Lipid-mediated Protein Organ Regeneration Signaling ... · Methods and Protocols Contents Isolation and Characterization of Human ... 45 in color. (Methods in Molecular Biology, Volume

Biomedicine springer.com/NEWSonline

16

J. Basu, Tengion, Inc., Winston-Salem, NC, USA; J. W. Ludlow, Zen-Bio, Research Triangle Park, NC, USA (Eds)

Organ RegenerationMethods and Protocols

Contents Isolation and Characterization of Human Adipose-Derived Stem Cells for Use in Tissue Engineering.- Isolation of Smooth Muscle Cells from Bladder for Generation of Engineered Urologic Organs.- Isolation of Urothelial Cells from Bladder Tissue.- Isolation of Pulsatile Cell Bodies from Esophageal Tissue.- Cell Isolation Through Whole Liver Perfusion and Preparation of Hepatocytes for Cytochrome P450 Analysis.- Ex Vivo Culture and Separation of Functional Renal Cells.- Isolation and Myogenic Differentiation of Mesenchymal Stem Cells (MSC) for Urologic Tissue Engineering.- Xeno-Free Adaptation and Culture of Human Pluripotent Stem Cells.- Re-verse Engineering Life: Physical and Chemical Mimetics for Controlled Stem Cell Differentiation into Cardiomyocytes.- Phenotypic Analysis of Bioactive Cells for Application in Regenerative Medicine.- Preparation and Evaluation of Natural Scaffold Materials for Kidney Regenerative Appli-cations.- Rapid Production of Autologous Fibrin Hydrogels for Cellular Encapsulation in Organ Regeneration.- Electrospinning Tubular Scaffolds with Tissue-Like Mechanical Properties and Biomimetic Surface Features.- Design, Fabrica-tion, and Preparation of Synthetic Scaffolds for Urologic Tissue Engineering.- Characterization of a PGA Based Scaffold for Use in a Tissue Engi-neered Neo-Urinary Conduit.- Migration Assay to Evaluate Cellular Interactions with Biomaterials for Tissue Engineering/Regenerative Medicine Applications. [...]

Fields of interestMolecular Medicine; Regenerative Medicine/Tis-sue Engineering

Target groupsProfessional/practitioner

Discount groupProfessional Non-Medical

Due March 2013

2013. X, 250 p. 104 illus., 45 in color. (Methods in Molecular Biology, Volume 1001)7 $139.00ISBN 978-1-62703-362-6

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D. G. Capelluto, Virginia Tech, Blacksburg, VA, USA (Ed)

Lipid-mediated Protein SignalingThis book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells.

Features 7 Summarizes innovative research in lipid-me-diated signaling 7 Presents contributions from internationally recognized scientists 7 Offers a valuable resource for cell biologists, structural bio-logists, and pharmacologists with interest in lipid signaling 7 Emphasizes on sphingolipid- and phospholipid-mediated protein signaling 7 Exa-mines lipid signaling from plasma membrane and intracellular organelles

Contents Sphingomyelin and its role in cellular signaling.- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of gangli-oside- and cholesterol-binding domains.- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.- Phosphoinositides and PDZ Domain Scaffolds.- PtdIns(4)P signalling and recognition systems.- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism.- Role of Phosphatidyli-nositol 3,4,5-trisphosphate in Cell Signaling.- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling.- Phosphatidic Acid-Me-diated Signaling.- Phosphatidylserine-mediated cellular signaling.- Cardiolipin-mediated cellular signaling.

Fields of interestBiomedicine general; Life Sciences, general; Spect-roscopy/Spectrometry

Target groupsResearch


Due May 2013

2013. XIV, 314 p. 44 illus., 29 in color. (Advances in Experimental Medicine and Biology, Volume 991) Hardcover7 $189.00ISBN 978-94-007-6330-2

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P. Capodaglio, Istituto Auxologico Italiano IRCCS, Piancavallo, Italy; J. Faintuch, São Paulo University, Brazil; A. Liuzzi, Istituto Auxologico Italiano IRCCS, Piancavallo, Italy (Eds)

