Upload
raoul
View
31
Download
0
Tags:
Embed Size (px)
DESCRIPTION
CHEMICAL, MECHANICAL AND ANTIMICROBIAL PROPERTIES OF SPUTTERED SILVER NANOCLUSTER-SILICA COMPOSITE THIN FILMS. M. Ferraris, S. Perero, M. Miola, S. Ferraris , A. Battiato, C. Manfredotti, E. Vittone, E. Vernè. THE PROBLEM. Medical devices Surfaces for everyday-life - PowerPoint PPT Presentation
Citation preview
CHEMICAL, MECHANICAL AND CHEMICAL, MECHANICAL AND ANTIMICROBIAL PROPERTIES OF ANTIMICROBIAL PROPERTIES OF
SPUTTERED SILVER SPUTTERED SILVER NANOCLUSTER-SILICA COMPOSITE NANOCLUSTER-SILICA COMPOSITE
THIN FILMSTHIN FILMSM. Ferraris, S. Perero, M. Miola, M. Ferraris, S. Perero, M. Miola, S. FerrarisS. Ferraris, A. , A. Battiato, C. Manfredotti, E. Vittone, E. VernèBattiato, C. Manfredotti, E. Vittone, E. Vernè
THE PROBLEMTHE PROBLEM
Bacterial Bacterial contaminationcontamination
Medical devicesMedical devices
Surfaces for everyday-lifeSurfaces for everyday-life
Surfaces used by hundreds of Surfaces used by hundreds of peoplepeople
… …
AIM of THE AIM of THE WORKWORK
Obtain an effective and versatile antibacterial Obtain an effective and versatile antibacterial layerlayer
Stable (thermally, chemically … )Stable (thermally, chemically … )
Applicable to different surfacesApplicable to different surfaces
With tailorable antibacterial activityWith tailorable antibacterial activity
Broad spectrum of activityBroad spectrum of activity
Low resistance developmentLow resistance development
This research activity is supported by:This research activity is supported by:
Regione Piemonte, Italy, with ‘‘NABLA- Nanostructured Regione Piemonte, Italy, with ‘‘NABLA- Nanostructured Antibacterial Layers.’’Antibacterial Layers.’’
EU Project-NASLA-FP7-SME-2010-1 (Project 262209)EU Project-NASLA-FP7-SME-2010-1 (Project 262209)
SILVERSILVER
well known antibacterial well known antibacterial agentagent
broad spectrum activitybroad spectrum activity
Low resistance Low resistance developmentdevelopment
SILICASILICA
Thermal, Thermal, chemical, chemical, mechanical mechanical stabilitystability
SILICASILICA
AgAg
SILICA TARGETSILICA TARGET SILVER TARGETSILVER TARGET
SPUTTERINGSPUTTERING
SILICASILICA AgAg
ArAr ArAr
SUBSTRATESUBSTRATE
SUBSTRATESUBSTRATE
SILVER NANOCLUSTERS-SILICA SILVER NANOCLUSTERS-SILICA ANTIBACTERIAL LAYERANTIBACTERIAL LAYER
CO-SPUTTERING: THE SILVER CO-SPUTTERING: THE SILVER NANOCLUSTERS-SILICA FILMNANOCLUSTERS-SILICA FILM
XPS CHARACTERIZATION OF THE XPS CHARACTERIZATION OF THE SPUTTERED LAYER (*)SPUTTERED LAYER (*)
528530532534536Binding Energy [eV]
0
10
20
30
40
50
60
70
Intensity[cps]
Filename: NablaAsDep
O1s
1|
2|
3|
O 1sO 1s
532.7 eV532.7 eV SiO2
Secondary Secondary componentscomponents carboxylic groups from contaminations
98100102104106Binding Energy [eV]
0
2
4
6
8
10
12
14
Intensity[cps]
Filename: NablaAsDep
Si2p1|
282284286288290Binding Energy [eV]
0
2
4
6
8
Intensity[cps]
Filename: NablaAsDep
C1s
1|
2|
3|
4|
Si 2pSi 2p
103.38 eV103.38 eV SiO2
(*) Experimental Physics Department /Centre of Excellence “Nanostructured Interfaces and surfaces”, University of Torino
282284286288290Binding Energy [eV]
0
2
4
6
8
Intensity[cps]
Filename: NablaAsDep
C1s
1|
2|
3|
4| C 1sC 1s
contaminantscontaminants
284.47 eV284.47 eV CH2
285.38 eV285.38 eV C-O and C-CO
288.49 eV288.49 eV COOH
364366368370372Binding Energy [eV]
0
10
20
30
40
50
Intensity[cps]
Filename: NablaAsDep
Ag3d 1|
Ag 3dAg 3d
368.48 eV368.48 eV Ag0
METALLIC SILVER METALLIC SILVER NANOCLUSTERS !NANOCLUSTERS !
