-
Komplexy zlata v
medicnthioglukza(Solganol)2,3,4,5-tetra-O-acetyl-1-1--D-S-thioglukozyl(triethylfosfin)zlatn
komplex (Auranofin)4-amino-2-merkapto-benzoov
kyselina(Krysolgan)thiomaltsodnozlatn(Myochrisin)thiopropanolsulfont(Allocrysine)
-
Koordinace zlata[ NC Au CN ]
-
CisplatinThe story of the invention of the anticancer drug
cisplatin is a story of chemistry hidden in the science of
biology
-
Normal and elongated E. coli: (a) scanning electron
microphoto-graph of normal E. coli (Gram-negative rods); scanning
electron micro-photograph of E. coli grown in medium containing a
few parts per million of cis-diamminedichloroplatinum(II) (same
magnification in all pictures). The platinum drug has inhibited
cell division, but not growth, leading to long filaments.The
serendipitous result of this experiment was that it was not the
electric fields that inhibited bacterial growth but rather a
platinum containing complex that later came to be known as
cisplatin.
-
CisplatinaTime sequence photographs of two mice with solid
Sarcoma 180 tumors. The mouse at the top was an untreated negative
control. She died on day 21 when the tumor weighed about 3g. The
bottom mouse was in the group treated on day 8 with an
intraperitoneal injection of cis-diamminedichloroplatinum(II). Her
tumor was completely regressed six days after treatment, and she
died of age-related causes almost 3 years later.
-
CisplatinaA group of researchers at Michigan State University
subsequently found that cisplatin could also be used to inhibit the
growth of cancer cells. For the past twenty years, cisplatin has
proven to be highly effective for the treatment of various cancers,
particularly testicular cancer.
-
CisplatinaOctober of 1996 - Tests revealed advanced testicular
cancer that had spread to his lungs and his brain.
He began an aggressive form of chemotherapy by the Platinol)
In May of 1998 Lance celebrated his victory over cancer and his
"official" return to U.S. cycling by winning the Sprint 56K
Criterium
1999- he won Tour de Franceand his son Luke was born happy and
healthy Oct 12th.
-
Komplexy platiny trans efekt
-
Hydrolza cisplatinypKa = 6,3pKa = 5,6pKa = 7,3
-
CisplatinaAplikacecisplatinydo organismu
-
Komplexy platiny CisplatinaMechanisms of cisplatin uptake and
efflux. In addition to passive diffusion, cisplatin is also
actively imported by the copper transporter CTR1.
Copper-transporting P-type adenosine triphosphate (ATP7B) has a
role in cisplatin efflux.Wang, Lippard, Nature Reviews Drug
Discovery, 2005
-
195Pt NMR spektrainterakce cisplatiny s DNA
-
Cisplatinastrukturn vlivcisplatinyvzan na DNA
-
CisplatinaNavznplatiny na DNA
-
CisplatinaNavzn platinyna guanidin v DNA
-
Komplexy platinyRTG struktura aduktucisplatiny a d(pGpG)
-
Komplexy platinyKomplex cisplatiny a DNA
-
Komplexy platiny Cisplatina
-
Strukturn zmny v DNA:Adukty DNA cisplatinaJamieson and Lippard,
Chem Rev, 99, 2467 (1999); Coste, et al, Nucleic Acids Res, 27,
1837 (1999).
-
Komplexy platiny CisplatinaBending: 32 3445Unwinding: 16
2079Interstrand cross-linkIntrastrand cross-link
-
Komplexy platiny CisplatinaCisplatin-DNA adducts may cause
various cellular responses:Wang, Lippard, Nature Reviews Drug
Discovery, 2005
-
Komplexy platiny CisplatinaMajor mechanisms of resistance to
cisplatin: Inactivation of cisplatin by glutathione,
metallothionein or other sulfur-containing molecules Increased
repair of cisplatin adducts Reduced cisplatin accumulation by
changing the profile of uptake /efflux Increased cisplatin adducts
tolerance and failure of apoptotic pathways
-
Metody molekulrnhoa bunnho zobrazovnCT computer tomography
MR magnetic resonance imaging
SPECT single photon emission computer tomography
PET positron emission tomography
Optick metody
-
Magnetick resonance + Komplexace radionuklid Vyaduje ligandy
Kontrastn ltky pro jednotliv zobrazovac techniky CT jodidov
derivty organickch ltek
MR komplexn sloueniny Gd(III)
SPECT 99mTc
PET 11C, 18F, ( 15O, 13N ), 68Ga
Optick metody fluorescenn znaky, organick ltky, komplexy
lanthanoid
-
MRI 200523 milions MR examinations in US ( 25 % )In world near
100 milions examinationsContrast agents are used for more than 35 %
Examinations
-
Principy NMR a MR NMR variabilita frekvence posice pk
-
Principy MR MR intensita pk (protony mol. vody) + prostorov
rozlien gradient mg. poleThe figure was adopted from U. S. patent
832 of Dr. R. Damadian on 3D MRI scanner. The patent was filled on
March 17, 1972 .
P. C. Lauterbur, P. Mansfield ( Nobel Prize 2003 ) , R. Ernst
(1991) Discrete Fourier Transormation
-
Principy MRKontrast v MR vznik na zklad odlin koncentrace vody v
rznch typech tkn a z rznho odlinho relaxanho asu proton vody.
Proton longitudinal podln T1 magnetick relaxan as Proton
transversal pn T2
T1 positivn kontrast, T2 negativn kontrast
-
Kontrastn ltky jsou uvny v ca 40 % vyeten Vce ne 95 %
kontrastnch ltek je zaloeno na Gd ( III )Proton longitudinal T1
paramagnetick sticeProton transversal T2 ferromagnetick
sticeKontrastn ltky pro MR
-
Kontrastn ltky pro NMR diagnostiku
-
Ligandy pro aplikaci v medicnH5dtpaH4dotaH3do3aH4teta
-
Struktura komplex[ Gd (dtpa)] 2[ Gd (dota)]
-
Pouvan kontrastn ltky
-
Ligandy pro aplikaci v medicnH5dtpaH4dota
GrafDTPA-BMA
67.39932.601
64.5435.46
61.64438.356
58.73441.266
55.83144.169
52.95447.046
50.12149.879
47.34852.652
44.64855.352
42.03257.968
39.50860.492
37.08562.915
34.76565.235
32.55367.447
30.44969.551
28.45471.546
26.56873.432
24.78775.213
23.1176.89
21.53478.466
20.05579.945
18.66881.332
17.3782.63
16.15783.843
15.02584.975
13.96886.032
12.98287.018
12.06487.936
11.2188.79
10.41589.585
9.67690.324
8.98891.012
8.3591.65
7.75692.244
7.20592.795
6.69493.306
6.21993.781
5.77894.222
5.36994.631
4.98995.011
4.63795.363
4.30995.691
4.00695.994
3.72496.276
3.46396.537
3.2296.78
2.99597.005
2.78697.214
2.59297.408
2.41297.588
2.24497.756
2.08997.911
1.94598.055
1.81198.189
1.68698.314
1.5798.43
1.46398.537
1.36398.637
1.2798.73
1.18498.816
1.10398.897
1.02998.971
0.95999.041
0.89599.105
0.83499.166
0.77899.222
0.72699.274
0.67899.322
0.63399.367
0.59199.409
0.55299.448
0.51599.485
0.48199.519
0.4599.55
0.4299.58
0.39399.607
0.36799.633
0.34399.657
0.32199.679
0.399.7
0.28199.719
0.26399.737
0.24699.754
0.2399.77
0.21699.784
0.20299.798
0.18999.811
0.17799.823
0.16699.834
0.15699.844
0.14699.854
0.13799.863
0.12999.871
0.12199.879
0.11399.887
0.10699.894
0.199.9
0.09499.906
0.08899.912
0.08399.917
0.07899.922
0.07399.927
0.06999.931
0.06599.935
0.06199.939
0.05899.942
0.05499.946
0.05199.949
0.04899.952
0.04599.955
0.04399.957
0.0499.96
0.03899.962
0.03699.964
0.03499.966
0.03299.968
0.0399.97
0.02999.971
