© Fraunhofer

MARINE BIOTECHNOLOGY

IN SCHLESWIG-HOLSTEIN

Dr. Marina Gebert

14.03.2017

© Fraunhofer

http://www.vliz.be/wiki/Portal:Marine_Biotechnology

(Aqua-)

Marine Biotechnology Workflow(Source: European Science Foundation)

Marine Biotechnology is part of global biotechnology and its specificity lies in the uniqueness of marine

living resources and their derived products and services through the use of a set of tools ranging from

biodiversity assessment to systems biology, from cultures to engineering.

© Fraunhofer

Target research area Examples

Food:

Development of food products and ingredients

of marine origin (algae, invertebrates, fish) with

optimal nutritional properties for human health

dietary supplements; functional food

selective breeding of aquaculture species

sustainable production of feed

zero-waste recirculation systems

Energy:

Development and demonstration of viable renewable

energy products and processes, notably through the

use of marine algae

microalgae resources for biofuel production

improve the photosynthetic efficiency

enhance lipid productivity

improve harvest, separation, purification

processes

Health:

Development of novel drugs, treatments and health

and personal care products

Finding novel bioactives

improve technical aspects

overcome the supply problem

anti cancer, biofilm inhibitors, antibiotics

Industrial Products and Processes:

Development of marine-derived molecules exploitable

by industry including enzymes, biopolymers and

biomaterials

develop enabling technologies for high

throughput enzyme screening

marine biopolymers as novel competitive

commercial products in food, cosmetics and

health

Environment:

Development of biotechnological approaches,

mechanisms and applications to address key

environmental issues

Develop automated high-resolution

biosensing technologies

Antifouling strategies

restauration of (marine) ecosystems

biosensors for routine analysis

Marine Biotechnology research priorities

Adapted from: European Science Foundation, Position Paper 15,

Marine Biotechnology: A New Vision and Strategy for Europe

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Masterplan Marine Biotechnology Schleswig-Holstein

Marine Biotechnology

Marine

bioresources

Technologies/

methods

Raw materials/

intermediate

products

Product areas

(examples)Application areas

uses benefits from produces develops products for is applied in

Macro-organisms:

Plants

Animals

Microorganisms:

bacteria

Genetics /

genomics

Biochemistry /

proteomics

Cell biology

techniques

Metabolomics

Cultivation

methods

Systems biology

Ecological methods

Proteins:

Collagen

Carbohydrates:

Agar

Lipids:

Omega-3

fatty acids

Secondary

metabolites:

Polyketides

Pharmaceuticals

Feed

Dietary

supplements

Antifouling

Cosmetics

Chemicals

Industrial

biotechnology

Biofuels

Health

Aquaculture

Food

Cosmetics

Industry

Energy

Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

Marine Biotechnology R&D in Schleswig-Holstein

Source: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

Marine Biotechnology companies in Schleswig-Holstein

Source: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

Examples of policy guidelines and initiatives on national

and international level

European level National level

Policy guidelines

• An Integrated Maritime Policy for the

European Union -The Blue Book

• Blue growth strategy

• High-tech strategy 2020 for Germany

• National research strategy bio economy

2030

• National masterplan of maritime

technologies

Initiatives

Programs • Horizon 2020 • Diverse federal programs, e.g. „KMU-

innovativ“, „Basic technologies for the

next generation of biotechnological

processes“

Projects and initiatives • Micro B3

• SUBMARINER

• Susfood

• ANIHWA

• INTERREG Baltic Blue Growth

• JPI Oceans, Marine KIC, EuroMarine,

Marine Fungi, …

• Food security through aquaculture in

Malawi

• Origin and function of metaorganisms

• Sun protection from macroalgae

• Offshore cultivation of microalgae

Networks, associations • ERA-Net MB

• ERASysBio

• ERA-NanoSci

• ERA-Net Bioenergy

• ETPs (European technology platforms)

• …

• Bundesverband Aquakultur e.V.

• Kieler Algenstammtisch

• Kompetenznetzwerk Aquakultur

• Maritimes Cluster Norddeutschland

• Nordverbund Marine Biotechnologie

Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

Companies involved in national or international funding

programs (n=17)

Source: Masterplan Marine Biotechnologie Schleswig-Holstein

No

Yes

Yes, european

Yes, european

and german

© Fraunhofer

Main challenges for MB companies during cooperation

with scientific institutions

Lacking financial means

„Slow“ structures at cooperation

partners

Uncertain legal structures (IPR,

liability)

Missing interest of cooperation

partner

Commercial risk is too high

Spatial distance

Communication during project

Finding cooperation partners and

making contact

Decreasing interest of partner during

cooperation

Want of confidence to cooperation

partner

Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

Main challenges for MB R&D Institutes during

cooperation with companies

Economic potential unclear

Communication and making

contacts is too difficult

Differing interests

Difficulties accessing information

Uncertain legal structures (IPR,

liability)

Spatial distance

Lacking financial means

Decreasing interest of partner during

cooperation

Missing interest of cooperation

partner

Competitive situation

Incapable of action

Adapted from: Masterplan Marine Biotechnologie Schleswig-Holstein

© Fraunhofer

The Fraunhofer-Gesellschaft at a Glance

The Fraunhofer-Gesellschaft undertakes applied research of direct utility

to private and public enterprise and of wide benefit to society.