Disabling ObesityFrom Determinants to Health Care Models

Features 7 Provides a current vision on obesity from a rehabilitative perspective 7 Deals with aetiology and epidemiology of obesity as well as with mor-bid obesity 7 Includes genetical, physiological, biomechanical determinants, functional limita-tions and disability, measures of disability, occu-pational issues as well as rehabilitation models and programs 7 Evidence-based discussion on effective care models and rehabilitation treatments

Contents An Up-To-Date Vision on the Aetiology and on the Epidemiology of Obesity and Morbid Obesity.- Physiological Bases of Physical Limitations During Exercise.- Biomechanics of Basic Activities.- The Obesity-Related Disability.- Critical Aspects in Nursing.- Effectiveness of Multidisciplinary Inpa-tient and Outpatient Rehabilitation on Functional Outcomes in Obese Patients with Orthopaedic Comorbidities.- Cardiac Rehabilitation.- Work Capacity, Sleep Apnoea and Respiratory Rehabili-tation.- Psychological Aspects and Rehabilitation Protocols Psychiatric Aspects.- Principles and Protocols in Nutritional Rehabilitation.- Bariatric Surgery: Current Techniques and Results.- Disa-bility in the Post-Obese Bariatric Patient: Old and New Problems.- Aesthetic Rehabilitation after Bariatric Surgery.- New Technologies for Impro-ving the Psychological Treatment.- Chronic Care Models for Obesity Management.

Fields of interestHuman Physiology; Rehabilitation; Human Genetics



Due March 2013

2013. IX, 300 p. 56 illus., 36 in color.7 $139.00ISBN 978-3-642-35971-2

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www.springer.com/978-1-62703-362-6



News 3/2013 Biomedicine

17

M. F. Casanova, A. S. El-Baz, University of Louisville, KY, USA; J. S. Suri, Biomedical Technologies, Inc., Denver, CO, USA (Eds)

Imaging the Brain in AutismData compiled by the Center for Disease Control and Prevention indicates an alarming and conti-nuing increase in the prevalence of autism. Despi-te intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomar-kers for autism.

Features 7 Looking at autism from an imaging perspec-tive 7 Ranging from the microscopic (i.e., post-mortem) to the macroscopic (fMRI) 7 Emphasis will be on techniques which have helped map the brain of the autistic person as well as normative individuals

Contents Introduction to Neuropathology.- The Neuropa-thology of Autism.- QEEG-Guided Neurofeedback for the Autism: Clinical Observations and Outco-mes.- Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism.- Evoked and Induced Gamma Frequency Oscillations in Autism.- Neurofeedback for Autistic Disorders: Emerging Empirical Evidence.- Structural Imaging in Autism.- Diffusion Tensor Magnetic Resonance Imaging in Autism.- Spectroscopic Brain Imaging in Autism.- Functional MRI in Autism.- Functio-nal Connectivity MRI in Autism.- EEG Analyses in the Assessment of Autistic Disorders.- Behavior Imaging®’s Assessment Technology.

Fields of interestBiomedicine general; Computer Imaging, Vision, Pattern Recognition and Graphics; Medicine/Pub-lic Health, general



Due April 2013

2013. XII, 448 p. 39 illus., 16 in color.7 $189.00ISBN 978-1-4614-6842-4

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W. C. Cho, Queen Elizabeth Hospital, Hong Kong (Ed)

Cancer Chemoprevention and Treatment by Diet TherapyFeatures 7 This is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment 7 This book brings together inter-national opinion leaders’ brilliant chapters and will contribute great to the cancer, academic, and clinical community by providing evidence-based information on the cancer chemoprevention and treatment effects by diet therapy 7 Although written primarily for medical and scientific profes-sionals, this book can be used as useful references to cancer patients and those who are interested in diet therapy for cancer

Contents Preface.- Effect of Dietary Resveratrol in the Treat-ment of Cancer.- Effect of Flavonoids from Fruits and Vegetables in the Prevention and Treatment of Cancer.- Beneficial Influence of Diets Enriched with Flaxseed and Flaxseed Oil on Cancer.- Can-cer Prevention with Green Tea Polyphenols.- Soy Foods: Towards the Development of Novel The-rapeutics for Breast Cancer.- Association between High Intake of Lycopene-rich Foods and Reduced Risk of Cancer.- Effect of Antioxidant-rich Foods and Supplements on Cancer Risk.- Effect of the Mediterranean Diet on Cancer Reduction.- Modu-lation of Proteasome Pathways by Nutraceuticals.- Attenuation of Multifocal Cell Survival Signaling by Bioactive Phytochemicals in the Prevention and Therapy of Cancer. Index.