0.02799.973
0.02699.974
0.02499.976
0.02399.977
0.02299.978
0.02199.979
0.0299.98
0.01999.981
0.01899.982
0.01799.983
0.01699.984
0.01599.985
0.01499.986
0.01499.986
0.01399.987
0.01299.988
0.01299.988
0.01199.989
0.01199.989
0.0199.99
0.0199.99
0.00999.991
0.00999.991
0.00899.992
0.00899.992
0.00899.992
0.00799.993
0.00799.993
0.00799.993
0.00699.994
0.00699.994
0.00699.994
0.00699.994
0.00599.995
0.00599.995
0.00599.995
0.00599.995
0.00599.995
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
Gd(III)
[GdL]
pH
% Gd(III)
Gd-DTPABMA
DTPA-BMA
167.39932.601
1.0264.5435.46
1.0461.64438.356
1.0658.73441.266
1.0855.83144.169
1.152.95447.046
1.1250.12149.879
1.1447.34852.652
1.1644.64855.352
1.1842.03257.968
1.239.50860.492
1.2237.08562.915
1.2434.76565.235
1.2632.55367.447
1.2830.44969.551
1.328.45471.546
1.3226.56873.432
1.3424.78775.213
1.3623.1176.89
1.3821.53478.466
1.420.05579.945
1.4218.66881.332
1.4417.3782.63
1.4616.15783.843
1.4815.02584.975
1.513.96886.032
1.5212.98287.018
1.5412.06487.936
1.5611.2188.79
1.5810.41589.585
1.69.67690.324
1.628.98891.012
1.648.3591.65
1.667.75692.244
1.687.20592.795
1.76.69493.306
1.726.21993.781
1.745.77894.222
1.765.36994.631
1.784.98995.011
1.84.63795.363
1.824.30995.691
1.844.00695.994
1.863.72496.276
1.883.46396.537
1.93.2296.78
1.922.99597.005
1.942.78697.214
1.962.59297.408
1.982.41297.588
22.24497.756
2.022.08997.911
2.041.94598.055
2.061.81198.189
2.081.68698.314
2.11.5798.43
2.121.46398.537
2.141.36398.637
2.161.2798.73
2.181.18498.816
2.21.10398.897
2.221.02998.971
2.240.95999.041
2.260.89599.105
2.280.83499.166
2.30.77899.222
2.320.72699.274
2.340.67899.322
2.360.63399.367
2.380.59199.409
2.40.55299.448
2.420.51599.485
2.440.48199.519
2.460.4599.55
2.480.4299.58
2.50.39399.607
2.520.36799.633
2.540.34399.657
2.560.32199.679
2.580.399.7
2.60.28199.719
2.620.26399.737
2.640.24699.754
2.660.2399.77
2.680.21699.784
2.70.20299.798
2.720.18999.811
2.740.17799.823
2.760.16699.834
2.780.15699.844
2.80.14699.854
2.820.13799.863
2.840.12999.871
2.860.12199.879
2.880.11399.887
2.90.10699.894
2.920.199.9
2.940.09499.906
2.960.08899.912
2.980.08399.917
30.07899.922
3.020.07399.927
3.040.06999.931
3.060.06599.935
3.080.06199.939
3.10.05899.942
3.120.05499.946
3.140.05199.949
3.160.04899.952
3.180.04599.955
3.20.04399.957
3.220.0499.96
3.240.03899.962
3.260.03699.964
3.280.03499.966
3.30.03299.968
3.320.0399.97
3.340.02999.971
3.360.02799.973
3.380.02699.974
3.40.02499.976
3.420.02399.977
3.440.02299.978
3.460.02199.979
3.480.0299.98
3.50.01999.981
3.520.01899.982
3.540.01799.983
3.560.01699.984
3.580.01599.985
3.60.01499.986
3.620.01499.986
3.640.01399.987
3.660.01299.988
3.680.01299.988
3.70.01199.989
3.720.01199.989
3.740.0199.99
3.760.0199.99
3.780.00999.991
3.80.00999.991
3.820.00899.992
3.840.00899.992
3.860.00899.992
3.880.00799.993
3.90.00799.993
3.920.00799.993
3.940.00699.994
3.960.00699.994
3.980.00699.994
40.00699.994
4.020.00599.995
4.040.00599.995
4.060.00599.995
4.080.00599.995
4.10.00599.995
4.120.00499.996
4.140.00499.996
4.160.00499.996
4.180.00499.996
4.20.00499.996
4.220.00499.996
4.240.00399.997
4.260.00399.997
4.280.00399.997
4.30.00399.997
4.320.00399.997
4.340.00399.997
4.360.00399.997
4.380.00399.997
4.40.00399.997
4.420.00299.998
4.440.00299.998
4.460.00299.998
4.480.00299.998
4.50.00299.998
4.520.00299.998
4.540.00299.998
4.560.00299.998
4.580.00299.998
4.60.00299.998
4.620.00299.998
4.640.00299.998
4.660.00299.998
4.680.00299.998
4.70.00299.998
4.720.00299.998
4.740.00199.999
4.760.00199.999
4.780.00199.999
4.80.00199.999
4.820.00199.999
4.840.00199.999
4.860.00199.999
4.880.00199.999
4.90.00199.999
4.920.00199.999
4.940.00199.999
4.960.00199.999
4.980.00199.999
50.00199.999
5.020.00199.999
5.040.00199.999
5.060.00199.999
5.080.00199.999
5.10.00199.999
5.120.00199.999
5.140.00199.999
5.160.00199.999
5.180.00199.999
5.20.00199.999
5.220.00199.999
5.240.00199.999
5.260.00199.999
5.280.00199.999
5.30.00199.999
5.320.00199.999
5.340.00199.999
5.360.00199.999
5.380.00199.999
5.40.00199.999
5.420.00199.999
5.440.00199.999
5.460.00199.999
5.480.00199.999
5.50.00199.999
5.520.00199.999
5.540100
5.560100
5.580100
5.60100
5.620100
5.640100
5.660100
5.680100
5.70100
5.720100
5.740100
5.760100
5.780100
5.80100
5.820100
5.840100
5.860100
5.880100
5.90100
5.920100
5.940100
5.960100
5.980100
60100
6.020100
6.040100
6.060100
6.080100
6.10100
6.120100
6.140100
6.160100
6.180100
6.20100
6.220100
6.240100
6.260100
6.280100
6.30100
6.320100
6.340100
6.360100
6.380100
6.40100
6.420100
6.440100
6.460100
6.480100
6.50100
6.520100
6.540100
6.560100
6.580100
6.60100
6.620100
6.640100
6.660100
6.680100
6.70100
6.720100
6.740100
6.760100
6.780100
6.80100
6.820100
6.840100
6.860100
6.880100
6.90100
6.920100
6.940100
6.960100
6.980100
70100
7.020100
7.040100
7.060100
7.080100
7.10100
7.120100
7.140100
7.160100
7.180100
7.20100
7.220100
7.240100
7.260100
7.280100
7.30100
7.320100
7.340100
7.360100
7.380100
7.40100
7.420100
7.440100
7.460100
7.480100
7.50100
7.520100
7.540100
7.560100
7.580100
7.60100
7.620100
7.640100
7.660100
7.680100
7.70100
7.720100
7.740100
7.760100
7.780100
7.80100
7.820100
7.840100
7.860100
7.880100
7.90100
7.920100
7.940100
7.960100
7.980100
80100
8.020100
8.040100
8.060100
8.080100
8.10100
8.120100
8.140100
8.160100
8.180100
8.20100
8.220100
8.240100
8.260100
8.280100
8.30100
8.320100
8.340100
8.360100
8.380100
8.40100
8.420100
8.440100
8.460100
8.480100
8.50100
8.520100
8.540100
8.560100
8.580100
8.60100
8.620100
8.640100
8.660100
8.680100
8.70100
8.720100
8.740100
8.760100
8.780100
8.80100
8.820100
8.840100
8.860100
8.880100
8.90100
8.920100
8.940100
8.960100
8.980100
90100
9.020100
9.040100
9.060100
9.080100
9.10100
9.120100
9.140100
9.160100
9.180100
9.20100
9.220100
9.240100
9.260100
9.280100
9.30100
9.320100
9.340100
9.360100
9.380100
9.40100
9.420100
9.440100
9.460100
9.480100
9.50100
9.520100
9.540100
9.560100
9.580100
9.60100
9.620100
9.640100
9.660100
9.680100
9.70100
9.720100
9.740100
9.760100
9.780100
9.80100
9.820100
9.840100
9.860100
9.880100
9.90100
9.920100
9.940100
9.960100
9.980100
100100
10.020100
10.040100
10.060100
10.080100
10.10100
10.120100
10.140100
10.160100
10.180100
10.20100
10.220100
10.240100
10.260100
10.280100
10.30100
10.320100
10.340100
10.360100
10.380100
10.40100
10.420100
10.440100
10.460100
10.480100
10.50100
10.520100
10.540100
10.560100
10.580100
10.60100
10.620100
10.640100
10.660100
10.680100
10.70100
10.720100
10.740100
10.760100
10.780100
10.80100
10.820100
10.840100
10.860100
10.880100
10.90100
10.920100
10.940100
10.960100
10.980100
110100
11.020100
11.040100
11.060100
11.080100
11.10100
11.120100
11.140100