Nearly 24,000

staff

More than 70%

is derived from

contracts with industry

and from publicly

financed research

projects.

Almost 30%

is contributed by the

German federal and

Länder Governments.

66 institutes and research units Fin

an

cin

gvo

lum

e

€2 billion

2014

Co

ntr

ac

tR

es

earc

h

€1.7

billion

Major infrastructure

capital expenditure and

defense research

© Fraunhofer

The Fraunhofer-Gesellschaft

in Germany

München

Holzkirchen

Freiburg

Efringen-

Kirchen

FreisingStuttgart

PfinztalKarlsruheSaarbrücken

St. IngbertKaiserslautern

DarmstadtWürzburg

Erlangen

Nürnberg

Ilmenau

Schkopau

Teltow

Oberhausen

Duisburg

EuskirchenAachenSt. Augustin

Schmallenberg

Dortmund

PotsdamBerlin

Rostock

LübeckItzehoe

Braunschweig

Hannover

Bremen

Bremerhaven

Jena

Leipzig

Chemnitz

Dresden

Cottbus

Magdeburg

Halle

Fürth

Wachtberg

Ettlingen

Kandern

Oldenburg

Freiberg

Paderborn

Kassel

GießenErfurt

Augsburg

Oberpfaffenhofen

Garching

Straubing

Bayreuth

Bronnbach

Prien

Fraunhofer Institution for Marine

Biotechnology and Cell Technology (EMB)

© Fraunhofer

Cell Technologies

Cell culture of aquatic organisms

In-vitro manipulation

Cryopreservation

Cellular test systems

Technical Center for Applied Food Research–

TFAL

Food and feed from aquatic resources

Food-Prototypes

Dietary supplements

Land-based integrated multitrophic

aquaculture

Integrated cultivation of plants/ algae and

animals in marine aquaculture systems

controlled environment

saving water

broader product range

Breeding of novel aquaculture candidates

Implementation of omnivor species

Reduction of fish meal and oil

Working group „Aquatic cell technology and Aquaculture“

© Fraunhofer

Koi-Herpes-Virus-

Diagnostics and containment of CyHV-3 in carp aquaculture

Control, 4 d Control, 6 d Control, 8 d

Virus I, 4 d Virus II, 6 d Virus II, 8 d

Quelle: http://www.laves.niedersachsen.de

Our expertise in fish cell culure development

allows us to develop novel cell lines (from skin,

gill, brain, head kidney,…) that can produce

high amounts of virus particles

Viruses are used as source material for the

development of vaccines

© Fraunhofer

Tecnical Center for Applied Food Research– TFAL

Utilization of marine ressources (from aquaculture facilities and wild catches) for:

• Development of novel food prototypes from marine ressources

• Development and analyses of dietary supplements for human and animal nutrition

• Development of innovative processing technologies

Example:

Lemonade made with macroalgae

(kiwi/quince flavour)

© Fraunhofer

Facilities at the Fraunhofer EMB

- One-of-a-kind, completely flexibe aquaculture facilities, containing the biggest

landbased marine IMTA in Germany

- 90 m³ outdoor pond for the cultivation of macroalgae

- 6 m³ ponds for mussels

- 3 circular ponds for fish rearing, 3,5 m³ each

- Classical recirculating aquaculture system with modern biofilters as reference

cycle (3 x 3,5 m³)

© Fraunhofer

Aquaculture in Malawi:Joint project of EMB, GMA and University of Malawi

Aquaponics for improving food security and sources of income for native people

Improving reproduction of native fish species (Oreochromis karongae) through

breeding and optimal larval rearing

Low Tech solutions for larval rearing using solar power for regions with insecure

energy supply

© Fraunhofer

Marine Bioeconomy in Schleswig-Holstein –

Activities of EMB

Marine resourcesMariculture

Industry, households

Biorefinery

Agrosystems

Aquaculture

Land

Coast

Sea

• Cellular and molecular biology

technologies for aquaculture

• Production, processing, extraction of

marine raw materials

• Development of novel food and feed

prototypes and ingredients from

marine resources

• Multitrophic aquaculture and novel

aquaculture candidates

© Fraunhofer

Sponsored by the

European Union,

European Fond for

regional development

(EFRE)

THANK YOU

Fraunhofer Institution for Marine Biotechnology (EMB)

Dr. Marina Gebert

Moenkhofer Weg 239 a

D- 23562 Luebeck

Tel.: +49 (0) 451/384 448 - 15

Fax: +49 (0) 451/384 448 - 12

E-Mail:

Marina.gebert@emb.fraunhofer.de

Internet:

http://www.emb.fraunhofer.de

© Fraunhofer

EU: Submariner (http://www.submariner-project.eu/)

ERA-Net „Marine Biotechnology“

(http://www.marinebiotech.eu/)

National: Nationaler Masterplan Maritime Technologien

(http://www.nmmt.de/)

Nationaler Strategieplan Aquakultur

(http://www.bundesverband-aquakultur.de/aktuelles/nationaler-

strategieplan-aquakultur-veroeffentlicht)

S-H: Masterplan Marine Biotechnologie (bei: http://dsn-online.de)

Associations: DAFA (http://www.dafa.de/)

KNAQ (http://www.knaq-sh.de/)

Bundesverband Aquakultur

(http://www.bundesverbandaquakultur.de/)

Links: