223

" XBD=342 XHG=138 YBD=223 YHG=189>determine " XBD=422 XHG=364 YBD=222 YHG=189>his " XBD=637 XHG=445 YBD=232 YHG=188>stability, " XBD=722 XHG=661 YBD=222 YHG=188>his " XBD=957 XHG=744 YBD=233 YHG=189>happiness " XBD=1060 XHG=980 YBD=221 YHG=188>and " XBD=1142 XHG=1081 YBD=221 YHG=188>his " XBD=1309 XHG=1164 YBD=222 YHG=188>useful-" XBD=231 XHG=139 YBD=272 YHG=249>ness. " XBD=363 XHG=284 YBD=271 YHG=238>The " XBD=615 XHG=398 YBD=282 YHG=238>proximity " XBD=696 XHG=652 YBD=271 YHG=236>of " XBD=863 XHG=729 YBD=277 YHG=237>death, " XBD=1092 XHG=902 YBD=281 YHG=236>hardship " XBD=1206 XHG=1125 YBD=270 YHG=237>and " XBD=1311 XHG=1241 YBD=270 YHG=237>the" XBD=314 XHG=139 YBD=331 YHG=287>ubiquity " XBD=383 XHG=341 YBD=320 YHG=286>of " XBD=648 XHG=407 YBD=319 YHG=286>destructive " XBD=802 XHG=675 YBD=319 YHG=285>forces " XBD=918 XHG=829 YBD=330 YHG=286>give " XBD=1145 XHG=947 YBD=319 YHG=286>existence " XBD=1198 XHG=1174 YBD=319 YHG=297>a " XBD=1312 XHG=1225 YBD=319 YHG=297>new" XBD=323 XHG=140 YBD=379 YHG=336>meaning. " XBD=425 XHG=377 YBD=368 YHG=335>In " XBD=528 XHG=448 YBD=368 YHG=335>this " XBD=644 XHG=552 YBD=374 YHG=345>war, " XBD=713 XHG=670 YBD=367 YHG=345>as " XBD=779 XHG=737 YBD=367 YHG=335>in " XBD=940 XHG=803 YBD=367 YHG=333>earlier " XBD=1070 XHG=964 YBD=374 YHG=345>ones, " XBD=1208 XHG=1096 YBD=367 YHG=334>there " XBD=1264 XHG=1231 YBD=367 YHG=334>is " XBD=1312 XHG=1289 YBD=367 YHG=345>a" XBD=352 XHG=140 YBD=429 YHG=384>significant " XBD=455 XHG=385 YBD=416 YHG=382>fall " XBD=530 XHG=489 YBD=416 YHG=383>in " XBD=634 XHG=565 YBD=415 YHG=382>the " XBD=888 XHG=670 YBD=426 YHG=382>frequency " XBD=968 XHG=923 YBD=416 YHG=382>of " XBD=1160 XHG=1000 YBD=416 YHG=382>suicide. " XBD=1313 XHG=1214 YBD=417 YHG=382>New" XBD=232 XHG=140 YBD=467 YHG=434>aims " XBD=312 XHG=254 YBD=466 YHG=431>for " XBD=461 XHG=336 YBD=465 YHG=431>which " XBD=527 XHG=484 YBD=465 YHG=434>to " XBD=641 XHG=551 YBD=471 YHG=430>live, " XBD=776 XHG=668 YBD=464 YHG=431>work " XBD=892 XHG=799 YBD=464 YHG=431>that " XBD=1083 XHG=916 YBD=464 YHG=431>satisfies " XBD=1244 XHG=1107 YBD=475 YHG=431>higher " XBD=1313 XHG=1269 YBD=464 YHG=441>as" XBD=219 XHG=141 YBD=516 YHG=481>well " XBD=287 XHG=246 YBD=515 YHG=493>as " XBD=420 XHG=314 YBD=514 YHG=492>more " XBD=676 XHG=447 YBD=514 YHG=479>immediate " XBD=838 XHG=705 YBD=520 YHG=479>needs, " XBD=892 XHG=869 YBD=512 YHG=491>a " XBD=1145 XHG=919 YBD=524 YHG=480>tightening " XBD=1219 XHG=1174 YBD=513 YHG=478>of " XBD=1312 XHG=1242 YBD=513 YHG=479>the" XBD=258 XHG=141 YBD=566 YHG=530>bonds " XBD=400 XHG=277 YBD=563 YHG=530>which " XBD=526 XHG=419 YBD=562 YHG=529>draw " XBD=615 XHG=544 YBD=562 YHG=539>our " XBD=885 XHG=634 YBD=573 YHG=530>community " XBD=1084 XHG=901 YBD=573 YHG=525>together " XBD=1183 XHG=1103 YBD=563 YHG=528>and " XBD=1313 XHG=1201 YBD=562 YHG=529>unite" XBD=170 XHG=141 YBD=615 YHG=581>it " XBD=283 XHG=192 YBD=613 YHG=580>with " XBD=373 XHG=305 YBD=612 YHG=579>the " XBD=475 XHG=395 YBD=611 YHG=581>rest " XBD=542 XHG=499 YBD=611 YHG=577>of " XBD=788 XHG=562 YBD=622 YHG=577>humanity, " XBD=978 XHG=814 YBD=622 YHG=578>provide " XBD=1053 XHG=1001 YBD=612 YHG=589>an " XBD=1310 XHG=1075 YBD=623 YHG=578>inspiration" XBD=257 XHG=141 YBD=663 YHG=629>which " XBD=378 XHG=288 YBD=662 YHG=628>does " XBD=528 XHG=411 YBD=661 YHG=627>much " XBD=601 XHG=558 YBD=661 YHG=629>to " XBD=748 XHG=632 YBD=661 YHG=626>offset " XBD=851 XHG=782 YBD=660 YHG=627>the " XBD=1185 XHG=883 YBD=661 YHG=627>circumstances |>" XBD=1311 XHG=1211 YBD=662 YHG=628>-that" XBD=223 XHG=141 YBD=713 YHG=678>lead " XBD=294 XHG=251 YBD=711 YHG=681>to " XBD=662 XHG=325 YBD=721 YHG=677>discouragement " XBD=775 XHG=695 YBD=710 YHG=676>and " XBD=993 XHG=806 YBD=710 YHG=677>neurosis.