11.160100
11.180100
11.20100
11.220100
11.240100
11.260100
11.280100
11.30100
11.320100
11.340100
11.360100
11.380100
11.40100
11.420100
11.440100
11.460100
11.480100
11.50100
11.520100
11.540100
11.560100
11.580100
11.60100
11.620100
11.640100
11.660100
11.680100
11.70100
11.720100
11.740100
11.760100
11.780100
11.80100
11.820100
11.840100
11.860100
11.880100
11.90100
11.920100
11.940100
11.960100
11.980100
120100
GrafDTPA
99.8630.0050.132
99.8260.0070.167
99.780.0090.211
99.7220.0120.266
99.6490.0160.335
99.5580.0220.421
99.4440.0280.528
99.3010.0370.662
99.1230.0490.828
98.9030.0641.034
98.6290.0831.288
98.2920.1081.6
97.8770.141.983
97.3690.1822.45
96.750.2343.016
96.0020.3013.698
95.1020.3844.514
94.030.4895.482
92.7630.6186.619
91.2820.7767.942
89.5690.9689.463
87.6121.19911.189
85.4041.47213.123
82.9491.79315.258
80.2552.16317.582
77.3432.58620.071
74.2393.06222.699
70.9773.59225.431
67.5944.17628.231
64.1314.8131.059
60.6295.49433.877
57.1266.22436.65
53.6586.99739.345
50.2577.80941.935
46.9498.65644.395
43.7569.53646.708
40.69510.44648.859
37.77711.38250.841
35.01112.34252.647
32.40113.32354.276
29.94814.32455.728
27.65115.34357.006
25.50716.37958.115
23.51117.4359.06
21.65718.49559.848
19.93919.57360.488
18.34920.66560.986
16.88121.76861.351
15.52722.88361.59
14.27824.00961.713
13.12925.14661.725
12.07226.29261.636
11.127.44961.451
10.20628.61561.178
9.38629.7960.824
8.63230.97460.394
7.9432.16559.894
7.30533.36459.331
6.72234.5758.708
6.18735.78258.031
5.69636.99957.305
5.24538.22156.534
4.83139.44855.721
4.45140.67754.872
4.10241.90953.989
3.78143.14253.077
3.48644.37652.138
3.21545.6151.175
2.96746.84250.192
2.73848.07149.191
2.52749.29748.175
2.33450.51947.147
2.15551.73546.109
1.99152.94545.064
1.8454.14744.012
1.70155.34142.958
1.57356.52541.902
1.45557.69840.847
1.34658.8639.794
1.24660.00938.745
1.15361.14537.702
1.06862.26736.665
0.98963.37335.637
0.91664.46434.619
0.84965.53933.612
0.78766.59632.617
0.7367.63531.635
0.67768.65630.667
0.62869.65829.715
0.58270.6428.777
0.5471.60327.857
0.50272.54526.953
0.46673.46726.067
0.43274.36825.199
0.40275.24824.35
0.37376.10723.519
0.34776.94522.708
0.32277.76121.916
0.378.55721.144
0.27979.3320.391
0.25980.08319.658
0.24180.81418.945
0.22481.52518.251
0.20982.21417.577
0.19482.88316.923
0.18183.53216.287
0.16884.1615.671
0.15784.76915.074
0.14685.35814.496
0.13685.92813.936
0.12786.47913.394
0.11887.01212.87
0.1187.52612.363
0.10388.02311.874
0.09688.50311.401
0.08988.96510.945
0.08389.41210.505
0.07889.84210.08
0.07390.2569.671
0.06890.6559.277
0.06391.048.897
0.05991.418.531
0.05591.7668.179
0.05292.1097.84
0.04892.4387.514
0.04592.7557.2
0.04293.0596.899
0.03993.3526.609
0.03793.6336.33
0.03593.9036.063
0.03294.1625.806
0.0394.415.559
0.02894.6495.323
0.02694.8785.095
0.02595.0984.877
0.02395.3094.668
0.02295.5114.467
0.0295.7054.275
0.01995.894.09
0.01896.0683.914
0.01796.2393.744
0.01696.4033.582
0.01596.5593.426
0.01496.7093.277
0.01396.8533.134
0.01296.992.997
0.01197.1222.866
0.01197.2482.741
0.0197.3692.621
0.0197.4852.506
0.00997.5952.396
0.00897.7012.29
0.00897.8032.19
0.00797.8992.093
0.00797.9922.001
0.00798.0811.912
0.00698.1661.828
0.00698.2471.747
0.00698.3251.67
0.00598.3991.596
0.00598.471.525
0.00598.5381.457
0.00498.6031.393
0.00498.6651.331
0.00498.7241.272
0.00498.7811.215
0.00398.8351.161
0.00398.8871.11
0.00398.9371.06
0.00398.9841.013
0.00399.0290.968
0.00399.0730.925
0.00299.1140.883
0.00299.1540.844
0.00299.1920.806
0.00299.2280.77
0.00299.2620.736
0.00299.2950.703
0.00299.3270.672
0.00299.3570.642
0.00299.3860.613
0.00299.4130.585
0.00199.4390.559
0.00199.4640.534
0.00199.4880.51
0.00199.5110.487
0.00199.5330.466
0.00199.5540.445
0.00199.5740.425
0.00199.5930.406
0.00199.6120.388
0.00199.6290.37
0.00199.6460.354
0.00199.6610.338
0.00199.6770.323
0.00199.6910.308
0.00199.7050.294
0.00199.7180.281
0.00199.7310.268
0.00199.7430.256
0.00199.7550.245
0.00199.7660.234
0.00199.7760.223
099.7860.213
099.7960.204
099.8050.195
099.8140.186
099.8220.178
099.830.17
099.8380.162
099.8450.155
099.8520.148
099.8590.141
099.8650.135
099.8710.129
099.8770.123
099.8820.117
099.8880.112
099.8930.107
099.8980.102
099.9020.098
099.9070.093
099.9110.089
099.9150.085
099.9190.081
099.9220.078
099.9260.074
099.9290.071
099.9320.068
099.9350.065
099.9380.062
099.9410.059
099.9440.056
099.9460.054
099.9490.051
099.9510.049
099.9530.047
099.9550.045
099.9570.043
099.9590.041
099.9610.039
099.9630.037
099.9640.035
099.9660.034
099.9680.032
099.9690.031
099.970.03
099.9720.028
099.9730.027
099.9740.026
099.9750.025
099.9770.023
099.9780.022
099.9790.021
099.980.02
099.980.019
099.9810.019
099.9820.018
099.9830.017
099.9840.016
099.9840.015
099.9850.015
099.9860.014
099.9860.013
099.9870.013
099.9880.012
099.9880.012
099.9890.011
099.9890.011
099.990.01
099.990.01
099.9910.009
099.9910.009
099.9910.009
099.9920.008
099.9920.008
099.9930.007
099.9930.007
099.9930.007
099.9940.006
099.9940.006
099.9940.006
099.9940.006
099.9950.005
099.9950.005
099.9950.005
099.9950.005
099.9960.004
099.9960.004
099.9960.004
099.9960.004
099.9960.004
099.9960.004
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
Gd(III)
[GdL]
[HGdL]
pH
% Gd(III)
Gd-DTPA
DTPA
199.8630.0050.132
1.0299.8260.0070.167
1.0499.780.0090.211
1.0699.7220.0120.266
1.0899.6490.0160.335
1.199.5580.0220.421
1.1299.4440.0280.528
1.1499.3010.0370.662
1.1699.1230.0490.828
1.1898.9030.0641.034
1.298.6290.0831.288
1.2298.2920.1081.6
1.2497.8770.141.983
1.2697.3690.1822.45
1.2896.750.2343.016
1.396.0020.3013.698
1.3295.1020.3844.514
1.3494.030.4895.482
1.3692.7630.6186.619
1.3891.2820.7767.942
1.489.5690.9689.463
1.4287.6121.19911.189
1.4485.4041.47213.123
1.4682.9491.79315.258
1.4880.2552.16317.582
1.577.3432.58620.071
1.5274.2393.06222.699
1.5470.9773.59225.431
1.5667.5944.17628.231
1.5864.1314.8131.059
1.660.6295.49433.877
1.6257.1266.22436.65
1.6453.6586.99739.345
1.6650.2577.80941.935
1.6846.9498.65644.395
1.743.7569.53646.708
1.7240.69510.44648.859
1.7437.77711.38250.841
1.7635.01112.34252.647
1.7832.40113.32354.276
1.829.94814.32455.728
1.8227.65115.34357.006
1.8425.50716.37958.115
1.8623.51117.4359.06
1.8821.65718.49559.848
1.919.93919.57360.488
1.9218.34920.66560.986
1.9416.88121.76861.351
1.9615.52722.88361.59
1.9814.27824.00961.713
213.12925.14661.725
2.0212.07226.29261.636
2.0411.127.44961.451
2.0610.20628.61561.178
2.089.38629.7960.824
2.18.63230.97460.394
2.127.9432.16559.894
2.147.30533.36459.331
2.166.72234.5758.708
2.186.18735.78258.031
2.25.69636.99957.305
2.225.24538.22156.534
2.244.83139.44855.721
2.264.45140.67754.872
2.284.10241.90953.989
2.33.78143.14253.077
2.323.48644.37652.138
