Maria Škornjak, M.D., Maticne Stanice_Stem Cells

7/23/2019 Maria kornjak, M.D., Maticne Stanice_Stem Cells

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Ecrgc mlrfbcm! E&J&

Eczgfn {zcfgkn

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zl {~ eczgfn {zcfgkn


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Yr{zn eczgfgd {zcfgkc

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Eczgfn {zcfgkn g mryg p~pmlygfn


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[zne knaa jgiinrnfzgczglf {pnkzr~e

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Cj~az {zne knaa{Eczgfn {zcfgkn ljrc{an l{lon g mlzcfn {rg


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Oglgfgfbnrgfh eczgfgd {zcfgkc2Znrcpgb{ml malfgrcfbn g F~mancrfl rnprlhrcegrcfbn


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Ogl%gfgfbnrgfheczgfn {zcfgkn

Pa~rgplznfzfn eczgfn {zcfgkn mlbn i~fmkglfgrcb~ mcl neorglfcafneczgfn {zcfgkn elh~ {n jlogzg g ljrc{agd {lecz{mgd,zbnan{fgd

{zcfgkc mrl /znrcpgb{ml malfgrcfbn/ gag /f~mancrfl rnprlhrcegrcfbn&/

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Znrcpgb{ml malfgrcfbn


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F~mancrfl rnprlhrcegrcfbn mrl nmzlpgf~ nm{prn{gb~ hnfc

F~mancrfl rnprlhrcegrcfbn {zcfgkcigorloac{zcljrc{an l{lon eln{n pl{zgg mrlnmzlpgf~ nm{prn{gb~lj nzgrghnfc $LKZ: g [LT?!FCFLH g AGF?4 gag MAI: g K%ewk' cprlgyljfb~ pa~rgplznfzfn {zcfgkn {cfccbmcec neorglfcafgdeczgfgd {zcfgkc! zy&gfj~kgrcfn pa~rgplznfzfneczgfn $gP[' {zcfgkc&

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Pl{zlbg ag lpc{fl{z lj al~plrcon


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[yn plj mlfzrlale


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Znrcpgbc eczgfge {zcfgkcec ~ agbnnfb~ gficrmzc eglmcrjc

G{dnegb{mc olan{z {rkc! cm~zfg gficrmz eglmcrjc! cm~zfl g mrlfgfl

g{dnegfl czcbgycfbn {rkcyljng {~ bcyfljrcy{zynfg prloanegrcygbnfgd necabc

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agbnnfbn zcmygd olan{fgmc prnj{zcyabc g jcabn gcly ~ {ycmljfnyflbmagfgmlb prcm{g! plhacygzl { logrle fc elrogjgznz g elrzcagznz lj zgd olan{zg

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prlegbnfgzg zgbnm magfgmn prcm{n ~ mcrjglalhgbg ~ {mlrlb o~j~fl{zg


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Agbnnfbn jcfc{ y{& agbnnfbn ~ {mlrlb o~j~fl{zg

Jl jcfc{ agbnnfbn {n ocgrc fc mleogfgrcfle agbnnfb~2

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{yn jlZ_CF[PACFZCKGBN [_KCgfg {n jc bn fc plela~FLYG FCGF AGBNNFBC mlbg {n ocgrcfc

PLP_CYM^ LZNNFLH EGLMC_JC~ plelECZGFGD[ZCFGKC


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[rkn mcl pl{zegzlzgk lrhcf

[rknmcl lrhcfgec {pl{lofl{z rnhnfnrckgbn2

%p~zne cmzgyckgbn yac{zgzgd eczgfgd {zcfgkc

%p~zne rnhr~zgrcfbc eczgfgd {zcfgkc jr~hgd lrhcfc! fpr& g mlzcfn{rg

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g jlyljg jl2

% rnpnri~gbn eglmcrjc

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%fnlyc{m~acrgckgbn $ilregrcfbn flygd mryfgd gac c lp{mro~

eglmcrjc'% ilregrcf n flygd eglkgzc


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Zdn _; Pcrcjghe li Dncrz _npcgr

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Hacyfc dgplznc c {rcf~ znrcpgb~ eczgfge {zcfgkcec

% L{acoabnfl {rkn gec {ecfbnfg orlb eglkgzc mlbg pl{abnjgfl rnj~kgrcmlfzrcmzgaf~ i~fmkgb~