MEASURING SULPHONAMIDE ACTIVITY

" XBD=275 XHG=190 YBD=864 YHG=830>THE " XBD=433 XHG=292 YBD=874 YHG=829>dosage " XBD=494 XHG=450 YBD=863 YHG=828>of " XBD=896 XHG=507 YBD=873 YHG=829>chemotherapeutic " XBD=1051 XHG=913 YBD=873 YHG=831>agents " XBD=1244 XHG=1069 YBD=874 YHG=828>depends " XBD=1313 XHG=1262 YBD=863 YHG=840>on" XBD=165 XHG=144 YBD=914 YHG=892>a " XBD=279 XHG=179 YBD=924 YHG=879>large " XBD=458 XHG=294 YBD=912 YHG=878>number " XBD=518 XHG=474 YBD=912 YHG=877>of " XBD=689 XHG=529 YBD=919 YHG=877>factors, " XBD=830 XHG=704 YBD=923 YHG=889>many " XBD=891 XHG=847 YBD=912 YHG=877>of " XBD=1030 XHG=902 YBD=912 YHG=878>which " XBD=1168 XHG=1045 YBD=912 YHG=878>relate " XBD=1227 XHG=1184 YBD=912 YHG=881>to " XBD=1313 XHG=1243 YBD=912 YHG=878>the" XBD=239 XHG=145 YBD=963 YHG=929>host. " XBD=416 XHG=305 YBD=961 YHG=928>Even " XBD=549 XHG=446 YBD=961 YHG=928>their " XBD=745 XHG=580 YBD=961 YHG=928>in-vitro " XBD=923 XHG=777 YBD=969 YHG=928>action, " XBD=1150 XHG=956 YBD=968 YHG=927>however, " XBD=1312 XHG=1184 YBD=962 YHG=929>varies" XBD=289 XHG=144 YBD=1022 YHG=977>greatlv " XBD=433 XHG=310 YBD=1011 YHG=977>under " XBD=640 XHG=456 YBD=1011 YHG=976>different " XBD=900 XHG=665 YBD=1017 YHG=977>conditions, " XBD=1006 XHG=926 YBD=1010 YHG=977>and " XBD=1100 XHG=1029 YBD=1011 YHG=980>not " XBD=1216 XHG=1124 YBD=1021 YHG=977>long " XBD=1313 XHG=1240 YBD=1022 YHG=988>ago" XBD=174 XHG=145 YBD=1061 YHG=1029>it " XBD=273 XHG=198 YBD=1060 YHG=1038>was " XBD=467 XHG=299 YBD=1060 YHG=1026>counted " XBD=544 XHG=492 YBD=1060 YHG=1036>an " XBD=843 XHG=568 YBD=1060 YHG=1026>achievement " XBD=911 XHG=868 YBD=1060 YHG=1029>to " XBD=1208 XHG=937 YBD=1060 YHG=1026>demonstrate " XBD=1315 XHG=1234 YBD=1071 YHG=1037>any" XBD=299 XHG=146 YBD=1111 YHG=1077>in-vitro " XBD=479 XHG=310 YBD=1121 YHG=1076>activity " XBD=534 XHG=492 YBD=1110 YHG=1076>in " XBD=672 XHG=549 YBD=1120 YHG=1087>many " XBD=826 XHG=686 YBD=1120 YHG=1078>agents " XBD=886 XHG=842 YBD=1110 YHG=1074>of " XBD=1049 XHG=898 YBD=1121 YHG=1075>proved " XBD=1313 XHG=1063 YBD=1121 YHG=1075>therapeutic" XBD=264 XHG=146 YBD=1160 YHG=1125>value. " XBD=425 XHG=316 YBD=1160 YHG=1125>With " XBD=789 XHG=456 YBD=1170 YHG=1125>sulphonamides, " XBD=890 XHG=821 YBD=1159 YHG=1126>the " XBD=1067 XHG=920 YBD=1159 YHG=1124>factors " XBD=1313 XHG=1098 YBD=1170 YHG=1126>governing" XBD=299 XHG=146 YBD=1209 YHG=1175>in-vitro " XBD=487 XHG=319 YBD=1219 YHG=1175>activity " XBD=608 XHG=506 YBD=1208 YHG=1175>have " XBD=838 XHG=628 YBD=1208 YHG=1174>now been " XBD=1006 XHG=857 YBD=1219 YHG=1174>largely " XBD=1311 XHG=1025 YBD=1219 YHG=1174>disentangled." XBD=222 XHG=146 YBD=1258 YHG=1224>The " XBD=373 XHG=242 YBD=1257 YHG=1223>effects " XBD=438 XHG=394 YBD=1257 YHG=1223>of " XBD=638 XHG=454 YBD=1258 YHG=1224>different " XBD=789 XHG=659 YBD=1258 YHG=1223>media " XBD=913 XHG=810 YBD=1258 YHG=1224>have " XBD=1034 XHG=934 YBD=1258 YHG=1211>been " XBD=1250 XHG=1054 YBD=1258 YHG=1223>allocated " XBD=1313 XHG=1270 YBD=1257 YHG=1226>to