2.343.21545.6151.175
2.362.96746.84250.192
2.382.73848.07149.191
2.42.52749.29748.175
2.422.33450.51947.147
2.442.15551.73546.109
2.461.99152.94545.064
2.481.8454.14744.012
2.51.70155.34142.958
2.521.57356.52541.902
2.541.45557.69840.847
2.561.34658.8639.794
2.581.24660.00938.745
2.61.15361.14537.702
2.621.06862.26736.665
2.640.98963.37335.637
2.660.91664.46434.619
2.680.84965.53933.612
2.70.78766.59632.617
2.720.7367.63531.635
2.740.67768.65630.667
2.760.62869.65829.715
2.780.58270.6428.777
2.80.5471.60327.857
2.820.50272.54526.953
2.840.46673.46726.067
2.860.43274.36825.199
2.880.40275.24824.35
2.90.37376.10723.519
2.920.34776.94522.708
2.940.32277.76121.916
2.960.378.55721.144
2.980.27979.3320.391
30.25980.08319.658
3.020.24180.81418.945
3.040.22481.52518.251
3.060.20982.21417.577
3.080.19482.88316.923
3.10.18183.53216.287
3.120.16884.1615.671
3.140.15784.76915.074
3.160.14685.35814.496
3.180.13685.92813.936
3.20.12786.47913.394
3.220.11887.01212.87
3.240.1187.52612.363
3.260.10388.02311.874
3.280.09688.50311.401
3.30.08988.96510.945
3.320.08389.41210.505
3.340.07889.84210.08
3.360.07390.2569.671
3.380.06890.6559.277
3.40.06391.048.897
3.420.05991.418.531
3.440.05591.7668.179
3.460.05292.1097.84
3.480.04892.4387.514
3.50.04592.7557.2
3.520.04293.0596.899
3.540.03993.3526.609
3.560.03793.6336.33
3.580.03593.9036.063
3.60.03294.1625.806
3.620.0394.415.559
3.640.02894.6495.323
3.660.02694.8785.095
3.680.02595.0984.877
3.70.02395.3094.668
3.720.02295.5114.467
3.740.0295.7054.275
3.760.01995.894.09
3.780.01896.0683.914
3.80.01796.2393.744
3.820.01696.4033.582
3.840.01596.5593.426
3.860.01496.7093.277
3.880.01396.8533.134
3.90.01296.992.997
3.920.01197.1222.866
3.940.01197.2482.741
3.960.0197.3692.621
3.980.0197.4852.506
40.00997.5952.396
4.020.00897.7012.29
4.040.00897.8032.19
4.060.00797.8992.093
4.080.00797.9922.001
4.10.00798.0811.912
4.120.00698.1661.828
4.140.00698.2471.747
4.160.00698.3251.67
4.180.00598.3991.596
4.20.00598.471.525
4.220.00598.5381.457
4.240.00498.6031.393
4.260.00498.6651.331
4.280.00498.7241.272
4.30.00498.7811.215
4.320.00398.8351.161
4.340.00398.8871.11
4.360.00398.9371.06
4.380.00398.9841.013
4.40.00399.0290.968
4.420.00399.0730.925
4.440.00299.1140.883
4.460.00299.1540.844
4.480.00299.1920.806
4.50.00299.2280.77
4.520.00299.2620.736
4.540.00299.2950.703
4.560.00299.3270.672
4.580.00299.3570.642
4.60.00299.3860.613
4.620.00299.4130.585
4.640.00199.4390.559
4.660.00199.4640.534
4.680.00199.4880.51
4.70.00199.5110.487
4.720.00199.5330.466
4.740.00199.5540.445
4.760.00199.5740.425
4.780.00199.5930.406
4.80.00199.6120.388
4.820.00199.6290.37
4.840.00199.6460.354
4.860.00199.6610.338
4.880.00199.6770.323
4.90.00199.6910.308
4.920.00199.7050.294
4.940.00199.7180.281
4.960.00199.7310.268
4.980.00199.7430.256
50.00199.7550.245
5.020.00199.7660.234
5.040.00199.7760.223
5.06099.7860.213
5.08099.7960.204
5.1099.8050.195
5.12099.8140.186
5.14099.8220.178
5.16099.830.17
5.18099.8380.162
5.2099.8450.155
5.22099.8520.148
5.24099.8590.141
5.26099.8650.135
5.28099.8710.129
5.3099.8770.123
5.32099.8820.117
5.34099.8880.112
5.36099.8930.107
5.38099.8980.102
5.4099.9020.098
5.42099.9070.093
5.44099.9110.089
5.46099.9150.085
5.48099.9190.081
5.5099.9220.078
5.52099.9260.074
5.54099.9290.071
5.56099.9320.068
5.58099.9350.065
5.6099.9380.062
5.62099.9410.059
5.64099.9440.056
5.66099.9460.054
5.68099.9490.051
5.7099.9510.049
5.72099.9530.047
5.74099.9550.045
5.76099.9570.043
5.78099.9590.041
5.8099.9610.039
5.82099.9630.037
5.84099.9640.035
5.86099.9660.034
5.88099.9680.032
5.9099.9690.031
5.92099.970.03
5.94099.9720.028
5.96099.9730.027
5.98099.9740.026
6099.9750.025
6.02099.9770.023
6.04099.9780.022
6.06099.9790.021
6.08099.980.02
6.1099.980.019
6.12099.9810.019
6.14099.9820.018
6.16099.9830.017
6.18099.9840.016
6.2099.9840.015
6.22099.9850.015
6.24099.9860.014
6.26099.9860.013
6.28099.9870.013
6.3099.9880.012
6.32099.9880.012
6.34099.9890.011
6.36099.9890.011
6.38099.990.01
6.4099.990.01
6.42099.9910.009
6.44099.9910.009
6.46099.9910.009
6.48099.9920.008
6.5099.9920.008
6.52099.9930.007
6.54099.9930.007
6.56099.9930.007
6.58099.9940.006
6.6099.9940.006
6.62099.9940.006
6.64099.9940.006
6.66099.9950.005
6.68099.9950.005
6.7099.9950.005
6.72099.9950.005
6.74099.9960.004
6.76099.9960.004
6.78099.9960.004
6.8099.9960.004
6.82099.9960.004
6.84099.9960.004
6.86099.9970.003
6.88099.9970.003
6.9099.9970.003
6.92099.9970.003
6.94099.9970.003
6.96099.9970.003
6.98099.9970.003
7099.9980.002
7.02099.9980.002
7.04099.9980.002
7.06099.9980.002
7.08099.9980.002
7.1099.9980.002
7.12099.9980.002
7.14099.9980.002
7.16099.9980.002
7.18099.9980.002
7.2099.9980.002
7.22099.9990.001
7.24099.9990.001
7.26099.9990.001
7.28099.9990.001
7.3099.9990.001
7.32099.9990.001
7.34099.9990.001
7.36099.9990.001
7.38099.9990.001
7.4099.9990.001
7.42099.9990.001
7.44099.9990.001
7.46099.9990.001
7.48099.9990.001
7.5099.9990.001
7.52099.9990.001
7.54099.9990.001
7.56099.9990.001
7.58099.9990.001
7.6099.9990.001
7.62099.9990.001
7.64099.9990.001
7.66099.9990.001
7.68099.9990.001
7.701000
7.7201000
7.7401000
7.7601000
7.7801000
7.801000
7.8201000
7.8401000
7.8601000
7.8801000
7.901000
7.9201000
7.9401000
7.9601000
7.9801000
801000
8.0201000
8.0401000
8.0601000
8.0801000
8.101000
8.1201000
8.1401000
8.1601000
8.1801000
8.201000
8.2201000
8.2401000
8.2601000
8.2801000
8.301000
8.3201000
8.3401000
8.3601000
8.3801000
8.401000
8.4201000
8.4401000
8.4601000
8.4801000
8.501000
8.5201000
8.5401000
8.5601000
8.5801000
8.601000
8.6201000
8.6401000
8.6601000
8.6801000
8.701000
8.7201000
8.7401000
8.7601000
8.7801000
8.801000
8.8201000
8.8401000
8.8601000
8.8801000
8.901000
8.9201000
8.9401000
8.9601000
8.9801000
901000
9.0201000
9.0401000
9.0601000
9.0801000
9.101000
9.1201000
9.1401000
9.1601000
9.1801000
9.201000
9.2201000
9.2401000
9.2601000
9.2801000
9.301000
9.3201000
9.3401000
9.3601000
9.3801000
9.401000
9.4201000
9.4401000
9.4601000
9.4801000
9.501000
9.5201000
9.5401000
9.5601000
9.5801000
9.601000
9.6201000
9.6401000
9.6601000
9.6801000
9.701000
9.7201000
9.7401000
9.7601000
9.7801000
9.801000
9.8201000
9.8401000
9.8601000
9.8801000
9.901000
9.9201000
9.9401000
9.9601000
9.9801000
1001000
10.0201000
10.0401000
10.0601000
10.0801000
10.101000
10.1201000
10.1401000
10.1601000
10.1801000
10.201000
10.2201000
10.2401000
10.2601000
10.2801000
10.301000
10.3201000
10.3401000
10.3601000
10.3801000
10.401000
10.4201000
10.4401000
10.4601000
10.4801000
10.501000
10.5201000
10.5401000
10.5601000
10.5801000
10.601000
10.6201000
10.6401000
10.6601000
10.6801000
10.701000
10.7201000
10.7401000
10.7601000
10.7801000
10.801000
10.8201000
10.8401000
10.8601000
10.8801000