Fields of interestBiomedicine general; Complementary & Alterna-tive Medicine; Oncology



Due April 2013

2013. VIII, 327 p. 19 illus., 15 in color. (Evidence-based Anticancer Complementary and Alternative Medicine, Volume 5) Hardcover7 $189.00ISBN 978-94-007-6442-2

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A. J. Dannenberg, Weill Cornell Medical College, New York, NY USA; N. A. Berger, Case Western Reserve University, Cleveland, OH, USA (Eds)

Obesity, Inflammation and CancerFeatures 7 Provides the latest information implicating a link between obesity, inflammation and specific tumor types 7 Describes innovative research on novel NSAIDS, omega 3 fatty acids, natural products, vascular targeting, caloric restriction and exercise in regards to cancer therapy 7 Pre-sents research connecting persistent inflammation to some of the comorbidities associated with cancer survivorship

Contents Preface.- Obesity, Inflammation and Insulin Resis-tance.- Inflammasomes and Obesity.- Uncoupling Obesity from Cancer: Bromodomain Co-regula-tors that Control Inflammatory Networks.- Adipo-se Tissue Macrophages in Obesity, Inflammation and Cancer.- Dietary Fats as Mediators of Obesity, Inflammation and Colon Cancer.- Inflammation, Obesity, Barrett’s Esophagus and Esophageal Ade-nocarcinoma.- Obesity, Inflammation and Breast Cancer.- Obesity, Inflammation, Nonalcoholic Fatty Liver Disease and Hepatocellular Carcino-ma.- Obesity, Inflammation and Prostate Cancer.- Pharmacologic Interventions With NSAIDs.- Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective.- Natural Products as Anti-inflammatory Agents.- Calorie Restriction and Cancer Prevention: Established and Emerging Mechanisms.- Vascular Targeting of Adipose Tissue.- Anti-Inflammatory Effects of Exercise.- Index.

Fields of interestCancer Research; Human Physiology; Biomedici-ne general



Due May 2013

2013. X, 370 p. 36 illus., 29 in color. (Energy Balance and Cancer, Volume 7)7 $209.00ISBN 978-1-4614-6818-9

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18

Current Topics in Microbiology and ImmunologyR. W. Compans, M. D. Cooper, F. Melchers, Series editor: M. B. Oldstone, P. K. Vogt, T. Honjo, Y. Y. Gleba, B. Malissen, Y. Kawaoka, K. Aktories, R. Rappuoli, J. E. Galan

Volume 358

U. Dobrindt, Universität Münster, Germany; J. H. Hacker, Deutsche Akademie der Naturforscher Leopoldina, Halle, Germany; C. Svanborg, Lund University, Sweden (Eds)

Between Pathogenicity and CommensalismContents Between Commensalism and Pathogenicity:Bacterial and Host Aspects.- E. coli as an all-rounder: The thin line between com-mensalism and pathogenicity.- What distingu-ishes non-pathogenic, from medium and highly pathogenic staphylococci?.- Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung.- Lactobacillus: Host-Microbe Relationships.- Bacterial Moonlighting Proteins and Bacterial Virulence.- Symbionts and pathogens - what is the difference?.- Host-microbe Interaction in the Intestinal Tract.- Ecology and physiology of the intestinal tract.- The gut microflora and its variety of roles in health and disease.- Mammalian intestinal host-microbe relationships.- Contribution of the intestinal mi-crobiota to human health - from birth to 100 years of age.- Subject index.