" XBD=297 XHG=147 YBD=1307 YHG=1272>definite " XBD=592 XHG=329 YBD=1318 YHG=1274>antagonistic " XBD=865 XHG=621 YBD=1315 YHG=1272>substances, " XBD=939 XHG=895 YBD=1307 YHG=1272>of " XBD=1096 XHG=968 YBD=1307 YHG=1273>which " XBD=1312 XHG=1116 YBD=1317 YHG=1274>p-amino-" XBD=326 XHG=147 YBD=1357 YHG=1323>benzoate " XBD=379 XHG=347 YBD=1357 YHG=1323>is " XBD=467 XHG=399 YBD=1357 YHG=1323>the " XBD=681 XHG=488 YBD=1368 YHG=1322>principal " XBD=788 XHG=702 YBD=1357 YHG=1334>one. " XBD=967 XHG=843 YBD=1357 YHG=1323>These " XBD=1054 XHG=989 YBD=1357 YHG=1334>are " XBD=1164 XHG=1074 YBD=1357 YHG=1334>now " XBD=1313 XHG=1183 YBD=1367 YHG=1334>recog-" XBD=250 XHG=148 YBD=1406 YHG=1372>nised " XBD=346 XHG=277 YBD=1406 YHG=1375>not " XBD=416 XHG=374 YBD=1406 YHG=1384>as " XBD=682 XHG=445 YBD=1407 YHG=1376>extraneous " XBD=858 XHG=710 YBD=1407 YHG=1372>factors " XBD=975 XHG=888 YBD=1406 YHG=1375>sent " XBD=1047 XHG=1003 YBD=1407 YHG=1376>to " XBD=1218 XHG=1075 YBD=1417 YHG=1372>plague " XBD=1315 XHG=1245 YBD=1406 YHG=1372>the" XBD=469 XHG=149 YBD=1467 YHG=1421>chemotherapist " XBD=567 XHG=494 YBD=1456 YHG=1422>but " XBD=634 XHG=591 YBD=1456 YHG=1434>as " XBD=936 XHG=653 YBD=1460 YHG=1421>fundamental " XBD=1002 XHG=958 YBD=1456 YHG=1425>to " XBD=1094 XHG=1025 YBD=1456 YHG=1422>the " XBD=1252 XHG=1118 YBD=1456 YHG=1423>action " XBD=1320 XHG=1276 YBD=1456 YHG=1421>of" XBD=211 XHG=149 YBD=1504 YHG=1471>the " XBD=375 XHG=248 YBD=1515 YHG=1471>drugs. " XBD=511 XHG=429 YBD=1504 YHG=1471>The " XBD=873 XHG=552 YBD=1516 YHG=1471>sulphonamides " XBD=979 XHG=913 YBD=1505 YHG=1483>are " XBD=1315 XHG=1019 YBD=1505 YHG=1471>bacteriostatic" XBD=303 XHG=150 YBD=1554 YHG=1520>because " XBD=425 XHG=328 YBD=1565 YHG=1520>they " XBD=532 XHG=451 YBD=1558 YHG=1532>are " XBD=781 XHG=543 YBD=1565 YHG=1520>sufficiently " XBD=954 XHG=807 YBD=1555 YHG=1520>similar " XBD=1022 XHG=979 YBD=1554 YHG=1521>in " XBD=1245 XHG=1048 YBD=1554 YHG=1523>structure " XBD=1315 XHG=1272 YBD=1554 YHG=1523>to" XBD=504 XHG=147 YBD=1615 YHG=1570>p-aminobenzoate " XBD=599 XHG=556 YBD=1604 YHG=1573>to " XBD=734 XHG=644 YBD=1604 YHG=1574>oust " XBD=810 XHG=777 YBD=1604 YHG=1571>it " XBD=960 XHG=856 YBD=1604 YHG=1569>from " XBD=1080 XHG=1011 YBD=1604 YHG=1570>the " XBD=1317 XHG=1133 YBD=1604 YHG=1569>essential" XBD=325 XHG=152 YBD=1653 YHG=1619>bacterial " XBD=547 XHG=365 YBD=1664 YHG=1631>enzymes " XBD=714 XHG=587 YBD=1653 YHG=1620>which " XBD=823 XHG=753 YBD=1654 YHG=1632>use " XBD=907 XHG=862 YBD=1654 YHG=1621>it. " XBD=1055 XHG=962 YBD=1653 YHG=1620>This " XBD=1317 XHG=1095 YBD=1654 YHG=1619>functional" XBD=393 XHG=152 YBD=1713 YHG=1668>relationship " XBD=461 XHG=418 YBD=1703 YHG=1672>to " XBD=859 XHG=484 YBD=1713 YHG=1669>p-aminobenzoate " XBD=956 XHG=884 YBD=1703 YHG=1670>has " XBD=1071 XHG=981 YBD=1703 YHG=1680>now " XBD=1195 XHG=1096 YBD=1702 YHG=1669>been " XBD=1317 XHG=1219 YBD=1702 YHG=1669>used" XBD=188 XHG=149 YBD=1752 YHG=1721>to " XBD=304 XHG=221 YBD=1763 YHG=1719>give " XBD=550 XHG=337 YBD=1752 YHG=1718>numerical " XBD=722 XHG=586 YBD=1752 YHG=1718>values " XBD=800 XHG=757 YBD=1752 YHG=1721>to " XBD=904 XHG=835 YBD=1752 YHG=1718>the " XBD=1137 XHG=940 YBD=1752 YHG=1718>activities " XBD=1217 XHG=1173 YBD=1752 YHG=1717>of " XBD=1317 XHG=1247 YBD=1752 YHG=1718>the" XBD=321 XHG=151 YBD=1802 YHG=1767>different " XBD=688 XHG=357 YBD=1813 YHG=1767>sulphonamides. " XBD=826 XHG=744 YBD=1802 YHG=1768>The " XBD=963 XHG=861 YBD=1802 YHG=1769>ratio " XBD=1089 XHG=1001 YBD=1814 YHG=1768>S/P, " XBD=1254 XHG=1127 YBD=1802 YHG=1768>where " XBD=1316 XHG=1291 YBD=1803 YHG=1768>S" XBD=355 XHG=149 YBD=1863 YHG=1821>represents " XBD=468 XHG=400 YBD=1851 YHG=1818>the " XBD=814 XHG=515 YBD=1852 YHG=1819>concentration " XBD=904 XHG=860 YBD=1852 YHG=1817>of " XBD=969 XHG=946 YBD=1851 YHG=1830>a " XBD=1317 XHG=1016 YBD=1863 YHG=1817>sulphonamide" XBD=343 XHG=152 YBD=1912 YHG=1879>necessary " XBD=416 XHG=357 YBD=1901 YHG=1866>for " XBD=781 XHG=432 YBD=1902 YHG=1867>bacteriostasis in " XBD=864 XHG=795 YBD=1901 YHG=1868>the " XBD=1063 XHG=879 YBD=1913 YHG=1879>presence " XBD=1123 XHG=1078 YBD=1901 YHG=1867>of " XBD=1318 XHG=1134 YBD=1901 YHG=1867>different" XBD=454 XHG=153 YBD=1952 YHG=1918>concentrations " XBD=509 XHG=477 YBD=1951 YHG=1917>P " XBD=576 XHG=532 YBD=1951 YHG=1917>of " XBD=980 XHG=592 YBD=1962 YHG=1917>p-aminobenzoate, " XBD=1037 XHG=1004 YBD=1950 YHG=1918>is " XBD=1204 XHG=1059 YBD=1951 YHG=1917>almost " XBD=1317 XHG=1227 YBD=1951 YHG=1928>con-" XBD=251 XHG=152 YBD=2001 YHG=1970>stant " XBD=325 XHG=267 YBD=2001 YHG=1966>for " XBD=365 XHG=343 YBD=2001 YHG=1979>a " XBD=498 XHG=382 YBD=2012 YHG=1968>given " XBD=817 XHG=515 YBD=2012 YHG=1966>sulphonamide " XBD=915 XHG=835 YBD=2001 YHG=1967>and " XBD=955 XHG=932 YBD=2001 YHG=1979>a " XBD=1089 XHG=972 YBD=2012 YHG=1967>given " XBD=1317 XHG=1107 YBD=2012 YHG=1968>organism," XBD=225 XHG=153 YBD=2051 YHG=2014>and " XBD=271 XHG=240 YBD=2050 YHG=2017>is " XBD=309 XHG=290 YBD=2050 YHG=2028>a " XBD=506 XHG=329 YBD=2050 YHG=2028>measure " XBD=570 XHG=526 YBD=2051 YHG=2016>of " XBD=653 XHG=584 YBD=2051 YHG=2016>the " XBD=813 XHG=672 YBD=2062 YHG=2016>purely " XBD=1108 XHG=830 YBD=2051 YHG=2016>antibacterial " XBD=1260 XHG=1127 YBD=2050 YHG=2017>action " XBD=1323 XHG=1280 YBD=2051 YHG=2016>of" XBD=215 XHG=154 YBD=2101 YHG=2067>the " XBD=334 XHG=230 YBD=2112 YHG=2066>drug. " XBD=470 XHG=388 YBD=2100 YHG=2066>The " XBD=641 XHG=486 YBD=2100 YHG=2065>smaller " XBD=738 XHG=657 YBD=2100 YHG=2066>this " XBD=1000 XHG=752 YBD=2101 YHG=2066>ratio-that " XBD=1060 XHG=1016 YBD=2107 YHG=2067>is, " XBD=1147 XHG=1078 YBD=2100 YHG=2066>the " XBD=1320 XHG=1164 YBD=2100 YHG=2066>smaller" XBD=216 XHG=155 YBD=2150 YHG=2117>the " XBD=424 XHG=242 YBD=2161 YHG=2117>quantity " XBD=494 XHG=450 YBD=2150 YHG=2115>of " XBD=615 XHG=516 YBD=2161 YHG=2116>drug " XBD=793 XHG=641 YBD=2150 YHG=2115>needed " XBD=880 XHG=818 YBD=2150 YHG=2115>for " XBD=1321 XHG=905 YBD=2150 YHG=2116>bacteriostasis-the" XBD=252 XHG=158 YBD=2200 YHG=2177>more " XBD=425 XHG=273 YBD=2210 YHG=2165>affinity " XBD=538 XHG=445 YBD=2200 YHG=2165>does " XBD=628 XHG=559 YBD=2200 YHG=2166>the " XBD=750 XHG=650 YBD=2210 YHG=2165>drug " XBD=873 XHG=770 YBD=2200 YHG=2165>have " XBD=955 XHG=893 YBD=2200 YHG=2165>for " XBD=1045 XHG=975 YBD=2199 YHG=2165>the " XBD=1216 XHG=1065 YBD=2210 YHG=2168>system " XBD=1270 XHG=1236 YBD=2199 YHG=2166>it " XBD=1321 XHG=1289 YBD=2199 YHG=2166>is" XBD=374 XHG=157 YBD=2260 YHG=2216>disturbing. " XBD=532 XHG=428 YBD=2250 YHG=2215>Such " XBD=680 XHG=557 YBD=2249 YHG=2216>ratios " XBD=810 XHG=706 YBD=2249 YHG=2215>have " XBD=925 XHG=835 YBD=2250 YHG=2227>now " XBD=1051 XHG=951 YBD=2249 YHG=2215>been " XBD=1323 XHG=1076 YBD=2249 YHG=2215>determined" XBD=209 XHG=157 YBD=2299 YHG=2264>for " XBD=386 XHG=235 YBD=2300 YHG=2266>various " XBD=633 XHG=417 YBD=2310 YHG=2265>organisms " XBD=744 XHG=663 YBD=2299 