Master Chart Thesis Osa

Sleep Disorders in cohort of CKD Patients on Maintenance hemodialysis and CAPD

Aims and objectives of the study

1.To assess the prevalence of sleep disorders including sleep disordered breathing in CKD patients on maintenance haemodialysis (MHD) or continuous ambulatory peritoneal dialysis (CAPD) by validated self-administered questionnaire.

2.To correlate the predictability of questionnaire based results with clinical findings and polysomnography.

3.To assess the impact of dialysis modalit of renal replacement (HD VS CAPD ) on nature and severity of sleep disorders of breathing employing polysomonography.


2.To correlate the predictability of questionnaire based results with clinical findings and polysomnography.

3.To assess the impact of dialysis modalit of renal replacement (HD VS CAPD ) on nature and severity of sleep disorders of breathing employing polysomonography.


NAME AGE\SEX MRD NOOCCUPATION NKD RRT/DURATION DETAILS PET TESTSnoring/Years

Prabhakar 45/M 2188763 Clerk Crescentric GN HD/4 Years 2/WK, Early Morning Not Applicable 2Sampath Raj 58/M 1579199 KEB Mechanic HT Nephrosclerosis CAPD/2 Years 2.5*2, 7.5*1 UF 1.5L High Average 2Varghese 66/M 1598257 Rtd DN CAPD/6 Years 2.5*2, 1.5*1 UF Not Known 6PSB Murthy 67/M 2098855 Proffessor NK CAPD/1 Years 1.5*2, 2.5*1 UF 600 ml High Average 4Sathiah 60/M 2021623 KEB Mechanic DN CAPD/1 Year 2.5*1, 1.5*2 UF 1.5L High Average 15Antony 53/M 1643002 Police Constable NK HD/1 Year 3/WK Early Morning Not Applicable 5Armugana 50/M 2665621 Clerk CGN HD/1 Year 3/WK Afternoon Not Applicable 4Nagabhushan 54/M 2631619 Rly Mechanic CGN HD/1 Year 3/WK Evening Not Applicable 3Mehamood 45/M 1867525 Police Constable NK CAPD/8 Months 1.5*3, UF 2.5L Not Known 0Farooq 47/M 2258101 Clerk DN CAPD/3 Years 2.5*2, 7.5*1 UF 1.8L High Average 5Lourde swamy 40/M 2284572 Technician CGN HD/5 Years 3/WK Afternoon Not Applicable 6Manniyammal 72/F 2143550 House Wife NK HD/3 Years 3/WK Afternoon Not Applicable 2Krishne Gowda 35/M 2366133 Teacher NK HD/2 Years 2/WK, Early Morning Not Applicable 3Ramesh T 35/M 2313376 Clerk NK HD/1 Year 2/WK, Afternoon Not Applicable 1Raghavendra 63/M 1596657 Rtd Engineer DN CAPD/3 Years 2.5*2, 1.5*1 UF low average 6Dr.Tulusa Halur 50/F 2059086 Doctor CIN CAPD/2 Years 1.5*1,2.5*2, UF 1.2L Low Average 3Indiramma 67/M 2602873 House Wife HT Nephrosclerosis HD/1 Year 2/WK, Early Morning Not Applicable 3Renuka 45/F 2624241 House Wife DN HD 1 Year 2/WK, Early Morning Not Applicable 1D Sundari 65/F 2623500 House Wife DN CAPD 1 Year 2.5*2, 1.5*1 UF High Average 1Srinivas 56/M 2522051 Teacher DN HD 1 Year 2/WK, Early Morning Not Applicable 1Kotramma 63/F 2051638 House Wife NK CAPD 1 Year 2.5*2, 1.5*1 UF High Average 2Muniyelappa 45/M 1928876 Driver DN HD/2 Years 3/WK Afternoon Not Applicable 4Vasanthamma 45/F 1172153 House Wife ADPKD HD/1 Year 2/WK Early Morning Not Applicable 5Gopalkrishna 58/M 2338095 ITI engineer rtd DN CAPD 4 Years 1.5*3,UF 800 ml High Average 2Haleem Khan 58/M 2090501 Clerk DN HD/5 Years 3/WK Afternoon Not Applicable 4Chikkabyre Gowda 65/M 2098765 Rtd Engineer DN HD/1 Year 2/WK, Afternoon Not Applicable 1Mahadevan 60/M 1766751 Rtd Engineer DN HD 6 Years 3/WK, Early Morning Not Applicable 1Mr.Stbastin 58/F 2713686 House Wife CIN CAPD/2 Years 2.5*2, 1.5*1 UF Low Average 2Mosses 33/m 2134538 Teacher DN HD/5 Years 3/WK Afternoon Not Applicable 2Mr.Rajendra 65/M 2484297 CA NK HD/2 Years 3/WK, Early Morning Not Applicable 0