Fields of interestMedical Microbiology; Immunology; Vaccine



Due April 2013

2013. X, 380 p. 25 illus., 17 in color. Hardcover7 $209.00ISBN 978-3-642-36559-1

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L. D. Frappier, University of Toronto, ON, Canada

EBNA1 and Epstein-Barr Virus Associated TumoursThis SpringerBrief will a comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multi-ple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This Brief would offer a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions will also be discussed as well as implica-tions for tumourigenesis.

Features 7 Provide a comprehensive account of all EBNA1 functions and cellular effects 7 Discus-ses mechanistic basis of these EBNA1 functions and effects 7 Gives a balanced perspective by offering the most current evidence for and against EBNA1’s direct contribution to various cancers

Contents Introduction.- Roles of EBNA1 at EBV Episomes.- EBNA1-DNA Interactions.- EBNA1 Contributions to EBV-associated Tumours.- Cellular Effects of EBNA1.- Conclusion .

Fields of interestCancer Research; Virology; Medical Microbiology



Due April 2013

2013. V, 50 p. 5 illus. in color. (SpringerBriefs in Cancer Research, Volume 3)7 $49.95ISBN 978-1-4614-6885-1

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F. H. Gage, The Salk Institute for Biological Studies, La Jolla, CA, USA; Y. Christen, Fondation Ipsen, Boulogne Billancourt, France (Eds)

Programmed Cells from Basic Neuroscience to TherapyThe recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities.

Features 7 Presents latest research on neurodegenerative diseases 7 Presents prospects for novel thera-pies 7 Written by leading experts in the field

Contents Nuclear reprogramming by eggs and oocytes and eventual prospects of cell replacement thera-py.- iPS technology and disease research: issues to be resolved.- ES and iPS cells as tools for modeling human aging .-Characterizing neural circuitry with programmed human neurons.- Direct con-version of fibroblasts to neuronal cells.- Human pluripotent stem cells as tools for modelling neu-rodegeneration.- From Rett syndrome to classical autism: modeling autism spectrum disorders using human neurons.- Testing evolutionary principles in a dish using embryonic stem cells: the example of the Huntington‘s Disease gene.- Using stem cells to discover therapeutic targets in ALS and SMA .- Using stem cells to understand and treat Alzheimer‘s disease.- Using pluripotent stem cells to decipher mechanisms and identify treatments for diseases that affect the brain.- Modeling neural development and disease in human pluripotent stem cells.- Subject index.

Fields of interestNeurosciences; Stem Cells; Neurology



Due May 2013

2013. X, 140 p. 14 illus., 13 in color. (Research and Perspectives in Neurosciences, Volume 20)7 $139.00ISBN 978-3-642-36647-5

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19

J. Geigert, BioPharmaceutical Quality Solutions, Carlsbad, CA, USA

The Challenge of CMC Regulatory Compliance for BiopharmaceuticalsThis book highlights the challenges facing quality assurance/quality control (QA/QC) in today‘s biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufac-turing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval.

Features 7 Highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment 7 Presents the strategic importance and value generated by QA/QC for their involvement in control of manufac-turing 7 Revised 2nd Edition is broadened to include biopharmaceuticals (biotech drugs) and other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)

Contents Complexity of Biologica CMC Regulation.- Biolo-gics are Not Chemical Drugs.- An Effective CMC Strategy is Possible.- Challenge of Adventitious Agent Control.- Source Materials for Biologics.- Manufacture of the Biologic API.- The Biologic Final Product Process.- Complex Process-Related Impurities.- Molecular Structural Analysis.- Func-tional Activity (Potency).- Setting Specifications and Expiry Dates.- Demonstrating Product Com-parability.- CMC-Focused Regulatory Meetings.- References.