YHG=2264>and " XBD=919 XHG=773 YBD=2310 YHG=2265>drugs ; " XBD=1062 XHG=964 YBD=2309 YHG=2264>they " XBD=1193 XHG=1090 YBD=2299 YHG=2265>have " XBD=1324 XHG=1224 YBD=2299 YHG=2265>been" XBD=311 XHG=156 YBD=2349 YHG=2315>referred " XBD=375 XHG=332 YBD=2349 YHG=2318>to " XBD=441 XHG=399 YBD=2348 YHG=2326>as " XBD=942 XHG=465 YBD=2356 YHG=2314>antibacterial’indices,l " XBD=1008 XHG=965 YBD=2348 YHG=2325>or " XBD=1074 XHG=1032 YBD=2348 YHG=2325>as " XBD=1322 XHG=1097 YBD=2359 YHG=2315>measuring" XBD=436 XHG=158 YBD=2399 YHG=2365>bacteriostatic " XBD=671 XHG=470 YBD=2409 YHG=2366>potency,2 " XBD=785 XHG=705 YBD=2398 YHG=2364>and " XBD=921 XHG=817 YBD=2398 YHG=2364>their " XBD=1186 XHG=953 YBD=2409 YHG=2364>reciprocals " XBD=1322 XHG=1219 YBD=2398 YHG=2364>have" XBD=245 XHG=156 YBD=2449 YHG=2414>been " XBD=412 XHG=293 YBD=2448 YHG=2414>called " XBD=757 XHG=461 YBD=2448 YHG=2414>bacteriostatic " XBD=1043 XHG=808 YBD=2448 YHG=2416>constants.3 " XBD=1208 XHG=1095 YBD=2458 YHG=2413>They " XBD=1321 XHG=1255 YBD=2447 YHG=2425>are" XBD=325 XHG=156 YBD=2508 YHG=2463>formally " XBD=487 XHG=337 YBD=2498 YHG=2463>related " XBD=546 XHG=504 YBD=2498 YHG=2467>to " XBD=757 XHG=563 YBD=2497 YHG=2462>Ehrlich’s " XBD=1164 XHG=776 YBD=2508 YHG=2463>chemotherapeutic " XBD=1316 XHG=1183 YBD=2504 YHG=2462>index," XBD=296 XHG=156 YBD=2558 YHG=2513>though " XBD=393 XHG=326 YBD=2547 YHG=2513>the " XBD=646 XHG=427 YBD=2547 YHG=2514>connexion " XBD=706 XHG=673 YBD=2546 YHG=2513>is " XBD=791 XHG=735 YBD=2557 YHG=2512>by " XBD=1097 XHG=820 YBD=2558 YHG=2513>computation " XBD=1213 XHG=1133 YBD=2547 YHG=2513>and " XBD=1322 XHG=1248 YBD=2546 YHG=2517>not" XBD=219 XHG=157 YBD=2608 YHG=2568>yet " XBD=287 XHG=236 YBD=2607 YHG=2564>by experiment." XBD=278 XHG=202 YBD=2647 YHG=2613>The " XBD=432 XHG=294 YBD=2647 YHG=2612>results " XBD=494 XHG=451 YBD=2647 YHG=2612>of " XBD=632 XHG=508 YBD=2647 YHG=2613>WYSS " XBD=733 XHG=652 YBD=2646 YHG=2611>and " XBD=911 XHG=750 YBD=2652 YHG=2611>others,4 given " XBD=1100 XHG=1059 YBD=2646 YHG=2613>in " XBD=1183 XHG=1114 YBD=2646 YHG=2611>the " XBD=1321 XHG=1200 YBD=2653 YHG=2611>table," XBD=315 XHG=158 YBD=2697 YHG=2663>indicate " XBD=423 XHG=333 YBD=2696 YHG=2663>that " XBD=484 XHG=440 YBD=2696 YHG=2665>to " XBD=602 XHG=503 YBD=2697 YHG=2662>both " XBD=951 XHG=621 YBD=2707 YHG=2661>sulphanilamide " XBD=1054 XHG=971 YBD=2706 YHG=2662>(the " XBD=1173 XHG=1072 YBD=2695 YHG=2660>least " XBD=1322 XHG=1192 YBD=2696 YHG=2663>active" XBD=258 XHG=156 YBD=2757 YHG=2712>drug) " XBD=382 XHG=304 YBD=2746 YHG=2712>and " XBD=738 XHG=425 YBD=2757 YHG=2711>sulphathiazole " XBD=868 XHG=784 YBD=2756 YHG=2711>(the " XBD=1017 XHG=912 YBD=2745 YHG=2714>most " XBD=1206 XHG=1062 YBD=2756 YHG=2712>active) " XBD=1322 XHG=1252 YBD=2745 YHG=2711>the" XBD=459 XHG=157 YBD=2806 YHG=2761>susceptibilities " XBD=523 XHG=479 YBD=2796 YHG=2761>of " XBD=657 XHG=537 YBD=2795 YHG=2772>seven " XBD=894 XHG=676 YBD=2806 YHG=2761>organisms " XBD=1012 XHG=911 YBD=2794 YHG=2772>were " XBD=1072 XHG=1030 YBD=2794 YHG=2761>in " XBD=1324 XHG=1090 YBD=2806 YHG=2760>practically" XBD=220 XHG=159 YBD=2845 YHG=2811>the " XBD=337 XHG=236 YBD=2844 YHG=2822>same " XBD=492 XHG=356 YBD=2853 YHG=2811>order ; " XBD=594 XHG=524 YBD=2845 YHG=2811>the " XBD=713 XHG=609 YBD=2845 YHG=2811>ratio " XBD=909 XHG=731 YBD=2844 YHG=2810>between " XBD=994 XHG=925 YBD=2844 YHG=2810>the " XBD=1160 XHG=1011 YBD=2844 YHG=2810>indices " XBD=1237 XHG=1176 YBD=2844 YHG=2810>for " XBD=1323 XHG=1253 YBD=2844 YHG=2811>the" XBD=230 XHG=158 YBD=2893 YHG=2862>two " XBD=367 XHG=253 YBD=2904 YHG=2860>drugs " XBD=471 XHG=392 YBD=2894 YHG=2853>was " XBD=613 XHG=495 YBD=2894 YHG=2860>much " XBD=708 XHG=639 YBD=2894 YHG=2860>the " XBD=841 XHG=734 YBD=2893 YHG=2871>same " XBD=963 XHG=866 YBD=2893 YHG=2859>with " XBD=1085 XHG=988 YBD=2893 YHG=2859>each " XBD=1321 XHG=1112 YBD=2904 YHG=2860>organism." XBD=269 XHG=157 YBD=2951 YHG=2908>Thus, " XBD=321 XHG=281 YBD=2943 YHG=2921>as " XBD=482 XHG=337 YBD=2944 YHG=2909>GREEN " XBD=577 XHG=497 YBD=2943 YHG=2909>and " XBD=760 XHG=594 YBD=2943 YHG=2909>PARKIN " XBD=892 XHG=777 YBD=2954 YHG=2910>point " XBD=980 XHG=909 YBD=2943 YHG=2911>out " XBD=1050 XHG=998 YBD=2943 YHG=2920>on " XBD=1137 XHG=1066 YBD=2943 YHG=2920>our " XBD=1324 XHG=1155 YBD=2954 YHG=2910>opening" XBD=260 XHG=160 YBD=3002 YHG=2970>page, " XBD=310 XHG=279 YBD=2992 YHG=2960>it " XBD=358 XHG=326 YBD=2992 YHG=2959>is " XBD=399 XHG=376 YBD=2992 YHG=2970>a " XBD=561 XHG=416 YBD=3003 YHG=2958>fallacy " XBD=621 XHG=578 YBD=2993 YHG=2962>to " XBD=751 XHG=633 YBD=2992 YHG=2958>think " XBD=860 XHG=768 YBD=2993 YHG=2959>that " XBD=896 XHG=873 YBD=2992 YHG=2970>a " XBD=1125 XHG=910 YBD=3003 YHG=2958>particular " XBD=1323 XHG=1138 YBD=3003 YHG=2958>sulphon-" XBD=278 XHG=159 YBD=3040 YHG=3007>amide " XBD=326 XHG=296 YBD=3040 YHG=3008>is " XBD=500 XHG=348 YBD=3052 YHG=3008>specific " XBD=579 XHG=517 YBD=3042 YHG=3008>for " XBD=621 XHG=598 YBD=3042 YHG=3020>a " XBD=855 XHG=638 YBD=3052 YHG=3008>particular " XBD=1102 XHG=879 YBD=3052 YHG=3008>organism : " XBD=1204 XHG=1134 YBD=3041 YHG=3007>the " XBD=1325 XHG=1219 YBD=3041 YHG=3010>most" XBD=278 XHG=159 YBD=3089 YHG=3057>active " XBD=389 XHG=294 YBD=3100 YHG=3056>drug " XBD=558 XHG=403 YBD=3101 YHG=3058>against " XBD=647 XHG=574 YBD=3091 YHG=3068>one " XBD=860 XHG=663 YBD=3102 YHG=3058>organism " XBD=909 XHG=876 YBD=3091 YHG=3057>is " XBD=1122 XHG=924 YBD=3101 YHG=3056>normally " XBD=1205 XHG=1135 YBD=3090 YHG=3057>the " XBD=1326 XHG=1219 YBD=3091 YHG=3059>most" XBD=278 XHG=159 YBD=3138 YHG=3105>active " XBD=457 XHG=306 YBD=3150 YHG=3106>against " XBD=549 XHG=487 YBD=3140 YHG=3105>all. " XBD=696 XHG=632 YBD=3140 YHG=3105>All " XBD=895 XHG=724 YBD=3140 YHG=3106>workers " XBD=1038 XHG=924 YBD=3151 YHG=3117>agree " XBD=1108 XHG=1066 YBD=3140 YHG=3107>in " XBD=1326 XHG=1136 YBD=3151 YHG=3105>principle|>" XBD=247 XHG=161 YBD=3187 YHG=3154>with " XBD=372 XHG=265 YBD=3187 YHG=3154>these " XBD=530 XHG=389 YBD=3189 YHG=3155>results " XBD=624 XHG=550 YBD=3189 YHG=3155>but " XBD=732 XHG=643 YBD=3199 YHG=3156>give " XBD=936 XHG=752 YBD=3189 YHG=3155>different " XBD=1171 XHG=954 YBD=3189 YHG=3155>numerical " XBD=1326 XHG=1189 YBD=3189 YHG=3154>values" XBD=216 XHG=161 YBD=3235 YHG=3201>for " XBD=296 XHG=231 YBD=3236 YHG=3203>the " XBD=586 XHG=313 YBD=3238 YHG=3204>antibacterial " XBD=764 XHG=603 YBD=3245 YHG=3204>indices, " XBD=931 XHG=785 YBD=3239 YHG=3204>almost " XBD=1142 XHG=950 YBD=3249 YHG=3204>certainly " XBD=1327 XHG=1159 YBD=3238 YHG=3204>because" XBD=249 XHG=159 YBD=3296 YHG=3251>they " XBD=380 XHG=262 YBD=3297 YHG=3252>adopt " XBD=575 XHG=394 YBD=3287 YHG=3253>different " XBD=813 XHG=591 YBD=3288 YHG=3253>conditions " XBD=872 XHG=827 YBD=3288 YHG=3253>of " XBD=1035 XHG=878 YBD=3299 YHG=3254>growth " XBD=1130 XHG=1049 YBD=3288 YHG=3254>and " XBD=1328 XHG=1143 YBD=3288 YHG=3253>different

1. McIlwain, H. Brit. J. exp. Path. 1942, 23, 95.2. Rose, H. M. and Fox, C. L. jun. Science, 1942, 95, 412. 3. Wood, W. B. jun. J. exp. Med. 1942, 75, 369.4. Wyss, O., Grunbaugh, K. K. and Schmelkes, F. C. Proc. Soc. exp.

Biol., N.Y. 1942, 49, 618.

" XBD=1526 XHG=1371 YBD=222 YHG=189>criteria " XBD=1622 XHG=1578 YBD=222 YHG=187>of " XBD=1976 XHG=1669 YBD=222 YHG=188>bacteriostasis. " XBD=2138 XHG=2030 YBD=221 YHG=187>Thus " XBD=2313 XHG=2189 YBD=222 YHG=187>WYSS " XBD=2445 XHG=2365 YBD=221 YHG=187>and " XBD=2556 XHG=2495 YBD=221 YHG=187>his

" XBD=1587 XHG=1370 YBD=282 YHG=237>colleagues " XBD=1810 XHG=1616 YBD=271 YHG=237>observed " XBD=1905 XHG=1836 YBD=270 YHG=237>the " XBD=2124 XHG=1935 YBD=282 YHG=238>quantity " XBD=2197 XHG=2152 YBD=271 YHG=236>of " XBD=2319 XHG=2220 YBD=282 YHG=236>drug " XBD=2555 XHG=2347 YBD=282 YHG=248>necessary" XBD=1413 XHG=1368 YBD=319 YHG=288>to " XBD=1585 XHG=1442 YBD=320 YHG=286>reduce " XBD=1806 XHG=1616 YBD=320 YHG=286>bacterial " XBD=1989 XHG=1835 YBD=331 YHG=286>growth " XBD=2060 XHG=2019 YBD=320 YHG=287>in " XBD=2138 XHG=2093 YBD=320 YHG=287>16 " XBD=2287 XHG=2168 YBD=321 YHG=286>hours " XBD=2361 XHG=2318 YBD=320 YHG=288>to " XBD=2479 XHG=2391 YBD=320 YHG=285>half " XBD=2557 XHG=2504 YBD=320 YHG=286>its" XBD=1523 XHG=1369 YBD=368 YHG=334>normal " XBD=1727 XHG=1548 YBD=370 YHG=338>amount. WOOD " XBD=2120 XHG=1933 YBD=380 YHG=335>3 judged " XBD=2201 XHG=2145 YBD=380 YHG=335>by " XBD=2293 XHG=2224 YBD=369 YHG=336>the " XBD=2487 XHG=2319 YBD=369 YHG=335>absence " XBD=2557 XHG=2512 YBD=369 YHG=335>of" XBD=1510 XHG=1372 YBD=416 YHG=383>visible " XBD=1694 XHG=1540 YBD=428 YHG=384>growth " XBD=1866 XHG=1724 YBD=429 YHG=384>during " XBD=1919 XHG=1897 YBD=418 YHG=386>5 " XBD=2050 XHG=1951 YBD=429 YHG=384>days " XBD=2161 XHG=2080 YBD=418 YHG=384>and " XBD=2386 XHG=2189 YBD=419 YHG=384>therefore " XBD=2556 XHG=2416 YBD=430 YHG=384>placed

, i i

" XBD=1826 XHG=1536 YBD=1254 YHG=1233>ANTIBACTERIAL " XBD=1994 XHG=1847 YBD=1253 YHG=1233>INDICES " XBD=2061 XHG=2017 YBD=1253 YHG=1233>OF " XBD=2389 XHG=2085 YBD=1253 YHG=1233>SULPHONAMIDES -