Abbreviations

NKD Native kidney diseaseNK Not KnownDN Diabetic NephropathiCGN Chronic Glomerulo NephritisHT HypertensionADPKD Autosomal dominant polycytic diseaseCIN chronic interstetial nephritisHD hemodialysisCAPD chronic peritoneal dialysisWK weekUF ultrafiltrationEDS excessive day time sleepinessESS The Epworth Sleepiness Scale keyPSQ INDEX Pittsburg sleep quality indexBSQ Berlin Questionnaire DM diabetis mallitusCAD coronary artery diseaseSVD single vessel diseaseEPO erythropoitinBMI body mass indesNCS neck circumferanceHB hemoglobinTC/DC total and differential countPC platelet count BU/S.CR blood urea/serum creatinineTP/ALB total protein/albuminALP/GGT alkaline phosphatase/gama glutamile transferaseTSAT transferrin saturationRDI Respiratory Disturbance index

ODI Oxygen desaturation index PLM Periodic limb momentsTSD total sleep durationAHI Apnoea / hypoapnea indexRRT Renal Replacement TherapyCA/PO4 Calcium/PosphorusUA Uric acidRBS Random blood sugarsECG Electro cardiogramPET Peritoneal equilibration test

HISTORY ESS SCAPSQ INDEX BSQ COMORBIDITIESApnoea/Years Nocturia/Years DM/Years HT/Years HYPERLIPEDEMIA STROKE CARDICAC DISEASE

2 2 NORMAL 10 HR 4 4 YES NO NO2 2 NORMAL 12 HR 10 5 YES NO NO3 3 NORMAL 8 HR 20 10 NO NO CAD4 0 NORMAL 13 HR 0 5 NO NO CAD

15 5 EDS 12 HR 5 20 NO NO CAD5 3 NORMAL 19 LR 10 7 NO NO NO5 3 EDS 20 HR 0 6 YES NO NO4 4 EDS 15 HR 0 5 NO NO CAD-SVD2 5 NORMAL 17 LR 0 10 NO NO NO5 5 EDS 13 LR 5 4 YES YES 2 Years back Rt.MCA infarct NO6 0 EDS 11 HR 0 6 NO NO CAD0 0 NORMAL 6 LR 0 10 NO NO NO3 0 EDS 10 HR 0 8 YES NO NO0 0 EDS 14 LR 0 6 YES NO NO6 6 EDS 15 HR 20 10 NO NO CAD3 6 EDS 16 HR 0 10 NO NO NO2 0 NORMAL 15 LR 0 6 NO NO NO2 4 NORMAL 4 LR 10 6 NO NO CAD2 2 EDS 12 HR 5 5 NO NO NO2 2 NORMAL 14 LR 14 6 NO NO CAD0 0 NORMAL 14 LR 6 6 NO NO NO4 6 EDS 18 HR 8 4 YES NO CAD5 6 EDS 8 HR 0 6 NO NO NO2 0 NORMAL 10 LR 4 4 YES RT.MCA infarct 3 Years back CAD2 0 EDS 15 HR 6 6 NO NO CAD-TVD, S/P PTCA2 4 NORMAL 8 LR 6 6 NO NO CAD2 0 NORMAL 10 HR 8 5 NO NO NO1 6 NORMAL 8 LR 0 7 NO NO NO2 0 NORMAL 11 LR 6 6 NO NO CAD2 5 NORMAL 8 LR 0 10 NO NO NO

