotoxic and Targeted Agents

Nicole Leboeuf, MD, MPH

5:05 pm Hyperglycemia and Cushing Disease James Flory, MD

5:30 pm Mucositis and Stomatitis Rajesh Lalla, DDS, PhD, DABOM

6:00 pm Panel Discussion All Faculty

Networking Cocktail Reception 6:15 pm-7:00 pm

Saturday, October 277:30 am Breakfast

Immunotherapy-Related Adverse Events Session IMODERATOR: Matthew Hellman, MD

8:00 am Welcome and Introduction Matthew Hellman, MD

8:15 am irAE and Quality of Life, Chronic irAEs Douglas Johnson, MD

8:45 am Immune-Related GI Adverse Events Michael Dougan, MD, PhD

9:15 am Immune-Related Cardiac Events Carol L. Chen, MD

9:45 am Panel Discussion All Faculty

10:00 am Break

Immunotherapy-Related Adverse Events Session IIMODERATOR: Monica Girotra, MD

10:30 am Endocrinopathies Monica Girotra, MD

11:00 am Immune-Related Pulmonary Events Vickie Shannon, MD

11:30 am Immune-Related Neurologic Events Bianca Santomasso, MD, PhD

12:00 pm Immune-Related Dermatologic Toxicities Mario E. Lacouture, MD

12:30 pm Immune-Related Rheumatic Disorders Laura Capelli, MD, MHS, MS

1:00 pm Panel Discussion All Faculty

1:15 pm Closing Remarks Mario E. Lacouture, MD

1:30 pm Symposium Adjourn

Laura Cappelli, MD, MHS, MSAssistant Professor of MedicineDepartment of MedicineDivision of Clinical and Molecular RheumatologyJohns Hopkins Medical Center

Mariana Castells, MD, PhDDirector, Drug Hypersensitivity and Desensitization CenterDirector, Mastocytosis CenterBrigham and Women’s HospitalProfessor of MedicineHarvard Medical School

Carol L. Chen, MDAssociate AttendingCardiology ServiceMemorial Sloan Kettering Cancer Center

Kathryn Ciccolini, AGACNP-BC, NPHematology/Oncology ServiceMount Sinai Hospital/ Ruttenberg Cancer Center

Michael Dougan, MD, PhDDirector, Immunotherapy Mucosal Inflammation Program Division of GastroenterologyMassachusetts General Hospital

James Flory, MDAssistant Attending, Endocrine ServiceMemorial Sloan Kettering Cancer CenterAssistant ProfessorDepartment of Healthcare Policy and Research Weill Cornell Medical College

Shari B. Goldfarb, MDAssistant Attending, Breast Medicine ServiceMemorial Sloan Kettering Cancer Center

Korey Jaben, MDAssistant AttendingOphthalmic Oncology ServiceMemorial Sloan Kettering Cancer Center

Douglas Johnson, MDMember, Department of MedicineVanderbilt University Medical Center

Mark Kris, MDThe William and Joy Ruane Chair in Thoracic OncologyAttending Physician, Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterProfessor, Weill Cornell Medical College

Rajesh Lalla, DDS, PhD, DABOMAssociate Professor, Oral Medicine Associate Dean for ResearchUConn Health

Nicole Leboeuf, MD, MPHClinical Director, Cutaneous Oncology Director, Program in Skin Toxicities for Anticancer Therapy Assistant Professor in DermatologyHarvard Medical SchoolDana-Farber Cancer Institute

Joannie Lefebvre, MD, FRCPCAssistant Professor of ClinicDepartment of MedicineNephrology DivisionHôpital Maisonneuve-RosemontUniversité de Montréal

Charles Loprinzi, MDConsultant, Division of Medical OncologyDepartment of OncologyMayo Clinic

Bianca Santomasso, MD, PhDMember, Neuro-Oncology ServiceMemorial Sloan Kettering Cancer Center

Florian Scotte, MD, PhDHead, Department of Medical Oncology and Supportive CareHopital Foch

Vickie Shannon, MDDirector of Pulmonary RehabilitationProfessor, Department of Pulmonary MedicineDivision of Internal Medicine MD Anderson Cancer Center

Mehak Sharma, MDMember, PsychiatryMemorial Sloan Kettering Cancer Center

Gerald Soff, MDChief, Hematology ServiceCo-Director, Hematology-Oncology FellowshipMemorial Sloan Kettering Cancer CenterProfessor of Clinical Medicine, Weill Cornell Medical College

Anthony Yu, MDAssistant AttendingCardiology Service Memorial Sloan Kettering Cancer Center

MSK Course Director

MSK Organizing Committee

Course Faculty

Monica Girotra, MDAssociate Clinical Member, Endocrinology Memorial Sloan Kettering Cancer Center

Matthew Hellman, MDMedical Oncologist, LungMemorial Sloan Kettering Cancer Center

EARLY* GENERAL

MDs, DO, PhDs, PAs and NPs $350 $400

Pharmacists, Nurses and Other Healthcare Providers $250 $300

Residents and Fellows $200 $250

Industry Professionals** $650 $700

*Early registration expires September 1, 2018**Industry professionals may attend CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities.

Register Online:

mskcc.org/AdverseEvents Registration includes continental breakfast, lunch, and refreshment breaks. Please contact cme@mskcc.org at least one week prior to the course if you have any special dietary needs.

30% Discounted Rate for MSK Alumni and MSK Alliance Members: MSK offers a 30% discounted rate to all MSK Alumni and MSK Alliance members to attend a CME course. Please contact cme@mskcc.org for a promotion code or more information.

MSK Staff Registration: Registration is complimentary for MSK staff. However, you must register online: mskcc.org/AdverseEvents

ACCREDITATION STATEMENTMSK is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA CREDIT DESIGNATION STATEMENTMSK designates this live activity for a maximum of 12.50 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

ABIM MOC RECOGNITION STATEMENTSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 12.50 Medical Knowledge MOC Points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit

FACULTY DISCLOSURE It is the policy of MSK to make every effort to insure balance, independence, objectivity, and scientific rigor in all continuing medical education activities which it provides as an ACCME accredited provider. In accordance with ACCME guidelines and standards, all faculty participating in an activity provided by MSK are expected to disclose any significant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services which are discussed by the faculty members in an educational presentation. As required by the ACCME, when an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during an educational activity, MSK requires the speaker to disclose that the product is not labeled for the use under discussion or that the product is still investigational.

CONFERENCE LOCATION

ACCOMMODATIONSMSK has negotiated special rates and amenities at select hotels in Manhattan. For information on hotels in the area of MSK with discounted rates, please visit: mskcc.org/cme.

CONTACTMemorial Sloan Kettering Cancer CenterOffice of Continuing Medical Education w:e:

Memorial Sloan Kettering Cancer Center Mortimer B. Zuckerman Research Center417 East 68th Street New York, NY 10065

mskcc.org/cmecme@mskcc.org

@MSKCME #MSKAdverseEventsCME

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