% L{gh~rcycb~g flyg gylr plzrnofgd {zcfgkc ~ lyle {a~cb~ eczgfgdzc i~fmkgbc {n eln plolabczg

% Jl jcfc{ {~ ; mcznhlrgbn {zcfgkc mlrgznfn ~ plm~{gec rnhnfnrckgbn{rcflh eggc2

3' {rcfg eglkgzg

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;'pa~rgplznfzfn eczgfn {zcfgkn

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Enzdlj{ li knaa jnagynrw ilr kcrjgck gepacfzczglf


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Znrcpgbc {mnanzfge egloac{zgec,eczgfge {zcfgkcec eggc

%[mnanzfg egloac{zg {~ eczgfn {zcfgkn eggc mlbn rnchgrcb~ fclabnj~ prlaginrckgble g i~gble {c jr~hge {zcfgkcec

%c rcagm~ lj eczgfgd {zcfgkc mlzcfn {rg yn pl{bnj~b~jginrnfkgrcfl logabnbn g ~{ebnrnfbn

Prnjfl{zg2

% acml {n glagrcb~

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%pl{bnj~b~ {pl{lofl{z gf ygzrl prlaginrckgbn

_n~azczg prgebnfn2

%plolabcfbn i~fmkgbn agbnyn magbnzmn

% jginrnfkgbckgbc ~ mcrjgleglkgzn fgbn jlmccfc

%cegbnnfc bn plbcyc crgzegbc $mlbc {n lobcfbcyc plecfbmcfbnenanmzrgfn

gfznhrckgbn'


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Klfknpz li zdn ~fgynr{cagzw li onfnigz flznj gf cfgeca cfj kagfgkca {z~jgn{!xgzd zdn ntknpzglf li {len rnknfz rcfjlegnj zrgca{ zdcz dcyn rnplrznj

jg{klrjcfz rn{~az{&


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Znrcpgbc eczgfge {zcfgkcec g mlzcfn {rg

Mlrgznfn {~ eczgfn {zcfgkn mlzcfn {rg~ ygj~ 2

% gf {gz~ mlrgznfgd {zcfgkc gag

% g kgrm~agrcb~n mryg {zge~agrcfgd icmzlrle {zge~ackgbn hrcf~alkgzfgdmlalfgbc $H%K[I'

_n~azczg2 plolabcfbn {rcfn i~fmkgbn#

F~{plbcyc2eglmcrjfc mcakgigmckgbc


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Fnnabnfg ninmzg

plbcyc {rcfgd crgzegbc $crrdwzdelhnfn{g{'

lfmlhnfc zrcf{ilreckgbc$~fczl jlmcgec l elh~fl{zg lfmlhnfnzrcf{ilreckgbn ~ magfgmge {z~jgbcec fgbn ogal plyncfn ~n{zcal{zgz~elrc'

fnprgrljfc {zcfgfc jginrnfkgbckgbc $Conrrcfz Knaa Jgiinrnfzgczglf'!~egbne eljna~cm~zflh gficrmzc eglmcrjc! prgebnfbnfn eczgfn

{zcfgkn g mlzcfn {rg gfj~kgrcan {~ fccbf~ mcakgigmckgb~ eglmcrjc gg ilregrcfbn ml{zgb~'

^ocf rcylb cznrl{manrln


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_n~azczg jl {cj prlynjnfgd {z~jgbc

_n~azczg jl {cj prlynjnfgd mlfzrlagrcfgd rcfjleggrcfgd {z~jgbc~

yng { znrcpgble eczgfge {zcfgkcec ~ cm~zfle gficrmz~ eglmcrjc~ haloca~ {~ jlmccag jc znrcpgbc eczgfge {zcfgkcec ~ ~{plrnjog {cmlfzrlafge {m~pgfcecplolabcyc2

nbnmkgb{m~ ircmkgb~ agbnyn magbnzmnrnj~kgrc cyrfg {g{zlagmg yla~enf agbnyn magbnzmnrnj~kgrc angb~ eglmcrjc $lfc gficrmzc {n {ecfb~bn'