M. Ferraris et al., ADVANCED BIOMATERIALS, 2010, ISSN: 1868-4505.
M. Ferraris et al., MATERIALS CHEMISTRY AND PHYSICS 120 (2010) 123–126.
As Dep. 150 ºC 300 ºC 450 ºC 600 ºCAs Dep. 150 ºC 300 ºC 450 ºC 600 ºC
MORPHOLOGICAL AND CHEMICAL MORPHOLOGICAL AND CHEMICAL CHARACTERIZATIONCHARACTERIZATION
M. Ferraris et al., ADVANCED BIOMATERIALS, 2010, ISSN: 1868-4505.
M. Ferraris et al., MATERIALS CHEMISTRY AND PHYSICS 120 (2010) 123–126.
GammGamma ster.a ster.
EtO EtO ster.ster.
As Dep. 150 ºC 300 ºC 450 ºC 600 ºCAs Dep. 150 ºC 300 ºC 450 ºC 600 ºC
ANTIBACTERIAL ACTIVITY: inibition halo ANTIBACTERIAL ACTIVITY: inibition halo S. aureusS. aureus
M. Ferraris et al., ADVANCED BIOMATERIALS, 2010, ISSN: 1868-4505.
M. Ferraris et al., MATERIALS CHEMISTRY AND PHYSICS 120 (2010) 123–126.
As Dep. 150 ºC 300 ºC 450 ºC 600 ºCAs Dep. 150 ºC 300 ºC 450 ºC 600 ºC
Tape Tape adhesioadhesionn
Scratch Scratch resistancresistancee
0,0
5,0
10,0
15,0
20,0
25,0
AS DEP 150 300 450 600
Fir
st
cra
ck l
oad
[N
]
20 m 20 m
20 m 20 m
20 m
MECHANICAL PROPERTIESMECHANICAL PROPERTIES
Ag+ RELEASE
0
10
20
30
40
50
60
70
80
0 5 10 15 20 25 30
Days
g
AD
150°C
300°C
450°C
600°C
M. Ferraris et al., ADVANCED BIOMATERIALS, 2010, ISSN: 1868-4505.
M. Ferraris et al., MATERIALS CHEMISTRY AND PHYSICS 120 (2010) 123–126.
SILVER RELEASE (*) SILVER RELEASE (*)
(*) Traumatology and Work Medicine Department of C.T.O (Turin)
COATINGS ON POLYMERS FOR BIOMEDICAL COATINGS ON POLYMERS FOR BIOMEDICAL APPLICATIONS APPLICATIONS
TAPE TEST (ASTM D TAPE TEST (ASTM D 3359):3359): good adhesion of the coating to the substrate.
Antibacterial properties are Antibacterial properties are maintained after maintained after sterilization (chemical and sterilization (chemical and radiation)radiation)
The deposited film The deposited film maintains its properties maintains its properties after the common washing after the common washing procedures included in the procedures included in the medical devices production medical devices production routesroutes
Stability and silver release Stability and silver release in physiological solution in physiological solution UNDER INVESTIGATIONUNDER INVESTIGATION
Cellular tests UNDER Cellular tests UNDER INVESTIGATIONINVESTIGATION
COATINGS ON POLYMERS FOR AEROSPACE COATINGS ON POLYMERS FOR AEROSPACE APPLICATIONS APPLICATIONS
TAPE TEST TAPE TEST (ASTM D (ASTM D 3359):3359): good adhesion of the coating to the substrate
3 21
112233
Antibacterial Antibacterial activity connected activity connected to silver contentto silver content
Antibacterial Antibacterial activity activity maintained after maintained after agingaging
COATINGS ON MATERIALS FOR MOBILE COATINGS ON MATERIALS FOR MOBILE TELEPHONES APPLICATIONS TELEPHONES APPLICATIONS
ACOUSTIC ACOUSTIC FELTFELT
SCREENSCREEN
0
20
40
60
80
100
120
140
160
180
1 2 3 4 5
campioni
CF
U/c
m2
0 1 2 3 4
COATINGS ON MATERIALS FOR FOOD INDUSTRY COATINGS ON MATERIALS FOR FOOD INDUSTRY APPLICATIONS APPLICATIONS
TAPE TEST TAPE TEST good good adhesionadhesion
MILK MILK
AGEINAGEIN
GG
ANTIBACTERIAL ANTIBACTERIAL EFFECTEFFECT
COATINGS ON MATERIALS FOR EQUIPMENTS AND COATINGS ON MATERIALS FOR EQUIPMENTS AND PERSONNEL PROTECTIVE SYSTEMS PERSONNEL PROTECTIVE SYSTEMS
CONCLUSIONS AND FUTURE DEVELOPMENTS CONCLUSIONS AND FUTURE DEVELOPMENTS
Silver nanoclusters-silica antibacterial layer has been Silver nanoclusters-silica antibacterial layer has been deposited on model silica substrates and characterized deposited on model silica substrates and characterized after different thermal treatmentsafter different thermal treatments
Co-sputtering deposition technique allow to vary Co-sputtering deposition technique allow to vary silver content of the layer in order to obtain different silver content of the layer in order to obtain different antibacterial activitiesantibacterial activities
The layer has been effectively deposited on different The layer has been effectively deposited on different substrates from industrial partnerssubstrates from industrial partners
Particular tests are under investigation by industrial Particular tests are under investigation by industrial partners in order to optimize the layer for specific partners in order to optimize the layer for specific applications applications
ThankThanks!s!