Fields of interestPharmaceutical Sciences/Technology; Biomedici-ne general



Due May 2013

2nd ed. 2013. X, 390 p. 24 illus., 11 in color. Hardcover7 $209.00ISBN 978-1-4614-6915-5

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E. Gulbins, University of Duisburg-Essen, Germany; I. Petrache, Indiana University, Indianapolis, IN, USA (Eds)

Sphingolipids in DiseaseContents Sphingolipids in Cancer: Sphingosine Kinase / Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance.- Using ASMase knockout Mice to Model Human Diseases.- New Perspectives on the Role of Sphingosine 1-Phos-phate in Cancer.- Sphingolipids and Response to Chemotherapy.- Lung Cancer and Lung Injury: The Dual Role of Ceramide.- Sphingolipids Role in Radiotherapy for Prostate Cancer.- Sphingolipids in Cardio-Reno-vascular diseases: Sphingolipid Metabolism and Atherosclerosis.- Cardiovascular Effects of Sphingosine-1-Phosphate S1P.- Cross-Talk between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease.- Sphingolipids in Inflammation, Infection and Lung Diseases.- Sphingolipids in Lung Endothelial Biology and Regulation of Vas-cular Integrity.- Sphingolipids in Acute Lung Inju-ry.- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases.- Ceramide in Cystic Fibrosis.- Regulation of the Sphingosine Kinase/Sphingosine 1 Phosphate Pathway.- Bacte-rial Infections and Ceramide.- Viral Infections and Sphingolipids.- Ceramide in Plasma Membrane Repair.- Sphingolipids and Inflammatory Diseases of the Skin.- Sphingolipids in Diabetes.- Sphingo-lipids in Neuro-psychiatry and Muscle Diseases: Neuronal Forms of Gaucher Disease.- Sphingo-lipids in Neuroinflammation.- Sphingolipids in Psychiatric Disorders and Pain Syndromes.- Role of Sphingosine-1-Phosphate in Sceletal Muscle Cell Biology.

Fields of interestPharmacology/Toxicology; Cardiology; Cancer Research



Due March 2013

2013. VIII, 564 p. 38 illus., 34 in color. (Handbook of Experimental Pharmacology, Volume 216) Hardcover7 $459.00ISBN 978-3-7091-1510-7

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A. Haim, B. A. Portnov, University of Haifa, Israel

Light Pollution as a New Risk Factor for Human Breast and Prostate CancersContents Preface.- Introduction.- PART 1: ARTIFICIAL LIGHT AND HUMAN TEMPORAL ORGANI-ZATION.- Artificial light and its physicochemical properties (by Fabio Falchi).- Light and dark cycles as a basis of temporal organization.- The biological clock and its entrainment by photope-riod.- LAN exposure and its potential effects on daily rhythms and seasonal disruptions.- Melato-nin (MLT) –“hormone of darkness” and a “jack of all traits”.- PART II: LIGHT POLLUTION, ITS KNOWN HEALTH EFFECTS AND IMPACT ON ENERGY CONSERVATION.- Introduction and spread of artificial illumination – a human history retrospective.- Biological definition of light pol-lution.- Light pollution as a general stressor.- The effects of light pollution on animal rhythms and ecology.- Light pollution and hormone-dependent cancers: summary of accumulated empirical evi-dence.- PART III: LIGHT POLLUTION AND ITS POTENTIAL LINKS TO BREAST AND PROS-TATE CANCERS.- Geographic patterns of breast and prostate cancers (BC&PC) worldwide.- Light pollution and its association with breast and pros-tate cancers (BC&PC) in population-level studies.- Selected methodological issues of Light-at-Night (LAN) – Breast and Prostate Cancers (BC&PC) research.- Dark-less world – what is next? (Con-clusions and prospects for future research).- BIB-LIOGRAPHY.- ADDITIONAL READING.

Fields of interestCancer Research; Environmental Health; Biome-dicine general



Due March 2013

2013. X, 166 p. 26 illus., 16 in color.7 $139.00ISBN 978-94-007-6219-0

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20

P. A. Iaizzo, R. W. Bianco, University of Minnesota, Minneapolis, MN, US; A. J. Hill, Medtronic Inc., Mounds View, MN, US; J. D. St. Louis, University of Minnesota, Minneapolis, MN, US (Eds)

Heart ValvesFrom Design to Clinical Implantation

Features 7 Chapters written by scientists and clinicians from leading academic and industrial institu-tions across the world 7 A helpful reference for patients, educators, students, device designers/de-velopers, clinical study specialists, clinicians, and other associated healthcare providers 7 Follows a translational approach to heart valves