35.294117647058820.7588235294118

COFFEE TEHYPNOTICSEPO VITAMIN HEIGHT cms WEIGHT kgBMI HIP/WAIST RATIONCS cmsHB% TC\DC PC Lakh RBS

YES NO 2/WK 4 Years YES 4 Years 175 88 28.73 1.4 18 7.6 4402 70/23 2.3 123YES NO 2/WK 4 Years YES 3 Years 174 94 31 0.95 14 10.2 12403 79/20 2.7 230YES NO 2/WK 4 Years YES 6 Years 157 52 22 1.02 16 12.3 4201 76/23 2.8 239NO NO 2/WK 5 Years 4 Years 164 54 18.9 1.02 13 8.2 4905 85/15 2 115YES YES 2/WK 1 Year 3 Years 160 53 20.7 1.04 14 15 4201 73/27 1.5 115YES NO 3/WK 2 Years 167 65 23.3 1 14 8.4 5300 63/28 3 243YES NO 2/WK 2 Years 163 62 23.33 1 14 6.4 6702 72/25 4 103YES NO 2/WK 1 Year 152 59 23.33 0.95 16 6.7 6303 77/27 2 145YES YES 2/WK YES 167 64 22.94 0.94 16 7.3 7202 71/28 3.3 300YES NO ONCE/WK YES 171 67 22.91 1.04 16 11.2 7402 62/37 2.2 300YES NO 2/WK YES 165 69 25.3 1.02 16 10.5 6412 71/26 2.24 120YES NO 2/WK YES 143 44 21.56 1.04 13 11.9 10.900 78/15 2.48 93NO NO NO NO 165 75 27.54 1.02 15 4.7 5600 70/20 3 90NO NO 2/WK YES 145 55 26.15 1.09 16 9 5786 68/24 2.4 234NO NO 2/WK 3 Years YES 158 54 21.63 1.02 16 12.3 6802 71/18 2.3 188YES NO ONCE/WK YES 160 72 28.12 1.1 16 9.1 5800 75/16 2.2 73NO NO NO NO 144 51 24.9 1.2 13 13.1 5700 78/14 2 122YES YES 3/WK YES 165 77 28.28 1.02 18 8.9 5800 75/16 1.56 300YES YES NO NO 145 78 37.09 1.4 18 9.3 6802 71/18 2.3 243YES NO 2/WK YES 168 58 20.54 1 16 8.4 5200 60/14 1.2 240NO NO NO NO 144 75 36.16 1.4 18 10.2 10700 77/20 2 140YES NO 3/WK 1 Year YES 164 77 28.62 1.13 15 9.5 6802 71/18 2.3 224YES NO 3/WK YES 144 51 24.9 1.01 14 8.7 5300 60/39 1.2 101YES NO 3/WK NO 163 56 21.07 1.02 14 9.3 6802 71/18 2 243YES NO 3/WK YES 169 58 20.3 1.02 16 8.9 6802 71/18 3 240YES NO 2/WK YES 147 50 23.1 1.04 15 9.1 5800 75/16 2.2 73YES NO 3/WK YES 169 62 21.7 1.05 15 11.8 6802 71/18 1.4 230YES NO ONCE/WK YES 160 72 28.12 1.1 16 8.1 6800 75/16 2.2 173YES NO 3/WK YES 170 60 20.75 1.02 16 8 6802 81/10 3.4 240YES YES 2/WK YES 167 64 22.94 1.03 15 8.3 7202 71/28 2.9 300