10.901000
10.9201000
10.9401000
10.9601000
10.9801000
1101000
11.0201000
11.0401000
11.0601000
11.0801000
11.101000
11.1201000
11.1401000
11.1601000
11.1801000
11.201000
11.2201000
11.2401000
11.2601000
11.2801000
11.301000
11.3201000
11.3401000
11.3601000
11.3801000
11.401000
11.4201000
11.4401000
11.4601000
11.4801000
11.501000
11.5201000
11.5401000
11.5601000
11.5801000
11.601000
11.6201000
11.6401000
11.6601000
11.6801000
11.701000
11.7201000
11.7401000
11.7601000
11.7801000
11.801000
11.8201000
11.8401000
11.8601000
11.8801000
11.901000
11.9201000
11.9401000
11.9601000
11.9801000
1201000
GrafDOTA
99.99800.002
99.99700.003
99.99600.003
99.99600.004
99.99400.005
99.99300.007
99.9910.0010.008
99.9890.0010.01
99.9860.0010.013
99.9830.0010.016
99.9790.0020.02
99.9730.0020.025
99.9670.0030.03
99.9590.0030.038
99.9490.0040.047
99.9360.0060.058
99.920.0080.072
99.9010.010.089
99.8770.0130.111
99.8470.0160.137
99.810.0210.169
99.7640.0280.209
99.7070.0360.257
99.6370.0460.317
99.550.0590.391
99.4430.0760.48
99.3120.0980.59
99.1510.1260.724
98.9520.1610.886
98.710.2061.084
98.4140.2641.322
98.0540.3361.61
97.6170.4281.955
97.0890.5432.368
96.4550.6862.859
95.6960.8643.44
94.7941.0844.122
93.7291.3544.917
92.4831.6835.834
91.0372.0796.884
89.3762.5538.072
87.4883.1139.4
85.3663.76810.866
83.0124.52512.463
80.4335.3914.177
77.6436.36615.991
74.6647.45417.882
71.5248.65319.823
68.2569.95821.786
64.89611.36323.741
61.4812.8625.66
58.04514.4427.515
54.62416.09229.283
51.24917.80730.944
47.94719.57232.481
44.7421.37833.882
41.64823.21535.137
38.68525.07336.242
35.86226.94537.194
33.18428.82237.994
30.65630.69838.646
28.2832.56739.154
26.05334.42439.524
23.97336.26439.763
22.03638.08539.88
20.23639.88239.882
18.56841.65439.779
17.02443.39739.579
15.59945.11139.29
14.28446.79438.922
13.07448.44538.481
11.9650.06337.977
10.93851.64737.415
9.99953.19836.804
9.13854.71436.149
8.34956.19535.457
7.62657.64234.733
6.96459.05433.982
6.35960.43133.209
5.80661.77432.42
5.363.08331.617
4.83864.35830.804
4.41665.629.985
4.0366.80829.163
3.67867.98228.34
3.35669.12527.519
3.06370.23526.702
2.79571.31325.892
2.55172.3625.09
2.32873.37524.297
2.12474.36123.515
1.93975.31622.745
1.76976.24221.988
1.61577.13921.246
1.47478.00820.518
1.34578.84919.806
1.22879.66219.11
1.12180.44918.43
1.02481.2117.767
0.93581.94517.121
0.85382.65516.492
0.77983.34115.88
0.71284.00215.286
0.6584.64114.709
0.59485.25714.149
0.54285.85113.606
0.49686.42413.081
0.45386.97512.572
0.41487.50712.079
0.37888.01911.603
0.34688.51111.143
0.31688.98610.698
0.28989.44210.269
0.26489.8819.855
0.24290.3039.456
0.22190.7089.071
0.20291.0988.7
0.18591.4738.342
0.16991.8337.998
0.15592.1787.667
0.14292.517.348
0.1392.8287.042
0.11993.1346.747
0.10993.4286.464
0.193.7096.191
0.09193.9795.93
0.08494.2385.678
0.07794.4865.437
0.0794.7245.205
0.06594.9524.983
0.05995.1714.77
0.05495.384.565
0.0595.5814.369
0.04695.7744.181
0.04295.9584
0.03996.1343.827
0.03596.3033.661
0.03396.4653.502
0.0396.623.35
0.02896.7683.204
0.02596.913.065
0.02397.0462.931
0.02297.1762.803
0.0297.32.68
0.01897.4192.562
0.01797.5332.45
0.01697.6422.342
0.01497.7462.239
0.01397.8462.141
0.01297.9412.046
0.01198.0331.956
0.0198.121.87
0.0198.2031.787
0.00998.2831.708
0.00898.3591.632
0.00898.4321.56
0.00798.5021.491
0.00798.5691.425
0.00698.6321.362
0.00698.6931.301
0.00598.7521.243
0.00598.8071.188
0.00598.861.135
0.00498.9111.085
0.00498.961.036
0.00499.0060.99
0.00399.0510.946
0.00399.0930.904
0.00399.1340.863
0.00399.1720.825
0.00399.2090.788
0.00299.2450.753
0.00299.2790.719
0.00299.3110.687
0.00299.3420.656
0.00299.3710.627
0.00299.3990.599
0.00299.4260.572
0.00299.4520.547
0.00199.4770.522
0.00199.50.499
0.00199.5220.476
0.00199.5440.455
0.00199.5640.435
0.00199.5840.415
0.00199.6020.397
0.00199.620.379
0.00199.6370.362
0.00199.6540.346
0.00199.6690.33
0.00199.6840.315
0.00199.6980.301
0.00199.7120.288
0.00199.7250.275
0.00199.7370.262
0.00199.7490.251
0.00199.760.239
0.00199.7710.229
099.7810.218
099.7910.208
099.80.199
099.8090.19
099.8180.182
099.8260.173
099.8340.166
099.8410.158
099.8490.151
099.8550.144
099.8620.138
099.8680.132
099.8740.126
099.880.12
099.8850.115
099.890.11
099.8950.105
099.90.1
099.9040.095
099.9090.091
099.9130.087
099.9170.083
099.920.079
099.9240.076
099.9270.072
099.9310.069
099.9340.066
099.9370.063
099.940.06
099.9420.058
099.9450.055
099.9470.052
099.950.05
099.9520.048
099.9540.046
099.9560.044
099.9580.042
099.960.04
099.9620.038
099.9640.036
099.9650.035
099.9670.033
099.9680.032
099.970.03
099.9710.029
099.9720.028
099.9740.026
099.9750.025
099.9760.024
099.9770.023
099.9780.022
099.9790.021
099.980.02
099.9810.019
099.9820.018
099.9830.017
099.9830.017
099.9840.016
099.9850.015
099.9860.014
099.9860.014
099.9870.013
099.9870.013
099.9880.012
099.9880.011
099.9890.011
099.990.01
099.990.01
099.990.01
099.9910.009
099.9910.009
099.9920.008
099.9920.008
099.9920.008
099.9930.007
099.9930.007
099.9930.007
099.9940.006
099.9940.006
099.9940.006
099.9940.005
099.9950.005
099.9950.005
099.9950.005
099.9950.005
099.9960.004
099.9960.004
099.9960.004
099.9960.004
099.9960.004
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9970.003
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9980.002
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
099.9990.001
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
01000
Gd(III)
[GdL]
[HGdL]
pH
% Gd(III)
Gd-DOTA
DOTA
199.99800.002
1.0299.99700.003
1.0499.99600.003
1.0699.99600.004
1.0899.99400.005
1.199.99300.007
1.1299.9910.0010.008
1.1499.9890.0010.01
1.1699.9860.0010.013
1.1899.9830.0010.016
1.299.9790.0020.02
1.2299.9730.0020.025
1.2499.9670.0030.03
1.2699.9590.0030.038
1.2899.9490.0040.047
1.399.9360.0060.058
1.3299.920.0080.072
1.3499.9010.010.089
1.3699.8770.0130.111
1.3899.8470.0160.137
1.499.810.0210.169
1.4299.7640.0280.209
1.4499.7070.0360.257
1.4699.6370.0460.317
1.4899.550.0590.391
1.599.4430.0760.48
1.5299.3120.0980.59
1.5499.1510.1260.724
1.5698.9520.1610.886
1.5898.710.2061.084
1.698.4140.2641.322
1.6298.0540.3361.61
1.6497.6170.4281.955
1.6697.0890.5432.368
1.6896.4550.6862.859
1.795.6960.8643.44
1.7294.7941.0844.122
1.7493.7291.3544.917
1.7692.4831.6835.834
1.7891.0372.0796.884
1.889.3762.5538.072
1.8287.4883.1139.4
1.8485.3663.76810.866
1.8683.0124.52512.463
1.8880.4335.3914.177
1.977.6436.36615.991
1.9274.6647.45417.882
1.9471.5248.65319.823
1.9668.2569.95821.786
1.9864.89611.36323.741
261.4812.8625.66
2.0258.04514.4427.515
2.0454.62416.09229.283
2.0651.24917.80730.944
2.0847.94719.57232.481
2.144.7421.37833.882
2.1241.64823.21535.137
2.1438.68525.07336.242
2.1635.86226.94537.194
2.1833.18428.82237.994
