Li, M., et al.

Apc

PLC+/+ +/+ +/- -/-

+/+ Min/+

Supplementary Fig. 1

Li, M., et al. Supplementary Fig. 2

+/+

-/-

PLC

low-grade high-grade

Nor

mal

low

-gra

dead

enom

ahi

gh-g

rade

aden

oma

+/+ -/-PLC

N

T

N

T

N

T

N

T

Supplementary Fig. 3Li, M., et al.

Supplementary Fig. 4Li, M., et al.

+/+

-/-

PLC

low-grade

high-grade

+/+

-/-

PLC

DAPI TUNEL

Supplementary Fig. 5Li, M., et al.

+/+ -/-PLC

low

-gra

de

hig

h-g

rad

e

Supplementary Fig. 6Li, M., et al.

DAPI CD31

+/+

-/-

PLC

low-grade

high-grade

+/+

-/-

PLC

Supplementary Fig. 7Li, M., et al.

DAPI Gr-1+

/+-/

-

PLC

low-grade

high-grade

+/+

-/-

PLC

Supplementary Fig. 8Li, M., et al.

IL-6

0

1000

2000

3000

4000

5000

IGF-1

01234567

CD44

0

5

10

15

20

25

FGF10

01234567

MMP7

0

2

4

6

8

+/+ -/-PLC

Re

lativ

e m

RN

A le

vels

Re

lativ

e m

RN

A le

vels

+/+ -/-PLC

+/+ -/-PLC

+/+ -/-PLC

+/+ -/-PLC

***

***

***

**

***

Supplementary Fig. 9Li, M., et al.

anti-PLC Alcian Blue