" XBD=1597 XHG=1420 YBD=1317 YHG=1280>Compiled " XBD=1710 XHG=1620 YBD=1308 YHG=1280>from " XBD=1835 XHG=1733 YBD=1316 YHG=1281>Wyss " XBD=1894 XHG=1858 YBD=1308 YHG=1282>et " XBD=1978 XHG=1918 YBD=1309 YHG=1280>a1.4 " XBD=2072 XHG=2002 YBD=1307 YHG=1280>and " XBD=2234 XHG=2095 YBD=1309 YHG=1279>Wood.3 " XBD=2423 XHG=2281 YBD=1308 YHG=1278>Wood’s " XBD=2567 XHG=2446 YBD=1308 YHG=1279>values" XBD=1432 XHG=1375 YBD=1348 YHG=1329>are " XBD=1484 XHG=1448 YBD=1348 YHG=1320>in " XBD=1733 XHG=1498 YBD=1356 YHG=1320>parentheses. " XBD=1852 XHG=1780 YBD=1348 YHG=1320>The " XBD=1991 XHG=1867 YBD=1356 YHG=1320>figures " XBD=2059 XHG=2006 YBD=1348 YHG=1320>for |>" XBD=2235 XHG=2075 YBD=1348 YHG=1320>different " XBD=2440 XHG=2251 YBD=1357 YHG=1320>organisms " XBD=2513 XHG=2456 YBD=1348 YHG=1329>are " XBD=2566 XHG=2528 YBD=1347 YHG=1320>in" XBD=1434 XHG=1374 YBD=1388 YHG=1360>the " XBD=1548 XHG=1453 YBD=1387 YHG=1360>main " XBD=1797 XHG=1568 YBD=1397 YHG=1360>comparable, " XBD=1883 XHG=1818 YBD=1388 YHG=1360>but " XBD=1963 XHG=1900 YBD=1388 YHG=1363>not " XBD=2129 XHG=1982 YBD=1396 YHG=1360>entirely " XBD=2184 XHG=2147 YBD=1388 YHG=1369>so " XBD=2350 XHG=2204 YBD=1388 YHG=1360>because " XBD=2565 XHG=2369 YBD=1388 YHG=1360>conditions" XBD=1415 XHG=1375 YBD=1428 YHG=1399>of " XBD=1563 XHG=1428 YBD=1435 YHG=1400>growth " XBD=1665 XHG=1577 YBD=1427 YHG=1408>were " XBD=1744 XHG=1680 YBD=1427 YHG=1402>not " XBD=1899 XHG=1759 YBD=1428 YHG=1399>inform.

" XBD=1675 XHG=1378 YBD=1529 YHG=1483>sulphadiazine " XBD=1827 XHG=1710 YBD=1529 YHG=1484>equal " XBD=1903 XHG=1861 YBD=1519 YHG=1486>in " XBD=2109 XHG=1938 YBD=1530 YHG=1485>activity " XBD=2186 XHG=2142 YBD=1519 YHG=1487>to " XBD=2560 XHG=2222 YBD=1530 YHG=1484>sulphapyridine," XBD=1492 XHG=1379 YBD=1568 YHG=1533>while " XBD=1626 XHG=1510 YBD=1569 YHG=1534>RosE " XBD=1724 XHG=1644 YBD=1568 YHG=1534>and Fox " XBD=1990 XHG=1847 YBD=1579 YHG=1537>2 agree " XBD=2099 XHG=2002 YBD=1569 YHG=1535>with " XBD=2237 XHG=2113 YBD=1569 YHG=1534>Wyss " XBD=2296 XHG=2254 YBD=1568 YHG=1535>in " XBD=2475 XHG=2312 YBD=1580 YHG=1536>putting " XBD=2561 XHG=2491 YBD=1569 YHG=1535>the" XBD=1550 XHG=1379 YBD=1629 YHG=1584>activity " XBD=1612 XHG=1569 YBD=1618 YHG=1583>of " XBD=1932 XHG=1636 YBD=1630 YHG=1583>sulphadiazine " XBD=2069 XHG=1951 YBD=1630 YHG=1584>equal " XBD=2130 XHG=2086 YBD=1618 YHG=1587>to " XBD=2240 XHG=2148 YBD=1619 YHG=1584>that " XBD=2302 XHG=2259 YBD=1619 YHG=1584>of " XBD=2563 XHG=2317 YBD=1630 YHG=1584>sulphathia-" XBD=1474 XHG=1379 YBD=1668 YHG=1633>zole. " XBD=1584 XHG=1530 YBD=1668 YHG=1633>Of " XBD=1680 XHG=1610 YBD=1668 YHG=1633>the " XBD=1999 XHG=1712 YBD=1668 YHG=1630>conditions ’of " XBD=2179 XHG=2026 YBD=1679 YHG=1633>growth " XBD=2327 XHG=2199 YBD=1668 YHG=1634>which " XBD=2474 XHG=2355 YBD=1668 YHG=1634>affect " XBD=2564 XHG=2494 YBD=1668 YHG=1634>the" XBD=1811 XHG=1379 YBD=1724 YHG=1680>indices,JScHMELKES " XBD=1920 XHG=1839 YBD=1717 YHG=1683>and " XBD=2080 XHG=1947 YBD=1718 YHG=1684>others " XBD=2108 XHG=2094 YBD=1704 YHG=1686>5 " XBD=2238 XHG=2135 YBD=1717 YHG=1683>have " XBD=2402 XHG=2265 YBD=1718 YHG=1683>shown " XBD=2493 XHG=2423 YBD=1729 YHG=1684>pH " XBD=2563 XHG=2519 YBD=1718 YHG=1687>to" XBD=1428 XHG=1379 YBD=1767 YHG=1732>be " XBD=1487 XHG=1443 YBD=1767 YHG=1733>of " XBD=1776 XHG=1498 YBD=1767 YHG=1733>fundamental " XBD=2045 XHG=1786 YBD=1778 YHG=1734>importance, " XBD=2139 XHG=2059 YBD=1767 YHG=1733>and " XBD=2253 XHG=2150 YBD=1767 YHG=1733>have " XBD=2565 XHG=2265 YBD=1767 YHG=1733>demonstrated" XBD=1472 XHG=1379 YBD=1817 YHG=1782>that " XBD=1556 XHG=1486 YBD=1817 YHG=1783>the " XBD=1745 XHG=1571 YBD=1817 YHG=1783>increase " XBD=1803 XHG=1760 YBD=1817 YHG=1784>in " XBD=1991 XHG=1817 YBD=1828 YHG=1786>potency " XBD=2051 XHG=2006 YBD=1817 YHG=1782>of " XBD=2115 XHG=2062 YBD=1817 YHG=1782>all " XBD=2451 XHG=2130 YBD=1828 YHG=1782>sulphonamides " XBD=2564 XHG=2467 YBD=1817 YHG=1783>with" XBD=1554 XHG=1380 YBD=1867 YHG=1832>increase " XBD=1617 XHG=1575 YBD=1867 YHG=1833>in " XBD=1707 XHG=1638 YBD=1878 YHG=1833>pH " XBD=1761 XHG=1728 YBD=1867 YHG=1834>is " XBD=1825 XHG=1782 YBD=1867 YHG=1833>in " XBD=1989 XHG=1846 YBD=1867 YHG=1832>accord " XBD=2107 XHG=2009 YBD=1867 YHG=1833>with " XBD=2242 XHG=2129 YBD=1867 YHG=1832>other " XBD=2450 XHG=2264 YBD=1867 YHG=1832>evidence " XBD=2564 XHG=2471 YBD=1867 YHG=1833>that" XBD=1449 XHG=1379 YBD=1916 YHG=1882>the " XBD=1608 XHG=1474 YBD=1917 YHG=1882>actual " XBD=1880 XHG=1630 YBD=1928 YHG=1882>functioning " XBD=1995 XHG=1903 YBD=1928 YHG=1885>part " XBD=2064 XHG=2019 YBD=1917 YHG=1882>of " XBD=2107 XHG=2083 YBD=1917 YHG=1895>a " XBD=2433 XHG=2132 YBD=1928 YHG=1881>sulphonamide " XBD=2490 XHG=2456 YBD=1916 YHG=1883>is " XBD=2566 XHG=2513 YBD=1916 YHG=1894>an" XBD=1513 XHG=1381 YBD=1967 YHG=1933>anion. " XBD=1617 XHG=1567 YBD=1966 YHG=1932>In " XBD=1825 XHG=1633 YBD=1967 YHG=1932>solutions " XBD=1885 XHG=1841 YBD=1967 YHG=1932>of " XBD=2080 XHG=1897 YBD=1966 YHG=1932>different " XBD=2418 XHG=2096 YBD=1978 YHG=1932>sulphonamides " XBD=2564 XHG=2432 YBD=1966 YHG=1932>whose" XBD=1564 XHG=1382 YBD=2027 YHG=1982>strength " XBD=1620 XHG=1587 YBD=2016 YHG=1983>is " XBD=1831 XHG=1644 YBD=2026 YHG=1981>adjusted " XBD=1897 XHG=1853 YBD=2016 YHG=1985>to " XBD=2009 XHG=1921 YBD=2027 YHG=1983>give " XBD=2150 XHG=2033 YBD=2027 YHG=1982>equal " XBD=2356 XHG=2173 YBD=2027 YHG=1982>activity, " XBD=2449 XHG=2380 YBD=2016 YHG=1982>the " XBD=2563 XHG=2475 YBD=2015 YHG=1992>con-" XBD=1626 XHG=1383 YBD=2066 YHG=2032>centrations " XBD=1690 XHG=1646 YBD=2066 YHG=2031>of " XBD=1843 XHG=1704 YBD=2066 YHG=2033>anions " XBD=1928 XHG=1862 YBD=2066 YHG=2043>are " XBD=1991 XHG=1947 YBD=2066 YHG=2031>of " XBD=2075 XHG=2005 YBD=2066 YHG=2032>the " XBD=2202 XHG=2094 YBD=2066 YHG=2043>same " XBD=2337 XHG=2221 YBD=2066 YHG=2031>order " XBD=2400 XHG=2356 YBD=2066 YHG=2031>of " XBD=2564 XHG=2415 YBD=2076 YHG=2032>magni-