2.230.65630.69838.646
2.2228.2832.56739.154
2.2426.05334.42439.524
2.2623.97336.26439.763
2.2822.03638.08539.88
2.320.23639.88239.882
2.3218.56841.65439.779
2.3417.02443.39739.579
2.3615.59945.11139.29
2.3814.28446.79438.922
2.413.07448.44538.481
2.4211.9650.06337.977
2.4410.93851.64737.415
2.469.99953.19836.804
2.489.13854.71436.149
2.58.34956.19535.457
2.527.62657.64234.733
2.546.96459.05433.982
2.566.35960.43133.209
2.585.80661.77432.42
2.65.363.08331.617
2.624.83864.35830.804
2.644.41665.629.985
2.664.0366.80829.163
2.683.67867.98228.34
2.73.35669.12527.519
2.723.06370.23526.702
2.742.79571.31325.892
2.762.55172.3625.09
2.782.32873.37524.297
2.82.12474.36123.515
2.821.93975.31622.745
2.841.76976.24221.988
2.861.61577.13921.246
2.881.47478.00820.518
2.91.34578.84919.806
2.921.22879.66219.11
2.941.12180.44918.43
2.961.02481.2117.767
2.980.93581.94517.121
30.85382.65516.492
3.020.77983.34115.88
3.040.71284.00215.286
3.060.6584.64114.709
3.080.59485.25714.149
3.10.54285.85113.606
3.120.49686.42413.081
3.140.45386.97512.572
3.160.41487.50712.079
3.180.37888.01911.603
3.20.34688.51111.143
3.220.31688.98610.698
3.240.28989.44210.269
3.260.26489.8819.855
3.280.24290.3039.456
3.30.22190.7089.071
3.320.20291.0988.7
3.340.18591.4738.342
3.360.16991.8337.998
3.380.15592.1787.667
3.40.14292.517.348
3.420.1392.8287.042
3.440.11993.1346.747
3.460.10993.4286.464
3.480.193.7096.191
3.50.09193.9795.93
3.520.08494.2385.678
3.540.07794.4865.437
3.560.0794.7245.205
3.580.06594.9524.983
3.60.05995.1714.77
3.620.05495.384.565
3.640.0595.5814.369
3.660.04695.7744.181
3.680.04295.9584
3.70.03996.1343.827
3.720.03596.3033.661
3.740.03396.4653.502
3.760.0396.623.35
3.780.02896.7683.204
3.80.02596.913.065
3.820.02397.0462.931
3.840.02297.1762.803
3.860.0297.32.68
3.880.01897.4192.562
3.90.01797.5332.45
3.920.01697.6422.342
3.940.01497.7462.239
3.960.01397.8462.141
3.980.01297.9412.046
40.01198.0331.956
4.020.0198.121.87
4.040.0198.2031.787
4.060.00998.2831.708
4.080.00898.3591.632
4.10.00898.4321.56
4.120.00798.5021.491
4.140.00798.5691.425
4.160.00698.6321.362
4.180.00698.6931.301
4.20.00598.7521.243
4.220.00598.8071.188
4.240.00598.861.135
4.260.00498.9111.085
4.280.00498.961.036
4.30.00499.0060.99
4.320.00399.0510.946
4.340.00399.0930.904
4.360.00399.1340.863
4.380.00399.1720.825
4.40.00399.2090.788
4.420.00299.2450.753
4.440.00299.2790.719
4.460.00299.3110.687
4.480.00299.3420.656
4.50.00299.3710.627
4.520.00299.3990.599
4.540.00299.4260.572
4.560.00299.4520.547
4.580.00199.4770.522
4.60.00199.50.499
4.620.00199.5220.476
4.640.00199.5440.455
4.660.00199.5640.435
4.680.00199.5840.415
4.70.00199.6020.397
4.720.00199.620.379
4.740.00199.6370.362
4.760.00199.6540.346
4.780.00199.6690.33
4.80.00199.6840.315
4.820.00199.6980.301
4.840.00199.7120.288
4.860.00199.7250.275
4.880.00199.7370.262
4.90.00199.7490.251
4.920.00199.760.239
4.940.00199.7710.229
4.96099.7810.218
4.98099.7910.208
5099.80.199
5.02099.8090.19
5.04099.8180.182
5.06099.8260.173
5.08099.8340.166
5.1099.8410.158
5.12099.8490.151
5.14099.8550.144
5.16099.8620.138
5.18099.8680.132
5.2099.8740.126
5.22099.880.12
5.24099.8850.115
5.26099.890.11
5.28099.8950.105
5.3099.90.1
5.32099.9040.095
5.34099.9090.091
5.36099.9130.087
5.38099.9170.083
5.4099.920.079
5.42099.9240.076
5.44099.9270.072
5.46099.9310.069
5.48099.9340.066
5.5099.9370.063
5.52099.940.06
5.54099.9420.058
5.56099.9450.055
5.58099.9470.052
5.6099.950.05
5.62099.9520.048
5.64099.9540.046
5.66099.9560.044
5.68099.9580.042
5.7099.960.04
5.72099.9620.038
5.74099.9640.036
5.76099.9650.035
5.78099.9670.033
5.8099.9680.032
5.82099.970.03
5.84099.9710.029
5.86099.9720.028
5.88099.9740.026
5.9099.9750.025
5.92099.9760.024
5.94099.9770.023
5.96099.9780.022
5.98099.9790.021
6099.980.02
6.02099.9810.019
6.04099.9820.018
6.06099.9830.017
6.08099.9830.017
6.1099.9840.016
6.12099.9850.015
6.14099.9860.014
6.16099.9860.014
6.18099.9870.013
6.2099.9870.013
6.22099.9880.012
6.24099.9880.011
6.26099.9890.011
6.28099.990.01
6.3099.990.01
6.32099.990.01
6.34099.9910.009
6.36099.9910.009
6.38099.9920.008
6.4099.9920.008
6.42099.9920.008
6.44099.9930.007
6.46099.9930.007
6.48099.9930.007
6.5099.9940.006
6.52099.9940.006
6.54099.9940.006
6.56099.9940.005
6.58099.9950.005
6.6099.9950.005
6.62099.9950.005
6.64099.9950.005
6.66099.9960.004
6.68099.9960.004
6.7099.9960.004
6.72099.9960.004
6.74099.9960.004
6.76099.9970.003
6.78099.9970.003
6.8099.9970.003
6.82099.9970.003
6.84099.9970.003
6.86099.9970.003
6.88099.9970.003
6.9099.9970.003
6.92099.9980.002
6.94099.9980.002
6.96099.9980.002
6.98099.9980.002
7099.9980.002
7.02099.9980.002
7.04099.9980.002
7.06099.9980.002
7.08099.9980.002
7.1099.9980.002
7.12099.9980.002
7.14099.9990.001
7.16099.9990.001
7.18099.9990.001
7.2099.9990.001
7.22099.9990.001
7.24099.9990.001
7.26099.9990.001
7.28099.9990.001
7.3099.9990.001
7.32099.9990.001
7.34099.9990.001
7.36099.9990.001
7.38099.9990.001
7.4099.9990.001
7.42099.9990.001
7.44099.9990.001
7.46099.9990.001
7.48099.9990.001
7.5099.9990.001
7.52099.9990.001
7.54099.9990.001
7.56099.9990.001
7.58099.9990.001
7.6099.9990.001
7.6201000
7.6401000
7.6601000
7.6801000
7.701000
7.7201000
7.7401000
7.7601000
7.7801000
7.801000
7.8201000
7.8401000
7.8601000
7.8801000
7.901000
7.9201000
7.9401000
7.9601000
7.9801000
801000
8.0201000
8.0401000
8.0601000
8.0801000
8.101000
8.1201000
8.1401000
8.1601000
8.1801000
8.201000
8.2201000
8.2401000
8.2601000
8.2801000
8.301000
8.3201000
8.3401000
8.3601000
8.3801000
8.401000
8.4201000
8.4401000
8.4601000
8.4801000
8.501000
8.5201000
8.5401000
8.5601000
8.5801000
8.601000
8.6201000
8.6401000
8.6601000
8.6801000
8.701000
8.7201000
8.7401000
8.7601000
8.7801000
8.801000
8.8201000
8.8401000
8.8601000
8.8801000
8.901000
8.9201000
8.9401000
8.9601000
8.9801000
901000
9.0201000
9.0401000
9.0601000
9.0801000
9.101000
9.1201000
9.1401000
9.1601000
9.1801000
9.201000
9.2201000
9.2401000
9.2601000
9.2801000
9.301000
9.3201000
9.3401000
9.3601000
9.3801000
9.401000
9.4201000
9.4401000
9.4601000
9.4801000
9.501000
9.5201000
9.5401000
9.5601000
9.5801000
9.601000
9.6201000
9.6401000
9.6601000
9.6801000
9.701000
9.7201000
9.7401000
9.7601000
9.7801000
9.801000
9.8201000
9.8401000
9.8601000
9.8801000
9.901000
9.9201000
9.9401000
9.9601000
9.9801000
1001000
10.0201000
10.0401000
10.0601000
10.0801000
10.101000
10.1201000
10.1401000
10.1601000
10.1801000
10.201000
10.2201000
10.2401000
10.2601000
10.2801000
10.301000
10.3201000
10.3401000
10.3601000
10.3801000
10.401000
10.4201000
10.4401000
10.4601000
10.4801000
10.501000
10.5201000
10.5401000
10.5601000
10.5801000
10.601000
10.6201000
10.6401000
10.6601000
10.6801000
10.701000
10.7201000