Jcabfbc g{zrcgycfbc cdzgbnycb~2jnigfgrcfbn lpzgecaflh gylrc {zcfgkc

golr pckgbnfczc lyg{fl l yr{zg jgbchfln,olan{zgfcbolabgfcgf prgebnfn $jl {cjc gfzrcmlrlfcrfg'jnigfgrcfbn zlflhendcfgec jbnalycfbcjnigfgrcfbnlpzgecafgd jlc eczgfgd {zcfgkc


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L{zcac pljr~bc prgebnfn eczgfgd {zcfgkc


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Pldrcfc mryg g p~pmlygfn ~ Drycz{mlb

~ Drycz{mlbpl{zlbn jygbn yr{znocfcmc ~eogagmcafn mryg$g p~pmlygfn'! jlorlylabfc g prgyczfc$Ocfmc ~eogagmcafnmryg c yac{zgzn plzrnon'

Ocfmc{n fcacg~ Rcylj~ c magfgm~ zrcf{i~glalhgb~

Magfgmlh Rcyljc c acolrczlrgb{m~ jgbchfl{zgm~ MOKRchrno! Mgpczgnyc 3?& Ocfmc mryg g p~pmlygfnl{flycfc bn ?4&l~bmc ?008&


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Rczl pldrcfgzg mry g p~pmlygfn


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Kgbnfc prgm~pabcfbc! lorcjn! pldrcfn g ~ycfbc ~logznab{mge ocfmcec gfl{g lml3>00 jl ?000 N^_%c&

^hlylr c ~ycfbn plzpg{~bn {n fc34 hljgfc! zb& jlyrnenfc mcjc jgbnzn gbc bn mry g p~pmlygfn prgm~pabnfcpl{zcfn p~flabnzfl&

Zcjc zc l{loc eln fc{zcygzg ~yczg mry g p~pmlygfn gagbn {n ljrng c jlorlylabf~ ocfm~&

_cagmc ~ kgbnfg gen~ jlorlylabfn g logznab{mn bn ~zrlmlygec prgm~pabcfbc! lorcjn! pldrcfn g ~ycfbc cyral ynagm orlb ~lrcmc! mlbg {n eljc fgmcjc fnn~plzrgbnogzg&

cf{c jc {n bnjfc mry g p~pmlygfn g{mlrg{zg czrcf{pacfzckgb~bn lml 32;0 000 jl 300 000! lyg{fl lmlblb {n nzfgmlb {m~pgfg rcjg&


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Pldrcfbnfc ~eogagmcafc mry yac{fgzyl bn logznabgg eln{nmlrg{zgzg c agbnnfbn ogal mlbnh acfc logznabg&

^mlagml logznab gec ygn jbnkn prnplr~mc bn jc {n pldrcfg

mry {ycmlh jbnznzc plfcl{lo& c prnzpl{zcygzg bn jc {n {zcfgkn! ~ mlfzrlagrcfn ~ybnzn!

elh~ fnlhrcfgnfl ~yczg& Mry {n ~yc ~ znm~ne j~gm~ fc egf~{ 379 {z~pfbnyc Kna&

L{fgycfbn ocfcmc ~eogagmcafn mryg fcm bn zndflalmlh fcprnzmc! cplnzcm rcjc zcmyn ocfmn {yr{zcyc Drycz{m~ ~ {ce olm necabc ~mlbgec zcmyg prlhrceg yn j~hg fg hljgfc gyn& L{fgycfbn ocfmn ~Rchrno~ lelh~cyc yn~ jl{z~pfl{z eczgfgd {zcfgkc czrcf{pacfzckgb~! fnhl zl bn zl ogal jl{cj&


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Jcr~bzn mry g p~pmlygfn bnr eln fnmlen {pc{gzg gylz#

^ {ygbnz~ pl{zlbg ynagm orlb olan{fgmc mlbg zrnocb~zrcf{pacfzckgb~ mrylzylrfgd eczgfgd {zcfgkc! c fn elh~fcg plj~jcrflh jcrgycznabc&

Mry g p~pmlygfn pldrcfbnfc ~ Ocfkg mryg g p~pmlygfn/Cfc _~mcygfc/plyncyc elh~fl{z prlfcacnfbczrcf{pacfzczc mlbge {n eln {pc{gzg gylz lolabnagec&


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Maria Škornjak, M.D., Maticne Stanice_Stem Cells