BIOCHEMISTRYBU/S.CR SE CA PO4 CA*PO4 UA TP/ALB TB/DB AST/ALT ALP/GGT LIPIDS(CHO/HDL/ TSAT % FERRITIN47/7.3 136/5.2 8.9 5.3 47.17 5 6.3/3.2 0.3/0.4 32/34 124/123 214/23/128/32 12.8 76383/9.0 146/4.8 8 4.2 33.6 5.6 6.6/3.1 0.2/0.3 17/23 120/26 250/20/128/34 13 70094/9.3 142.4.3 8.2 3.4 27.88 5.4 6.8/2.8 0.4/0.2 19/28 134/56 123/28/43/33 27 35078/5.3 139/4.4 7.6 4.2 37.24 2.6 6.8/2.3 0.3/0.4 19/28 151/19 124/28/50/35 6 42116/9.4 114/5.3 8.1 4.7 38.07 4.3 6.8/3.5 0.3/0.4 13/23 154/34 115/22/26/103 30 352158/7.8 141/4.1 8.5 4.3 36.55 5 6.4/3.3 0.3/0.2 14/13 151/19 250/36/41/100 27 122143/10.6 134/4.3 8 3.7 29.6 5.4 6.3/3.4 0.4/0.3 14/13 151/19 250/36/131/62 88 500142/8.2 138/5.2 7.6 4.1 31.16 4.3 7.4/3.4 0.3/0.4 16/24 357/39 104/37/47/81 48 266100/6 139/4.5 8.3 3 24.9 2.3 6.9/3.1 0,5/0.6 13/24 315/114 161/41/93/66 18 160200/11 131/3.8 7 3.5 24.5 7.3 6.6/2.6 0.3/0.4 13/24 478/22 272/28/120/200 23 222198/9.8 141/4 8.3 6.4 53.12 6 6.3/2.4 0.2/0.1 23/24 128/48 115/22/26/103 15 2087/5.5 136/4 8.3 6.5 54 6.2 6.4/2.5 0.3/01 35/30 97/34 119/29/20/111 20 210350/22.7 134/4.8 5.8 11 63.8 10.3 6/2.9 0.3/01 45/49 125/33 272/27/113/193 87.4 60899/9 145/4.3 8.5 6.4 55.25 7.6 6.5/2.3 0.3/0.4 23/32 98/43 132/54/111/123 23% 322100/10 142/4.9 9 4 36 5.4 7/3.2 0.3/01 20/25 136/39 128/23/43/33 23 27078/10.2 148/3.8 8.5 7.3 62.05 7.3 5.3/2.9 0.3/01 17/23 55/21 115/22/26/103 30 50090/8.3 148/3.8 8.9 3.6 32.04 7.4 6.1/3.8 0.2/0.1 16/30 55/25 161/41/93/66 20 175109/7.6 126/4.6 6.9 3 20.7 8 5.3/2.3 0.5/0.3 37/17 81/30 172/48/98/86 15 20190/9.1 130/3.8 7.8 5.4 42.12 6.8 5/2.1 0.3/0.1 29/36 97/49 115/22/26/103 35 61699/7.3 136/4 6.1 5.7 44.53 10.1 6.2/1.8 0.2/0.1 30/28 137/78 138/23/43/344 37 617196/8.3 132/4.2 8.6 5.7 42.42 6.5 7.4/3.4 0.7/0.2 15/25 87/25 140/42/53/130 16 2264/7 140/4.3 9 4.1 36.9 6.3 7.2/3.9 0.3/01 10/27 97/40 220/26/129/341 15 230134/7 148/3.8 8 2.6 20.8 6.7 5.5/2.7 0.9/0.3 34/39 159/99 115/22/26/103 11 326142/8.2 141/4 8.2 3.4 27.88 5.7 6.3/3.0 0.4/0.3 23/24 97/34 272/27/113/193 20 210191/9.0 130/3.8 8.2 2.1 17.22 5 6.0/2.3 0.5/0.3 47/42 169/72 140/42/53/130 25 185178/10.2 148/3.8 8.8 7 61.6 7.3 5.3/2.0 0.3/01 17/23 155/21 115/122/26/103 21 181100/12.7 141/5.0 9.6 3.3 31.68 3 7.6/2.0 0.3/0.2 20/23 158/53 158/49/80/68 21 124178/10.2 148/3.8 8.5 7.3 62.05 7 5.3/2.9 0.3/01 217/23 155/21 115/22/26/103 25 432191/9.0 130/3.8 8.9 4 35.6 5 6.0/2.7 0.5/0.3 41/32 169/72 147/62/63/132 25 185120/7.3 139/4.5 9 3 27 4 6.9/3.1 0.5/0.6 34/34 315/114 165/41/88/76 20 180