10.7401000
10.7601000
10.7801000
10.801000
10.8201000
10.8401000
10.8601000
10.8801000
10.901000
10.9201000
10.9401000
10.9601000
10.9801000
1101000
11.0201000
11.0401000
11.0601000
11.0801000
11.101000
11.1201000
11.1401000
11.1601000
11.1801000
11.201000
11.2201000
11.2401000
11.2601000
11.2801000
11.301000
11.3201000
11.3401000
11.3601000
11.3801000
11.401000
11.4201000
11.4401000
11.4601000
11.4801000
11.501000
11.5201000
11.5401000
11.5601000
11.5801000
11.601000
11.6201000
11.6401000
11.6601000
11.6801000
11.701000
11.7201000
11.7401000
11.7601000
11.7801000
11.801000
11.8201000
11.8401000
11.8601000
11.8801000
11.901000
11.9201000
11.9401000
11.9601000
11.9801000
1201000
Konstanty
DOTADTPADTPA-BMA
Hl11.710.799.37
H2L9.78.644.38
H3L4.594.283.31
H4L4.142.71.4
H5L2.352
H6L1.71.6
H7L0.7
GdL24.722.3916.86
HGdL2.32.39
11.710.799.37
21.419.4313.75
25.9923.7117.06
30.1326.4118.46
32.4828.41
34.1830.01
30.71
24.722.3916.86
2724.78
GrafDTPA-BMA
67.39932.601
64.5435.46
61.64438.356
58.73441.266
55.83144.169
52.95447.046
50.12149.879
47.34852.652
44.64855.352
42.03257.968
39.50860.492
37.08562.915
34.76565.235
32.55367.447
30.44969.551
28.45471.546
26.56873.432
24.78775.213
23.1176.89
21.53478.466
20.05579.945
18.66881.332
17.3782.63
16.15783.843
15.02584.975
13.96886.032
12.98287.018
12.06487.936
11.2188.79
10.41589.585
9.67690.324
8.98891.012
8.3591.65
7.75692.244
7.20592.795
6.69493.306
6.21993.781
5.77894.222
5.36994.631
4.98995.011
4.63795.363
4.30995.691
4.00695.994
3.72496.276
3.46396.537
3.2296.78
2.99597.005
2.78697.214
2.59297.408
2.41297.588
2.24497.756
2.08997.911
1.94598.055
1.81198.189
1.68698.314
1.5798.43
1.46398.537
1.36398.637
1.2798.73
1.18498.816
1.10398.897
1.02998.971
0.95999.041
0.89599.105
0.83499.166
0.77899.222
0.72699.274
0.67899.322
0.63399.367
0.59199.409
0.55299.448
0.51599.485
0.48199.519
0.4599.55
0.4299.58
0.39399.607
0.36799.633
0.34399.657
0.32199.679
0.399.7
0.28199.719
0.26399.737
0.24699.754
0.2399.77
0.21699.784
0.20299.798
0.18999.811
0.17799.823
0.16699.834
0.15699.844
0.14699.854
0.13799.863
0.12999.871
0.12199.879
0.11399.887
0.10699.894
0.199.9
0.09499.906
0.08899.912
0.08399.917
0.07899.922
0.07399.927
0.06999.931
0.06599.935
0.06199.939
0.05899.942
0.05499.946
0.05199.949
0.04899.952
0.04599.955
0.04399.957
0.0499.96
0.03899.962
0.03699.964
0.03499.966
0.03299.968
0.0399.97
0.02999.971
0.02799.973
0.02699.974
0.02499.976
0.02399.977
0.02299.978
0.02199.979
0.0299.98
0.01999.981
0.01899.982
0.01799.983
0.01699.984
0.01599.985
0.01499.986
0.01499.986
0.01399.987
0.01299.988
0.01299.988
0.01199.989
0.01199.989
0.0199.99
0.0199.99
0.00999.991
0.00999.991
0.00899.992
0.00899.992
0.00899.992
0.00799.993
0.00799.993
0.00799.993
0.00699.994
0.00699.994
0.00699.994
0.00699.994
0.00599.995
0.00599.995
0.00599.995
0.00599.995
0.00599.995
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00499.996
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00399.997
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00299.998
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0.00199.999
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
0100
Gd(III)
[GdL]
pH
% Gd(III)
Gd-DTPABMA
DTPA-BMA
167.39932.601
1.0264.5435.46
1.0461.64438.356
1.0658.73441.266
1.0855.83144.169
1.152.95447.046
1.1250.12149.879
1.1447.34852.652
1.1644.64855.352
1.1842.03257.968
1.239.50860.492
1.2237.08562.915
1.2434.76565.235
1.2632.55367.447
1.2830.44969.551
1.328.45471.546
1.3226.56873.432
1.3424.78775.213
1.3623.1176.89
1.3821.53478.466
1.420.05579.945
1.4218.66881.332
1.4417.3782.63
1.4616.15783.843
1.4815.02584.975
1.513.96886.032
1.5212.98287.018
1.5412.06487.936
1.5611.2188.79
1.5810.41589.585
1.69.67690.324
1.628.98891.012
1.648.3591.65
1.667.75692.244
1.687.20592.795
1.76.69493.306
1.726.21993.781
1.745.77894.222
1.765.36994.631
1.784.98995.011
1.84.63795.363
1.824.30995.691
1.844.00695.994
1.863.72496.276
1.883.46396.537
1.93.2296.78
1.922.99597.005
1.942.78697.214
1.962.59297.408
1.982.41297.588
22.24497.756
2.022.08997.911
2.041.94598.055
2.061.81198.189
2.081.68698.314
2.11.5798.43
2.121.46398.537
2.141.36398.637
2.161.2798.73
2.181.18498.816
2.21.10398.897
2.221.02998.971
2.240.95999.041
2.260.89599.105
2.280.83499.166
2.30.77899.222
2.320.72699.274
2.340.67899.322
2.360.63399.367
2.380.59199.409
2.40.55299.448
2.420.51599.485
2.440.48199.519
2.460.4599.55
2.480.4299.58
2.50.39399.607
2.520.36799.633
2.540.34399.657
2.560.32199.679
2.580.399.7
2.60.28199.719
2.620.26399.737
2.640.24699.754
2.660.2399.77
2.680.21699.784
2.70.20299.798
2.720.18999.811
2.740.17799.823
2.760.16699.834
2.780.15699.844
2.80.14699.854
2.820.13799.863
2.840.12999.871
2.860.12199.879
2.880.11399.887
2.90.10699.894
2.920.199.9
2.940.09499.906
2.960.08899.912
2.980.08399.917
30.07899.922
3.020.07399.927
3.040.06999.931
3.060.06599.935
3.080.06199.939
3.10.05899.942
3.120.05499.946
3.140.05199.949
3.160.04899.952
3.180.04599.955
3.20.04399.957
3.220.0499.96
3.240.03899.962
3.260.03699.964
3.280.03499.966
3.30.03299.968
3.320.0399.97
3.340.02999.971
3.360.02799.973
3.380.02699.974
3.40.02499.976
3.420.02399.977
3.440.02299.978
3.460.02199.979
3.480.0299.98
3.50.01999.981
3.520.01899.982
3.540.01799.983
3.560.01699.984
3.580.01599.985
3.60.01499.986
3.620.01499.986
3.640.01399.987
3.660.01299.988
3.680.01299.988
3.70.01199.989
3.720.01199.989
3.740.0199.99
3.760.0199.99
3.780.00999.991
3.80.00999.991
3.820.00899.992
3.840.00899.992
3.860.00899.992
3.880.00799.993
3.90.00799.993
3.920.00799.993
3.940.00699.994
3.960.00699.994
3.980.00699.994
40.00699.994
4.020.00599.995
4.040.00599.995
4.060.00599.995
4.080.00599.995
4.10.00599.995
4.120.00499.996
4.140.00499.996
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4.180.00499.996
4.20.00499.996
4.220.00499.996
4.240.00399.997
4.260.00399.997
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4.30.00399.997
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4.340.00399.997
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4.40.00399.997
4.420.00299.998
4.440.00299.998
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4.520.00299.998
4.540.00299.998
4.560.00299.998
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50.00199.999
5.020.00199.999
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5.10.00199.999
5.120.00199.999
5.140.00199.999
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5.180.00199.999
5.20.00199.999
5.220.00199.999
5.240.00199.999
5.260.00199.999
5.280.00199.999
5.30.00199.999
5.320.00199.999
5.340.00199.999
5.360.00199.999
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5.40.00199.999
5.420.00199.999
5.440.00199.999
5.460.00199.999
5.480.00199.999
