LeukemiaRaid Marji MDAcute Leukemia:Essentials: Short course of symptoms Fatigue, fever, easy bruising, bleeding Cytopenias - or pancytopenia More than 20% blasts in bone marro !lasts in peripheral blood in "0% casesAcute Myeloid Leukemia (AML):Incidence: 2#$ per %00,000 people per year &igher among men than omen '2#" vs %#"( Most common leu)emia in adults '*0% of cases( +ast ma,ority of patients 65 years or older65 years or olderAcute Myeloid Leukemia (AML):Etiology: -enetic .adiation /o0ic chemical e0posure Medication '1l)ylating-agents, /opoisomerase-22 inibitors, Chloramphenicol, 3henylbuta4one, Chloro5uine, and Metho0ypsoralen(Acute Myeloid Leukemia (AML):Most Common Presenting !: Fatigue '60%( 1nore0ia '$0-70%( 8eight loss '$0-70%( Fever ithout evident cause '%0%( 9asy !ruising '6%( !leeding '6%(Acute Myeloid Leukemia (AML):ym"toms: :onspecific Most related to anemia, leu)ocytosis, leu)openia, leu)ocyte dysfunction, or thrombocytopenia Symptoms usually present for $ months or more before diagnosis is madeAcute Myeloid Leukemia (AML):#t$er Common !: !one pain ;ymphadenopathy :on-specific cough &eadaches 90cessive diaphoresis Symptoms secondary to mass lesions 'granulocytic sarcoma or chloroma(Acute Myeloid Leukemia (AML):P$ysical %indings: Fever Splenomegaly Sternal tenderness Multiple bruises !leeding 'gingivae most common(