Contents Part I - ANATOMY, PHYSIOLOGY, CONGE-NITAL DEFECTS, and DISEASE.- The anatomy and function of the atrioventricular valves.- The anatomy and function of the semilunar valves.- Congenital heart defects that include cardiac valve abnormalities.- Acquired valve disease and proces-ses.- Part II - VALVE REPAIR AND REPLACE-MENT.- History of heart valve repair.- Heart valve disease.- Advanced 3D imaging and transcatheter valve repair/ implantation.- Transcatheter mitral repair and replacement.- Percutaneous pulmonary valve implantation: the first transcatheter valve.- Transcatheter aortic valve implantation.- Tissue engineered heart valves.- Part III - TESTING AND REGULATORY ISSUES.- In vitro testing of heart valve substitutes.- Numerical methods for design and evaluation of prosthetic heart valves.- Animal models for cardiac valve research.- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies.- Successful development and regulatory approval of replace-ment cardiac valves.- Clinical trial requirements for cardiac valves.- Index.

Fields of interestBiomedicine general; Cardiology; Cardiac Surgery

Target groupsGraduate


Due February 2013

2013. XIII, 440 p. 169 illus., 111 in color. Hardcover7 $209.00ISBN 978-1-4614-6143-2

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R. L. Jirtle, University of Wisconsin-Madison, Madison, WI, USA; F. L. Tyson, National Institutes of Health, Research Triangle Park, NC, USA (Eds)

Environmental Epigenomics in Health and DiseaseEpigenetics and Disease Origins

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to envi-ronmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA me-thylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis.

Features 7 Provides evidence that environmental expo-sures during early development can alter the risk of developing medical conditions 7 Presents epigenetic processes that occur in human embry-onic stem cells, as well as in differentiating cells and organs such as the brain, discussing autism, schizophrenia and even sexual dimorphism in the developing brains of males and females. 7 Sum-marizes the latest epigenetic advances in the understanding of cancer development and pro-gression, with a special focus on DNA methylation alterations and their value in clinical oncology for cancer management

Fields of interestHuman Genetics; Cancer Research; Gene Func-tion



Due April 2013

2013. X, 314 p. 40 illus., 33 in color. (Epigenetics and Human Health)7 $189.00ISBN 978-3-642-23379-1

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R. L. Jirtle, University of Wisconsin-Madison,WI, USA; F. L. Tyson, NIH, Research Triangle Park, NC, USA (Eds)

Environmental Epigenomics in Health and DiseaseEpigenetics and Complex Diseases

Contents Preface.- Epigenetic programming of the brain.- Epigenetics and maternal brain evolution.- So-cial environment and DNA methylation: A mechanism for linking nurture and nature.- Sex differences in epigenetic programming of brain differentiation: Implications for mental health and disease.- Epigenetics and neurological disorders.- Phenotypic plasticity, pleiotropy, and the growth-first theory of imprinting.- The imprinted brain: How genes set the balance between autism and psychosis.- Epigenetics at the interface of genetics and environmental factors in autism.- Epigenomic and non-coding RNA regulation in addictive processes.- Epigenetic therapies in neurological diseases.- Epigenetics, nutrition, diabetes, and obesity.- Nutrition, histone epigenetic marks, and disease.- Chromatin switching and gene dynamics associated with type 2 diabetes.- Developmental epigenetic programming in diabetes and obesity.- Epigenetics and cancer.- Developmental repro-gramming by environmental estrogens: How early life exposures affect cancer risk in adulthood.- Hu-man cancer epigenetics.- Epigenetics and the law.- Legal and ethical implications of epigenetics.- Sub-ject index.

Fields of interestHuman Genetics; Cancer Research; Neurosciences



Due May 2013

2013. X, 310 p. 24 illus., 13 in color. (Epigenetics and Human Health)7 $209.00ISBN 978-3-642-36826-4

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21

P. D. Katsikis, Drexel University College of Medicine, Philadelphia, PA, USA; S. P. Schoenberger, La Jolla Institute for Allergy and Immunology, CA, USA; B. Pulendran, Emory University, Atlanta, GA, USA (Eds)

Crossroads Between Innate and Adaptive Immunity IVThis volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”.