5.50.00199.999
5.520.00199.999
5.540100
5.560100
5.580100
5.60100
5.620100
5.640100
5.660100
5.680100
5.70100
5.720100
5.740100
5.760100
5.780100
5.80100
5.820100
5.840100
5.860100
5.880100
5.90100
5.920100
5.940100
5.960100
5.980100
60100
6.020100
6.040100
6.060100
6.080100
6.10100
6.120100
6.140100
6.160100
6.180100
6.20100
6.220100
6.240100
6.260100
6.280100
6.30100
6.320100
6.340100
6.360100
6.380100
6.40100
6.420100
6.440100
6.460100
6.480100
6.50100
6.520100
6.540100
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6.840100
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70100
7.020100
7.040100
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7.10100
7.120100
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7.180100
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7.220100
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7.30100
7.320100
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7.40100
7.420100
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7.640100
7.660100
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7.840100
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80100
8.020100
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8.220100
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8.820100
8.840100
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8.940100
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90100
9.020100
9.040100
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9.120100
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9.220100
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9.320100
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9.640100
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9.840100
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9.940100
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9.980100
100100
10.020100
10.040100
10.060100
10.080100
10.10100
10.120100
10.140100
10.160100
10.180100
10.20100
10.220100
10.240100
10.260100
10.280100
10.30100
10.320100
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10.380100
10.40100
10.420100
10.440100
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10.50100
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10.540100
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10.60100
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10.640100
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10.840100
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10.940100
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10.980100
110100
11.020100
11.040100
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11.10100
11.120100
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11.160100
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11.20100
11.220100
11.240100
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11.820100
11.840100
11.860100
11.880100
11.90100
11.920100
11.940100
11.960100
11.980100
120100
GrafDTPA
99.8630.0050.132
99.8260.0070.167
99.780.0090.211
99.7220.0120.266
99.6490.0160.335
99.5580.0220.421
99.4440.0280.528
99.3010.0370.662
99.1230.0490.828
98.9030.0641.034
98.6290.0831.288
98.2920.1081.6
97.8770.141.983
97.3690.1822.45
96.750.2343.016
96.0020.3013.698
95.1020.3844.514
94.030.4895.482
92.7630.6186.619
91.2820.7767.942
89.5690.9689.463
87.6121.19911.189
85.4041.47213.123
82.9491.79315.258
80.2552.16317.582
77.3432.58620.071
74.2393.06222.699
70.9773.59225.431
67.5944.17628.231
64.1314.8131.059
60.6295.49433.877
57.1266.22436.65
53.6586.99739.345
50.2577.80941.935
46.9498.65644.395
43.7569.53646.708
40.69510.44648.859
37.77711.38250.841
35.01112.34252.647
32.40113.32354.276
29.94814.32455.728
27.65115.34357.006
25.50716.37958.115
23.51117.4359.06
21.65718.49559.848
19.93919.57360.488
18.34920.66560.986
16.88121.76861.351
15.52722.88361.59
14.27824.00961.713
13.12925.14661.725
12.07226.29261.636
11.127.44961.451
10.20628.61561.178
9.38629.7960.824
8.63230.97460.394
7.9432.16559.894
7.30533.36459.331
6.72234.5758.708
6.18735.78258.031
5.69636.99957.305
5.24538.22156.534
4.83139.44855.721
4.45140.67754.872
4.10241.90953.989
3.78143.14253.077
3.48644.37652.138
3.21545.6151.175
2.96746.84250.192
2.73848.07149.191
2.52749.29748.175
2.33450.51947.147
2.15551.73546.109
1.99152.94545.064
1.8454.14744.012
1.70155.34142.958
1.57356.52541.902
1.45557.69840.847
1.34658.8639.794
1.24660.00938.745
1.15361.14537.702
1.06862.26736.665
0.98963.37335.637
0.91664.46434.619
0.84965.53933.612
0.78766.59632.617
0.7367.63531.635
0.67768.65630.667
0.62869.65829.715
0.58270.6428.777
0.5471.60327.857
0.50272.54526.953
0.46673.46726.067
0.43274.36825.199
0.40275.24824.35
0.37376.10723.519
0.34776.94522.708
0.32277.76121.916
0.378.55721.144
0.27979.3320.391
0.25980.08319.658
0.24180.81418.945
0.22481.52518.251
0.20982.21417.577
0.19482.88316.923
0.18183.53216.287
0.16884.1615.671
0.15784.76915.074
0.14685.35814.496
0.13685.92813.936
0.12786.47913.394
0.11887.01212.87
0.1187.52612.363
0.10388.02311.874
0.09688.50311.401
0.08988.96510.945
0.08389.41210.505
0.07889.84210.08
0.07390.2569.671
0.06890.6559.277
0.06391.048.897
0.05991.418.531
0.05591.7668.179
0.05292.1097.84
0.04892.4387.514
0.04592.7557.2
0.04293.0596.899
0.03993.3526.609
0.03793.6336.33
0.03593.9036.063
0.03294.1625.806
0.0394.415.559
0.02894.6495.323
0.02694.8785.095
0.02595.0984.877
0.02395.3094.668
0.02295.5114.467
0.0295.7054.275
0.01995.894.09
0.01896.0683.914
0.01796.2393.744
0.01696.4033.582
0.01596.5593.426
0.01496.7093.277
0.01396.8533.134
0.01296.992.997
0.01197.1222.866
0.01197.2482.741
0.0197.3692.621
0.0197.4852.506
0.00997.5952.396
0.00897.7012.29
0.00897.8032.19
0.00797.8992.093
0.00797.9922.001
0.00798.0811.912
0.00698.1661.828
0.00698.2471.747
0.00698.3251.67
0.00598.3991.596
0.00598.471.525
0.00598.5381.457
0.00498.6031.393
0.00498.6651.331
0.00498.7241.272
0.00498.7811.215
0.00398.8351.161
0.00398.8871.11
0.00398.9371.06
0.00398.9841.013
0.00399.0290.968
0.00399.0730.925
0.00299.1140.883
0.00299.1540.844
0.00299.1920.806
0.00299.2280.77
0.00299.2620.736
0.00299.2950.703
0.00299.3270.672
0.00299.3570.642
0.00299.3860.613
0.00299.4130.585
0.00199.4390.559
0.00199.4640.534
0.00199.4880.51
0.00199.5110.487
0.00199.5330.466
0.00199.5540.445
0.00199.5740.425
0.00199.5930.406
0.00199.6120.388
0.00199.6290.37
0.00199.6460.354
0.00199.6610.338
0.00199.6770.323
0.00199.6910.308
0.00199.7050.294
0.00199.7180.281
0.00199.7310.268
0.00199.7430.256
0.00199.7550.245
0.00199.7660.234
0.00199.7760.223
099.7860.213
099.7960.204
099.8050.195
099.8140.186
099.8220.178
099.830.17
099.8380.162
099.8450.155
099.8520.148
099.8590.141
099.8650.135
099.8710.129
099.8770.123