0" XBD=1510 XHG=1384 YBD=2170 YHG=2135>tude.6 " XBD=1603 XHG=1562 YBD=2170 YHG=2136>It " XBD=1660 XHG=1627 YBD=2170 YHG=2136>is " XBD=1924 XHG=1685 YBD=2182 YHG=2136>apparently " XBD=2010 XHG=1941 YBD=2170 YHG=2136>the " XBD=2216 XHG=2035 YBD=2181 YHG=2148>group - |>" XBD=2409 XHG=2231 YBD=2205 YHG=2099>S<gH2 " XBD=2569 XHG=2440 YBD=2169 YHG=2134>which0 B0-

" XBD=1646 XHG=1384 YBD=2269 YHG=2234>simulates - |>" XBD=1808 XHG=1663 YBD=2320 YHG=2195>C( 0- " XBD=1865 XHG=1822 YBD=2269 YHG=2238>at " XBD=1952 XHG=1883 YBD=2269 YHG=2235>the " XBD=2071 XHG=1971 YBD=2280 YHG=2235>drug " XBD=2281 XHG=2088 YBD=2280 YHG=2237>receptor. " XBD=2423 XHG=2315 YBD=2268 YHG=2234>Thus " XBD=2567 XHG=2437 YBD=2268 YHG=2233>differ- B0- C5

" XBD=1498 XHG=1385 YBD=2373 YHG=2350>ences " XBD=1725 XHG=1546 YBD=2373 YHG=2339>between " XBD=1836 XHG=1766 YBD=2373 YHG=2339>the " XBD=2161 XHG=1883 YBD=2373 YHG=2338>antibacterial " XBD=2353 XHG=2205 YBD=2374 YHG=2338>indices " XBD=2445 XHG=2401 YBD=2372 YHG=2337>of " XBD=2567 XHG=2498 YBD=2371 YHG=2337>the" XBD=1706 XHG=1385 YBD=2434 YHG=2388>sulphonamides " XBD=1796 XHG=1735 YBD=2423 YHG=2388>for " XBD=1844 XHG=1820 YBD=2422 YHG=2400>a " XBD=1985 XHG=1867 YBD=2433 YHG=2390>given " XBD=2207 XHG=2008 YBD=2433 YHG=2389>organism " XBD=2387 XHG=2237 YBD=2432 YHG=2387>largely " XBD=2567 XHG=2411 YBD=2432 YHG=2387>depend" XBD=1437 XHG=1385 YBD=2472 YHG=2449>on " XBD=1528 XHG=1459 YBD=2472 YHG=2439>the " XBD=1719 XHG=1552 YBD=2472 YHG=2441>amount " XBD=1788 XHG=1743 YBD=2472 YHG=2438>of " XBD=1927 XHG=1807 YBD=2472 YHG=2439>anion " XBD=1991 XHG=1949 YBD=2472 YHG=2439>in " XBD=2117 XHG=2012 YBD=2471 YHG=2438>their " XBD=2345 XHG=2140 YBD=2472 YHG=2437>solutions.