Features 7 Covers the prestigious Aegean Conferen-ces 7 Edited by experts on vaccines and immune response 7 Draws on research in multiple fields of immunologic research

Contents Is Transcription the Dominant Force during Dynamic Changes in Gene Expression?.- MicroR-NAs: Key Components of Immune Regulation.- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV.- Natural Killer cell Licensing during Viral Infection.- Bridging Innate NK cell Functions with Adaptive Immunity.- Control of Innate Immunity by Memory CD4 T cells.- Stra-tegies and Implications for Prime-Boost Vaccina-tions to Generate Memory CD8 T Cells.- Blimp1: Driving Terminal Differentiation to a T.- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis.- Impact of Differential Glycosylation on IgG Activity.- Mu-rine Model of Chronic Respiratory Inflammati-on.- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1.- Influenza Vaccines: What do we Want and How can we Get it?.

Fields of interestImmunology; Microbiology; Virology



Due March 2013

2013. X, 172 p. 15 illus., 12 in color. (Advances in Experimental Medicine and Biology, Volume 785) Hardcover7 $189.00ISBN 978-1-4614-6216-3

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Y. Kohwi, C. T. McMurray, Lawrence Berkeley National Laboratory, CA, USA (Eds)

Trinucleotide Repeat ProtocolsContents A Brief History of Triplet Repeat Disease.- Huntington‘s Disease and Cell Therapies: Past, Present and Future.- Transcranial Two-Photon Imaging of Synaptic Structures in the Cortex of Awake Head-Restrained Mice.- In vivo Imaging of Synapse Plasticity in the Mouse Motor Cortex.- Pluripotent Hybrid Stem Cells from Transgenic Huntington’s Disease Monkey.- Mesenchymal Stem Cells for Trinucleotide Repeat Disorders.- Lentiviral-Mediated Gene Transfer of siRNAs for the Treatment of Huntington‘s Disease.- Purifi-cation of dFMR1-Containing Complexes Using Tandem Affinity Purification.- Combined FISH and Immunofluorescent Staining Methods to Co-localize Proteins and mRNA in Neurons and Brain Tissue.- Epigenetic Modifications of the FMR1 Gene.- The CGG Repeat and the FMR1 Gene.- Study of Oxidative Damage and Antioxidant Systems in Two Huntington´s Disease Rodent Models.- Regulation of Ataxin-1 Phosphorylation and Its Impact on Biology.- Towards Understan-ding Region-Specificity of Triplet Repeat Diseases: Coupled Immunohistology and Mass Spectro-metry Imaging.- Antibodies and Intrabodies Against Huntingtin: Production and Screening of Monoclonals and Single-Chain Recombinant Forms.- Cell Recovery from DM1 Transgenic Mouse Tissue to Study (CTG)n Instability and DM1 Pathogenesis.- Markerless Modification of Trinucleotide Repeat Loci in BACs.- DRPLA: Recent Advances in Research Using Transgenic Mouse Models.

Fields of interestMolecular Medicine; Gene Expression; Neurology



Due April 2013

2nd ed. 2013. XX, 322 p. 64 illus., 24 in color. (Methods in Molecular Biology, Volume 1010)7 $119.00ISBN 978-1-62703-410-4

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A. Kramer, Charité Universitätsmedizin Berlin, Germany; M. Merrow, LMU München, Germany (Eds)

Circadian ClocksThis book provides the reader with a contem-porary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.

Feature 7 A timely book about the widespread impact of circadian clocks for a broad readership in basic science but also translational and clinical medicine

Fields of interestPharmacology/Toxicology; Human Physiology; Neurosciences



Due March 2013

2013. X, 334 p. 57 illus., 33 in color. (Handbook of Experimental Pharmacology, Volume 217) Hardcover7 $419.00ISBN 978-3-642-25949-4

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Documents

Lipid-mediated Protein Organ Regeneration Signaling ... · Methods and Protocols Contents Isolation and Characterization of Human ... 45 in color. (Methods in Molecular Biology, Volume