ECHO CARDIOGRAPHY USG ABDOMEN ECGRDI/Hour AHI

EF 60%, NORMAL Bilateral Small Sized Kidneys Normal 50.3 50.3EF 65%, Concentric LVH Normal Sized Kidneys, Grade 2 RPC LVH 163.1 163.6EF 45%, RWMA Bilateral Small Sized Kidnyes with Multiple Cysts LVH 66.9 66.9EF 20%, RWMA Dilated Chambers Bilateral Small Sized Kidnyes with Grade 2 RPC LVH 145.5 145.5EF 40%, Concentric LVH, LVDD Dialated Chambers Normal LVH 45.2 44.5EF 54%, Concentric LVH, LVDD DIL LA/LV Bilateral Small Sized Kidneys LVH 48.1 48.1EF 64%, LVDD Bilateral Small Sized Kidneys LVH 46 46EF 40 %, Global Hypokinesia, RWMA Bilateral Small Sized Kidneys LVH, OLD IWMI 34.9 29.8EF 60%, Normal Bilateral Small Sized Kidneys LVH, OLD IWMI 94.6 94.6EF 40%, Concentric LVH, RWMA, LVDD NORMAL OLD AWMI, LVH 172 172EF 45%, Concentric LVH Bilateral Small Sized Kidneys OLD IWMI 169.1 169.1EF 60%, Concentric LVH, RWMA Bilateral Small Sized Kidneys OLD AWMI 169.1 169.1EF 62%, Concentric LVH Bilateral Small Sized Kidneys LVH 64.7 64.7EF 40%,LVDD,RWMA Bilateral Small Sized Kidneys LVH,OLD IWMI 189.1 189.1EF 45%, Concentric LVH, RWMA, Mild MR Normal OLD IWMI 72.3 72.3EF 60%, Normal Bilateral Small Sized Kidneys LVH 54.1 54.1EF 38%, LVDD, RWMA Bilateral Small Sized Kidneys OLD AWMI 163.4 163.4EF 56%, RWMA, Severe TR, PAH, LVDD NORMAL 1 Degree Heart Block 82.7 82.7EF 60%, Concentric LVH, Severe TR, Severe PAH NORMAL LVH 175.7 175.7EF 62%, Normal NORMAL LVH 50.1 50.1EF 40%, Concentric LVH NORMAL LVH 80.7 80.6EF 35 %, Global Hypokinesia Heptospspleenomegaly LVH, OLD AWMI 92.8 91.7EF 45%, Concentric LVH Multiple cysts in liver and kidney LVH 64 64EF 45%, Concentric LVH, RWMA, Mild MR NORMAL LVH OLD IWMI 179.7 179.7EF 60%,mild MR, TR, PAH, LVDD Bilateral Small Sized Kidneys OLD IWMI 38.7 38.7EF 40%, Concentric LVH LV GLOBAL HYPOKINESIA Bilateral Small Sized Kidneys LVH 54.1 54.1EF 70%, Concentric LVH, LVDD NORMAL WPW Syndrome 119.4 119.4EF 60%, Normal Bilateral Small Sized Kidneys LVH 63.8 63.8EF 60%,mild MR, TR, PAH, LVDD Bilateral Small Sized Kidneys OLD IWMI 66.5 66.5EF 55% NORMAL Bilateral Small Sized Kidneys LVH, OLD IWMI 163.1 163.1

POLYSOMNOGRAPHYAROUSAL INDEX ODI % TSD Mins PLM/Hour IMPRESSION

33.5 7.1 325.5 16.3 Moderate OSA66.9 19.3 469 84 Severe OSA45.4 9.6 305 2.2 Severe OSA

122.5 18.3 142.5 18.1 severe SARD with OSA and CA42 5.1 376 12.6 Severe OSA

21.8 1.8 394 5 Severe OSA40 3.6 428 21.26 Severe OSA

36.3 0.5 407 15.6 Severe OSA83.2 77.3 336 20 Severe OSA102 50.7 387 15.6 Moderate OSA

87 30.4 407 27 Severe OSA87 30.4 407 27 OSA

33.9 75.3 241 1.2 Severe OSA88 35.4 397 29 OSA

47.4 20 310 4 Severe OSA49.9 28 425 13.8 Severe OSA

89 33.4 407 27 Moderate OSA80 49.8 417 30.2 Moderate OSA

100.7 49.9 360 16.8 Severe OSA49.9 29 420 14 Severe OSA

81 49.8 407 32.1 Moderate OSA92.7 23.9 364.5 10.2 Moderate OSA

33 77 244 1.5 Severe OSA107.7 49.9 357 14.8 Moderate OSA

34.5 20.4 285.5 20.4 Severe OSA49.9 28 425 13.8 Severe OSA54.5 29.5 404.5 27.4 Severe OSA63.3 56.1 413 9.2 Severe OSA19.5 17.4 304 81.9 Severe OSA66.9 19.3 405.5 84 OSA

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