" XBD=1486 XHG=1436 YBD=2522 YHG=2488>In " XBD=1597 XHG=1513 YBD=2534 YHG=2488>the " XBD=1765 XHG=1611 YBD=2521 YHG=2487>clinical " XBD=1861 XHG=1792 YBD=2521 YHG=2499>use " XBD=1935 XHG=1890 YBD=2521 YHG=2486>of " XBD=2281 XHG=1959 YBD=2532 YHG=2487>sulphonamides " XBD=2434 XHG=2309 YBD=2532 YHG=2498>many " XBD=2569 XHG=2460 YBD=2520 YHG=2497>more" XBD=1814 XHG=1384 YBD=2571 YHG=2525>factors-differences " XBD=1909 XHG=1866 YBD=2570 YHG=2537>in " XBD=2177 XHG=1961 YBD=2581 YHG=2536>solubility, " XBD=2273 XHG=2230 YBD=2570 YHG=2537>in " XBD=2570 XHG=2325 YBD=2581 YHG=2536>absorption," XBD=1659 XHG=1386 YBD=2621 YHG=2587>detoxication " XBD=1773 XHG=1692 YBD=2620 YHG=2586>and " XBD=2007 XHG=1806 YBD=2620 YHG=2586>excretion " XBD=2096 XHG=2042 YBD=2630 YHG=2586>by " XBD=2198 XHG=2128 YBD=2620 YHG=2586>the " XBD=2323 XHG=2231 YBD=2620 YHG=2586>host " XBD=2440 XHG=2357 YBD=2621 YHG=2585>and " XBD=2573 XHG=2472 YBD=2620 YHG=2597>even" XBD=1427 XHG=1384 YBD=2671 YHG=2637>in " XBD=1697 XHG=1446 YBD=2681 YHG=2636>availability " XBD=1797 XHG=1717 YBD=2669 YHG=2635>and " XBD=2063 XHG=1818 YBD=2670 YHG=2638>cost-must " XBD=2133 XHG=2084 YBD=2670 YHG=2635>be " XBD=2277 XHG=2152 YBD=2669 YHG=2635>taken " XBD=2381 XHG=2296 YBD=2670 YHG=2636>into " XBD=2573 XHG=2403 YBD=2670 YHG=2639>account" XBD=1427 XHG=1385 YBD=2720 YHG=2687>in " XBD=1649 XHG=1463 YBD=2730 YHG=2686>choosing " XBD=1754 XHG=1684 YBD=2719 YHG=2685>the " XBD=1890 XHG=1790 YBD=2730 YHG=2685>drug " XBD=2014 XHG=1926 YBD=2719 YHG=2684>best " XBD=2182 XHG=2051 YBD=2719 YHG=2685>suited " XBD=2261 XHG=2216 YBD=2720 YHG=2688>to " XBD=2321 XHG=2297 YBD=2719 YHG=2697>a " XBD=2572 XHG=2356 YBD=2731 YHG=2685>particular" XBD=1569 XHG=1386 YBD=2781 YHG=2747>purpose. " XBD=1700 XHG=1622 YBD=2769 YHG=2735>For " XBD=1923 XHG=1730 YBD=2776 YHG=2735>instance, " XBD=2012 XHG=1955 YBD=2769 YHG=2747>we " XBD=2185 XHG=2045 YBD=2770 YHG=2734>choose " XBD=2572 XHG=2216 YBD=2781 YHG=2735>sulphaguanidine" XBD=1429 XHG=1385 YBD=2820 YHG=2788>to " XBD=1596 XHG=1457 YBD=2819 YHG=2785>attack " XBD=1828 XHG=1622 YBD=2819 YHG=2784>intestinal " XBD=2072 XHG=1854 YBD=2829 YHG=2785>organisms " XBD=2292 XHG=2099 YBD=2831 YHG=2785>although " XBD=2376 XHG=2323 YBD=2820 YHG=2787>its " XBD=2573 XHG=2408 YBD=2820 YHG=2786>in-vitro" XBD=1558 XHG=1387 YBD=2879 YHG=2835>activity " XBD=1611 XHG=1579 YBD=2868 YHG=2835>is " XBD=1721 XHG=1633 YBD=2868 YHG=2834>low. " XBD=1841 XHG=1778 YBD=2868 YHG=2833>On " XBD=1931 XHG=1861 YBD=2868 YHG=2834>the " XBD=2062 XHG=1948 YBD=2868 YHG=2834>other " XBD=2205 XHG=2083 YBD=2876 YHG=2834>hand, " XBD=2271 XHG=2228 YBD=2869 YHG=2835>in " XBD=2361 XHG=2291 YBD=2870 YHG=2836>the " XBD=2509 XHG=2377 YBD=2870 YHG=2836>choice " XBD=2577 XHG=2532 YBD=2869 YHG=2834>of" XBD=1701 XHG=1388 YBD=2929 YHG=2883>sulphathiazole " XBD=1776 XHG=1714 YBD=2917 YHG=2882>for " XBD=2110 XHG=1790 YBD=2928 YHG=2883>staphylococcal " XBD=2204 XHG=2124 YBD=2918 YHG=2884>and " XBD=2352 XHG=2217 YBD=2919 YHG=2884>mixed " XBD=2575 XHG=2363 YBD=2920 YHG=2884>infections" XBD=1667 XHG=1388 YBD=2968 YHG=2933>antibacterial " XBD=1819 XHG=1696 YBD=2967 YHG=2932>index " XBD=1882 XHG=1848 YBD=2967 YHG=2934>is " XBD=1981 XHG=1912 YBD=2967 YHG=2933>the " XBD=2237 XHG=2013 YBD=2980 YHG=2935>overriding " XBD=2573 XHG=2270 YBD=2969 YHG=2934>consideration." XBD=1497 XHG=1389 YBD=3016 YHG=2983>Thus " XBD=1711 XHG=1517 YBD=3027 YHG=2982>although " XBD=1882 XHG=1731 YBD=3016 YHG=2982>studies " XBD=1944 XHG=1902 YBD=3016 YHG=2984>in " XBD=2069 XHG=1963 YBD=3018 YHG=2984>vitro " XBD=2237 XHG=2090 YBD=3018 YHG=2987>cannot " XBD=2413 XHG=2256 YBD=3018 YHG=2983>include " XBD=2486 XHG=2433 YBD=3018 YHG=2984>all " XBD=2574 XHG=2504 YBD=3018 YHG=2985>the" XBD=1536 XHG=1388 YBD=3066 YHG=3031>factors " XBD=1692 XHG=1563 YBD=3066 YHG=3032>which " XBD=1831 XHG=1728 YBD=3066 YHG=3032>have " XBD=1912 XHG=1867 YBD=3066 YHG=3034>to " XBD=1995 XHG=1947 YBD=3066 YHG=3032>be " XBD=2264 XHG=2035 YBD=3068 YHG=3032>considered " XBD=2344 XHG=2302 YBD=3066 YHG=3034>in " XBD=2575 XHG=2383 YBD=3078 YHG=3034>practical" XBD=1715 XHG=1389 YBD=3126 YHG=3081>chemotherapy, " XBD=1840 XHG=1770 YBD=3126 YHG=3084>yet " XBD=1992 XHG=1895 YBD=3116 YHG=3082>with " XBD=2121 XHG=2051 YBD=3117 YHG=3083>the " XBD=2342 XHG=2182 YBD=3127 YHG=3085>present " XBD=2473 XHG=2404 YBD=3117 YHG=3094>use " XBD=2581 XHG=2536 YBD=3118 YHG=3083>of" XBD=1546 XHG=1389 YBD=3165 YHG=3130>defined " XBD=1720 XHG=1589 YBD=3165 YHG=3131>media " XBD=1854 XHG=1754 YBD=3176 YHG=3131>they " XBD=1955 XHG=1889 YBD=3166 YHG=3143>are " XBD=2125 XHG=1990 YBD=3177 YHG=3133>giving " XBD=2206 XHG=2159 YBD=3165 YHG=3143>us " XBD=2358 XHG=2239 YBD=3176 YHG=3131>fairly " XBD=2577 XHG=2392 YBD=3167 YHG=3136>accurate" XBD=1650 XHG=1389 YBD=3215 YHG=3179>information " XBD=1751 XHG=1707 YBD=3215 YHG=3180>of " XBD=1916 XHG=1796 YBD=3225 YHG=3184>great " XBD=2162 XHG=1971 YBD=3227 YHG=3181>practical " XBD=2346 XHG=2217 YBD=3215 YHG=3180>value. " XBD=2579 XHG=2418 YBD=3216 YHG=3181>Animal" XBD=1651 XHG=1391 YBD=3275 YHG=3230>experiment, " XBD=1727 XHG=1694 YBD=3264 YHG=3231>it " XBD=1882 XHG=1773 YBD=3265 YHG=3231>must " XBD=1976 XHG=1927 YBD=3266 YHG=3230>be " XBD=2302 XHG=2020 YBD=3271 YHG=3229>remembered, " XBD=2578 XHG=2350 YBD=3265 YHG=3231>introduces" XBD=1478 XHG=1391 YBD=3313 YHG=3290>new " XBD=1591 XHG=1509 YBD=3314 YHG=3280>and " XBD=1822 XHG=1619 YBD=3314 YHG=3280>unknown " XBD=1998 XHG=1851 YBD=3315 YHG=3279>factors " XBD=2071 XHG=2028 YBD=3313 YHG=3283>to " XBD=2171 XHG=2102 YBD=3313 YHG=3280>the " XBD=2326 XHG=2203 YBD=3322 YHG=3279>study " XBD=2400 XHG=2356 YBD=3314 YHG=3280>of " XBD=2580 XHG=2427 YBD=3314 YHG=3281>human" XBD=1614 XHG=1390 YBD=3363 YHG=3328>infections.

5. Schmelkes, F. C., Wyss, O., Marks, H. C., Ludwig, B. J. andStrandskov, F. B. Proc. Soc. exp. Biol., N.Y. 1942, 50, 145.

6. Fox, C. L. jun. and Rose, H. M. Ibid, 1942, 50, 142.